Navigation Links
Repair in the developing heart
Date:10/15/2008

If the heart becomes diseased during its embryonic/fetal development, it can regenerate itself to such an extent that it is fully functional by birth, provided some of the heart cells remain healthy. Dr. Jrg-Detlef Drenckhahn of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch made this discovery together with colleagues from Australia. They were able to demonstrate in female mice that the healthy cells of the heart divide more frequently and thus displace the damaged tissue. "Hopefully, our results will lead to new therapies in the future," Dr. Drenckhahn said. "With the right signals, a heart that has been damaged for example through infarction might be stimulated to heal itself." (Developmental Cell, 15, 521-533, October 14, 2008)*.

For the heart to be able to beat, it needs energy. If the energy production in the heart cells is disturbed, then the embryo will actually die of heart dysfunction. But if only a portion of the cells is affected, this is not the case: With the aid of the remaining healthy cells, the embryo manages to regenerate the heart.

The scientists switched off a gene (Holocytochrome C synthase, abbreviated Hccs) in the developing hearts of mice a gene that is essential for energy production. Results showed that the embryos died when all cells in the heart were affected by the defective energy production. However, the animals that still had some healthy myocardial cells survived, and at the time of birth they had a heart that was fully able to function.

The gene Hccs is located on one of the sex chromosomes, the X chromosome. In contrast to male animals who have only one X chromosome, females have two X chromosomes. Some of the altered female mice have an X chromosome with the defective Hccs gene and one with the intact Hccs gene. However, in the cells of the female animals, only one X chromosome is active. Depending on which one is expressed, either healthy or diseased heart cells develo
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
2. Cardiac cell transplant studies show promise in cardiac tissue repair
3. Duke-NIEHS team shows how DNA repairs may reshape the genome
4. Milkweeds evolutionary approach to caterpillars: Counter appetite with fast repair
5. Researchers reveal structure of protein that repairs damage to cancer cells
6. Stem cells offer cartilage repair hope for arthritis sufferers
7. Is DNA repair a substitute for sex?
8. Wildcat Power Cord repairs cruciate ligament in dairy cows knee
9. Researchers probe a DNA repair enzyme
10. Building the future -- 21st century nano tools to repair the nervous system
11. Yale receives $8.4 million to study DNA repair in cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, reminds investors ... Chief Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA ... 5-7, 2015. The three-day conference is organized ... is speaking in is themed Global Fraud: Where is ...
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... California, San Diego and the University of Hawaii will ... as collaborative ties to Asian institutions to learn more ... off a much-feared pandemic in the region of the ... , "We will use modern high-throughput biology ...
... noise, like the crackle heard on AM radio when lightning ... devices. But within cells, a similar kind of biochemical "noise" ... according to a new study led by a UT Southwestern ... of pharmacology, said his research and that of his colleagues ...
... findings that help shape our understanding of how tool ... that chimpanzees, at least under some conditions, are capable ... prey. The work, reported by Jill Pruetz of Iowa ... Cambridge, will appear online in the journal Current Biology ...
Cached Biology News:Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu 2Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu 3Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu 4Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu 5Cells use 'noise' to make cell-fate decisions 2Cells use 'noise' to make cell-fate decisions 3Chimpanzees found to use tools to hunt mammalian prey 2
(Date:5/26/2015)... Just the characterization of being a ... need does not guarantee immediate acceptance. In particular, ... many prior failures is often met with significant skepticism. ... an irony that is often an unappreciated aspect of ... Asymmetrex has found that building acceptance of ...
(Date:5/25/2015)... Phenome Networks, a software-as-a-service plant breeding ... beginning May 31st, of its next-generation Phenome One software. ... Phenome Networks’ lead in the plant breeding market, through ... breeding workflow based on years of experience with plant ... and more. The new version of Phenome One, Phenome ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Knowledgent ... white paper that explores the potential of big data ... white paper was developed to help life sciences and ... leverage data to gain critical business insights. , The ... amounts of data driven by patient profiling, compliance and ...
(Date:5/21/2015)... May 21, 2015 Specialty Pharmacy ... and been admitted to BPA Worldwide as a ... will track audience data for Specialty Pharmacy Times ... , “By becoming a member of BPA Worldwide, ... providing our clients with the most reliable, unequaled ...
Breaking Biology Technology:In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 2In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 3Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 2Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 3New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2Specialty Pharmacy Times Joins BPA Worldwide 2
... 27, 2011 Cord Blood America, Inc . ( ... umbilical cord blood stem cell preservation company focused ... families nationwide and internationally, is pleased to announce it has ... Las Vegas laboratory for the National Children,s Leukemia Foundation (NCLF), ...
... 22, 2011 In recognition of the International Year of ... The Changing Role of Chemistry in Drug Discovery ... along with insights from industry experts, the new report forecasts ... the report suggests, a much more targeted, patient-specific approach will ...
... Mich., Dec. 22, 2011  Neogen Corporation (NASDAQ: NEOG ... of FY 2012, which ended Nov. 30, increased 2.2% from ... the quarter was $5,237,000, or $0.22 per share, compared to ... $0.26 per share. Year-to-date revenues for the first ...
Cached Biology Technology:Cord Blood America Announces Exclusive Agreement With National Children's Leukemia Foundation to Store Stem Cells 2Thomson Reuters Research Forecasts the Onset of the Targeted Drug Discovery Era 2Thomson Reuters Research Forecasts the Onset of the Targeted Drug Discovery Era 3Neogen Reports Second Quarter Results 2Neogen Reports Second Quarter Results 3Neogen Reports Second Quarter Results 4Neogen Reports Second Quarter Results 5Neogen Reports Second Quarter Results 6
Request Info...
...
Request Info...
Agarose-LE, 500 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: