Navigation Links
Researchers develop novel molecular blood group typing technique
Date:4/9/2014

Philadelphia, PA, April 10, 2014 Scientists in France have designed a new system for molecular blood group typing that offers blood banks the possibility of extensive screening of blood donors at a relatively low cost. Their approach is described in the current issue of The Journal of Molecular Diagnostics.

Although blood transfusion is generally safe, alloimmunization (when an antibody is formed in response to an antigen that is not present on a person's own red blood cells [RBCs]) remains a dreaded complication, particularly in patients with sickle cell diseases.

"This may cause problems, ranging from delayed hemolytic transfusion reaction to difficulty in obtaining matched RBCs. Where patients have alloantibodies, producing a sufficient quantity of extensively typed blood units will never be feasible using conventional serologic donor screening methods," explains lead investigator Jean-Charles Brs, PhD, of the Etablissement Franais du Sang Pyrnes Mditerrane, Montpellier.

The standard technique, conventional hemagglutination, is a lengthy procedure and involves only a limited range of antigen testing. In this antibody-based agglutination, RBCs suspended in liquid collect into clumps when bound by the antigen-specific antibody. Dr. Brs adds, "In the French Blood Service, the Etablissement Franais du Sang (EFS), blood donation qualification laboratories test all blood donations for A, B, O, Rhesus (RH1), and KEL (KEL1) blood groups, but only 5% to 10% of donations are tested for other clinically significant antigens."

The investigators therefore developed a new flexible DNA microarray platform for molecular blood group typing. This includes two robotic workstations that allow processing from blood sample to the genotype. A pilot study shows promising results for responding to blood donor laboratories' requirements for simple, low-cost screening.

For small batch production, the cost of genotyping, includi
'/>"/>

Contact: Eileen Leahy
mdmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover how the kissing disease virus hijacks human cells
2. Researchers say Neanderthals were no strangers to good parenting
3. UNC researchers show how cancer cells may respond to mechanical force
4. Dartmouth researchers identify potential therapeutic target for deadly brain cancer
5. Researchers find arid areas absorb unexpected amounts of atmospheric carbon
6. Researchers receive $1.14 million to study threats to honey bees
7. Swedish researchers show impact of long-term vitamin D insufficiency on fracture risk
8. Guelph researchers solve part of hagfish slime mystery
9. Researchers design trees that make it easier to produce paper
10. Researchers manipulate tiny objects with ultrasound
11. UCSB researchers create first regional Ocean Health Index
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... -- Earlier this year Donald Spector , Chairman of ... the most prolific inventors in the world, got a ... to third party agencies. Spector envisioned this technology even ... earliest known patents in this area. Now major technology ... care, elder care and hospital applications. This technology has ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws ... efficiency are piloting the North American and European automotive ... accidents growing, gesture recognition systems that are intuitive and ... mark in the industry. New analysis ... Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... computation of haplotypes provides insight into genetic basis of ... map of genetic variation which can give clues to ... technologies collect genotypes, or information from the individual's ... to the variations between individuals' DNA at the level ...
... figured out the fate of healthy protein when it ... yeast: The protein converts to the prion form, rendering ... , This quick-change "mating" maneuver sheds important light on ... cause fatal brain ailments such as mad cow disease ...
... virus in tissues from patients who died of a ... the strain of virus in the measles vaccine caused ... issue of The Journal of Infectious Diseases, now available ... many more cases of the disease, known as subacute ...
Cached Biology News:U-M scientists say fused genes trigger the development of prostate cancer 2U-M scientists say fused genes trigger the development of prostate cancer 3U-M scientists say fused genes trigger the development of prostate cancer 4Prions rapidly 'remodel' good protein into bad, Brown study shows 2New study shows measles immunization may prevent fatal brain infection 2
(Date:11/28/2014)... The report provides qualitative insights on ... sub-segments of the market, in order to provide information ... rates and market sizes for each sub-segment of the ... growth. It also includes analysis of the company profiles ... the financial performances, product portfolios, and developments of each ...
(Date:11/27/2014)... The Europe Thermal Protective Clothing ... provide crucial revenue forecasts. It estimates the market ... a CAGR of 7.5%, from 2013 to 2018. ... Thermal Protective Clothing market report for a glimpse ... by various tables and figures. , http://www.micromarketmonitor.com/market/europe-thermal-protective-clothing-5957050557.html ...
(Date:11/27/2014)... -- Research and Markets  has announced ... Report 2014" report to their offering. ... Palmitic Acid Industry Report 2014 is a professional and ... palmitic acid industry. The report provides a ... and industry chain structure. The palmitic acid market analysis ...
(Date:11/27/2014)... Spartan Bioscience today announced that it ... Safety (MFDS) regulatory approval for its Spartan RX ... less than 60 minutes from a non-invasive cheek swab. ... for doctors to determine therapeutic strategies for drugs metabolized ... of the world’s most commonly prescribed drugs such as ...
Breaking Biology Technology:Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 2Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 3Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 4Glycomics Market by Application, Product & End-Users is estimated to reach $928.11 Million by 2019 - New Research Report by MarketsandMarkets 5The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3Global Palmitic Acid Industry Report 2014 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 3
... of Ablation Therapy Using HALO System Demonstrated for, ... Progression, SAN DIEGO, May 19 Booth ... a technology leader in the design and manufacture,of ... presentation,of a landmark study entitled, "A Randomized, Multicenter, ...
... size allows for treatment of smaller-diameter diseased saphenous vein ... ... Boston Scientific,Corporation (NYSE: BSX ) today announced the launch of its ... designed to contain,and remove embolic material that may be dislodged during an ...
... 19 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ), ... and marketing biopharmaceutical products,primarily in China, will present ... in New York on Thursday, May 22, 2008 ... webcast live and can be accessed on the,Webcasts ...
Cached Biology Technology:Presentation of Landmark Clinical Trial Evaluating Endoscopic Treatment for Pre-cancerous Condition of Esophagus 2Presentation of Landmark Clinical Trial Evaluating Endoscopic Treatment for Pre-cancerous Condition of Esophagus 3Boston Scientific Announces Launch of Expanded Size Range of FilterWire EZ(TM) Embolic Protection System 2Boston Scientific Announces Launch of Expanded Size Range of FilterWire EZ(TM) Embolic Protection System 3Boston Scientific Announces Launch of Expanded Size Range of FilterWire EZ(TM) Embolic Protection System 4