Navigation Links
Research shows how PCBs promote dendrite growth, may increase autism risk
Date:4/25/2012

(SACRAMENTO, Calif.) New research from UC Davis and Washington State University shows that PCBs, or polychlorinated biphenyls, launch a cellular chain of events that leads to an overabundance of dendrites the filament-like projections that conduct electrochemical signals between neurons and disrupts normal patterns of neuronal connections in the brain.

"Dendrite growth and branching during early development is a finely orchestrated process, and the presence of certain PCBs confuses the conductor of that process," said Pamela Lein, a developmental neurobiologist and professor of molecular biosciences in the UC Davis School of Veterinary Medicine. "Impaired neuronal connectivity is a common feature of a number of conditions, including autism spectrum disorders."

Reported today in two related studies in the journal Environmental Health Perspectives, the findings underscore the developing brain's vulnerability to environmental exposures and demonstrate how PCBs could add to autism risk.

"We don't think PCB exposure causes autism," Lein said, "but it may increase the likelihood of autism in children whose genetic makeup already compromises the processes by which neurons form connections."

The senior authors of the studies were Lein and Isaac Pessah, chair of molecular biosciences in the School of Veterinary Medicine and director of the Center for Children's Environmental Health at UC Davis. Both are researchers with the UC Davis MIND Institute, which is dedicated to finding answers to autism and other neurodevelopmental disorders. The lead author was Gary Wayman of Washington State University's Program in Neuroscience, who first described the molecular pathway that controls the calcium signaling in the brain that guides normal dendrite growth.

Wayman found that key cellular players, called calcium and calmodulin kinases, are activated by increased calcium levels. Activated calmodulin kinase then turns on th
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers announce GenomeSpace environment to connect genomic tools
2. BGI and Aspera collaborate on high-speed data exchange to advance genome research
3. Evidence shows that anti-depressants likely do more harm than good, researchers find
4. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
5. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
6. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
7. Researchers find mechanism that gives plants balance
8. Research is ensuring stormwater systems are designed for the future
9. New research underscores the health benefits of fibers, including bone health
10. Research on carbon-consuming life-forms in Antarctica published in JoVE
11. Climate change may create price volatility in the corn market, say Stanford and Purdue researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... lab experiments using tissue samples cultured from cystic fibrosis ... the UNC Marsico Lung Institute have shown that a ... of another CF drug. , The finding, published today ... how a mutant CFTR protein becomes unstable and loses ... of the two drugs. The research offers several insights ...
(Date:7/23/2014)... are disappearing, and though conservationists are examining several possible ... rain and light pollution, a key piece of the ... once they leave their breeding sites, and what threats ... answer this question, a team of researchers out of ... map produced for a songbird, using tracking from both ...
(Date:7/23/2014)... This news release is available in German . ... shape and stability to cells, drive metabolic processes and ... into complex three-dimensional shapes. Scientists at the Max Planck ... that proteins can be constructed of similar amino acid ... suggests that the proteins that exist today arose from ...
Breaking Biology News(10 mins):UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2Protein evolution follows a modular principle 2
... Mirror neurons, many say, are what make us human. They ... we perform a particular action but also when we watch someone ... is the mechanism by which we can "read" the minds of ... how we discern a grimace from a grin, a smirk from ...
... According to a University of Illinois study, omega-3 fatty ... little-known omega-3 may have implications for treating male infertility. ... gene responsible for an enzyme important in making docosahexaenoic acid ... infertile, producing few if any misshaped sperm that can,t get ...
... An international research team co-led by the Ontario ... specific lymphoma cells a discovery that will accelerate ... of non-Hodgkins lymphoma. The research findings, published ... show how the scientists used a chemical compound to ...
Cached Biology News:UCLA researchers make first direct recording of mirror neurons in human brain 2UCLA researchers make first direct recording of mirror neurons in human brain 3U of I study: Lack of omega-3 fatty acid linked to male infertility 2
(Date:7/24/2014)... (PRWEB) July 24, 2014 Draper ... , is proud to announce that for 6 ... different countries will converge on the Draper University ... an intensive, experiential program focused on entrepreneurship, building ... selective school, currently running its sixth cohort, continues ...
(Date:7/23/2014)... 24, 2014 Lyfebulb, the International Pemphigus ... and NASDAQ OMX First North Premier, ... announced a collaboration to increase awareness of unmet ... an event attended by more than sixty patients, ... a health and wellness company dedicated to serving ...
(Date:7/23/2014)... Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna University of Technology ... in embedding nearly perfect semiconductor crystals into a ... hybrid nanowires, very fast and multi-functional processing units ... the future. The research results will be published ... Nano-optoelectronics are considered the cornerstone of future chip ...
(Date:7/23/2014)... , July 23, 2014  Having the right ... is vital to accelerating business growth and achieving clinical ... Hospital Association (AHA) Leadership Summit, July 20-22, 2014, in ... panel of hospital executives and healthcare experts discussing how ... Joanne Carrocino , President & Chief Executive Officer of ...
Breaking Biology Technology:Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5A crystal wedding in the nanocosmos 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2
... Characterization of nucleotide and nucleoside analogs from Taraxacum mongolicum, ... time using liquid chromatography tandem mass spectrometry (LC/MS/MS). The ... and nucleoside standards with product and precursor scans of ... be major active ingredients which have anti-Herpes simplex virus ...
... A very straightforward method for the analysis of ... oxydemeton-methyl, vamidothion, and monocrotophos in water has been developed. ... onto a RP18 HPLC column with a polar endcapping. ... a tandem mass spectrometer operated in multiple reaction-monitoring mode. ...
... , ... the quantitation of , pesticide residues in food ... very sensitive, selective, and rugged LC/MS/MS technologies. In this , ... is described. In particular the role of the collision cell in the ...
Cached Biology Technology:Isolation and Characterization of Anti-Viral Nucleoside Compounds from the Chinese Herb Taraxacum Mongolicum 2Isolation and Characterization of Anti-Viral Nucleoside Compounds from the Chinese Herb Taraxacum Mongolicum 3Determination of Polar Organophosphorus Pesticides in Aqueous Samples by Direct Injection Using HPLC/MS/MS 2Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 2Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 3Fast Multi-Residue Pesticide Analysis in Soil and Vegetable Samples 4
Mouse monoclonal antibody raised against a full length recombinant YARS. NCBI Entrez Gene ID = YARS...
Mouse monoclonal antibody raised against a partial recombinant JRKL. NCBI Entrez Gene ID = JRKL...
... imaging system for detection of very low ... size. Equipped with an extreme sensitive camera ... or plants in tumor research, infectious disease ... blots. NightOWL is the only imager with ...
... cell sorter sets a new standard for ... a revolutionary new design in instrumentation, this ... multicolor analysis. The BD FACSAria instrument is ... fixed-alignment cuvette flow cell. This new ...
Biology Products: