Navigation Links
Queen's University Belfast makes significant cancer breakthrough
Date:8/8/2012

A major breakthrough by scientists at Queen's University Belfast could lead to more effective treatments for throat and cervical cancer. The discovery could see the development of new therapies, which would target the non-cancerous cells surrounding a tumour, as well as treating the tumour itself.

Researchers at Queen's Centre for Cancer Research and Cell Biology have found that the non-cancerous tissue, or 'stroma', surrounding cancers of the throat and cervix, plays an important role in regulating the spread of cancer cells.

The discovery opens the door for the development of new treatments which, by targeting this non-cancerous tissue, could prevent it being invaded by neighbouring cancer cells.

The research, led by Professor Dennis McCance, has just been published in the European Molecular Biology Organization Journal. Professor McCance said: "Cancer spreads as the result of two-way communication between the cancer cells in a tumour and the non-cancerous cells in the surrounding tissue.

"We already know that cancer cells are intrinsically programmed to invade neighbouring healthy tissue. But the cells in the non-cancerous tissue are also programmed to send messages to the cancer cells, actively encouraging them to invade. If these messages sent from the healthy tissue to the tumour - can be switched-off, then the spread of the cancer will be inhibited.

"What we have discovered is that a particular protein in non-cancerous tissue has the ability to either open or close the communication pathway between the healthy tissue and the tumour. When the Retinoblastoma protein (Rb) in non-cancerous tissue is activated, this leads to a decrease in factors that encourage invasion by cancer cells. And so, the cancer doesn't spread."

The Rb protein is found in both cancer and non-cancerous tissue. Its importance in regulating the growth of cancer cells from within tumours is already well-documented, but this is the first time scientists have identified the role of the Rb found in healthy tissue, in encouraging or discouraging the spread of cancer.

The research was conducted using three-dimensional tissue samples, grown in Professor McCance's lab, to replicate the stroma tissue found around cancers of the throat and cervix.

Speaking about the potential implications for cancer treatment, Professor McCance continued: "Current treatments for cancer focus on targeting the tumour itself, in order to kill the cancer cells before they spread. This discovery opens the door for us to develop new treatments that would target the normal tissue surrounding a tumour, as opposed to the tumour itself. By specifically targeting pathways controlled by the Rb protein, it would be possible to switch-off the messages that encourage cancer cells to invade, and inhibit the spread of the tumour.

"Our research has focussed on cancers of the throat and cervix. But it is possible that Rb or other proteins in the healthy tissue surrounding other types of cancer, may play a similar role in regulating the spread of tumour cells. Therefore, the implications of this discovery could go far beyond throat and cervical cancer, and that is something we plan to investigate further."


'/>"/>

Contact: Anne-Marie Clarke
comms.officer@qub.ac.uk
44-028-909-75320
Queen's University Belfast
Source:Eurekalert

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a medical ... (IV) therapy, today announced receipt of its ISO 13485 Certification, the ... the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection ... "This is an important ...
(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
Breaking Biology Technology: