Navigation Links
Rapamycin: Limited anti-aging effects
Date:7/25/2013

This news release is available in German.

The findings are reported in the current issue of the "Journal of Clinical Investigation" (published online on July 25, 2013).

The body's repair mechanisms begin to fail with increasing age. As a result, signs of wear and tear appear and the risk for many diseases, including Alzheimer's disease, diabetes, cardiovascular disorders and cancer, increases. "Current efforts to develop therapies against age-related diseases target these disorders one by one," says Dr. Dan Ehninger, research group leader at the DZNE site in Bonn. "Influencing the aging process itself may be an alternative approach with the potential to yield broadly effective therapeutics against age-related diseases."

In this context, the substance rapamycin is noteworthy. Rapamycin is used in recipients of organ transplants, as it keeps the immune system in check and can consequently prevent rejection of the foreign tissue. In 2009, US scientists discovered another effect: Mice treated with rapamycin lived longer than their untreated counterparts. "Rapamycin was the first drug shown to extend maximal lifespan in a mammalian species. This study has created quite a stir," says Ehninger.

For Ehninger and his team, this finding motivated further studies: "We wanted to address if rapamycin slows down aging in mice or, alternatively, if it has an isolated effect on lifespan - without broadly modulating aging."

Not a youth elixir

Together with scientists from the Helmholtz Zentrum Mnchen and other colleagues, Ehninger's group investigated if rapamycin influences aging in mice. The results are sobering: "Our results indicate that rapamycin extends lifespan, but it has only limited effects on the aging process itself," is Ehning
'/>"/>

Contact: Dr. Dirk Förger
presse@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Oysters could rebound more quickly with limited fishing and improved habitat
2. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
3. Most coral reefs are at risk unless climate change is drastically limited
4. Ducks Unlimited Canada and Canadian Light Source partnership to shed light on wetlands
5. Scientists sequence genome of sacred lotus, which likely holds anti-aging secrets
6. Hydrogen sulfide: The next anti-aging agent?
7. Anti-aging elixir for solar cells
8. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
9. Key target responsible for triggering detrimental effects in brain trauma identified
10. Adverse effects of phthalates on ovarian response to IVF
11. Time is of the essence for reducing the long-term effects of iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE ... collaboration catalyst that provides the connective tissue that enhances ... enabling them to easily share client-level information; earned a ... to expand to organizations serving seniors aging in community ... Diego" partner on December 11 th 4-6p. ...
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:12/3/2014)... IRVINE, Calif. , Dec. 2, 2014 /PRNewswire/ ... of globally deployed, innovative test solutions for military, ... the newest version of its successful TS-900 ... the performance and features of high-end systems to ... with outstanding value compared to traditional ATE. ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... has pieced together how the hominid Australopithecus sediba ... million years ago. Their research, which appears in six papers ... also shows that Au. sediba had a notable ... and more flexible lower back. Together, the studies offer ...
... purposely set to burn crop residues and get the ... evidenced in this image from the MODIS instrument on ... these types of fires can be found at this ... was collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) ...
... new treatment for alcoholism called nalmefene is effective and ... says a new study published this week in ... as the primary treatment goal for alcohol dependence, and ... relapse prevention. However, relapse rates remain high and a ...
Cached Biology News:New research reveals how human ancestor walked, chewed, and moved 2New research reveals how human ancestor walked, chewed, and moved 3A new treatment option for alcohol dependence: Reduced consumption rather than abstinence 2
(Date:12/17/2014)... 17, 2014 Once more, EMAAR ... larger packaged waste water treatment plant to phase one ... City (KAEC). Two years ago Bioshaft successfully supplied and ... serving two residential towers with an occupancy of 900 ... quarter million gallons per day and was signed on ...
(Date:12/17/2014)... -- Vermillion, Inc. (NASDAQ: VRML ), a bio-analytic ... next step in its expanded strategy to rebuild the ... naming of current Chief Operating Officer, Valerie Palmieri ... Chairman of the Board and CEO James LaFrance ... are effective January 1, 2015. "Jim and ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to announce that the ... PVM technology , is now available. The new ... continuously captures high-resolution images under a wide range ... a report pairing the most relevant images to ... compelling blend of high resolution images and trend ...
(Date:12/15/2014)... COPENHAGEN, Denmark , Dec. 15, 2014 /PRNewswire/ ... its innovative TransCon technology to address significant unmet ... from its ongoing Phase 2 pediatric study to ... growth hormone deficiency, or GHD.  This interim analysis ... the anticipated total enrollment in the study, completing ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4
... OLDSMAR, Fla., July 10 Cryo-Cell,International, Inc. (OTC ... largest and most established family cord blood banks, ... months ended May 31, 2008., Consolidated revenues ... relatively flat, as compared to approximately $4.5,million for ...
... Today,s Pharmaceutical Research,and Manufacturers of America ... practice,of providing non-educational materials to physicians ... of the physician/industry representative interaction,says Jim ... leading non-profit,organization dedicated to educating and ...
... Robust ... Pipeline -, ... and MacroChem Corporation (OTC Bulletin Board:,MACM) announced today that they had ... the issuance of 2.5,million shares of Access Pharmaceuticals, common stock. MacroChem,s ...
Cached Biology Technology:Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 2Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 3Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 4Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 5Cryo-Cell International, Inc. Reports Second Quarter 2008 Results 6CMR Institute: Education Key to Physician/Representative Relationship 2Access Pharmaceuticals Signs Merger Agreement to Acquire MacroChem Corp. 2Access Pharmaceuticals Signs Merger Agreement to Acquire MacroChem Corp. 3Access Pharmaceuticals Signs Merger Agreement to Acquire MacroChem Corp. 4
... and efficient method for purification of DNA fragments ... fragments selectively absorbed in the spin column after ... room temperature for PCR product with equal volume ... DNA can be purified with a single prep ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
Fujifilm BAS-1800II provides the ideal configuration for a low-cost imager that requires only a small amount of space in the laboratory. The small imager for accurate high-throughput screening...
Request Info...
Biology Products: