Navigation Links
Rapamycin: Limited anti-aging effects
Date:7/25/2013

This news release is available in German.

The findings are reported in the current issue of the "Journal of Clinical Investigation" (published online on July 25, 2013).

The body's repair mechanisms begin to fail with increasing age. As a result, signs of wear and tear appear and the risk for many diseases, including Alzheimer's disease, diabetes, cardiovascular disorders and cancer, increases. "Current efforts to develop therapies against age-related diseases target these disorders one by one," says Dr. Dan Ehninger, research group leader at the DZNE site in Bonn. "Influencing the aging process itself may be an alternative approach with the potential to yield broadly effective therapeutics against age-related diseases."

In this context, the substance rapamycin is noteworthy. Rapamycin is used in recipients of organ transplants, as it keeps the immune system in check and can consequently prevent rejection of the foreign tissue. In 2009, US scientists discovered another effect: Mice treated with rapamycin lived longer than their untreated counterparts. "Rapamycin was the first drug shown to extend maximal lifespan in a mammalian species. This study has created quite a stir," says Ehninger.

For Ehninger and his team, this finding motivated further studies: "We wanted to address if rapamycin slows down aging in mice or, alternatively, if it has an isolated effect on lifespan - without broadly modulating aging."

Not a youth elixir

Together with scientists from the Helmholtz Zentrum Mnchen and other colleagues, Ehninger's group investigated if rapamycin influences aging in mice. The results are sobering: "Our results indicate that rapamycin extends lifespan, but it has only limited effects on the aging process itself," is Ehning
'/>"/>

Contact: Dr. Dirk Förger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Oysters could rebound more quickly with limited fishing and improved habitat
2. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
3. Most coral reefs are at risk unless climate change is drastically limited
4. Ducks Unlimited Canada and Canadian Light Source partnership to shed light on wetlands
5. Scientists sequence genome of sacred lotus, which likely holds anti-aging secrets
6. Hydrogen sulfide: The next anti-aging agent?
7. Anti-aging elixir for solar cells
8. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
9. Key target responsible for triggering detrimental effects in brain trauma identified
10. Adverse effects of phthalates on ovarian response to IVF
11. Time is of the essence for reducing the long-term effects of iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... Mass , March 23, 2015 SoundView Technology ... of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was ... user feedback on their experience with the Wocket in multiple ... at CVS, Whole Foods and other retailers, making both debit ... Kris Tuttle also says, "If the company meets their ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the ...
(Date:3/17/2015)... 2015 MedNet Solutions , a ... study management systems, is pleased to announce that ... Outsourcing in Clinical Trials Southeast conference – March ... excellent forum for MedNet to showcase iMedNet ... (SaaS) eClinical technology platform. We strongly ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... of mythological beliefs. Some cultures prize them for their ... as dagger handles or good luck charms. But new ... by explaining how the horn gets its distinctive curve ... details about the structural materials that form the horn ...
... of Michigan Medical School have discovered a previously unknown ... and renal failure in children: recessive mutations in a ... the mutant gene is important to scientists because PLCE1 ... a vital role in the kidney's ability to remove ...
... found that aged mice undergoing weekly light-cycle shifts--similar to ... shift work--experienced significantly higher death rates than did old ... same eight-week period. The findings may not come as ... the research nonetheless provides, in rather stark terms, new ...
Cached Biology News:Scientists crack rhino horn riddle 2Mutant gene causes severe kidney disease in infants 2Mutant gene causes severe kidney disease in infants 3Mutant gene causes severe kidney disease in infants 4Chronic jet-lag conditions hasten death in aged mice 2
(Date:3/31/2015)... , March 31, 2015  Bayer HealthCare ... Institute of Massachusetts Institute of Technology (MIT) and ... discovery. The goal of this new part of ... genetics to help create new cardiovascular therapies. ... with the Broad Institute to the area of ...
(Date:3/31/2015)... and NEW YORK ... (NASDAQ: PTBI ), a biopharmaceutical company advancing ... announced today that its Korean marketing partner, Hanmi ... marketing approval in Korea from the country,s Ministry ... Korea Testing & Research Institute (KTR) for MuGard, ...
(Date:3/31/2015)... 2015 Today, Cryos International, the world’s ... their U.S. facilities and inventory from New York City ... experience, Cryos’ relocation is a reflection of their increasing ... Orlando was completed during the first weekend of spring, ... place on April 6. The new facility in the ...
(Date:3/30/2015)... March 30, 2015 With recent advancements ... you the government, major companies are getting into the ... setting future mandates for renewable energy production, many homeowners ... , Solara Power is a new solar distribution company ... available that allow qualifying homeowners to enjoy the benefits ...
Breaking Biology Technology:Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 2Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 3PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 2PlasmaTech Biopharmaceuticals' Partner Hanmi Pharmaceuticals Receives Marketing Approval For MuGard In Korea 3Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2Solara Power Announces Residential Solar Power with No Up-Front Fees 2
... Hagens, BODY WORLDS 2:,The Original Exhibition of Real ... this Saturday, February 2nd. The acclaimed exhibition,includes the ... a special feature on,the brain., BODY WORLDS ... healthy and unhealthy organs, body section and slices, ...
... Feb. 1 ,Genzyme Corp. (Nasdaq: GENZ ) and ... they have received clearance under the,Hart-Scott-Rodino Antitrust Improvements Act ... Based on this approval, Genzyme will pay,Isis $150 million ... for,$30 per share., Upon completion of final contracts, ...
... Therapeutics (Amex:,CXM) announced that it has completed ... and other accredited or qualified investors,that was ... Asset Management,Company acted as the sole placement ... http://www.newscom.com/cgi-bin/prnh/20051018/CARDIUMLOGO ), The securities were offered ...
Cached Biology Technology:Maryland Science Center Unveils Anatomical Exhibition, Body Worlds 2, on Saturday, February 2 2Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 2Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 3Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 4Cardium Completes $5.3 Million Registered Direct Offering 2Cardium Completes $5.3 Million Registered Direct Offering 3Cardium Completes $5.3 Million Registered Direct Offering 4
... Each kit contains sufficient materials for 1,464 array ... Membrane: 4 each , Blocker BSA ... Goat Anti-Mouse Antibody, HRP-conjugated: 10 g ... , 10% Tween-20: 2 x 10 ml ...
... Accurate Results Laser Capture Microdissection (LCM) ... and accuracy of molecular assays by starting ... multi-cellular structures isolated from whole tissue or ... in 1996 at the National Institutes of ...
Mouse monoclonal antibody raised against a partial recombinant DHX8. NCBI Entrez Gene ID = DHX8...
... can design custom microarrays to detect alternative ... Proprietary algorithms are used to identify ... high quality, spliced cDNAs aligned to the ... a custom SpliceArray is profiled with a ...
Biology Products: