Navigation Links
Queen's University Belfast makes significant cancer breakthrough
Date:8/8/2012

A major breakthrough by scientists at Queen's University Belfast could lead to more effective treatments for throat and cervical cancer. The discovery could see the development of new therapies, which would target the non-cancerous cells surrounding a tumour, as well as treating the tumour itself.

Researchers at Queen's Centre for Cancer Research and Cell Biology have found that the non-cancerous tissue, or 'stroma', surrounding cancers of the throat and cervix, plays an important role in regulating the spread of cancer cells.

The discovery opens the door for the development of new treatments which, by targeting this non-cancerous tissue, could prevent it being invaded by neighbouring cancer cells.

The research, led by Professor Dennis McCance, has just been published in the European Molecular Biology Organization Journal. Professor McCance said: "Cancer spreads as the result of two-way communication between the cancer cells in a tumour and the non-cancerous cells in the surrounding tissue.

"We already know that cancer cells are intrinsically programmed to invade neighbouring healthy tissue. But the cells in the non-cancerous tissue are also programmed to send messages to the cancer cells, actively encouraging them to invade. If these messages sent from the healthy tissue to the tumour - can be switched-off, then the spread of the cancer will be inhibited.

"What we have discovered is that a particular protein in non-cancerous tissue has the ability to either open or close the communication pathway between the healthy tissue and the tumour. When the Retinoblastoma protein (Rb) in non-cancerous tissue is activated, this leads to a decrease in factors that encourage invasion by cancer cells. And so, the cancer doesn't spread."

The Rb protein is found in both cancer and non-cancerous tissue. Its importance in regulating the growth of cancer cells from within tumours is already well-documented, but this is the first time scien
'/>"/>

Contact: Anne-Marie Clarke
comms.officer@qub.ac.uk
44-028-909-75320
Queen's University Belfast
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Air pollution regulations over the last decade in Taiyuan, ... there, accounting for a greater than 50% reduction in ... 2001 and 2010, according to researchers at the Columbia ... School of Public Health, the Shanxi Medical University, the ... and Shanghai Fudan University School of Public Health. , ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/2/2014)... others are done in by it. New research at ... so-called stress gap in mice with very similar genetic ... better understand the development of psychiatric disorders such as ... unique experiences as it goes through its life. And ... expression of genes, and as a result, affect an ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Exceptionally well preserved insect fossils from the Rhône Valley 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3
... of 1000, the leading scientific evaluation service, has highlighted research ... Birds use plumage colour to recognize and select potential mates. ... a striking colour change, as demonstrated by two closely related ... in the American Naturalist -- selected and reviewed ...
... the possibility that flies and other insects that encounter nanomaterial ... could pick up and transport nanoparticles on their bodies, transferring ... The study on carbon nanoparticles barely 1/5,000th the width ... issue of ACS, Environmental Science & Technology , a ...
... an advance that could help ease the antibiotic drought, ... test that enlists pinhead-sized worms in efforts to discover ... ACS Chemical Biology , a monthly journal. ... that existing methods for identifying germ-fighting drugs involve adding ...
Cached Biology News:
(Date:9/2/2014)... ON , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... totalling $2.1 million. The orders consist of three large odour ... Canada . "These orders are consistent with ... said Peter Bruijns , President and CEO. "After a ... market, we are now beginning to see sales growth. Our ...
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
(Date:8/31/2014)... Dallas, Texas (PRWEB) August 31, 2014 ... Global Polyacrylamide Industry” is a professional and ... The report provides basic Polyacrylamide information, including ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/29/2014)... August 29, 2014 The global ... billion in 2019. It is expected to grow ... 2019, and was valued at $1.8 billion in ... Transparency Market Research. , For more information regarding ... . , The research report, titled “Companion Diagnostics ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... , QUEBEC CITY , Jan. 22 ... TSX: AEZ) (the "Company"), a late-stage drug development company specialized ... 21, 2010 , the Company received a letter from the ... the minimum closing bid price of its common shares had ...
... , ... Bioamber,( http://www.bio-amber.com/ ) , a joint venture between US-based DNP,( ... )(Agro-industrie Recherches et Développements),announces the successful start-up and commissioning of ... , the plant has been,producing renewable succinic acid from wheat ...
... ... contouring, will be presented at the upcoming ICAD & 3rd ECAA Asia conference. Dr. ... Y. Yu will present his latest clinical data showing successful reduction of acne using TriPollar. ... (PRWEB) January 20, ...
Cached Biology Technology:Æterna Zentaris Receives NASDAQ Notification Related to Minimum Bid Price 2Æterna Zentaris Receives NASDAQ Notification Related to Minimum Bid Price 3Bioamber Commissions World's First Renewable Succinic Acid Plant 2Bioamber Commissions World's First Renewable Succinic Acid Plant 3TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 2TriPollar Technology Clinically Proven to Significantly Reduce Stretch Marks and Acne 3
Collected from animals of U.S. origin.Collected from animals of U.S. origin. *Can be used in cell growth studies and immunoassays. *Sterility tested, * Mycoplasma tested upon request, *Endoto...
...
Mouse monoclonal [Ley 37D/G6] to LKB1 ( Abpromise for all tested applications). entrezGeneID: 6794 SwissProtID: Q15831...
... Solid phase reagent ... purification; Easy & unique ... Compatible with detergents and ... & recover non-envelop viruses ...
Biology Products: