Navigation Links
Reducing gene-damaging impurities in medicines
Date:9/29/2010

Drug manufacturers have been adjusting to strict new government standards that limit the amount of potentially harmful impurities in medicine, according to the cover story of the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. The impurities are "genotoxic," capable of damaging the DNA in genes.

C&EN Senior Correspondent Ann Thayer notes that internationally accepted regulations long have limited the levels of impurities permitted in prescription drugs. But guidelines have not covered so-called genotoxic impurities (GTIs), substances that can potentially increase the risk of cancer. That changed in 2007, after European regulators put guidelines in place and the U.S. Food and Drug Administration soon after followed suit. The challenging new limits for GTIs are about 1,000 times lower than the levels allowed for most other impurities.

Although drug companies are complying with the guidelines, some regard the limits as too strict, the article notes. Some industry scientists also question the approaches proposed to categorize and test for GTIs. Nevertheless, drug companies are working to change or control their manufacturing methods so that GTIs either do not form in the first place or form at much lower levels.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Forest peoples rights key to reducing emissions from deforestation
2. Providing toilets, safe water is top route to reducing world poverty: UN University
3. Pollinator decline not reducing crop yields just yet
4. Reducing the damage of a heart attack
5. Effectiveness of progesterone in reducing preterm births may be altered by genetic predisposition
6. Biofuels can provide viable, sustainable solution to reducing petroleum dependence
7. Reducing CO2 through technology and smart growth
8. Reducing animal experiments through top-class research
9. Reducing the roadworks
10. The coming of biofuels: Study shows reducing gasoline emissions will benefit human health
11. Reducing risk of hospitalization in the elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... a room in the intensive care unit (ICU) ... may increase the odds of acquiring such bacteria, ... issue of Archives of Internal Medicine, one of ... significant illness and death in hospitals: methicillin-resistant Staphylococcus ...
... cold seeps--strange clams, mussels and sea snails that thrive in ... marine mollusk community as a whole, according to a new ... published by AAAS, the nonprofit science society. , On average, ... geological record is a full epoch earlier than that of ...
... Boston have demonstrated that it may be possible to ... the heart from scarring. Working with rats, they combined ... division with a naturally occurring growth factor that encourages ... heart-muscle cells to multiply and the heart to regain ...
Cached Biology News:Transmission of antibiotic-resistant bacteria linked to previous intensive care unit room occupants 2Ocean seep mollusks may share evolutionary history with other deep-sea creatures 2Ocean seep mollusks may share evolutionary history with other deep-sea creatures 3Rescuing injured hearts by enhancing regeneration 2Rescuing injured hearts by enhancing regeneration 3
(Date:4/21/2015)... April 21, 2015  Novogen Limited (ASX:NRT; NASDAQ: ... advises that it has entered into definitive agreements ... shares plus one attaching 6-month option and half ... share issued, to institutional investors in ... placement for aggregate gross proceeds of approximately AU$15,500,000 ...
(Date:4/21/2015)... PRC Clinical, a Clinical ... the ACRP 2015 Global Conference and Exhibition on April ... of Clinical Research Professionals (ACRP) Global Conference and Exhibition ... on the conduct of clinical trials. ACRP supports clinical ... recognized industry certifications. , The ACRP 2015 Global ...
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, 2015 ... announced today that it will release its first quarter ... 28, 2015. United Therapeutics will host a ... a.m. Eastern Time.  The teleconference is accessible by dialing ... the teleconference will be available for one week and ...
(Date:4/21/2015)... New York (PRWEB) April 21, 2015 ... and Fertility Authority, LLC, announced that it has secured ... Byers (KPCB), TPG Biotech, SR One and Merck Serono ... efforts to provide patients the best fertility outcomes by ... is the largest online marketplace for families seeking fertility ...
Breaking Biology Technology:Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 2Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 3Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 4Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 5Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 6PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 2Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2
... Holdings, Inc. (Nasdaq: NHWK ), the leading ... United States, today announced that,Tim Mayleben, NightHawk,s President ... for personal reasons. Mayleben will remain with,NightHawk in ... and is,expected to resign from the board of ...
... Martek Biosciences,(Nasdaq: MATK ) announced today that ... eye and heart health, is now available in,two new ... Grapefruit Lychee and Marionberry Guava, join 10 existing flavors ... line is,available at natural food stores nationwide., "We ...
... Board of Directors, Ron ... Vice President Legal Affairs -, SEATTLE, Feb. 13 ... development of therapeutics for,autoimmune and inflammatory disorders, today announced ... of Dendreon Corporation,(Nasdaq: DNDN ), to the Company,s ...
Cached Biology Technology:NightHawk Radiology Holdings, Inc. Announces Senior Executive Departures 2NightHawk Radiology Holdings, Inc. Announces Senior Executive Departures 3Martek's life'sDHA(TM) Now Featured in Two New Flavors of Rachel's(R) Wickedly Delicious Yogurt from WhiteWave Foods 2Martek's life'sDHA(TM) Now Featured in Two New Flavors of Rachel's(R) Wickedly Delicious Yogurt from WhiteWave Foods 3VLST Corporation Announces Board and Executive Management Appointments 2VLST Corporation Announces Board and Executive Management Appointments 3