Navigation Links
Researchers decipher modus operandi of potential Alzheimer's drug
Date:2/20/2013

This press release is available in German.

The study published in "Angewandte Chemie" might help to work out strategies for developing potential drugs. As the team of scientist including Markus Zweckstetter and Eckhard Mandelkow report, methylene blue inactivates molecular residues that promote the bonding of tau proteins.

Methylene blue is a multi-talented substance with a long history. The synthetic compound was first produced in 1876, and since then has served not only as a blue dye, but also as a medical drug for example to treat malaria and prevent urinary tract infections. It is now also being debated as a potential treatment for Alzheimer's disease.

Methylene blue works in many ways. With regard to Alzheimer's, it is interesting to note that it prevents the clumping of "tau proteins". Such aggregates are typical in numerous forms of dementia: The protein clumps accumulate in the brain cells, disrupt their function, and can even kill them.

"Tau proteins are actually extremely important, because they stabilize the transport routes inside each nerve cell," explains Prof. Eckhard Mandelkow, who works at the German Center for Neurodegenerative Diseases (DZNE) and the caesar research center in Bonn. "However, in cases of Alzheimer's, they stop doing their job. The transport routes inside the cells break down, and supplies essential for the survival of the cells can no longer reach their destination. In addition, the tau proteins stick together. These aggregates are also harmful and are a typical characteristic of the disease."

Such characteristics can be reproduced in animal studies. Previously, another team of scientists led by Dr. Eva-Maria Mandelkow was able to prove that methylene blue is able to alleviate the symptoms of an illness in mice and threadworms. However, no significant data from human patients ha
'/>"/>

Contact: Dirk Frger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford researchers develop tool for reading the minds of mice
2. Researchers in Manchester find genetic key to preventing spine tumors
3. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
4. UTSW researchers identify new enzyme that acts as innate immunity sensor
5. Researchers make racehorses fertile
6. USC researchers find possible genetic clues to organ development, birth defects
7. Researchers discover Achilles heel for lymphoid leukemia
8. Researchers find Asian needle ants displacing other aggressive invaders
9. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
10. UT Dallas researchers pushing the boundaries of virtual reality
11. Polar bear researchers urge governments to act now and save the species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... the Monell Center reveals that simply believing that an ... asthmatics for at least 24 hours following exposure. The ... health-related outcomes. , "Asthmatics often are anxious about scents ... harmful, our bodies react as if that odor is ... a Monell physiologist. "Both patients and care providers need ...
(Date:7/22/2014)... A new study that examined the survival rates ... bycatch in commercial longline fishing operations found large ... bigeye thresher, dusky, and scalloped hammerhead being the ... University of Miami (UM) Rosenstiel School of,Marine and ... Science and Policy, provides,new information to consider for ...
(Date:7/22/2014)... Highly purified crystals that split light with uncanny ... optics and, potentially, computers that manipulate light instead ... techniques, such as etching them with a precise ... expensive. , Now, researchers at Princeton and Columbia ... allow scientists to customize and grow these specialized ...
Breaking Biology News(10 mins):In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3New study reveals vulnerability of sharks as collateral damage in commercial fishing 2Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3
... 2012 -- Researchers in the Department of Health ... Public Health assessed the impact of pollution on ... levels. Their results show that ozone, even at ... of the world, has significant negative impacts on ...
... of California, San Diego have built a small fleet ... air quality in real time on their smart phones. ... from chronic conditions, such as asthma, who need to ... air-quality monitoring system capable of delivering real-time data to ...
... Calif. (December 18, 2012) The Hass Avocado ... of the unique, positive benefits of consuming fresh ... are currently underway to investigate the relationship between ... avocados, potential positive role in weight management and ...
Cached Biology News:Ozone levels have sizeable impact on worker productivity 2Small, portable sensors allow users to monitor exposure to pollution on their smart phones 2Small, portable sensors allow users to monitor exposure to pollution on their smart phones 3Small, portable sensors allow users to monitor exposure to pollution on their smart phones 4Hass Avocado Board study published in Food & Function journal 2
(Date:7/22/2014)... 22, 2014 Nuclear reactors are used ... by controlled fission chain reaction in nuclear reactors is ... used to drive a power- generating turbine. Currently nuclear ... world’s total electricity production. Nuclear reactor market is expected ... planned and proposed nuclear reactor projects. , Early buyers ...
(Date:7/22/2014)... 2014 Two new members were elected ... at its annual Shareholders Meeting on June 13: Kerry ... The PFM Group, and Stephen T. Zarrilli, President and ... the election of Michael A. DiPiano, Managing General Partner ... Richard P. Jaffe, Esq., of Duane Morris LLP, as ...
(Date:7/22/2014)... Massachusetts en SHENZHEN, China ... Co., LTD, (BGI Tech), een dochtermaatschappij van BGI, ,s ... de wereldwijde introductie aan van een nieuwe service ten ... sector meest geavanceerde platform van Complete Genomics. ... dat binnen de sector in hoog aanzien staat vanwege ...
(Date:7/22/2014)... 2014  The Broad Institute today announced an ... Ted Stanley aimed at galvanizing scientific research ... on molecular understanding to hundreds of millions of ... Stanley commitment – the largest ever in psychiatric ... in general – will support research by a ...
Breaking Biology Technology:Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 2Nuclear Energy Market: Global Industry Analysis, Size, Share, Analysis, Growth and Forecast 2013 - 2019 3Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10
... routinely runs such tests on samples sent in from all ... towards a truly personalised medicine. And researchers are exploring new ... a molecular scale: the genes that are being read or ... bloodstream; and the length of the telomeres capping its chromosomes. ...
... yoghurt have a note telling you that the product contains ... spatial arrangement of their atoms. The two"isomers", L(+) and D(-), ... to the right or left respectively. Of course the capacity ... not confined to solutions of yoghurt. Light interacts in one ...
... In what became known as the ,Scotch tape technique," researchers ... Graphene is a single layer of carbon atoms arranged in ... Graphene is a wonder material. It is one-hundred-times better ... And, at just one atom thick, it is so thin ...
Cached Biology Technology:CNIO researchers take part in the most comprehensive personalized medicine study performed to date 2CNIO researchers take part in the most comprehensive personalized medicine study performed to date 3Designer lights from the physics lab 2Straintronics: Engineers create piezoelectric graphene 2Straintronics: Engineers create piezoelectric graphene 3Straintronics: Engineers create piezoelectric graphene 4
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... Pro260 reagents and supplies, for 10 ... sufficient to perform protein analysis with ... electrophoresis system. Supplied are 3 x ... Pro260 stain, 60 microliters Pro260 ladder ...
...
... achieve high experimental throughput, minimum input ... 4 up to 16 culture ... provides users with proven fermentation results ... yeast, fungi or any other microbial ...
Biology Products: