Navigation Links
Quantitative imaging application to gut and ear cells are reported in 2 Nature papers
Date:1/15/2012

BOSTON, MA -- From tracking activities within bacteria to creating images of molecules that make up human hair, several experiments have already demonstrated the unique abilities of the revolutionary imaging technique called multi-isotope imaging mass spectometry, or MIMS, developed by researchers at Brigham and Women's Hospital (BWH). MIMS can produce high-resolution, quantitative three-dimensional images of stable isotope tags within subcellular compartments in tissue sections or cells.

With its use of stable isotopes as tracers, MIMS has opened the door for biomedical researchers to answer various biological questions, as two new studies have demonstrated. These studies looked at the use of MIMS in tracking cell division in intestinal stem cells, lipid turnover in Drosophila flies, protein turnover in ear cells, and opened the way to human application by detecting the formation of new white blood cells. Both studies will be published in Nature online on January 15, 2012 and in print on January 26, 2012.

In the first study, researchers used MIMS to test the much debated "immortal strand hypothesis" which claims that as stem cells divide, the older template DNA remains together in a stem cell, as the newer DNA is passed to cells that differentiate forming the digestive lining of the small intestine.

By tagging DNA with stable isotope tracers, researchers tracked DNA replication as cells divided. They found that in any situation DNA segregation was random, thereby disproving the immortal strand hypothesis.

The research opened another door by studying lipid metabolism within single lipid droplets of the fat body and of the central nervous system of Drosophila larvae. The researchers were also able to translate their work to humans. In a pilot study, they used MIMS to successfully track the formation of new white blood cells after administering isotope tracers in a healthy human volunteer.

The second study
'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. NPL unveils quantitative means of monitoring ultrasonic cleaning systems
2. SNM releases new fact sheet on breast cancer and molecular imaging
3. Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight
4. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
5. Similarities in imaging the human body, Earths crust focus of conference at UH
6. UNC expands brain imaging study of infants at risk for autism
7. Studies on imaging and tracking transplanted cells
8. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
9. SNM Symposium on Multimodality Cardiovascular Molecular Imaging
10. Ultrasound imaging now possible with a smartphone
11. First neuroimaging study examining motor execution in children with autism reveals new insights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... September 29, 2014 -- Plants have a ... help the pants extract nutrients and defend against ... from contaminating fruits and vegetables. Now, scientist have ... inside of seeds; thus ensuring that sprouting plants ... the University of Notre Dame, presented their findings ...
(Date:9/29/2014)... story from 2009, "human activities in this area of the ... oil is increasingly grown for use as a cooking oil ... It has become the most widely produced edible oil in ... surpass that of soybean oil. , The environmental effects of ... to grow the crop, and the preferred method is fire. ...
(Date:9/29/2014)... should use ventilation when cooking with a gas stove, ... new study showed an association between gas kitchen stove ... "In homes where a gas stove was used without ... than in homes where a gas stove was used ... the College of Public Health and Human Sciences at ...
Breaking Biology News(10 mins):Plants prepackage beneficial microbes in their seeds 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... girl or fighting like a boy is hardwired into fruit ... Nature Neuroscience advance online publication by a research team from ... Vienna. The results confirm that a gene known as "fruitless" ... findings mark a milestone in an unlikely new animal model ...
... highly drug-resistant tuberculosis are emerging and action must be ... editorial in this week's BMJ. , The authors say ... control strategies, especially in countries where tuberculosis control practices ... assess the extent of the spread of these highly ...
... helping to provide a cheap, easy and safe way ... in humans. Researchers from the University of Bath have ... bacterial gene sequences by testing them in caterpillars to ... known as Rapid Virulence Annotation (RVA) allows them to ...
Cached Biology News:Fighting like a girl or boy determined by gene in fruit flies 2Fighting like a girl or boy determined by gene in fruit flies 3World-wide warning of highly drug-resistant tuberculosis 2Caterpillars tell us how bacteria cause disease 2Caterpillars tell us how bacteria cause disease 3
(Date:9/30/2014)... 2014 The custom stainless steel fabrication ... Show 2014. The Boston Area Chapter of ISPE (International ... day-long event for Wed., Oct. 1 at Gillette Stadium ... the largest in ISPE Boston’s long history, with more ... attendees expected. , HOLLOWAY AMERICA President David Simpson ...
(Date:9/30/2014)... Lyme Research Alliance (LRA), the ... at universities, today announced the awarding of seven grants ... and cure for Lyme and other tick-borne diseases. ... in its history—over 20 grant proposals—a 100 percent increase ... to receive so many solid applications from talented scientists ...
(Date:9/30/2014)... 30, 2014 SoundConnect, ... company is dedicated to supporting business communication solutions, ... Julie Power, a carrier services specialist ... solutions stays connected and productive at all times. ... movement of businesses to cloud communications services. ...
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4SoundConnect Expands Carrier Services Division 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2
... Calif., Oct. 28 Voler Systems ( http://www.volersystems.com ), ... 50% growth over the same period last year. , ... our strong results. Medical firms are turning to Voler ... to production of devices for human use. We remain ...
... 27 Microfluidics International Corporation (OTC Bulletin Board: MFLU) ... 2009 financial results on Monday, November 2, 2009, after ... http://www.newscom.com/cgi-bin/prnh/20090811/NE59652LOGO ) , Michael C. ... Byczko, Vice President of Finance and Chief Accounting Officer, ...
... response to requests from clients, Schulman Associates IRB (Schulman) has ... Canadian Board,s first official meeting is scheduled for this week. ... the U.S. and Canada, Canadian and U.S. Board members will ... "Our clients have asked us to provide review services in ...
Cached Biology Technology:Voler Systems Reports 50% Growth 2Microfluidics International Corporation to Report Third Quarter 2009 Financial Results on November 2, 2009 2Microfluidics International Corporation to Report Third Quarter 2009 Financial Results on November 2, 2009 3Schulman Associates IRB Establishes an Institutional Review Board in Canada 2
... for proteomic scale kinase profiling, quantitative measurement ... research built on the flexible and powerful ... are available as part of our comprehensive ... Probe Content Our standard ...
... Pathway Studio Enterprise is integrated informatics ... regulatory mechanisms and drug response modeling. ... the worlds largest knowledge base of ... with MedScan module capable of extracting ...
... Evaluated for its amino acid acceptor activity using ... Ala, Asp, Gly, Ile, Lys, Pro, Thr, Val, ... Unit Definition: One unit will yield an A ... water (1 cm light path). Physical ...
... Dithiothreitol DTT White solid.. PACKAGED UNDER ... thiols, so reaction is "driven" to completion. A ... waxy surfactant found in many other preparations. Blocks ... Purity: ≥97% by titration. Contaminants: Heavy ...
Biology Products: