Navigation Links
Research reveals lipids' unexpected role in triggering death of brain cells
Date:11/12/2009

The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.

The work provides the first evidence that a lipid can initiate the suicidal, or apoptotic, response in cells. The findings involve a lipid called GM1-ganglioside. Lipids are fat-like molecules. GM1 builds up with devastating results in the brain cells of patients with GM1-gangliosidosis because they lack the enzyme required to break down that molecule.

Working in mice missing this key enzyme, researchers reported new details of how GM1 accumulation inside certain structures in brain cells disrupts their internal calcium balance. This imbalance ultimately leads to the programmed cell death known as apoptosis. The work appears in the November 13 online edition of Molecular Cell.

"The finding is essential for understanding the causes of progressive loss of brain cells, characteristic of this disease," said Alessandra d'Azzo, Ph.D., of St. Jude Genetics and Tumor Cell Biology. She is the senior author of the report and holds the Jewelers for Children Endowed Chair in Genetics and Gene Therapy. The work also provides hints for a strategy to intervene in the disease process.

The research led d'Azzo and her colleagues to propose that the death of brain cells and neurodegeneration that strikes GM1-gangliosidosis patients is a two-step process. The investigators demonstrated that blocking the first step in this process prevented cells from self-destructing, which was not the case when just the second step was inhibited. They predicted the discovery might have important implications for developing new treatments for this catastrophic disease.

The findings also have implications for scientists studying other aspects of the cross-talk between intracellular compartments, involving calci
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers gather in the UK to measure the impossible
2. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
3. Carnegie Mellon researchers to develop probes to study cellular GPS
4. Escaped proteins add to hearing loss in elderly, UF researchers find
5. CBS and OMD Partner to Provide the Agency With Access to the Networks Television City Research Facility in Las Vegas
6. Researchers complete draft genome sequence for cassava
7. £3.2m ($5.4 million) research project to capture brilliance of butterfly wings
8. Monell Center joins with CAS to host Beijing meeting on taste and smell research
9. Genomic research will enable greener cleanup of military explosive test sites
10. Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
11. MSU researcher: Obesity significantly cuts odds of successful pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
(Date:6/17/2015)... GERMANTOWN, Maryland , June 17, 2015 ...   Produktlinie mit DNA-Tests verbessert den Analyseprozess und ... QGEN ; Frankfurt Prime Standard: QIA) hat heute in ... Produktlinie Investigator ® für ... Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten eine ...
(Date:6/16/2015)... 16, 2015  With the increasing number and severity ... top concern. The recent compromise of Federal employee ... strong authentication within government agencies. HYPR Corp. ... password (OTP) authenticator, has been submitted for testing and ... 3 validation for tamper proofing. The ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... vary greatly in their dependence on the global food ... its most common food in its regional hinterland, while ... Copenhagen hinterland produces less than half of the consumption ... researchers have mapped the food systems of capital cities, ...
... Sciences faculty members whose research has resulted in ... startup companies have been named fellows of the ... Wittwer, M.D., Ph.D., professor of pathology and research ... of internal medicine and chief of the Division ...
... 11, 2013) In a study of older mice, wolfberries ... protection against the flu virus. The research, led by scientists ... Aging (USDA HNRCA) at Tufts University, suggests the wolfberry may ... role in the ability of the immune system to defend ...
Cached Biology News:Scientists map food security and self-provision of major cities 2Scientists map food security and self-provision of major cities 3Researchers named to National Academy of Inventors 2Researchers named to National Academy of Inventors 3Researchers named to National Academy of Inventors 4Older mice fed wolfberries show reduced risk for flu virus with vaccine 2
(Date:6/30/2015)... WASHINGTON , June 30, 2015  NASA astronaut ... launch next month on his first mission to the ... interviews from 8 to 9 a.m. EDT Tuesday, July 7. ... Center in Star City, Russia . The ... on NASA Television highlighting his mission training. To ...
(Date:6/30/2015)... ... June 30, 2015 , ... Noblis, Inc., a leading provider ... paper published this week in the scientific journal Viruses ( http://www.mdpi.com/1999-4915/7/6/2763 ), that ... used to detect the Ebola virus. Noblis worked with the Department of Defense’s ...
(Date:6/30/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: ... on the development of autologous cell therapies, announced today ... clinical trial of RCT-01, being tested for the ... enrolled and their tissue biopsy sent for processing ... of non-bulbar dermal sheath (NBDS) cells isolated from ...
(Date:6/29/2015)... ... ... This cutting edge standard making is a madatory tool for use in ... is the world’s first cuvette-shaped, solid-state filter that lets metrologists and quality control personnel ... calibration standards, such as those made from didymium glass were only able to operate ...
Breaking Biology Technology:NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 2RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 3RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 4FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3
... OrganicGardenGrower.com Introduces ... and fun. , ... (PRWEB) October 19, 2009 -- It,s no longer a complicated process for anyone to grow ... the demand for healthy, fresh fruits and veggies grow, so has the demand of individuals ...
... 19 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc.,(OTC Bulletin Board: LTUS) ("Lotus" ... and licensed national seller of pharmaceutical,products in the People,s Republic ... Lotus,s priorities for the balance of 2009 are, ... do for its most valuable customers, ...
... EMERYVILLE, Calif., Oct. 19 Neurobiological Technologies, Inc. (Nasdaq: ... to the NASDAQ Stock Market LLC ("NASDAQ") that NTI intends ... Commission ("SEC") on or about October 28, 2009 to effect ... NTI,s stockholders approve the dissolution of the company pursuant to ...
Cached Biology Technology:The Growing Demand for Organic Gardening Sprouts New Self Sustaining Innovations 2The Growing Demand for Organic Gardening Sprouts New Self Sustaining Innovations 3Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 2Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 3Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 4
...
... feature a dual strength adhesive system which facilitates ... The adhesives on either side of the frame ... to the glass has an easy release adhesive ... forms a stronger bond. This means that when ...
... Cultures (ECACC) has been offering training courses ... institutes for over seven years. We offer ... candidates to cell culture and a Level ... areas such as planning and management of ...
... cover slips for in situ hybridization,in ... on glass slides., Constant probe ... not adsorb probes. , Ready-to-use-Hybri-slips do ... , Avoid RNA degradation-Hybri-slips are supplied ...
Biology Products: