Navigation Links
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
Date:2/24/2013

t which have specific activities in diseased states. "This finding is positive from a therapeutic viewpoint because it means that if you remove CPEB1 from healthy cells, its function can be taken over by any other CPEB protein. In contrast, in tumors only CPEB1 has the capacity to shorten these regions, thus affecting only tumor cells", states Italian researcher Felice Alessio Bava, first author of the paper, and post-doctoral fellow with Mndez's group who, this year, has obtained his doctorate degree through the "la Caixa" International Fellowship Programme. This study provides further evidence of the potential of CPEB proteins as therapeutic targets. In 2011, in a study published in Nature Medicine, Mndez identified that CPEB4 "switches on" hundreds of genes linked to tumor growth. This new study explains that the overexpression of CPEB4 in tumors is because CPEB1 has also "released the brakes that keep CPEB4 at low levels in a healthy tissue". "The fact that these proteins control each other is also advantageous from a therapeutic point of view", asserts Mndez, "because partial inhibition, by a drug, would be amplified, thus allowing tumor cell reprogramming. The amplification should make it easier to find a viable compound".

The lab has developed a system to screen therapeutic molecules for a drug that can inhibit the action of CPEB in tumors while having few secondary effects on healthy cells. "There is no drug currently available that influences the regulation of gene expression at this level. Our findings open up a pioneering therapeutic window. We are optimistic about the potential of CPEB proteins as targets", says Mndez.

The action of CPEB proteins should be considered in the design of other therapeutic strategies

The study published in Nature includes a meticulous genomic analysis of RNA molecules that are processed in different ways depending on whether CPBE1 is present. The study provides a list of between 200 a
'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Brown University researchers build robotic bat wing
2. Researchers say sunlight yields more efficient carbon dioxide to methanol model
3. Researchers decipher modus operandi of potential Alzheimers drug
4. Stanford researchers develop tool for reading the minds of mice
5. Researchers in Manchester find genetic key to preventing spine tumors
6. When It Comes To Genetic Code, Researchers Prove Optimum Isnt Always Best
7. UTSW researchers identify new enzyme that acts as innate immunity sensor
8. Researchers make racehorses fertile
9. USC researchers find possible genetic clues to organ development, birth defects
10. Researchers discover Achilles heel for lymphoid leukemia
11. Researchers find Asian needle ants displacing other aggressive invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
(Date:10/2/2014)... CARTES SECURE CONNEXIONS 2014 Conference: A ... CARTES SECURE CONNEXIONS 2014 is being held at ... November 2014. This 29 th  international meeting for the ... will bring together the global community of a constantly ... of conferences will set the pace for the event. ...
(Date:10/1/2014)... Novel detection technology is ... The life science field has seen ... years. Some are shooting stars and others become ... detection technology that has raised much enthusiasm among ... is becoming commercially available. With their unique advantages, ...
(Date:9/30/2014)... think of nature as something that we enjoy when we ... Or do we think of ourselves as a part of ... what about a house? , The answers to these ... our actions, our speech and in cultural artifacts. , A ... Washington, the American Indian Center of Chicago and the Menominee ...
Breaking Biology News(10 mins):CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 2CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 3CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 4First-of-a-kind Solution for Utilizing Photon Upconversion 2The cultural side of science communication 2
... of tiny particles at an interface between oil and ... may take longer to reach equilibrium than previously thought. ... at what we thought would be a very simple ... investigator Vinothan Manoharan, Associate Professor of Chemical Engineering and ...
... of Georgia geneticist Jonathan Arnold has been named a Fellow ... honor bestowed on him by his peers for "scientifically or ... Arnold, a professor in the genetics department of the Franklin ... members who will be presented with an official certificate and ...
... onto trains would have an outsized impact on air quality ... WisconsinMadison. Much of that impact boils down to simple ... Nelson Institute for Environmental Studies. For each ton they carry, ... diesel fuel. Trains can move a ton more than 400 ...
Cached Biology News:Slow road to stability for emulsions 2Slow road to stability for emulsions 3For Midwesterners, more boxcars mean cleaner air 2
(Date:10/1/2014)... Oct. 1, 2014 Pfanstiehl has announced ... EP), manufactured in the USA ... long been recognized for playing a key role ... body of evidence that media supplementation with mannose ... protein glycosylation," according to Dr. Christopher Wilcox ...
(Date:10/1/2014)... participants committed to not only creating unique business card ... tweaking and testing virtual models and 3D test prints ... “I enjoyed being involved as a judge,” stated a ... a commendable range exploring the technical capabilities of the ... the creativity of the contestants.” , Array Architects is ...
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... BOSTON, MA (PRWEB) September 30, 2014 ... company, SoundConnect announces four new-hosted collaboration ... innovative bundles deliver high quality conferencing experiences for ... collaboration packages to choose from, businesses have optimized ... bundled solutions include audio only minutes ...
Breaking Biology Technology:Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Array Architects Challenges Staff to Create with 3D Printer 2Digital Agency Studio PMG Launches New Case Studies on Website 2SoundConnect Launches New Audio, Web and Video Bundles 2
... Aaron Mitchell, managing principal at global management consulting firm ... of 2011 by Consulting Magazine. Mitchell was recognized for directing ... several years and during a major, recent product launch. ... top consultants," said Mitchell, who has more than 10 years ...
... 1, 2011 Reportlinker.com announces that a ... its catalogue: Biochips and ... http://www.reportlinker.com/p0350354/Biochips-and-Microarrays---Technologiesmarkets-and-companies.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics This ... based on technologies and applications. The report ...
... Reportlinker.com announces that a new market ... Osteosarcoma Therapeutics - Pipeline ... http://www.reportlinker.com/p0546797/Osteosarcoma-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Forecasts to 2017 Summary ...
Cached Biology Technology:Managing Principal at ZS Associates Named One of Consulting Magazine's Top 25 Consultants of 2011 2Reportlinker Adds Biochips and Microarrays - Technologies, markets and companies 2Reportlinker Adds Biochips and Microarrays - Technologies, markets and companies 3Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 9Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017 10
Profilin-1/2 (FL-140)...
Immunogen: Synthetic peptide: N(171) H G F L S A D Q QL I K(183) Storage: -20 C, Avoid Freeze/Thaw Cycles...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
HIV-1 TAT (vN-21)...
Biology Products: