Navigation Links
Research reveals lipids' unexpected role in triggering death of brain cells
Date:11/12/2009

The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.

The work provides the first evidence that a lipid can initiate the suicidal, or apoptotic, response in cells. The findings involve a lipid called GM1-ganglioside. Lipids are fat-like molecules. GM1 builds up with devastating results in the brain cells of patients with GM1-gangliosidosis because they lack the enzyme required to break down that molecule.

Working in mice missing this key enzyme, researchers reported new details of how GM1 accumulation inside certain structures in brain cells disrupts their internal calcium balance. This imbalance ultimately leads to the programmed cell death known as apoptosis. The work appears in the November 13 online edition of Molecular Cell.

"The finding is essential for understanding the causes of progressive loss of brain cells, characteristic of this disease," said Alessandra d'Azzo, Ph.D., of St. Jude Genetics and Tumor Cell Biology. She is the senior author of the report and holds the Jewelers for Children Endowed Chair in Genetics and Gene Therapy. The work also provides hints for a strategy to intervene in the disease process.

The research led d'Azzo and her colleagues to propose that the death of brain cells and neurodegeneration that strikes GM1-gangliosidosis patients is a two-step process. The investigators demonstrated that blocking the first step in this process prevented cells from self-destructing, which was not the case when just the second step was inhibited. They predicted the discovery might have important implications for developing new treatments for this catastrophic disease.

The findings also have implications for scientists studying other aspects of the cross-talk between intracellular compartments, involving calci
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers gather in the UK to measure the impossible
2. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
3. Carnegie Mellon researchers to develop probes to study cellular GPS
4. Escaped proteins add to hearing loss in elderly, UF researchers find
5. CBS and OMD Partner to Provide the Agency With Access to the Networks Television City Research Facility in Las Vegas
6. Researchers complete draft genome sequence for cassava
7. £3.2m ($5.4 million) research project to capture brilliance of butterfly wings
8. Monell Center joins with CAS to host Beijing meeting on taste and smell research
9. Genomic research will enable greener cleanup of military explosive test sites
10. Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
11. MSU researcher: Obesity significantly cuts odds of successful pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... French . NAIROBI ... African soils looming as a major threat to food security ... over the last five years, 1.7 million African farmers in ... million hectares and helped them double or even triple crop ... Revolution in Africa (AGRA) focuses on intensive efforts initiated five ...
(Date:8/22/2014)... release is available in German . ... substances, in PCFs proteins are fixated in a way ... crystals. Next, the HZB and Fudan University researchers are ... as functional materials. Their findings are being published today ... 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone knows that ...
(Date:8/22/2014)... birds and the bees. But that old expression ... The fertilization process for flowering plants is particularly ... and female reproductive cells. New research from an ... and including Carnegie,s Wolf Frommer, David Ehrhardt, and ... process that guides flowering plant fertilization. It is ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4Proteins: New class of materials discovered 2Calcium and reproduction go together 2
... (Nov. 4, 2010) Columbia University Medical Center has ... in Cardiovascular Research, with the 2010 Lewis Katz Visiting ... renowned heart failure expert from University of Texas Southwestern ... winners of the 2010 Lewis Katz Cardiovascular Research Prize ...
... Nov. 4, 2010 BIO-key International, Inc. (OTC Bulletin ... biometric identification solutions, today announced plans to release third ...  In conjunction with the release, BIO-key has scheduled a ... Internet on Thursday, November 11, 2010 at 10:00 a.m. ...
... amount of water flowing in streams and rivers has ... that were assessed in a new nationwide USGS study. ... river ecosystems and loss of native species. ... to date of stream flow alteration," said Bill Werkheiser, ...
Cached Biology News:Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 2Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 3Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 4Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 5BIO-key® Announces Third Quarter 2010 Earnings Release and Conference Call Schedule 2Most river flows across the US are altered by land and water management 2
(Date:8/21/2014)... 2014  Decision Resources Group finds that the ... and Mexico currently faces ... approved agents, the anticipated label extension of Boehringer ... of emerging biologics will substantially increase the competitiveness ... IL-5 inhibitors will introduce a new dynamic to the ...
(Date:8/21/2014)... HONG KONG , Aug. 21, 2014  China Cord ... today announced its plan to release financial results for ... August 28, 2014, after market close in the US.  ... call at 8:00 a.m. ET on Friday, August 29, ... brief overview of the Company,s recent developments, followed by ...
(Date:8/21/2014)... 21, 2014 Ontotext S4 , ... Ontotext . Now the same enterprise hardened ... structured and unstructured data is available to start-ups and ... enterprise technology. Organizations that do not have resources to ... can use S4 since there is no need for ...
(Date:8/21/2014)... of last week RENU 28, the world's first and only ... purchase in Australia and New Zealand, and the response has ... if you think about the definition of aging, it's really ... your body. If you think about the definition of anti-aging, ... RENU 28 does is it works with these tiny little ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2
... CALGARY, Feb. 11 /PRNewswire-FirstCall/ - SemBioSys Genetics ... of therapeutic,proteins for metabolic and cardiovascular diseases, today ... of the Company, will be,presenting a corporate update ... on Wednesday, February 13, 2008 at the Waldorf ...
... Fla., Feb. 11 Further to Phlo,Corporation,s ("Phlo"") (OTC: ... Roll Out to Metropolitan New York City Account,Base," an ... distributor in Metropolitan New York City has sold and ... key account base,as part of such roll out. AQISS(TM) ...
... Feb. 11 Santaris Pharma, the,Danish biopharmaceutical company ... McCullagh, President and Chief Executive,Officer, will be presenting ... for,2008 at the Biotechnology Industry Organisation,s 10th Annual ... February 11th at 12:30 pm,US Eastern Standard Time ...
Cached Biology Technology:SemBioSys to present at the 10th Annual BIO CEO & Investor Conference 2Phlo Affiliate Reports Progress in New York City Metropolitan Area Roll-Out 2Santaris Pharma to Present at 10th Annual Biotechnology Industry Organisation CEO & Investor Conference - February 11th, 2008 2
alpha/beta-Tubulin Antibody Ship: Hot Store: -20 C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
TXNL2 Antibody...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Biology Products: