Navigation Links
Research shows skeleton to be endocrine organ
Date:8/13/2007

Bones are typically thought of as calcified, inert structures, but researchers at Columbia University Medical Center have now identified a surprising and critically important novel function of the skeleton. Theyve shown for the first time that the skeleton is an endocrine organ that helps control our sugar metabolism and weight and, as such, is a major determinant of the development of type 2 diabetes.

The research, published in the August 10 issue of Cell, demonstrates that bone cells release a hormone called osteocalcin, which controls the regulation of blood sugar (glucose) and fat deposition through synergistic mechanisms previously not recognized. Usually, an increase in insulin secretion is accompanied by a decrease in insulin sensitivity. Osteocalcin, however, increases both the secretion and sensitivity of insulin, in addition to boosting the number of insulin-producing cells and reducing stores of fat.

In this published research, authors show that an increase in osteocalcin activity prevents the development of type 2 diabetes and obesity in mice. This discovery potentially opens the door for novel therapeutic avenues for the prevention and treatment of type 2 diabetes.

The discovery that our bones are responsible for regulating blood sugar in ways that were not known before completely changes our understanding of the function of the skeleton and uncovers a crucial aspect of energy metabolism, said Gerard Karsenty, M.D., Ph.D., chair of the department of Genetics and Development at Columbia University Medical Center, Paul Marks Professor in the Basic Sciences, and senior author of the paper. These results uncover an important aspect of endocrinology that was unappreciated until now.

Karsenty and his colleagues had previously shown that leptin, a hormone released by fat cells, acts upon and ultimately controls bone mass. They reasoned that bones must in turn communicate with fat, so they searched bone-forming
'/>"/>

Contact: Susan Craig
sc2756@columbia.edu
212-305-9746
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... out of York University shows a surprisingly effective way ... fungus: moose saliva (yes moose saliva). , Published ... inhibits a grassendophyte mutualism" shows that moose and reindeer ... a fungus called epichlo festucae that produces the toxin ... , "Plants have evolved defense mechanisms to protect themselves, ...
(Date:7/24/2014)... have similar counterparts in humans, affect the connections between ... into the hippocampus, an area of the brain that ... creation of memories. The results of the study have ... Brain function depends on the active communication between nerve ... woven together into a dense network where they constantly ...
(Date:7/24/2014)... funded by the New Jersey Recovery Fund and conducted ... Planning and Public Policy at Rutgers University has found ... about the likelihood of community-based rebuilding solutions. Of the ... they were "pessimistic" or "very pessimistic" that the parts ... rebuilt better than they were before the storm; another ...
Breaking Biology News(10 mins):Moose drool inhibits growth of toxic fungus: York U research 2A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... molecular and protein signatures that predict rapid onset of ... transplant. The markers appeared soon after transplant and ... Such early detection of susceptibility to hepatitis C virus-induced ... treatment options after a transplant. Also, because the ...
... charcoal preserved in deeply buried sediments in Egypt,s Nile ... a huge drought 4,200 years ago associated with the ... the pyramid-building time. "Humans have a long history ... Bernhardt, a researcher with the U.S. Geological Survey. "Along ...
... NC Leukemia and lymphoma patients who receive life-saving ... side effects that significantly decrease quality of life, can ... In chronic Graft vs. Host Disease ... and the recipient,s body often cause these immune cells ...
Cached Biology News:Molecular and protein markers discovered for liver transplant failure from hepatitis C 2Molecular and protein markers discovered for liver transplant failure from hepatitis C 3Molecular and protein markers discovered for liver transplant failure from hepatitis C 4Climate and drought lessons from ancient Egypt 2B cell survival holds key to chronic graft vs. host disease 2
(Date:7/24/2014)... 24, 2014 Your cell phone ... modeling lithium-ion battery storage capacity. , New research ... theoretical model created at Lawrence Livermore National ... predicts how carbon components will perform as electrodes. ... the urgent need for higher-performance batteries. Several key ...
(Date:7/24/2014)... Three companies from the angelMD network were ... Competition. Out of 700 competition entrants, Chiron Health, Litesprite, ... round. In this round twenty teams are invited to ... mentoring from thought-leaders and medical entrepreneurs from all over ... commitment to the Livestrong vision around the Big C ...
(Date:7/24/2014)... , July 24, 2014 WIRB-Copernicus Group ... regulatory and ethical review services for clinical research, ... Formerly a division of Richmond, VA ... leading biosafety and biosecurity consulting firm in ... addition, WCG,s biosafety division – WCG Biosafety™ – ...
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 ... http://www.draperuniversity.com , is proud to announce that for ... 17 different countries will converge on the Draper ... for an intensive, experiential program focused on entrepreneurship, ... highly selective school, currently running its sixth cohort, ...
Breaking Biology Technology:Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3
... United States Department of Energy will invest up to ... Centers, including $125 million for a center led by the ... cellulosic ethanol. , ,The Madison bioenergy research facility , ... Center, will operate in collaboration with Michigan State University ...
... In the age of digital everything, print still captures the ... of everything Internet. , ,There's no clearer example than ... when the company was no more than a brief ... on a windy afternoon and Eileen unwound a vision for ...
... Adelante, Atras!* (For a translation, scroll to the end). The ... buyers alike modifying their steps as the Internet changes everything. ... us have adopted at least some of these changes (both ... information, communicate, interact with each other, or buy and sell ...
Cached Biology Technology:UW-Madison to receive $125M for bioenergy research center 2UW-Madison to receive $125M for bioenergy research center 3Blurb shows that print still captures imaginations 2Blurb shows that print still captures imaginations 3Online retailing "tango" is adding some steps 2Online retailing "tango" is adding some steps 3Online retailing "tango" is adding some steps 4Online retailing "tango" is adding some steps 5Online retailing "tango" is adding some steps 6
... neurons in vesicles called synaptosomes. ... bouton. Synaptosomes may be centrifuged ... cellular debris. Abnormalites in neurotransmitter release ... condtions. Conditions of release may ...
... Detection Systems allow non-radioactive detection of ... systems, biotinylated lysine residues are incorporated ... the need for labeling with [35-S]methionine ... biotinylated lysine is added to the ...
... Series Hybridization chambers with forced convection ... ambient up to 99.9 C / 212 F ... and reproducible results DS controller Timer ... with an accuracy of a tenth of a ...
... microarray data using Asuragens bioinformatics expertise. We ... to extensive data analysis using the most ... in combination with the Gene Expression Profiling ... ,Normalization and basic statistical analysis including publication ...
Biology Products: