Navigation Links
Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
Date:11/3/2013

WASHINGTON, Nov. 3, 2013 /PRNewswire/ -- Although very rare, the use of oral contraceptive can lead to benign tumors in the liver. The tumors, known as hepatocellular adenomas, can become malignant. It is, however, difficult for physicians to assess the risk of these tumors becoming malignant.

The study's researchers examined and classified data from 250 patients with hepatocellular adenomas. They examined classical adenomas (223), borderline lesions between adenomas and carcinomas (18), and carcinomas (9). The data was examined using whole exome sequencing, CGH-SNP analyses, and methylome analyses.

Researchers were able to identify the genetic determinants of malignant transformation as well as the key factors at stages of the transformation. "Our work reported for the first time a molecular mechanism of malignant transformation of hepatocellular adenomas to carcinomas," lead researcher, Camilla Pilati, PhD, said, "Surprisingly, we were able to identify the chronology of the genetic defects that accumulate in hepatocytes to promote their malignant transformation. In this line, we identified genetic alteration that acts at early and late steps of the malignant transformation process, in the accumulation of early genetic alteration at the origin of the malignant transformation of the hepatocytes."

Two genes with somatic mutations -- one in the early stages and one in the later stages -- were identified in the malignant transformation. Mutations of beta-catenin are associated with many forms of cancer, and beta-catenin activation and TERT promoter mutations in the early and later stages, respectively, were identified in the malignancy process. In addition, the researchers were able to identify factors that determined adenomas that were not at a high risk of becoming carcinoma.

"This work provided new insights about the major genetic determinants of malignant transformation and thei
'/>"/>

SOURCE American Association for the Study of Liver Diseases (AASLD)
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
2. University of Louisville researchers sign global licensing agreement
3. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
4. Researchers quantify toxic ocean conditions during major extinction 93.9 million years ago
5. Researchers discover how cancer invisibility cloak works
6. Oregon researchers say supplement cuts muscle loss in knee replacements
7. BUSM researchers identify molecule that could aid lung cancer detection, treatment
8. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
9. Researchers show how plants tell the time
10. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
11. Researchers capture images of open channel that moves proteins across cell membranes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Advances in stem cell research will provide enormous ... Basically, stem cells could replicate any other cells ... Alzheimer,s disease, repairing damaged spinal cords, treating kidney, ... whole. The potential for profit is staggering. Prof. ... that this field of research still faces myriad ...
(Date:8/1/2014)... August 1, 2014 The Journal of Nutrition ... and Best Great Educational Material (GEM) awards, which were ... (SNEB) annual conference, "Nutrition Education Impact: Local to Global," ... These annual awards recognize the authors of the ... JNEB, as judged by members of the JNEB Journal ...
(Date:8/1/2014)... at The Scripps Research Institute (TSRI) have identified a ... in brown fat cells. , The study, which ... the Proceedings of the National Academy of Sciences ... fat thermogenesis," which is of great interest to medical ... also protect against diabetes. , "This finding offers new ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3
... Washington, D.C. (January 25, 2011) -- In ... displays, touch panels, electronic ink, and solar cells, ... physicists in Iran have created a spintronic device ... being pursued by the semiconductor and electronics industries ...
... theory of natural selection on the realization that genetic ... Some individuals are better adapted to a given environment ... pass on their genes to future generations. But exactly ... poses somewhat of a puzzle to evolutionary biologists. ...
... Duke University bioengineers have developed a new method ... DNA sequences. These novel sequences of recombinant DNA ... types of drugs and bioengineered tissues. Current methods for ... the researchers said, which has hindered the development of ...
Cached Biology News:Armchair nanoribbons made into spintronic device 2Evolution by mistake 2Evolution by mistake 3Evolution by mistake 4New method for rapidly producing protein-polymers 2
(Date:7/31/2014)... , July 31, 2014 Nearly 20,000 ... th Annual Meeting & Clinical Lab Expo in ... meeting featured never-before-seen breakthroughs in diagnostic research and technology ... they need. As of Wednesday, July 30, ... AACC Annual Meeting & Clinical Lab Expo, with more ...
(Date:7/31/2014)... have mapped the sound-processing part of the mouse brain ... and the trees in view. Their imaging technique allows ... within mice, and it enabled the team to watch ... other. The results, which represent a step toward better ... July 31 the journal Neuron . , In ...
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... , July 31, 2014 Research ... "Global Genomics Market 2014-2018" report to their ... Genomics is the study of the genetic material ... be a strong basis for the discovery and development ... human diseases or health conditions. Genomics is supported by ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... AvidBiotics Corp. announced the issuance of foundational ... massive diversity within precisely targeted sites of protein-encoding ... to as Diversity Generating Retroelements (DGR) and patents ... and in Europe (#1,173,995). UCLA and AvidBiotics ...
... Exchange Symbol: MS , EDMONTON, Nov. 12 /PRNewswire-FirstCall/ - ... operational results for the three and nine months ended ... license and collaboration agreement between BioMS Medical and Eli ... with the effect that all commercial rights to dirucotide ...
... Regado Biosciences, a privately held company leading the ... that David Mazzo, PhD, CEO and President, will be ... Conference at the St. Regis Hotel in New York ... (EST) on Tuesday, November 17 and will include an ...
Cached Biology Technology:AvidBiotics Corp. Granted Key U.S. and European Patents on Unique Protein Modification Platform 2BioMS Medical Announces Third Quarter 2009 Results 2BioMS Medical Announces Third Quarter 2009 Results 3BioMS Medical Announces Third Quarter 2009 Results 4BioMS Medical Announces Third Quarter 2009 Results 5BioMS Medical Announces Third Quarter 2009 Results 6BioMS Medical Announces Third Quarter 2009 Results 7BioMS Medical Announces Third Quarter 2009 Results 8Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
A431 cells stimulated with EGF Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
... 'The Gene Construction KitTM allows graphic ... drawing options. It has an award winning ... DNA sequences in addition to providing sophisticated ... GCK was named the "Best Plasmid Mapping ...
... collects data from balances and scales with RS232 ... other program. If you can type the weight ... collection process Simple to use parser extracts ... , Add user information , Collect data at ...
Biology Products: