Navigation Links
Research from CHORI scientists demonstrates first genome methylation in fruit fly
Date:3/27/2014

March 27, 2013, Oakland, CA A group of scientists from Children's Hospital Oakland Research Institute and UC Berkeley report the first mapping of genome methylation in the fruit-fly Drosophila melanogaster in their paper "Genome methylation in D. melanogaster is found at specific short motifs and is independent of DNMT2 activity," published this month in Genome Research.

This paper represents a major advance in the study of DNA methylation in insects. No previous study has succeeded in pinpointing the location of DNA methylation in the fly genome. The common opinion in the field was that the fly does not have genomic methylation. But Drs. Sachiko Takayama and Joseph Dhahbi, co-first authors who carried out the key work, and Drs. David Martin and Dario Boffelli, who led the project, found otherwise. The authors were able to detect genomic methylation in the fly by solving the main technical hurdle: fly methylation is relatively rare, and they developed a sensitive method that allowed them to detect it.

Why is this finding important? Methylation is a stable chemical modification of the genome; in humans and other vertebrates it participates in controlling when and where genes are on and off, but its functions in other organisms are not understood. The finding suggests that genome methylation may have a hitherto uncharacterized function. While the authors still do not know what genome methylation does in the fly, they were able to find that the DNA sequence patterns that associate with methylation are very different from the patterns seen in humans, or in other animal or plant species to date.

Drosophila is one of the classic model organisms, with very well established tools to study its biology. The researchers' description of methylation in the fly will facilitate the use of this powerful experimental system to study methylation. Drosophila has only one known enzyme that could establish DNA methylation, and the researchers show that this enzyme is not responsible for the methylation patterns they detected. The fly genome has been studied very deeply, but the finding suggests that a new enzyme lies undiscovered within it.


'/>"/>

Contact: Melinda Krigel
mkrigel@mail.cho.org
510-428-3069
Children's Hospital & Research Center Oakland
Source:Eurekalert

Related biology news :

1. GW researcher invents mini heart to help return venous blood
2. Clemson researcher touts surgical safety checklist to save lives
3. Researchers at IRB discover a key regulator of colon cancer
4. Researchers reveal the dynamics behind Arctic ecosystems
5. IRCM researchers uncover a new function for an important player in the immune response
6. HFSP research funding for the Helmholtz Zentrum München
7. UGA researchers explore function of cancer-causing gene
8. CASIS-sponsored research heads to space station aboard SpaceX-3
9. Distinguished researcher to speak at NJIT on preventing bone loss
10. Researchers present comprehensive roadmap of blood cells
11. Research produces strong evidence for a new class of antidepressant drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... , March 24, 2017 The Controller General ... Controller Mr. Abdulla Algeen have received the prestigious international IAIR ... Continue Reading ... ... picture) and Deputy Controller Abdulla Algeen (small picture on the right) have ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
Breaking Biology Technology: