Navigation Links
Queen's University Belfast makes significant cancer breakthrough
Date:8/8/2012

A major breakthrough by scientists at Queen's University Belfast could lead to more effective treatments for throat and cervical cancer. The discovery could see the development of new therapies, which would target the non-cancerous cells surrounding a tumour, as well as treating the tumour itself.

Researchers at Queen's Centre for Cancer Research and Cell Biology have found that the non-cancerous tissue, or 'stroma', surrounding cancers of the throat and cervix, plays an important role in regulating the spread of cancer cells.

The discovery opens the door for the development of new treatments which, by targeting this non-cancerous tissue, could prevent it being invaded by neighbouring cancer cells.

The research, led by Professor Dennis McCance, has just been published in the European Molecular Biology Organization Journal. Professor McCance said: "Cancer spreads as the result of two-way communication between the cancer cells in a tumour and the non-cancerous cells in the surrounding tissue.

"We already know that cancer cells are intrinsically programmed to invade neighbouring healthy tissue. But the cells in the non-cancerous tissue are also programmed to send messages to the cancer cells, actively encouraging them to invade. If these messages sent from the healthy tissue to the tumour - can be switched-off, then the spread of the cancer will be inhibited.

"What we have discovered is that a particular protein in non-cancerous tissue has the ability to either open or close the communication pathway between the healthy tissue and the tumour. When the Retinoblastoma protein (Rb) in non-cancerous tissue is activated, this leads to a decrease in factors that encourage invasion by cancer cells. And so, the cancer doesn't spread."

The Rb protein is found in both cancer and non-cancerous tissue. Its importance in regulating the growth of cancer cells from within tumours is already well-documented, but this is the first time scien
'/>"/>

Contact: Anne-Marie Clarke
comms.officer@qub.ac.uk
44-028-909-75320
Queen's University Belfast
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... mobile app called TX Invasives is now available from ... of Texas at Austin for identifying harmful non-native plant, ... species in the United States cause about $137 billion ... agricultural crops, clog waterways, kill native plants and more. ... app for reporting where invasive species occur, we,re more ...
(Date:8/28/2014)... German . ... to a striking pattern of blue stripes alternating with golden ... cells, and yellow cells emerge during growth in the skin ... mosaic to compose the characteristic colour pattern. ,While ... interact to form proper stripes, the embryonic origin of the ...
(Date:8/28/2014)... at the University of Minnesota have developed an animal ... used for muscle regeneration research as well as studies ... The research is published in the current edition of ... no treatment for FSHD, which is thought by many ... FSHD is an unusual genetic disorder because, unlike most ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3UMN researchers find animal model for understudied type of muscular dystrophy 2
... sounds like a crime novel on a dime-store shelf. But "An ... prime suspect is very, very small. Rice University evolutionary ... cells to starve in a slime mold seem to have an ... pushes those that keep on eating into sacrificing themselves for the ...
... Climate change is about more than just polar bears. ... research into climate change communication has been published in ... efforts of journalists, campaigners and politicians to engage the ... strategies, can communicate climate change messages against a backdrop ...
... disease that has wiped out more than 100 species, scientists ... frog species in Panama: Pristimantis educatoris , from Omar ... Province near the Colombian border. , In 1989 researchers realized ... the cause: a fungal disease called chytridiomycosis. In 2004 Karen ...
Cached Biology News:A Dicty mystery solved 2Beyond polar bears? Experts look for a new vision of climate change to combat skepticism 22 new frog species discovered in Panama's fungal war zone 2
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... Technologies recently made its way to San Jose ... strategic partners - and the courtship continues. , ... expand its product lineup beyond its current variety of ... in discussions with larger firms interested in marketing and ...
... and Commerce (T.E.C.) Center , a high-tech incubator located ... Economic Development grant to improve technology services for tenants. ... Wisconsin Department of Commerce , will be announced ... , ,Dr. Edward Clarke, president of the T.E.C. Center ...
... emulation for many. It is also a unique organization. The ... than an investment portfolio. It operates in a diverse set ... to financial services and broadcasting. It is huge - $150 ... businesses and global in its markets and operational scope. , ...
Cached Biology Technology:Platypus ready to unveil new commercial lines 2Platypus ready to unveil new commercial lines 3Platypus ready to unveil new commercial lines 4T.E.C. Center to receive Commerce grant 2Growth through the eyes of GE's Immelt 2Growth through the eyes of GE's Immelt 3Growth through the eyes of GE's Immelt 4Growth through the eyes of GE's Immelt 5
... The Bio-Stack is compatible with ... systems. Speed, ease of use and ... routine microplate process. When used with ... reagent dispenser, the Bio-Stacks small footprint ...
... step in the evolution of laboratory automation. ... delivers labware to multiple laboratory instruments, LabLinx ... throughput of ordinary microplate robots. It allows ... configurations to meet any labs specific automation ...
... a fast and versatile automated strip washer ... Dual-ActionTM 16-channel manifold. This breakthrough design allows ... aspiration manifolds for overfill washing and overflow ... The problem of fitting dispense and aspirate ...
... potential applications for the use of small ... expression via the RNA interference (RNAi) pathway ... and molecular biology fields. siRNA for experimental ... chemically or enzymatically, and then transfected into ...
Biology Products: