Navigation Links
Researchers decipher modus operandi of potential Alzheimer's drug
Date:2/20/2013

tries to prevent harmful reactions with the help of antioxidants," says Eckhard Mandelkow. "However, with age and in cases of neurodegenerative diseases such as Alzheimer's, this protective system weakens allowing tau proteins to aggregate."

Beta sheets also important

Zweckstetter stresses that along with the disulfide bridges, another mechanism is important for the clumping of tau proteins. "Tau proteins aggregate particularly quickly when disulfide bonds form. These work like a trigger. However, tau proteins can also aggregate without these bridges, albeit more slowly."

This is due to the structure of the molecule, the backbone of which can fold like an accordion in some places. Such regions can pile up to "beta sheets" when two proteins come together closely enough and in the appropriate orientation. "Our experiments also show a distinct effect of methylene blue on the regions that want to form these beta sheets." Thus, methylene blue, particularly its derivatives "Azure A" and "Azure B", which are expected to be predominantly present in the body, also appear to inhibit the aggregation of beta sheets. "Steric hindrance occurs," Zweckstetter guesses. "When an inhibitor attaches to a beta sheet region of the tau protein, no other tau molecule can lock on."

There are other substances besides methylene blue that can suppress the aggregation of tau proteins. Some of them focus explicitly on preventing the build-up of beta sheets. The researchers believe that an effective treatment could ultimately require a combination of various substances: "Certainly, one conclusion of our study is that there are different ways to disrupt the pathogenic aggregation of tau proteins."


'/>"/>

Contact: Dirk Frger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford researchers develop tool for reading the minds of mice
2. Researchers in Manchester find genetic key to preventing spine tumors
3. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
4. UTSW researchers identify new enzyme that acts as innate immunity sensor
5. Researchers make racehorses fertile
6. USC researchers find possible genetic clues to organ development, birth defects
7. Researchers discover Achilles heel for lymphoid leukemia
8. Researchers find Asian needle ants displacing other aggressive invaders
9. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
10. UT Dallas researchers pushing the boundaries of virtual reality
11. Polar bear researchers urge governments to act now and save the species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... pollutants released by unconventional oil and gas production are ... today in the open access journal Environmental Health ... were found. The study is the first to be ... production sites and could be used to supplement official ... from reserves that do not readily flow to the ...
(Date:10/29/2014)... largest study of its kind to date, researchers have ... heighten the risk for autism. Joseph Buxbaum, Ph.D., Icahn ... Mark Daly, Ph.D., Broad Institute of Harvard and MIT, ... from affected children, parents and unrelated people. They identified ... to the risk for autism spectrum disorder (ASD) – ...
(Date:10/29/2014)... open for the Society of Interventional Radiology,s ... is the one place where interventional radiologists, ... care professionals can come together to find ... being presented, discussed and tested. , ... image-guided medicine, SIR 2015 will feature essential ...
Breaking Biology News(10 mins):Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... New tires allow race cars to take tight turns ... advantages: They are not necessary for basic flight but help ... escape a predator, you don,t have to be fast, you ... world authority on animal behavior, ecology and evolution and the ...
... deliveries and having them at term but before completing ... likely to have a baby with serious complications including ... , UAB researchers, led by Alan T.N. Tita, M.D., ... and Gynecology Division of Maternal-Fetal Medicine, and colleagues reported ...
... remarkable new discovery shows the four-eyed spookfish to be the ... to focus light in its eyes. Professor Julian Partridge ... years of vertebrate evolution, and many thousands of vertebrate species ... have solved the fundamental optical problem faced by all eyes ...
Cached Biology News:Hind wings help butterflies make swift turns to evade predators, study finds 2Repeat C-section before 39 weeks raises risk of neonatal illness 2Spookfish uses mirrors for eyes 2
(Date:10/25/2014)... 23, 2014 ViaDerma, Inc ... company devoted to bringing new products to market, ... , ViaDerma has developed an innovative, patent-pending dual ... mass transfer of pharmaceutical active ingredients to penetrate ... immediate localized therapy. The transdermal delivery method also ...
(Date:10/25/2014)... According to new market research report "Data Center ... Telecom), by Design Types (Electrical, Mechanical), and by ... Tier 4) - Global Forecast to 2019", published ... Construction Market into various segments with an in-depth ... also identifies the factors driving this market, various ...
(Date:10/25/2014)... 24, 2014 The Workgroup ... leading nonprofit authority on the use of health ... announces its appointment of four new co-chairs to ... leaders include:, ,     Peter Dumont, Senior ... Pupo, Specialist Leader, Deloitte Consulting LLP , ...
(Date:10/25/2014)... Today, Nerium International, a leader in ... its “Reflect Your Youth” contest, an effort launched to ... difference in their skin since using Nerium’s product line, ... life as a result of their newfound confidence. , ... by Nerium International to inspire conversations focused on the ...
Breaking Biology Technology:ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2
... Cephalon, Inc.,(Nasdaq: CEPH ) today announced its ... to an Abbreviated New Drug Application (ANDA),submitted to ... Watson,Laboratories, Inc., requesting approval to market and sell ... In its Notice,Letter, Watson alleges that the U.S. ...
... Thermo Fisher,Scientific Inc. (NYSE: TMO ), the ... to a record $2.55 billion in the first quarter,of ... translation,increased revenues by 4%, and acquisitions, net of divestitures, ... were $.53 in 2008,versus $.31 in the year-ago period. ...
... Munich, Germany, April 24, 2008 / b3c ... group at Stanford University are working on a project ... are introduced in a statistically expected and controlled ratio ... ,Sloning will utilize its core technology, Slonomics™, a unique ...
Cached Biology Technology:Cephalon Notified of Generic Fentanyl Buccal Tablet Filing 2Cephalon Notified of Generic Fentanyl Buccal Tablet Filing 3Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 2Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 3Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 4Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 5Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 6Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 7Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 8Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 9Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 10Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 11Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 12Thermo Fisher Scientific Reports Record 2008 First Quarter Revenues and Operating Performance 13Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library 2
... DNase is a preparation of deoxyribonuclease ... DNA to produce 3-hydroxyl oligonucleotides. This ... applications where maintaining the integrity of ... qualified for use with the Core ...
... Type Liquid. In 100 mM KCl, ... EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW CYCLES. ... monomeric protein of 765 amino acids encoded by ... both positive and negative supercoiled DNAs without the ...
Request Info...
... III digests duplex DNA in a 3'-> ... or nick, producing stretches of single-stranded DNA. ... Exonuclease III proceeds at a uniform rate ... rate of exonucleolytic excision of deoxyribonucleotides by ...
Biology Products: