Navigation Links
Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
Date:8/24/2012

This press release is available in Spanish.

Researchers headed by Maria Macias an ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona) and Joan Massagu, a Howard Hughes Medical Institute investigator at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, have identified a new molecular mechanism that plays a crucial role in the control of the activation of certain genes associated with cancer.

Through detailed structural and biochemical studies, the researchers identified a key domain present in a family of proteins called Smads, whose binding determines whether the transcription of genes controlled by the TGF-beta and BMP signaling cascades will be bound by activators or labeled for degradation. These processes are critical to the correct development and maintenance of tissues and organisms.

When looking at inhibitory Smads , the researchers found that the specific domain binds directly and constitutively to their targets. This is in contrast to what happens with receptor-activated Smads, where the proteins must first undergo processing by phosphorylation a chemical change whereby the proteins are first activated and then labeled for degradation after completing their transcriptional function. The study appears online today (August 23) in the journal Structure.

Smads are key proteins in the signaling pathways of the hormones TGF-beta and BMP, which are known to participate in the control of stem cell pluripotency and differentiation and in the development and maintenance of metazoan organisms. In this study, the researchers looked at the interactions of Smad7 a protein inhibitor of TGF-beta signaling with molecules implicated in the cascade, including three ubiquitin ligases and YAP, a transcription coactivator. They identified the domains in the four proteins that interact with the same re
'/>"/>

Contact: Sarah Sherwood
sarah.sherwood@irbbarcelona.org
34-934-034-636
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U of M researchers: Newly discovered genetic markers could signal colon cancer development
2. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
3. ORNL researchers improve soil carbon cycling models
4. Researchers identify key culprit causing muscle atrophy
5. Researchers demonstrate control of devastating cassava virus in Africa
6. Researchers pursue red flag for schizophrenia relapse
7. A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7
8. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
9. Wayne State researchers working to improve genetic analysis, disorder detection
10. Superbird stuns researchers
11. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/24/2015)... Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of ... report to their offering. This report analyzes the ... the following Segments: Face Biometrics, and Voice Biometrics. The report provides ... Japan , Europe , ... Africa , and Latin America ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... PARK, MD, Nov. 25, 2008 -- Researchers in Ohio ... magnetic resonance -- the physical phenomenon that allows MRI ... the human body. Their discovery, a new mathematical ... informative and sharper images. As described in ...
... -- Dieters or those who consume fewer calories during flu ... virus, according to research by Michigan State University nutritional immunology ... November issue of the Journal of Nutrition , Gardner ... to die during the first few days of infection than ...
... The Oklahoma Experimental Program to Stimulate Competitive Research (EPSCoR) ... National Science Foundation (NSF) and the Oklahoma State Regents ... annual support is renewable for the next five years ... new theme area, "Building Oklahoma,s Leadership Role in Cellulosic ...
Cached Biology News:New discovery may enhance MRI scans, lead to portable MRI machines 2Feed a cold, feed a fever: Research shows calorie cut makes it harder to fight flu 2Oklahoma EPSCoR receives $20 million for biofuels research 2
(Date:3/27/2015)... 2015   SurePure, Inc . (OTCQB: SURP), ... that the Company has completed the verification process ... SurePure ("SURP") securities on OTCQB, an electronic quote ... development stage companies. On March 26, ... requirements designed to improve marketplace integrity and enhance ...
(Date:3/27/2015)... 2015  Peter Walter was chosen as winner of ... work on how proteins are transported between cellular compartments ... that cells use to handle stress tied to the ... of biochemistry at the University of California, San Francisco. ... of human diseases related to defective protein folding and ...
(Date:3/27/2015)... March 27, 2015 Working in collaboration ... in London , Richmond Pharmacology is the ... Phase 3 study for an investigational RNAi therapeutic being developed ... affecting the nerves and heart. Read press ... Based at St Georges University of ...
(Date:3/27/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the global pharmaceutical, biotechnology, ... Investigational New Drug (IND) application for WuXi MedImmune,s ... been accepted for review by the China Food ... September 2012, MedImmune, the global biologics research and ...
Breaking Biology Technology:SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3
... ... out of top five ,global pharmaceutical companies. , ... Rochester, NY (PRWEB) December 1, 2009 -- iCardiac Technologies, ... today that a top five pharmaceutical company has selected iCardiac as a preferred vendor ...
... ... veteran of the high-technology industry, has formed nanoEdge™ Technologies, a business development and intellectual ... to invest in promising technologies and act as a nanotechnology incubator. , ... Monterey, CA (PRWEB) December 1, ...
... Mass November 30, 2009 An international ... and ETH Zrich have demonstrated compact, multibeam, and ... the light spectrum (infrared). By contrast, typical lasers ... wavelength. The innovative multibeam lasers have potential use ...
Cached Biology Technology:Another Top Five Pharmaceutical Company Selects iCardiac as Preferred Provider of ECG Core Lab Services 2Silicon Valley Veteran Launches New Venture on the “nanoEdge” of the Emerging Nanotechnology Revolution 2Silicon Valley Veteran Launches New Venture on the “nanoEdge” of the Emerging Nanotechnology Revolution 3Silicon Valley Veteran Launches New Venture on the “nanoEdge” of the Emerging Nanotechnology Revolution 4Scientists demonstrate multibeam, multi-functional lasers 2
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
6-keto Prostaglandin F1α EIA Antiserum 6-keto-PGF1alpha EIAs prostaglandins antisera enzyme immunoassays reagents 6-keto-PGF1.alpha....
Biology Products: