Navigation Links
RING finger protein 5 may guide treatment for muscle disease in older adults
Date:4/4/2008

team developed three mouse models: one knockout model in which the RNF5 gene was missing, and two in which cells could be triggered to overproduce RNF5, with expression either limited to skeletal muscle, -or within muscle and a variety of other organs.

A comparison of normal and knockout mice exposed to muscle-damaging toxin showed slower healing in the knockouts compared with the normal mice, demonstrating the importance of RNF5 in muscle repair.

Pathologic changes within muscles of the transgenic models with RNF5 overexpression were similar to those found in muscle biopsies from patients with sIBM. Overproduction of RNF5 caused a rapid and significant muscle degeneration, weight loss and muscle weakness. Followed by extensive muscle regeneration. Similar to what is often seen in patients with IBM, muscle specimens from RNF5 overexpressing animals revealed the presence of structures known as rimmed vacuoles and congophilic inclusions, hallmarks of this disease.

The researchers also found increased levels of markers characteristic of ER stress, a phenomenon that has been linked with a variety of human diseases, including sIBM. It is believed that ER stress is a response to misfolded-protein buildup; sensing the backlog, the ER recruits helpers through the Unfolded Protein Response (UPR)chaperonins that increase the export of misfolded proteins to enable their breakdown and recycling. But, with prolonged stress, the UPR eventually fails to handle the overload, resulting in the accumulation of misfolded proteins in the cytoplasmic vacuoles, structures within the cell cytoplasm which are characteristic of sIBM patients.

Whether RNF5 is the primary cause for sIBM, or an important contributor in the development of this muscle disorder is yet to be determined. Dr. Ronai, lead author of the study, says the link established between ER stress, RNF5 and sIBM strengthen one theory stating that ER stress is causative for the disease and
'/>"/>

Contact: Andrea Moser
amoser@burnham.org
858-646-3146
Burnham Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. DHS Begins Collecting 10 Fingerprints From International Visitors at New Yorks John F. Kennedy International Airport
2. Ancient lemurs little finger poses mystery
3. bioMETRX Incorporates OKIs Fingerprint Engine in its smartTOUCH Product Line
4. Futronic FS88 USB2.0 Fingerprint Reader Gets FIPS 201/PIV Certification from FBI
5. Northern right whales head south to give birth, leave genetic fingerprints with NOAA researchers
6. Futronic Announces Microsoft Vista and Windows 2008 Server Support for Its Fingerprint Logon Software
7. M2SYS Introduces Revolutionary Biometric Artificial Intelligence Technology to Significantly Reduce Fingerprint Software False Reject Rates
8. DHS Begins Collecting 10 Fingerprints From International Visitors at Detroit Metropolitan Wayne County Airport
9. DHS Begins Collecting 10 Fingerprints From International Visitors at Orlando International Airport
10. DHS Begins Collecting 10 Fingerprints From International Visitors at Miami International Airport
11. DHS Begins Collecting 10 Fingerprints From International Visitors at San Francisco International Airport
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
RING finger protein 5 may guide treatment for muscle disease in older adults
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, 2015 /PRNewswire/ ... human interface solutions, announced today that it will report ... 2015 on Thursday, July 30, 2015 after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. ... molecular diagnostics, today announced the launch of a ... Company,s Precision Cancer Monitoring℠ (PCM) technology for predicting ... one or a combination of the novel immunotherapy ... (nivolumab), a PD-1 inhibitor. The 50-patient study will ...
Breaking Biology News(10 mins):Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... alliance of conservation groups battling global extinctions has saved ... species. , American Bird Conservancy (ABC), Conservation International (CI), ... the 1,600-acre site on the northwest slope of the ... coast of Colombia, before its development for vacation homes. ...
... The University of Manchester and the Manchester Metropolitan University ... ancient spiders trapped in amber more than 30 millions ... the Baltic (Poland) and the Dominican (Caribbean) regions has ... back to the Cenozoic period. , It is the ...
... the U.S. Geological Survey released a report describing the ... 1992-2001. The report concludes that pesticides are typically present ... agricultural areas of the Nation, but are less common ... pesticides are seldom at concentrations likely to affect humans. ...
Cached Biology News:Crucial site for endangered frogs and birds saved 2Amber reveals ecology of 30 million year old spiders 2Pesticides in the nation's streams and ground water 2Pesticides in the nation's streams and ground water 3Pesticides in the nation's streams and ground water 4
(Date:7/28/2015)... 2015 Tauriga Sciences, Inc. (OTCQB:  TAUG) or ... today announced that its stockholders approved an increase in ... the Company from 1,000,000,000 to 2,500,000,000 at its Special ... the Law Offices of Nixon Peabody LLP in Midtown ... were 480,655,929 shares of common stock represented either by ...
(Date:7/28/2015)... NEWPORT BEACH, Calif. , July 28, 2015 ... company, announced that it has hit a milestone ... Putty. Signafuse was FDA 510(k) cleared in early ... standalone use in posterolateral spine fusion procedures.  This ... graft products, as less than 6% of new ...
(Date:7/28/2015)... RESEARCH TRIANGLE PARK, N.C., July 28, 2015  United ... its financial results for the second quarter ended ... nearly 300% as compared to the second quarter ... said Roger Jeffs, Ph.D., United Therapeutics, President and ... was due to an increase in the number ...
(Date:7/27/2015)... OAKS, Calif. , July 27, 2015  Amgen ... report its second quarter financial results on Thursday, July ... markets. The announcement will be followed by a conference ... Participating in the call from Amgen will be ... and other members of Amgen,s senior management team. ...
Breaking Biology Technology:Tauriga Sciences, Inc. Stockholders Approve Increase In Authorized Common Stock 2Tauriga Sciences, Inc. Stockholders Approve Increase In Authorized Common Stock 3Revolutionary Bone Graft Exceeds Expectations 2United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2015 Financial Results 11Amgen Announces Webcast of 2015 Second Quarter Financial Results 2
... , Interleukin 13 is a recently described cytokine ... is responsible for both positive and negative responses , ... to modulate macrophage functions as well as play ... and differentiation of hematopoietic stem cells. In addition, , ...
... and their metabolites are, important intracellular signals ... of hormones and growth, factors.The discovery of ... the 3 position of, the inositol ring ... and potential intracellular signals., Phosphoinositide 3-kinase has been ...
... S and CHT , Ceramic ... Henry Lai, PhD, and Samuel G Franklin, PhD, Bio-Rad Laboratories, Inc., , ... , Introduction , ... , using the conventional process composed of a protein ...
Cached Biology Technology:Purification of rIL-13 Using an UNO Q1 Column 2Purification of Phosphoinositide 3-Kinase With UNO Columns 2Purification of Murine IgG1 Using UNOsphere S and CHT , Ceramic Hydroxyapatite Chromatography, Rev A 2Purification of Murine IgG1 Using UNOsphere S and CHT , Ceramic Hydroxyapatite Chromatography, Rev A 3Purification of Murine IgG1 Using UNOsphere S and CHT , Ceramic Hydroxyapatite Chromatography, Rev A 4