Navigation Links
Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
Date:2/1/2013

Philadelphia, Pa. The shortened daylight of a Maine winter may make for long, dark nights but it has shone a light on a novel experimental approach to fighting inflammatory breast cancer (IBC), an especially deadly form of breast cancer.

The new approach enlists the active form of Vitamin D3, called calcitriol, which is delivered therapeutically by quantum dots. Quantum dots are an engineered light-emitting nanoscale delivery vehicle. This new preliminary work shows the dots can be used to rapidly move high concentrations of calcitriol to targeted tumor sites where cancer cells accumulate, and also through the lymph system where the cancer spreads. With this approach, the calcitriol can fight on multiple fronts and the targeted location can be visualized with an imaging system tracking the quantum dots. The research will be presented at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

University of Delaware cancer researcher Anja Nohe was living in Maine when she first received funding from the Maine Cancer Foundation to determine the effect of calcitriol on breast cancer cells. Reading cancer literature helped her make connections between cancer, vitamin D, and the daylight regime of higher latitudes. "By talking with talented colleagues about these ideas, the foundation was set for the current project," she says. After moving to the University of Delaware, she began working with Kenneth Van Golen, "an expert in the biology of IBC," to evaluate calcitriol.

Compared to other forms of breast cancer, IBC is especially difficult to treat. It has a five-year survival rate of 40% versus 87% for all other breast cancers. A big part of what makes IBC treatment difficult is its multi-site growth pattern. Current aggressive treatments such as combinations of chemotherapy, surgery and radiation, have failed to significantly improve IBC survival rates.

This early experimental work on
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
2. High Brightness Tetrapod Quantum Dots Developed
3. Quantum communication: Each photon counts
4. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
5. Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
6. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
7. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
8. Cancerous tumors deliver pro-metastatic information in secreted vesicles
9. iView Systems iTrak® version 5.5 delivers optimized Incident Reporting
10. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
11. OSCs Oakley Cluster delivers on performance efficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Except when that predator runs so fast that it essentially ... is the fastest creature on Earth. Some of these half-inch-long ... five miles per hour). The fastest human can do about ... tiger beetle, a person would have to hit 480 miles ... At peak speeds, everything becomes a blur. They can,t gather ...
(Date:11/4/2014)... of Utah engineers developed the first room-temperature fuel cell ... without needing to ignite the fuel. These new fuel ... power and sensors. , A study of the new ... journal ACS Catalysis . , Fuel cells convert ... fuel and an oxygen-rich source such as air. If ...
(Date:11/4/2014)... , November 4, 2014   ... vertical market growth   Fuel3D , a ... closed a funding round totaling $6.4 million (£4 million). This ... funding secured earlier this year and paves the way for ... 2015. The funding round was led by Chimera ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... LAKE CITY, Sept. 8, 2011 The University of Utah ... research aimed at developing new materials for uses ranging from ... cells. The new Center of Excellence in Materials ... years by a $12 million grant from the National Science ...
... A new, open-access article (DOI: 10.1603/IPM10024) in the ... summary of the various species of thrips present in U.S. ... general description of thrips biology, and management practices currently available ... to infest cotton seedlings in the United States and constitute ...
... The 60th Annual Meeting of the American Society of ... kind in the world -- will bring together in one ... bacteria, viruses, parasites and other pathogens that each year kill ... clinicians and other experts in tropical medicine and global health ...
Cached Biology News:$21.5 million for materials research at the University of Utah 2$21.5 million for materials research at the University of Utah 3Latest on malaria, dengue, radiation threats, bedbugs, cholera in Haiti at ASTMH Annual Meeting 2Latest on malaria, dengue, radiation threats, bedbugs, cholera in Haiti at ASTMH Annual Meeting 3
(Date:11/26/2014)... 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con ... europeo in occasione di Hi Europe 2014 (dal 2 ... Si tratta della curcumina con la maggiore biodisponibilità ... cristalli) e ingredienti approvati dalle norme europee. ... della pianta curcumina ( Curcuma longa ) che è ...
(Date:11/24/2014)...  Last week, Representatives Gus Bilirakis ... a bold bipartisan step on behalf of patients ... Original co-sponsors of the legislation include Representatives McCaul ... drug makers and innovators to "repurpose" major market ... which opens the door to the development of ...
(Date:11/24/2014)... One of the most extensive, widely cited digital ... now available to high school and junior college students and ... international society for optics and photonics , announced today that ... Library available to high schools for free and two-year ... to all areas of life in today’s world,” said SPIE ...
(Date:11/24/2014)... 24, 2014  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... Ltd.,  Case No. 3:13-cv-03494-M and  Spherix v. Uniden ... in the United States District Court for the ... On November 21, 2014 the ...
Breaking Biology Technology:La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2
... OSTE ), a leader in the emerging field of ... States Food and Drug,Administration ("FDA") has cleared its 510(k) ... In spinal applications, Plexur,M(TM) may be used in conjunction ... Osteotech received FDA clearance for Plexur M(TM) to be ...
... Arena Pharmaceuticals,Inc. (Nasdaq: ARNA ) today announced ... the NASDAQ Global Market closes on Tuesday, August,5, ... and Chief,Executive Officer, and Robert E. Hoffman, Arena,s ... a conference call at 5:00 p.m.,Eastern Time (2:00 ...
... Strong Starts ... Maintains 2008 Earnings Guidance Despite New Spending for Pre-Launch ... AMRIX Investment, FRAZER, Pa., July 29 Cephalon, Inc. (Nasdaq:,CEPH) today ... million for the second quarter 2007 and the company,s,sales guidance of $455 ...
Cached Biology Technology:Osteotech's Plexur M(TM) Biocomposite Receives FDA Clearance in Spine 2Arena Pharmaceuticals to Report Second Quarter 2008 Financial Results and to Host Conference Call and Webcast on Tuesday, August 5, 2008 2Arena Pharmaceuticals to Report Second Quarter 2008 Financial Results and to Host Conference Call and Webcast on Tuesday, August 5, 2008 3Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 2Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 3Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 4Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 5Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 6Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 7Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 8Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 9Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 10Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 11Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 12Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 13Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 14Cephalon Exceeds Both Sales and Earnings Guidance for Second Quarter of 2008 15
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
Attoglow Western Blot Enhancing Kit contains Millennium Enhancer which can significantly boost Western blot signals, and is compatible with other enhancing mechanisms to achieve multiplied enhancing ...
Immunogen: Synthetic peptide: S(399) P W S E L E F Q F P D D K D P V W E F(418) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Biology Products: