Navigation Links
Researcher tricks immune system in diabetic mice
Date:11/20/2008

unrong Luo, assistant professor of medicine in nephrology at the Feinberg School, was co-principal investigator for the study.

In the study, researchers took a type of white blood cell from the islet donor's spleen, called splenocytes, and treated them with a chemical that masked the cells' identity. They then injected these chemically treated cells into diabetic mice before and after the mice underwent islet cell transplantation. As a result, the immune system of the mice didn't try to reject the cells, because it didn't perceive them as foreign and dangerous.

When the same test was done without pre-treated cells, the immune system rejected the transplanted islets within 15 days.

In an upcoming study, Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as occurs in type 1 diabetes. Researchers will use therapies that prevent the autoimmune system's response against its own beta cells (which are part of the islets) as well as prevent the recipient's immune responses against the transplanted islet cells.

"We have ways we can do both," Miller said. "Hopefully this next study will show we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that together, we hopefully can cure an animal who became diabetic from autoimmune disease." If successful, the next step would be testing the technique on human subjects.

Miller said this technique also has applications for treating other autoimmune diseases such as multiple sclerosis.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... Jan. 30, 2015  It is gratifying to see ... potential for genomic science as a means to better ... and treatment.  I was honored to participate in today,s ... medicine program. Since the 1980s my ... genomics—from the first sequenced genome of a free living ...
(Date:1/22/2015)... - Today, FindBiometrics, the leading source of biometrics industry news, interviews ... design. "When we launched FindBiometrics 12 years ago ... , founder and CEO of FindBiometrics. "Now it,s maturing very ... key players on a very broad scale.  We are known ...
(Date:1/22/2015)... Jan. 16, 2015  A man-made form of insulin delivered ... mental capabilities in adults with mild cognitive impairment and ... by researchers at Wake Forest Baptist Medical Center. ... amnesic mild cognitive impairment (MCI) or mild to moderate ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... researchers and a colleague from India unveiled a new ... was presented at the 63rd annual meeting of the ... The cancer treatment uses hyperthermia to elevate the ... tissue at a lower degree of body heat. The ...
... clocks adjust to having less sunlight in the winter could help ... Scientists studying the daily activity cycle in plants known ... enables the plant,s genes to respond to the times of dawn ... in between. This system helps the plant to reset its ...
... engineering researchers in the University of Minnesota,s College of ... at higher temperatures may be an effective tool in ... solid waste to 130 degrees Fahrenheit (55 degrees Celsius) ... antibiotic resistance. These genes are used by bacteria to ...
Cached Biology News:Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative 2University of Minnesota engineering researcher finds new way to fight antibiotic-resistant bacteria 2
(Date:3/5/2015)... e2b teknologies , a premier Sage ... Ohio, today announced a leading independent multi-specialty physician group ... to the latest version of Sage 100 ERP ... its kind in the region, the organization has an ... efficiency and data accessibility are paramount to their ongoing ...
(Date:3/4/2015)... The UPMC Center for Health Security today ... Emerging Leaders in Biosecurity Initiative (ELBI). As part of ... of biosecurity, UPMC has selected 28 US and international ... backgrounds, including biological science, medicine, policy, the military, think ... the vision and support of the Defense Threat Reduction ...
(Date:3/4/2015)... , March 4, 2015 /CNW/ - Resverlogix Corp. ... has completed a collaborative research program with ...  Using Fast Collective Evolution Technology (FACET), Emerald ... all measurements obtained from each of 798 ... 2 clinical trials ASSERT, SUSTAIN and ASSURE. ...
(Date:3/4/2015)... South Korea , March 4, 2015 ... biopesticide company, in August of last year. As part ... Kyung Bon Koo continuing his role as ... , President of Vegalab S.A., will work alongside Koo ... Photo - http://photos.prnewswire.com/prnh/20150303/179218 ...
Breaking Biology Technology:Physician Group Practice Chooses e2b teknologies to Support Its Upgrade to Sage 100 ERP 2014 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3
... , Abstract ... two new columns , with differing surface treatment procedures and ... wide range of sample types. , , ... recent years, many new octadecylsilane (ODS) chemistries have been , ...
... Introduction , It is ... more efficient at the expense of higher back pressure compared to columns , ... usually traded , off by reducing column length, which ... lower column back pressure. , Recently, two lines of 5 ...
... Vin, DataApex Ltd., Praha, Czech Republic www.dataapex.com , ... Berek, Polymer Institute SAV, Bratislava, Slovak Republic, ... , Determination ... with concentration or mass,selective detectors is a simple, affordable solution ...
Cached Biology Technology:TSKgel ODS-100Z and TSKgel ODS-100V column series provides a universal solution for the analysis of samples containing acidic, basic, polar & non-polar compounds 2TSKgel ODS-100Z and TSKgel ODS-100V column series provides a universal solution for the analysis of samples containing acidic, basic, polar & non-polar compounds 3Three Micron TSK-GEL ODS-100V Columns for High Throughput LCMS 2Practical Aspects of Evaluation of Chromatographic Data in Size Exclusion Chromatography 2Practical Aspects of Evaluation of Chromatographic Data in Size Exclusion Chromatography 3Practical Aspects of Evaluation of Chromatographic Data in Size Exclusion Chromatography 4Practical Aspects of Evaluation of Chromatographic Data in Size Exclusion Chromatography 5
... cocktail is tailored to efficiently ... suspensions of non-human primate (Rhesus ... using the StemSep (or compatible ... system, achieving a 2.6 Log ...
...
...
... DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any electrophoresis agarose available, allowing, ... preparation of very ... ...
Biology Products: