Navigation Links
Research shows skeleton to be endocrine organ
Date:8/13/2007

Bones are typically thought of as calcified, inert structures, but researchers at Columbia University Medical Center have now identified a surprising and critically important novel function of the skeleton. Theyve shown for the first time that the skeleton is an endocrine organ that helps control our sugar metabolism and weight and, as such, is a major determinant of the development of type 2 diabetes.

The research, published in the August 10 issue of Cell, demonstrates that bone cells release a hormone called osteocalcin, which controls the regulation of blood sugar (glucose) and fat deposition through synergistic mechanisms previously not recognized. Usually, an increase in insulin secretion is accompanied by a decrease in insulin sensitivity. Osteocalcin, however, increases both the secretion and sensitivity of insulin, in addition to boosting the number of insulin-producing cells and reducing stores of fat.

In this published research, authors show that an increase in osteocalcin activity prevents the development of type 2 diabetes and obesity in mice. This discovery potentially opens the door for novel therapeutic avenues for the prevention and treatment of type 2 diabetes.

The discovery that our bones are responsible for regulating blood sugar in ways that were not known before completely changes our understanding of the function of the skeleton and uncovers a crucial aspect of energy metabolism, said Gerard Karsenty, M.D., Ph.D., chair of the department of Genetics and Development at Columbia University Medical Center, Paul Marks Professor in the Basic Sciences, and senior author of the paper. These results uncover an important aspect of endocrinology that was unappreciated until now.

Karsenty and his colleagues had previously shown that leptin, a hormone released by fat cells, acts upon and ultimately controls bone mass. They reasoned that bones must in turn communicate with fat, so they searched bone-forming
'/>"/>

Contact: Susan Craig
sc2756@columbia.edu
212-305-9746
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 3, 2015 Despite a lack of ... such as consumer electronics, automotive, storage and telecommunication ... technology (SMT) screen printers. Innovations in electronics and ... push the adoption curve up. Meanwhile, sale volumes ... glue dispensers are indispensable in the production of ...
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source ... launch of its new website design. "When we ... infancy", says Peter O,Neill , founder and CEO of ... industry needs involvement from the key players on a very ...
(Date:1/22/2015)... , Jan. 15, 2015  BellBrook Labs, a ... discovery, announced the launch of a TR-FRET (time ... company,s Transcreener UDP Assay, a high throughput screening ... new assay will allow for sensitive detection of ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... that protects metals against corrosion in seawater has ... Sheffield Hallam University. At the Society for General ... Jeanette Gittens and colleagues described how they had ... coating which then protected an aluminium alloy from ...
... Institutes of Health (NIH) researchers have identified a gene that ... cancer. The finding is reported today in the journal ... of a group of enzymes implicated in skin cancer and ... found that one-quarter of human melanoma tumors had changes, or ...
... insight into mechanisms that allow invasive tumor cells to move, ... new understanding about how to stop cancer from spreading. A ... is the process that most often leads to death from ... Nature Cell Biology , researchers say that a molecule ...
Cached Biology News:Skin cancer study uncovers new tumor suppressor gene 2Skin cancer study uncovers new tumor suppressor gene 3Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells 2
(Date:3/4/2015)... CA (PRWEB) March 04, 2015 ... leader in Personalized Medicine, is excited to announce ... Genetic Testing to Optimize the Management of Pain”. ... available at Medscape.com for the next year. The ... professionals how to recognize inadequate pain treatments, integrate ...
(Date:3/4/2015)... San Jose, California (PRWEB) March 04, 2015 ... Chain Reaction (PCR) represents one of the fastest growing ... among cell biologists in subcellular visualization is driving growth ... The need for deeper understanding of gene expressions will ... reagents market. Expanding applications in fields ranging from pharma, ...
(Date:3/3/2015)... DIEGO and TORONTO, March 3, 2015 /PRNewswire/ - Aptose ... developing new therapeutics and molecular diagnostics that target the ... the quarter and seventh-month period ended December 31, 2014. ... its fiscal year end from May 31 to December ... we are reporting today are for the quarter and ...
(Date:3/3/2015)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... control projects in North America , the ... "Bidding activity in 2015 continues to be robust" said ... volume year for bidding in 2014, we are pleased to see ... reflect the organization,s renewed focus on select market segments where we ...
Breaking Biology Technology:Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 2Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 3Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 4Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 5Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 6Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 7Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 8Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 9Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 10Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 11Aptose Biosciences reports results for the quarter and seven months ended December 31, 2014 12
... the atomic forces that cause friction, thanks to a ... Pennsylvania, the University of Houston and the U.S. Department ... by Robert Carpick of the University of Pennsylvania, found ... that had been coated with different isotopes of hydrogen ...
... CARMIEL, Israel, Nov. 2 Protalix,BioTherapeutics, Inc. (Amex: ... Aviezer,Ph.D., its President and Chief Executive Officer, will ... Conference. Dr. Aviezer,s presentation,will take place at 3:00 ... Hotel in New York City. Dr. Aviezer,s ...
... Confirmed, REINACH and BASEL, Switzerland, November 2 ... on its late-stage,investigational antibiotic iclaprim at the 9th ... VKliPha) which takes place,1-3 November in Kiel, Germany. ... substantial volume of data on iclaprim that is ...
Cached Biology Technology:Heavier hydrogen on the atomic scale reduces friction 2Protalix BioTherapeutics to Present at CIBC World Markets 18th Annual Healthcare Conference 2Arpida Presents Data on Iclaprim at Scientific Congress in Germany 2Arpida Presents Data on Iclaprim at Scientific Congress in Germany 3Arpida Presents Data on Iclaprim at Scientific Congress in Germany 4
Edited by I.H. Pawlowitzki, J.H. Edwards and E.A. Thompson (1997) • This volume covers: Linkage in dominant recessive and oligogenic disease, Model free (non-parametric) methods, Tools for gene ...
... TOPO Cloning is the ... for cloning PCR products. ... Zero Blunt TOPO vectors ... activated with topoisomerase I. ...
Applications: ISH...
... Immunogen: Recombinant human IDO (Indoleamine-pyrrol ... the ~44 kDa human IDO ... control: IFN-Gamma-stimmulated Human peripheral blood ... reactivity with mouse and rat ...
Biology Products: