Navigation Links
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
Date:2/24/2013

t which have specific activities in diseased states. "This finding is positive from a therapeutic viewpoint because it means that if you remove CPEB1 from healthy cells, its function can be taken over by any other CPEB protein. In contrast, in tumors only CPEB1 has the capacity to shorten these regions, thus affecting only tumor cells", states Italian researcher Felice Alessio Bava, first author of the paper, and post-doctoral fellow with Mndez's group who, this year, has obtained his doctorate degree through the "la Caixa" International Fellowship Programme. This study provides further evidence of the potential of CPEB proteins as therapeutic targets. In 2011, in a study published in Nature Medicine, Mndez identified that CPEB4 "switches on" hundreds of genes linked to tumor growth. This new study explains that the overexpression of CPEB4 in tumors is because CPEB1 has also "released the brakes that keep CPEB4 at low levels in a healthy tissue". "The fact that these proteins control each other is also advantageous from a therapeutic point of view", asserts Mndez, "because partial inhibition, by a drug, would be amplified, thus allowing tumor cell reprogramming. The amplification should make it easier to find a viable compound".

The lab has developed a system to screen therapeutic molecules for a drug that can inhibit the action of CPEB in tumors while having few secondary effects on healthy cells. "There is no drug currently available that influences the regulation of gene expression at this level. Our findings open up a pioneering therapeutic window. We are optimistic about the potential of CPEB proteins as targets", says Mndez.

The action of CPEB proteins should be considered in the design of other therapeutic strategies

The study published in Nature includes a meticulous genomic analysis of RNA molecules that are processed in different ways depending on whether CPBE1 is present. The study provides a list of between 200 a
'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Brown University researchers build robotic bat wing
2. Researchers say sunlight yields more efficient carbon dioxide to methanol model
3. Researchers decipher modus operandi of potential Alzheimers drug
4. Stanford researchers develop tool for reading the minds of mice
5. Researchers in Manchester find genetic key to preventing spine tumors
6. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
7. UTSW researchers identify new enzyme that acts as innate immunity sensor
8. Researchers make racehorses fertile
9. USC researchers find possible genetic clues to organ development, birth defects
10. Researchers discover Achilles heel for lymphoid leukemia
11. Researchers find Asian needle ants displacing other aggressive invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
(Date:4/17/2014)... In the most densely forested and most densely populated ... of human needs, values and practices. Disturbances associated with ... agriculture and development, have set the stage for management ... study reports. , The report Five anthropogenic factors ... in the Northern United States was published ...
(Date:4/17/2014)... of stem cell therapies to cure a variety of ... populations based on cell surface markers. Researchers from the ... is highly expressed in a type of stem cells ... in an article in BioResearch Open Access , ... The article is available free on the ...
(Date:4/17/2014)... detection cartridge developed at Sandia National Laboratories and recently ... faster and cheaper. , Bacillus anthracis , ... soils all over the world and can cause serious, ... The bacteria can survive in harsh conditions for decades. ... occur through skin contact, inhalation of spores or eating ...
Breaking Biology News(10 mins):Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... men prefer beer when they drink alcohol, taking in at ... of the beverage. Far fewer (around five percent) prefer wine. ... beverages and a riskier approach to alcohol or other substances? ... Preventive Medicine at the University of Zurich and Lausanne University ...
... has shown for the first time evidence of ... bipolar disorder, major depressive disorder and schizophrenia and ... attention deficit-hyperactivity disorder (ADHD), according to a study ... Advance Online publication. The root cause of ...
... NEW YORK CITY Morning sickness, shiny hair, and ... what expectations do pregnant women impose on their ... perspectives on pregnancy? Danielle Bessett, an assistant ... present her research on this issue at the 108th ...
Cached Biology News:Young beer-drinkers binge-drink more frequently 2New patterns found in the genetic relationship of 5 major psychiatric disorders 2Cultural mythologies strongly influence women's expectations about being pregnant 2Cultural mythologies strongly influence women's expectations about being pregnant 3
(Date:1/15/2014)... Jan. 15, 2014  Bill Jacobs Automotive, a group of car ... up with the Heartland Blood Center and offering free oil ... drive takes place Saturday, Jan. 18 at the Bill Jacobs ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer health ... EmblemHealth , the New York -based ... RedBrick Compass health assessment, combined with the RedBrick Journeys ... EmblemHealth is among the first health plans in the ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... it not been for the war in Iraq, 2003 might ... forgot. Certainly, in the world of information technology, that may ... happened slowly. Customers took their time. But for some activity ... then, must explain why the predictions I so carefully made ...
... robotic rover Spirit, which bounced to a near pinpoint ... 3) after a seven-month flight, promises a trove of ... , ,John Valley, a UW-Madison professor of geology and ... to be from Mars, expects the latest mission to ...
... - Fiserv Health, an operating group of Fiserv, ... a care management company targeting the self-funded health care ... health plan management, claims processing and administration services for ... addition of Avidyn Health, Fiserv Health now has an ...
Cached Biology Technology:The Year Ahead in IT 2The Year Ahead in IT 3The Year Ahead in IT 4The Year Ahead in IT 5Fiserv Launches Avidyn Health to Target Healthcare Costs 2
... The Freedom EVO series offers versatile liquid ... successfully automate a wide variety of life ... four different base sizes (75, 100, 150 ... access to a platform that will advance ...
... and conveniently controls the temperature at your lab ... levels up to 99 C*, with the "plus" ... as 5 C. The thermoblocks for 0.2 ml**, ... microplates enable a high degree of flexibility for ...
384 Well PCR Plate Carrier for Thermo-Sealer...
... Cell Cultures (ECACC) has been offering training ... government institutes for over seven years. We ... introduce candidates to cell culture and a ... specialist areas such as planning and management ...
Biology Products: