Navigation Links
Research shows skeleton to be endocrine organ
Date:8/13/2007

Bones are typically thought of as calcified, inert structures, but researchers at Columbia University Medical Center have now identified a surprising and critically important novel function of the skeleton. Theyve shown for the first time that the skeleton is an endocrine organ that helps control our sugar metabolism and weight and, as such, is a major determinant of the development of type 2 diabetes.

The research, published in the August 10 issue of Cell, demonstrates that bone cells release a hormone called osteocalcin, which controls the regulation of blood sugar (glucose) and fat deposition through synergistic mechanisms previously not recognized. Usually, an increase in insulin secretion is accompanied by a decrease in insulin sensitivity. Osteocalcin, however, increases both the secretion and sensitivity of insulin, in addition to boosting the number of insulin-producing cells and reducing stores of fat.

In this published research, authors show that an increase in osteocalcin activity prevents the development of type 2 diabetes and obesity in mice. This discovery potentially opens the door for novel therapeutic avenues for the prevention and treatment of type 2 diabetes.

The discovery that our bones are responsible for regulating blood sugar in ways that were not known before completely changes our understanding of the function of the skeleton and uncovers a crucial aspect of energy metabolism, said Gerard Karsenty, M.D., Ph.D., chair of the department of Genetics and Development at Columbia University Medical Center, Paul Marks Professor in the Basic Sciences, and senior author of the paper. These results uncover an important aspect of endocrinology that was unappreciated until now.

Karsenty and his colleagues had previously shown that leptin, a hormone released by fat cells, acts upon and ultimately controls bone mass. They reasoned that bones must in turn communicate with fat, so they searched bone-forming
'/>"/>

Contact: Susan Craig
sc2756@columbia.edu
212-305-9746
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... and other forms of dementia, but the research community ... of Washington bioengineers have a designed a peptide structure ... normal proteins into a state that,s linked to widespread ... diabetes and Lou Gehrig,s disease. The synthetic molecule blocks ... into an abnormally folded form by targeting a toxic ...
(Date:7/28/2014)... that 73 percent of adult survivors of childhood cancer ... and related health problems by failing to follow a ... of the journal Cancer . , Almost 32 ... in the study had metabolic syndrome, an umbrella term ... obesity, elevated triglyceride and other abnormalities that often occur ...
(Date:7/28/2014)... Research and Markets has announced the addition ... report to their offering. ... biological data. These systems capture biological traits such as ... hand measurements from the subject and compare the data ... of a biometrics system is to identify and verify ...
Breaking Biology News(10 mins):New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3Biometrics Market in Latin America 2014-2018 2
... on Contact Metallic copper surfaces kill microbes ... in the February 2011 issue of the journal ... in minutes, by causing massive membrane damage after about ... Grass of the University of Nebraska, Lincoln. This is ...
... Qqest and M2SYS Technology, a global biometrics research and ... to offer TimeForce time and attendance customers the added ... their PC. M2SYS, RightPunch(TM) solution enables the ... interface with Qqest,s TimeForce time and attendance system, providing ...
... cancer, and development of new cancer therapeutics, has focused ... of focus is the life and death of a ... cell death, is a fundamental process of cells including ... involve many different proteins and their interactions with each ...
Cached Biology News:Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4Tips from the journals of the American Society for Microbiology 5Tips from the journals of the American Society for Microbiology 6Tips from the journals of the American Society for Microbiology 7Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 2Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 3Designing new molecular tools to study the life and death of a cancer cell 2Designing new molecular tools to study the life and death of a cancer cell 3Designing new molecular tools to study the life and death of a cancer cell 4
(Date:7/28/2014)... and COLLEGE STATION, Texas , July 28, 2014 ... theatlashotel.com will be a 177-key, 4-star boutique hotel in the ... Bryan , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... As the first hotel within ATLAS , ... a mixture of standard rooms and suites, a sleek restaurant and ...
(Date:7/25/2014)... NY (PRWEB) July 26, 2014 ... Review, H2, 2014" provides data on the Ischemic ... report provides elemental information and data relating to ... Stroke. , View full global Ischemic Stroke Research ... includes an overview of the trial numbers and ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
(Date:7/25/2014)... 2014 Lawrence Livermore scientists Charles Westbrook ... list of " The World's Most Influential Scientific Minds ... 3,000 researchers who were identified by analyzing citation data ... published the highest-impact work (2002-2012 and 2012-2013). The two ... combustion modeling . , "This recognition is a great ...
Breaking Biology Technology:Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4
... 2009 Senomyx, Inc. (Nasdaq: SNMX ), ... discover and develop novel flavor ingredients for the food, ... SA has selected a new flavor ingredient, which was ... for development activities and evaluation of commercial potential in ...
... -- American Oriental,Bioengineering, Inc. (NYSE: AOB ), ... manufacture and commercialization of,a broad range of prescription and ... Company,s participation in the following conferences: , , ... May 6-8 at the Ritz Carlton in, ...
... Breakthrough biotechnology research is providing new applications ... and diabetes, two leading health concerns among consumers. ... Advana Science, www.advanascience.com , will ... this dynamic consumer healthy category at VitaFoods International ...
Cached Biology Technology:SENOMYX ANNOUNCES NESTLE'S SELECTION OF A NEW FLAVOR INGREDIENT FOR EVALUATION OF COMMERCIAL POTENTIAL 2SENOMYX ANNOUNCES NESTLE'S SELECTION OF A NEW FLAVOR INGREDIENT FOR EVALUATION OF COMMERCIAL POTENTIAL 3Industry Expert Reveals Cutting Edge Biotechnology Science for Nutraceutical and Functional Food Applications 2
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
... The Bio-Plex suspension array system, 100-240 ... technology) for simultaneous quantitative analysis of up ... single microplate well. The suspension array is ... sets, each of which may be conjugated ...
... fluidics (HTF) system, 100-240 V, is an ... system that automates delivery of up to ... Bio-Plex array reader. The HTF system automatically ... sheath container to constantly maintain a reservoir ...
Cell Culture Flask, 75 cm, nontreated polystyrene...
Biology Products: