Navigation Links
Research breakthrough: Impaired autophagy associated with age-related macular degeneration
Date:8/21/2013

A new study published in the prestigious PLoS One journal changes our understanding of the pathogenesis of age-related macular degeneration (AMD). The researchers found that degenerative changes and loss of vision are caused by impaired function of the lysosomal clean-up mechanism, or autophagy, in the fundus of the eye. The results open new avenues for the treatment of the dry form of AMD, which currently lacks an efficient treatment. The University of Eastern Finland played a leading role in the study, which also involved research groups from Italy, Germany and Hungary.

AMD is the most common cause of visual impairment in the Western world, and the number of AMD patients is expected to soar in the upcoming decades. AMD is divided into the dry and wet form of the disease, and 85% of AMD patients suffer from dry AMD. Unfortunately, an efficient treatment involving injections into the eye only exists for the wet form of the disease.

AMD is a storage disease in which harmful protein accumulations develop behind the retina. These accumulations are indicative of the severity of the disease. As the disease progresses, retinal sensory cells in the central vision area are damaged, leading to loss of central vision. The cell biological mechanisms underlying protein accumulations remain largely unknown.

For the first time ever, the present study showed that AMD is associated with impaired lysosomal autophagy, which is an important clean-up mechanism of the fundus of the eye. This renders the cells in the fundus of the eye unable to dispose of old, deformed or otherwise faulty proteins, which, in turn, leads to the development of protein accumulations and loss of vision. The study can be regarded as a breakthrough, as the results change our understanding of the pathogenesis of AMD and also open new avenues for the treatment of the dry form of AMD. Drugs inhibiting the impairment of autophagy could possibly even stop the progression o
'/>"/>

Contact: Kai Kaarniranta
kai.kaarniranta@uef.fi
358-440-593-290
University of Eastern Finland
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
(Date:6/23/2015)... BEACH GARDENS, Fla. , June 23, ... multi-factor identity management and authentication solutions, today announced ... Altus strong, multi-factor authentication solution.  The enhancements ... of use of the DigitalPersona Altus platform ... biometric reader compatibility. In today,s ...
(Date:6/17/2015)... GERMANTOWN, Maryland , and HILDEN, Germany ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) today launched ... DNA evidence in forensic laboratories in the United ... integrated solution to simultaneously analyze multiple key genomic markers (short ... Investigator ® Quality Sensor to evaluate the quality of ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... In the jungles of Central and South America, a ... finding food by following hordes of army ants ... assistant curator of genetic resources at the LSU Museum ... first witnessed this peculiarity in 1989 when he accompanied ...
... for cleaning up contaminated sites by growing plants able to ... plants break certain kinds of pollutants into harmless byproducts that ... or release into the air. The problem with plants that ... slow and halts completely when growth stops in winter. Using ...
... a progressive neurodegenerative disorder characterized by extensive neuronal ... and neurofibrillary tangles. Neuronal and synaptic losses in ... specific brain areas involved in memory processing. ... of A" plays a seminal role in the ...
Cached Biology News:LSU professor studies army-ant-following birds 2Scientists ramp up ability of poplar plants to disarm toxic pollutants 2Scientists ramp up ability of poplar plants to disarm toxic pollutants 3Scientists ramp up ability of poplar plants to disarm toxic pollutants 4Paradigm shift in Alzheimers's research: new treatments 2Paradigm shift in Alzheimers's research: new treatments 3Paradigm shift in Alzheimers's research: new treatments 4
(Date:6/30/2015)... June 30, 2015  Juniper Pharmaceuticals, Inc. (Nasdaq: ... developing therapeutics that address unmet medical needs in ... Elston will present at the Cantor Fitzgerald ... 8, 2015Time: , 4:45 PM EDTLocation: , Le ... archive): , www.juniperpharma.com, under  ,Investor, or  ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... Study will provide new insights on mechanics of fecal microbiota transplantation in C. ... to study the microbiome of patients undergoing fecal microbiota transplantation (FMT) as a ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... services to the federal government, announced in a paper published this week in ... a potential problem with the diagnostic techniques currently used to detect the Ebola ...
(Date:6/30/2015)... DENVER, CO (PRWEB) , ... June 30, 2015 , ... ... technologies, today announced that it has hired Gem Swartz to head up its account ... as senior account director. Both Gem and Amanda bring senior account management and delivery ...
Breaking Biology Technology:Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4Matrix Marketing Group Expands Client Services Team 2
... June 18 PacificGMP and Pacific Biopharma,Group ... definitive merger agreement,and will develop a cGMP ... (CMO) in Taizhou, China. At,approximately 200,000 square ... (CQB), will be one of the largest ...
... Inverness Medical,Innovations, Inc. (Amex: IMA ), a ... the consumer and professional markets, today,announced that Ron ... Finance, will attend the Jefferies 2nd Annual Healthcare,Conference ... presentation is,scheduled for Wednesday, June 25 at 3:15pm ...
... June 18 Danube Pharmaceuticals, Inc., a,privately held ... of innovative drugs for ophthalmology, is pleased,to announce ... as its Chief,Executive Officer., "I am honored ... point in its history as it advances its ...
Cached Biology Technology:PacificGMP to Merge With Pacific Biopharma Group and Create Innovative US-Compliant cGMP Contract Biomanufacturing Facility in China 2Inverness Medical Innovations to Present at Jefferies 2nd Annual Healthcare Conference held on June 25, 2008 2Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 2Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 3
... Multimode Detectors provide unmatched value and ... and automation needs. Capable of performing ... the same instrument, the DTX Series ... can be integrated seamlessly with Beckman ...
Sf21 Insect Cells (Live) in Max-XP Medium...
... The BioGenex Super Sensitive ... is a novel product ... non-biotin polymeric technology. This ... signal to noise ratio ...
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
Biology Products: