Navigation Links
Repair in the developing heart
Date:10/15/2008

If the heart becomes diseased during its embryonic/fetal development, it can regenerate itself to such an extent that it is fully functional by birth, provided some of the heart cells remain healthy. Dr. Jrg-Detlef Drenckhahn of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch made this discovery together with colleagues from Australia. They were able to demonstrate in female mice that the healthy cells of the heart divide more frequently and thus displace the damaged tissue. "Hopefully, our results will lead to new therapies in the future," Dr. Drenckhahn said. "With the right signals, a heart that has been damaged for example through infarction might be stimulated to heal itself." (Developmental Cell, 15, 521-533, October 14, 2008)*.

For the heart to be able to beat, it needs energy. If the energy production in the heart cells is disturbed, then the embryo will actually die of heart dysfunction. But if only a portion of the cells is affected, this is not the case: With the aid of the remaining healthy cells, the embryo manages to regenerate the heart.

The scientists switched off a gene (Holocytochrome C synthase, abbreviated Hccs) in the developing hearts of mice a gene that is essential for energy production. Results showed that the embryos died when all cells in the heart were affected by the defective energy production. However, the animals that still had some healthy myocardial cells survived, and at the time of birth they had a heart that was fully able to function.

The gene Hccs is located on one of the sex chromosomes, the X chromosome. In contrast to male animals who have only one X chromosome, females have two X chromosomes. Some of the altered female mice have an X chromosome with the defective Hccs gene and one with the intact Hccs gene. However, in the cells of the female animals, only one X chromosome is active. Depending on which one is expressed, either healthy or diseased heart cells develo
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
2. Cardiac cell transplant studies show promise in cardiac tissue repair
3. Duke-NIEHS team shows how DNA repairs may reshape the genome
4. Milkweeds evolutionary approach to caterpillars: Counter appetite with fast repair
5. Researchers reveal structure of protein that repairs damage to cancer cells
6. Stem cells offer cartilage repair hope for arthritis sufferers
7. Is DNA repair a substitute for sex?
8. Wildcat Power Cord repairs cruciate ligament in dairy cows knee
9. Researchers probe a DNA repair enzyme
10. Building the future -- 21st century nano tools to repair the nervous system
11. Yale receives $8.4 million to study DNA repair in cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
(Date:7/28/2014)... calls himself the bug hunter, but the target of ... found and identified with special methods and instruments. Benjamin ... Veterinary Diagnostic Laboratory at Kansas State University, recently published ... G, which is an important find in the United ... but didn,t know what it was," Hause said. "We ...
(Date:7/28/2014)... DUBLIN , July 28, 2014 ... the "Biometrics Market in Latin America 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Biometrics measure and analyze biological ... facial patterns, irises, eye retinas, voice patterns, and hand ... one or more stored templates. The main purpose of ...
Breaking Biology News(10 mins):Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Biometrics Market in Latin America 2014-2018 2
... DURHAM, N.H. University of New Hampshire ... $498,115 to advance understanding of the actinorhizal plants, ... and contaminated soils. The United States ... of molecular, cellular and biomedical sciences, $399,000 to ...
... toads have existed for 360 million years and survived when ... to make many of them extinct, according to an article ... The fungus, Batrachochytrium dendrobatidis (Bd), was found ... America and north-eastern Australia in the 1990,s. Bd infects over ...
... for Child Health Research has found evidence that the amount ... in different ways. The study has just been published ... author Colleen O,Leary said the analysis was drawn from a ... questionnaire three months after the baby,s delivery, and were then ...
Cached Biology News:UNH prof. receives nearly $500,000 to research environmentally significant plants 2New study links alcohol in pregnancy to child behavior problems 2
(Date:7/29/2014)... 29, 2014 ... zur Erfassung biologischer Daten in Verbindung mit ... patentiert. Das LBS nimmt gleichzeitig mehrere Blutproben ... Patienten und sucht erhöhte biologische Aktivitäten in ... die Entdeckung und Entwicklung neuer Medikamente und ...
(Date:7/28/2014)... The Workgroup for Electronic Data Interchange (WEDI), the ... IT to create efficiencies in healthcare information exchange, announced ... has developed an issue brief titled, “What is the ... Workgroup, a part of WEDI’s Strategic National HPID Implementation ... Medicaid Services (CMS) to identify common misuse of the ...
(Date:7/28/2014)... CA and Annapolis Junction, MD (PRWEB) July 28, 2014 ... and research leader in personalized medicine, will be exhibiting ... services at this year’s International Spine Intervention Society’s ... take place July 30th-August 3rd, at the Hyatt Regency, ... designed to enhance the knowledge and clinical competence of ...
(Date:7/28/2014)... July 28, 2014 ... Identification Market by Products (Consumables, Instruments, Services), Methods (Phenotypic, ... User (Detection, Characterization) - Global Forecasts to ... Market is estimated at $896.5 Million in ... Million by 2019, growing at a CAGR ...
Breaking Biology Technology:PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3
... Savient,Pharmaceuticals, Inc. (Nasdaq: SVNT ) today announced ... Pharmaceuticals,will present a corporate update at the upcoming Lazard ... scheduled to begin on Tuesday, November 18, 2008 at,9:25 ... St. Regis Hotel in New,York City November 18-19, 2008., ...
... PharmAthene, Inc.,(NYSE Alternext US: PIP), a biodefense ... today reported,financial and operational results for the third ... For the third quarter of 2008, PharmAthene recognized ... the same period of 2007. For the nine,months ...
... Stops Bleeding Wins Professor Venture Fair at,U-Md. Bioscience Day, ... of,Maryland professor and doctoral student team who invented a ... a group of venture,capitalists and the title of "Best ... Sponsored by the university,s Office of Technology Commercialization,the ...
Cached Biology Technology:Savient Pharmaceuticals to Present at the Lazard Capital Markets 5th Annual Healthcare Conference on November 18th 2Pharmathene Reports Third Quarter 2008 Financial and Operational Results 2Pharmathene Reports Third Quarter 2008 Financial and Operational Results 3Pharmathene Reports Third Quarter 2008 Financial and Operational Results 4Pharmathene Reports Third Quarter 2008 Financial and Operational Results 5Pharmathene Reports Third Quarter 2008 Financial and Operational Results 6Pharmathene Reports Third Quarter 2008 Financial and Operational Results 7Nano-Velcro Sticks With Venture Capitalists 2Nano-Velcro Sticks With Venture Capitalists 3