Navigation Links
Researchers develop novel molecular blood group typing technique
Date:4/9/2014

Philadelphia, PA, April 10, 2014 Scientists in France have designed a new system for molecular blood group typing that offers blood banks the possibility of extensive screening of blood donors at a relatively low cost. Their approach is described in the current issue of The Journal of Molecular Diagnostics.

Although blood transfusion is generally safe, alloimmunization (when an antibody is formed in response to an antigen that is not present on a person's own red blood cells [RBCs]) remains a dreaded complication, particularly in patients with sickle cell diseases.

"This may cause problems, ranging from delayed hemolytic transfusion reaction to difficulty in obtaining matched RBCs. Where patients have alloantibodies, producing a sufficient quantity of extensively typed blood units will never be feasible using conventional serologic donor screening methods," explains lead investigator Jean-Charles Brs, PhD, of the Etablissement Franais du Sang Pyrnes Mditerrane, Montpellier.

The standard technique, conventional hemagglutination, is a lengthy procedure and involves only a limited range of antigen testing. In this antibody-based agglutination, RBCs suspended in liquid collect into clumps when bound by the antigen-specific antibody. Dr. Brs adds, "In the French Blood Service, the Etablissement Franais du Sang (EFS), blood donation qualification laboratories test all blood donations for A, B, O, Rhesus (RH1), and KEL (KEL1) blood groups, but only 5% to 10% of donations are tested for other clinically significant antigens."

The investigators therefore developed a new flexible DNA microarray platform for molecular blood group typing. This includes two robotic workstations that allow processing from blood sample to the genotype. A pilot study shows promising results for responding to blood donor laboratories' requirements for simple, low-cost screening.

For small batch production, the cost of genotyping, includi
'/>"/>

Contact: Eileen Leahy
mdmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover how the kissing disease virus hijacks human cells
2. Researchers say Neanderthals were no strangers to good parenting
3. UNC researchers show how cancer cells may respond to mechanical force
4. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
5. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
6. Researchers receive $1.14 million to study threats to honey bees
7. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
8. Guelph researchers solve part of hagfish slime mystery
9. Researchers design trees that make it easier to produce paper
10. Researchers manipulate tiny objects with ultrasound
11. UCSB researchers create first regional Ocean Health Index
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... 13, 2009) Boston College Chemistry Professor Udayan Mohanty ... Foundation Fellowship for his theoretical studies of rare chemical ... among the 180 scientists, artists and scholars chosen from ... to receive a Guggenheim this year, Mohanty credited his ...
... of the "longevity" protein SIRT1. By speeding the destruction of ... will be published online April 13 ( www.jcb.org ) and ... Journal of Cell Biology . The yeast ... stretch lifespan. Whether SIRT1 slows aging in mammals isn,t certain, ...
... Here is the latest American Chemical Society (ACS) Weekly ... news from ACS, 34 peer-reviewed journals and Chemical & ... Chemical Society as the source for this information. ... ARTICLE # 1 FOR IMMEDIATE RELEASE, Solving the ...
Cached Biology News:American Chemical Society Weekly PressPac -- April 8, 2009 2American Chemical Society Weekly PressPac -- April 8, 2009 3American Chemical Society Weekly PressPac -- April 8, 2009 4American Chemical Society Weekly PressPac -- April 8, 2009 5American Chemical Society Weekly PressPac -- April 8, 2009 6American Chemical Society Weekly PressPac -- April 8, 2009 7American Chemical Society Weekly PressPac -- April 8, 2009 8American Chemical Society Weekly PressPac -- April 8, 2009 9American Chemical Society Weekly PressPac -- April 8, 2009 10American Chemical Society Weekly PressPac -- April 8, 2009 11
(Date:5/27/2015)... May 27, 2015  RXi Pharmaceuticals Corporation (NASDAQ: ... discovering and developing innovative therapies primarily in the ... on the status of the Company,s Series A ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ... 21 shares of Series A Preferred Stock and ...
(Date:5/26/2015)... and BELLINGHAM, Washington, USA (PRWEB) May 26, 2015 ... signed a formal partnership with the Max Planck ... for Extreme and Quantum Photonics. The center will link ... field of photonics, and will be only the third ... of SPIE, the international society for optics and ...
(Date:5/26/2015)... Rialto, CA (PRWEB) May 26, 2015 ... devices and solutions in the human and animal ... company’s annual Vetericyn® Future Innovators of Agriculture College ... high school senior who exhibits a passionate commitment ... positions. , This year’s winners, Alexis Pedrow ...
(Date:5/26/2015)... , May 26, 2015  Sangamo BioSciences, Inc. (NASDAQ: ... president and CEO, will provide an update on the progress ... overview of the company,s business strategy at 1:30pm ET on ... Conference. The conference is being held in New ... webcast live and may be accessed via a link on ...
Breaking Biology Technology:RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3Third Max Planck Centre in North America Inaugurated at University of Ottawa 2Third Max Planck Centre in North America Inaugurated at University of Ottawa 3Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2
... Jan. 11 Maxygen, Inc.,(Nasdaq: MAXY ), ... protein drugs, today announced that it will present ... on Thursday,January 17, 2008 at 7:45 a.m. Eastern ... A live webcast of the presentation can be,accessed ...
... - Vasogen Inc.,(NASDAQ: VSGN ; TSX:VAS), a biotechnology ... technologies targeting the chronic inflammation,underlying cardiovascular and neurological ... on Wednesday, January 16, 2008. A conference,call will ... management will,provide a Company update and discuss year-end ...
... (NYSE: CRY ),a biomaterials, medical device and tissue ... a lawsuit will be filed against it in,the Superior ... The lawsuit concerns an individual who contracted an ... 2006. Meniscal,transplants are commonly used for patients with significant ...
Cached Biology Technology:Vasogen to Conduct Year-end 2007 Conference Call 2Vasogen to Conduct Year-end 2007 Conference Call 3Vasogen to Conduct Year-end 2007 Conference Call 4CryoLife Responds to Inaccurate Assertions from Plaintiff's Attorney 2CryoLife Responds to Inaccurate Assertions from Plaintiff's Attorney 3
... is a new-generation siRNA transfection reagent that ... 1 nM siRNA in a wide variety ... cell viability. Using low siRNA concentrations avoids ... when transfecting siRNA at higher concentrations, thereby ...
... and Tissue Staining Kits are intended for ... of histological and cytological specimens. These kits ... manufactured by either R&D Systems or by ... the formation of the Avidin-Biotin Complex (ABC) ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
... an easy-to-use siRNA transfection reagent that has ... in a variety of cell lines. jetSI-ENDO ... optimized, straightforward protocol. High levels of gene ... transfection of 20 to 100 nM of ...
Biology Products: