Navigation Links
Researchers decipher modus operandi of potential Alzheimer's drug
Date:2/20/2013

s been collected so far. Furthermore, to date it was unknown, why methylene blue had the observed effect. "Methylene blue inhibits the aggregation process," Eckhard Mandelkow emphasizes. "But the way in which this happens was unknown until now."

The study now published in "Angewandte Chemie" reveals the nature of this process: Markus Zweckstetter's research group at the DZNE site in Gttingen and the Max Planck Institute for Biophysical Chemistry in Gttingen in collaboration with the Mandelkow team have been able to prove that methylene blue deactivates molecular residues which promote the bonding of tau proteins. Moreover, the researchers found indications that the substance acts as a spacer to keep the proteins apart. These findings could lead to the development of modified forms of methylene blue and new types of treatment.

Background:

Methylene blue tackles sulphur groups

NMR spectroscopy, a powerful technique for investigating biomolecules, was centrally important to the current study. "We found that methylene blue reacts with certain elements in the tau proteins called cysteines," Prof. Zweckstetter summarizes.

This reaction is highly effective. Methylene blue specifically modifies the tau proteins at critical spots: Of the up to 441 elements which a tau protein can consist of particularly the two cysteines are modified. The elements directly modified are the so-called SH groups, molecular appendages comprising sulphur and hydrogen which are typical of cysteines. Oxygen atoms now couple with them.

"This chemical transformation prevents tau proteins from bonding together," says Zweckstetter. "Otherwise SH groups from different proteins would react and form a so-called disulfide bridge. Now, this is no longer possible, because the reaction with methylene blue eliminates the SH groups."

In a healthy organism, the formation of these disulfide bridges is suppressed naturally. "The cell
'/>"/>

Contact: Dirk Frger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford researchers develop tool for reading the minds of mice
2. Researchers in Manchester find genetic key to preventing spine tumors
3. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
4. UTSW researchers identify new enzyme that acts as innate immunity sensor
5. Researchers make racehorses fertile
6. USC researchers find possible genetic clues to organ development, birth defects
7. Researchers discover Achilles heel for lymphoid leukemia
8. Researchers find Asian needle ants displacing other aggressive invaders
9. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
10. UT Dallas researchers pushing the boundaries of virtual reality
11. Polar bear researchers urge governments to act now and save the species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Jan. 26, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... corporate website ( http://www.nxt-id.com/ ) as part of its ... wallet. The Company launched its new consumer website for ... Pereira , CEO of NXT-ID said, "Our new corporate ...
(Date:2/5/2015)... 28, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... Global Online CEO Conference on January 29 th ... Pereira , CEO of NXT-ID will present and host ... Wocket smart wallet and its full suite of biometric ...
(Date:2/5/2015)... Calif. , Feb. 3, 2015 ... technology, demand from industries such as consumer electronics, ... market for surface mount technology (SMT) screen printers. ... to automatic control will push the adoption curve ... will remain steady as glue dispensers are indispensable ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3
... the first time points to a developmental mechanism linking ... and observed defects in brain wiring, according to a ... yesterday in Nature Neuroscience . These findings may ... disability and many other brain disorders. The present ...
... Shenzhen, China- An international research consortium, led by Fujian ... first genome sequence of the diamondback moth (DBM), the ... work provides wider insights into insect adaptation to host ... management. The latest study was published online today in ...
... microorganisms that live inside salt deposits in the acidic and ... extreme conditions of these microniches appear to be similar to ... Europa. This possibility should be borne in mind on missions ... doses of radiation, lack of moisture and extreme temperature and ...
Cached Biology News:New discovery in autism-related disorder reveals key mechanism in brain development and disease 2The genome of diamondback moth provides new clues for sustainable pest management 2The genome of diamondback moth provides new clues for sustainable pest management 3The saline hiding places for bacteria in Río Tinto could be like those on Mars 2
(Date:2/27/2015)... 2015 A paper published today, " ... " in Science Translational Medicine, demonstrates ... reduce the risk associated with investing in the ... levels of funding for developing so-called "orphan" drugs. ... collaboration between scientists at the National Center for ...
(Date:2/27/2015)... SAN DIEGO , Feb. 27, 2015  Pfenex ... in the development of biosimilar therapeutics, today announced that ... San Francisco Marriott Marquis on March 2 nd ... will participate on a panel discussing the current state ... World of Biosimilars . For more ...
(Date:2/26/2015)... NEW YORK , Feb. 26, 2015 ... commenced Factual Stock Report coverage on MabVax Therapeutics ... Inc. (MBVX) is a clinical stage biotechnology company focused ... address unmet medical needs in the treatment of cancer. ... products based on the protective immune responses generated by ...
(Date:2/26/2015)... , Feb. 26, 2015   Regulus Therapeutics Inc ... leading the discovery and development of innovative medicines targeting ... Ph.D., President and Chief Executive Officer of Regulus, will ... 35 th Annual Healthcare Conference on Wednesday, March ... being held at the Boston Marriott Copley Place.  ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 5Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3
... 26, 2011 Sangamo BioSciences, Inc. (Nasdaq: SGMO ... quarter and full year 2010 financial results on Wednesday, February ... be followed by a conference call at 5:00 p.m. ET, ... webcast. During the conference call, the company will review the ...
... Calif., Jan. 26, 2011 Novel solutions to 21st ... Institute,s fourth annual executive education conference for female leaders ... 3-5, 2011. The Women Innovate Conference will ... and business ranging from small start-ups to global corporations. ...
... Ind. - Researchers are developing a new class ... advanced optical technologies, including ultrapowerful microscopes and computers, ... The new materials could make possible "nanophotonic" ... assistant professor of electrical and computer engineering at ...
Cached Biology Technology:Sangamo BioSciences Announces Fourth Quarter and Full Year 2010 Conference Call and Webcast 2KGI Hosts Fourth Annual Conference for Women in Life Science Industry 2KGI Hosts Fourth Annual Conference for Women in Life Science Industry 3New materials may bring advanced optical technologies, cloaking 2
... PBL's bioassays for interferons are cytopathic effect inhibition ... Sample types include; tissue culture supernatents; serum ... these assays, one unit is defined as the ... the cytopathic effect of viral infection by 50%. ...
Request Info...
...
... is >95%\nNEN Radiolabeled Ligands\n\nReceptor-related research has long ... new radiolabeled ligands selected to keep pace ... range of products and services for receptor ... state-of-the-art radioligands. If you do not find ...
Biology Products: