Navigation Links
RING finger protein 5 may guide treatment for muscle disease in older adults
Date:4/4/2008

team developed three mouse models: one knockout model in which the RNF5 gene was missing, and two in which cells could be triggered to overproduce RNF5, with expression either limited to skeletal muscle, -or within muscle and a variety of other organs.

A comparison of normal and knockout mice exposed to muscle-damaging toxin showed slower healing in the knockouts compared with the normal mice, demonstrating the importance of RNF5 in muscle repair.

Pathologic changes within muscles of the transgenic models with RNF5 overexpression were similar to those found in muscle biopsies from patients with sIBM. Overproduction of RNF5 caused a rapid and significant muscle degeneration, weight loss and muscle weakness. Followed by extensive muscle regeneration. Similar to what is often seen in patients with IBM, muscle specimens from RNF5 overexpressing animals revealed the presence of structures known as rimmed vacuoles and congophilic inclusions, hallmarks of this disease.

The researchers also found increased levels of markers characteristic of ER stress, a phenomenon that has been linked with a variety of human diseases, including sIBM. It is believed that ER stress is a response to misfolded-protein buildup; sensing the backlog, the ER recruits helpers through the Unfolded Protein Response (UPR)chaperonins that increase the export of misfolded proteins to enable their breakdown and recycling. But, with prolonged stress, the UPR eventually fails to handle the overload, resulting in the accumulation of misfolded proteins in the cytoplasmic vacuoles, structures within the cell cytoplasm which are characteristic of sIBM patients.

Whether RNF5 is the primary cause for sIBM, or an important contributor in the development of this muscle disorder is yet to be determined. Dr. Ronai, lead author of the study, says the link established between ER stress, RNF5 and sIBM strengthen one theory stating that ER stress is causative for the disease and
'/>"/>

Contact: Andrea Moser
amoser@burnham.org
858-646-3146
Burnham Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. DHS Begins Collecting 10 Fingerprints From International Visitors at New Yorks John F. Kennedy International Airport
2. Ancient lemurs little finger poses mystery
3. bioMETRX Incorporates OKIs Fingerprint Engine in its smartTOUCH Product Line
4. Futronic FS88 USB2.0 Fingerprint Reader Gets FIPS 201/PIV Certification from FBI
5. Northern right whales head south to give birth, leave genetic fingerprints with NOAA researchers
6. Futronic Announces Microsoft Vista and Windows 2008 Server Support for Its Fingerprint Logon Software
7. M2SYS Introduces Revolutionary Biometric Artificial Intelligence Technology to Significantly Reduce Fingerprint Software False Reject Rates
8. DHS Begins Collecting 10 Fingerprints From International Visitors at Detroit Metropolitan Wayne County Airport
9. DHS Begins Collecting 10 Fingerprints From International Visitors at Orlando International Airport
10. DHS Begins Collecting 10 Fingerprints From International Visitors at Miami International Airport
11. DHS Begins Collecting 10 Fingerprints From International Visitors at San Francisco International Airport
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
RING finger protein 5 may guide treatment for muscle disease in older adults
(Date:12/17/2014)... Va. , Dec. 15, 2014 The Defense ... easier to detect and prevent counterfeit microcircuits from entering ... started performing an in-house microcircuit anti-counterfeit initiative dubbed DNA ... microcircuits while increasing their reliability throughout the supply chain. ...
(Date:12/17/2014)... 16, 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... Chemical Sensor Market 2015-2019" report to their offering. ... One major trend upcoming in this market is the ... sensors help in recording of patient data for quick ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... offering. One major trend emerging in ... in technology, it is important to upgrade biometric solutions ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Bloomington and eight collaborating institutions report in this ... live in rocks 2.8 kilometers below Earth's surface. ... uranium to convert water molecules to useable energy. ... of Earth's biosphere, the three-dimensional shell that encompasses ...
... Look no further than the air around you. It ... bacteria, according to a first-of-its-kind census of airborne microbes ... Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). , ... the bacteria in air samples taken from the Texas ...
... By studying a gene earlier linked to deafness in humans, ... which components of the inner ear send messages to the ... 2006, issue of the journal Cell, published by Cell Press. ... are profoundly deaf. The animals' deafness results from an inability ...
Cached Biology News:Bacteria that use radiated water as food 2Bacteria that use radiated water as food 3Study finds the air rich with bacteria 2Study finds the air rich with bacteria 3Study finds the air rich with bacteria 4Critical hearing gene helps send auditory messages to brain 2Critical hearing gene helps send auditory messages to brain 3
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 PlasmaTech ... care in critical areas, announced the closing of an underwritten ... to purchase up to an aggregate 3,500,000 shares of common ... $.01 per warrant.  The warrants have a per share exercise ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... is designed to introduce cutting edge communication technology, ... of platform upgrades. This webinar series demonstrates online ... quest to leverage web conferencing’s most innovative and ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ) announced ... Phase I/II clinical trial to investigate the use of REOLYSIN(R) for ... Dr. James Markert , Division Director of Neurosurgery, and Professor, ... , , , ...
... ... Solutions (HDS) has recently expanded its healthcare provider databases with the launching of ... Practitioners and Physician Assistants at either their home postal or email address. , ... (Vocus) April 23, 2010 ...
... PLAINES, Ill. , April 22 UOP LLC, a Honeywell (NYSE: ... using Honeywell UOP,s renewable jet fuel process technology powered a U.S. Navy F/A-18 ... of alternative fuels in military aircraft. , ... The F/A-18 Super Hornet, dubbed the Green Hornet by the Navy, was ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Completes Patient Enrollment in Phase I Portion of U.S. Phase I/II Recurrent Malignant Gliomas Clinical Trial 2Oncolytics Biotech(R) Inc. Completes Patient Enrollment in Phase I Portion of U.S. Phase I/II Recurrent Malignant Gliomas Clinical Trial 3Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 2Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 3Honeywell Green Jet Fuel(TM) Powers U.S. Navy Green Hornet for Biofuels Certification Flight 2Honeywell Green Jet Fuel(TM) Powers U.S. Navy Green Hornet for Biofuels Certification Flight 3Honeywell Green Jet Fuel(TM) Powers U.S. Navy Green Hornet for Biofuels Certification Flight 4