Navigation Links
Research reveals lipids' unexpected role in triggering death of brain cells
Date:11/12/2009

The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.

The work provides the first evidence that a lipid can initiate the suicidal, or apoptotic, response in cells. The findings involve a lipid called GM1-ganglioside. Lipids are fat-like molecules. GM1 builds up with devastating results in the brain cells of patients with GM1-gangliosidosis because they lack the enzyme required to break down that molecule.

Working in mice missing this key enzyme, researchers reported new details of how GM1 accumulation inside certain structures in brain cells disrupts their internal calcium balance. This imbalance ultimately leads to the programmed cell death known as apoptosis. The work appears in the November 13 online edition of Molecular Cell.

"The finding is essential for understanding the causes of progressive loss of brain cells, characteristic of this disease," said Alessandra d'Azzo, Ph.D., of St. Jude Genetics and Tumor Cell Biology. She is the senior author of the report and holds the Jewelers for Children Endowed Chair in Genetics and Gene Therapy. The work also provides hints for a strategy to intervene in the disease process.

The research led d'Azzo and her colleagues to propose that the death of brain cells and neurodegeneration that strikes GM1-gangliosidosis patients is a two-step process. The investigators demonstrated that blocking the first step in this process prevented cells from self-destructing, which was not the case when just the second step was inhibited. They predicted the discovery might have important implications for developing new treatments for this catastrophic disease.

The findings also have implications for scientists studying other aspects of the cross-talk between intracellular compartments, involving calci
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers gather in the UK to measure the impossible
2. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
3. Carnegie Mellon researchers to develop probes to study cellular GPS
4. Escaped proteins add to hearing loss in elderly, UF researchers find
5. CBS and OMD Partner to Provide the Agency With Access to the Networks Television City Research Facility in Las Vegas
6. Researchers complete draft genome sequence for cassava
7. £3.2m ($5.4 million) research project to capture brilliance of butterfly wings
8. Monell Center joins with CAS to host Beijing meeting on taste and smell research
9. Genomic research will enable greener cleanup of military explosive test sites
10. Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
11. MSU researcher: Obesity significantly cuts odds of successful pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... commonly found in dead bodies and is used in ... to as the post mortem interval. A report of ... Tamil Nadu is provided for the first time based ... DNA barcoding. This study, significant in forensic investigations was ... . , Chrysomya megacephala is commonly found ...
(Date:7/23/2014)... struggle to deal with ever-growing piles of electronic waste ... just how much there is and where it really ... Science & Technology , their study found that nearly ... into just seven developing countries with major potential ... Knut Breivik and colleagues note that the export from ...
(Date:7/23/2014)... bacterial group called SUP05 will play an increasingly important ... oceans as oxygen minimum zones expand, according to research ... National Academy of Sciences . , University of British ... fjord, Canada,s Saanich Inlet, to chart how microbial community ... study paints a very detailed picture of how SUP05 ...
Breaking Biology News(10 mins):Dead body feeding larvae useful in forensic investigations 2Research charts the ecological impact of microbial respiration in the oxygen-starved ocean 2
... animal compares males to choose a mate, she can't order ... to rely on external cues that may indicate genetic quality. ... the peacock's tail, as cues that females might use. , ... between male genetic quality and ornament quality can be maintained. ...
... progenitor cells differentiate into cartilage cells when one master ... College of Medicine researchers in a report that appears ... of Sciences. , Skeletons are made of bone and ... stem cell, said Dr. Brendan Lee, associate professor of ...
... into brain cells on a new three-dimensional scaffold of ... living body than any other cell culture system. , ... invention-which may one day replace the ubiquitous Petri dish ... PLoS ONE. Shuguang Zhang, associate director of MIT's Center ...
Cached Biology News:Female pronghorns choose mate based on substance as well as show 2Signaling for cartilage 2MIT creates 3-D scaffold for growing stem cells 2MIT creates 3-D scaffold for growing stem cells 3
(Date:7/23/2014)... , July 23, 2014 ... ), the global specialty biopharmaceutical company, and ArmaGen, ... a worldwide licensing and collaboration agreement for AGT-182, ... potential treatment of both the central nervous system ... syndrome (MPS II). This collaboration strengthens Shire,s rare ...
(Date:7/23/2014)... OncLive® is pleased to announce ... its Strategic Alliance Partnership program. , By ... Lineberger will have the opportunity to work with ... cutting-edge research initiatives, community-directed cancer prevention programs, and ... with OncLive to educate their peers by providing ...
(Date:7/22/2014)... The Board of Directors of BD (Becton, Dickinson ... quarterly dividend of 54.5 cents per common share payable on ... 2014. The indicated annual dividend rate is $2.18 per share. ... leading medical technology company that partners with customers and stakeholders ... health needs. Our innovative solutions are focused on improving drug ...
(Date:7/22/2014)... 22, 2014   BioTE Medical , a ... bio-identical hormone pellets, today announced the addition of ... company.   Dr. Rouzier is joining the BioTE Medical ... Dr. Rouzier was residency trained in Family ... a board certified emergency physician still practicing at ...
Breaking Biology Technology:Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3Dr. Neal Rouzier Joins BioTE Medical 2Dr. Neal Rouzier Joins BioTE Medical 3
... RFID investment wholly on the basis of anticipated savings ... chain are merely deluding themselves. In fact, if a ... means that gross inefficiencies exist in its operations, and ... applying RFID. , ,The benefits of RFID related to ...
... Wis. - When Milwaukee-based coffee chain Stone ... the company chose an emerging tool to enhance customer ... company's technology and marketing director, the blog can bring ... that goes beyond mere press releases or other traditional ...
... business and technology leaders is asking Wisconsin Gov. Jim ... for the Biomedical Technology Alliance (BTA), which ... industry in southeastern Wisconsin. , ,The funding was previously ... 15-1, and endorsed by the Doyle administration, but is ...
Cached Biology Technology:The key to finding RFID's ROI 2The key to finding RFID's ROI 3The key to finding RFID's ROI 4Business blogs increase customer interactions 2Business blogs increase customer interactions 3Business blogs increase customer interactions 4Business blogs increase customer interactions 5Budget axe could cut SE Wisconsin tech alliance funding 2Budget axe could cut SE Wisconsin tech alliance funding 3
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
PC based system for superior chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
Biology Products: