Navigation Links
Purdue researcher invents molecule that stops SARS
Date:11/11/2008

WEST LAFAYETTE, Ind. - A Purdue University researcher has created a compound that prevents replication of the virus that causes SARS and could lead to a treatment for the disease.

"The outbreak of SARS in 2003 led to hundreds of deaths and thousands of illnesses, and there is currently no treatment," said Arun Ghosh, the Purdue professor that led the molecular design team. "Although it is not currently a threat, there is the concern that SARS could return or be used as a biological weapon. It is important to develop a treatment as a safeguard."

According to the Centers for Disease Control and Prevention, the virus can be transmitted through coughing or sneezing, and the infection can quickly spread from person to person. SARS, or Severe Acute Respiratory Syndrome, spread through two dozen countries over a period of a few months before it was contained. A total of 8,098 people worldwide became ill and 774 died.

In addition to its ability to block the SARS virus, the molecular compound that inhibits the virus provides new insights into a group of proteins found in a range of diseases including childhood croup, herpes and cancer, Ghosh said.

"The molecular inhibitor we developed is very potent against the SARS virus by binding to and blocking the use of a specific protein, called papain-like protease, or PLpro, involved in viral replication and evasion of the immune system," said Ghosh who has a joint appointment in chemistry and medicinal chemistry and molecular pharmacology. "This is the first design and discovery of an inhibitor for this class of proteins. We are hopeful that this will open the door to new treatments for other diseases as well."

Ghosh's group teamed with a research group led by Andrew Mesecar at the University of Illinois at Chicago. The National Institutes of Health infectious disease biodefense program selected the team and funded the research that has been published in the online version of the jo
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Purdue researchers obtain a snapshot clarifying how materials enter cells
3. Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
4. Purdue researchers click nutrition with camera diet study
5. Clemson researchers advance nano-scale electromechanical sensors
6. MSU researcher studies ties between cholesterol drugs, muscle problems
7. Damage inflicted during cardiac attacks more widespread, MSU researchers find
8. Battling bacteria in the blood: Researchers tackle deadly infections
9. Researchers use chemical from medicinal plants to fight HIV
10. Yale researchers unravel mystery of brain aneurysms
11. Montana State University researchers find gene that regulates molds resistance to drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... factors, both genetic and environmental, have been blamed ... schizophrenia. Some, such as a family history of ... with Toxoplasma gondii , a parasite transmitted ... still viewed with skepticism. , A new study ... epidemiology at the University of Pennsylvania,s School of ...
(Date:10/29/2014)... all the rage. Thousands of scientists worldwide are conducting ... titanium dioxide nanoparticles from sun creams can get through ... from electronic products are as hazardous for the lungs ... food can get into the blood via the intestinal ... are flowing – and the number of scientific projects ...
(Date:10/29/2014)... in German . ... and Peter Schlögelhofer at the Max F. Perutz Laboratories ... University of Vienna dived into the process of meiosis ... display an inversion of the standard meiotic phases. The ... Nature Communications . , Meiosis is the two-step ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3Meiotic cell division 'the other way round' 2
... Damselfish are killing head corals and adding stress ... poor condition from global climate change, coral diseases, hurricanes, ... favorite homestead, will take the pressure off the other ... online journal PLoS ONE . The small, ...
... miles of the nation,s infrastructure of water ... of its useful life, but the mostly ... attention because of this "invisibility," said Sunil ... and environmental engineering (CEE). http://www.cee.vt.edu/index.php?do=view&content=0&apps=2&level=2&id=17&pid=b024555fa7f439a27509de488a7b5749 ...
... most likely to occur on Sunday, in less than 6 ... wearing black and white bathing suits, a first of its ... analyzed statistics from shark attacks that occurred in Florida,s Volusia ... 1956 and 2008. They also spent a year observing people ...
Cached Biology News:Distressed damsels stress coral reefs 2Efforts underway at Virginia Tech to address deterioration of nation's water pipes 2Case study analyzes why, where and when of leading shark attack site 2Case study analyzes why, where and when of leading shark attack site 3
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Calif. , Oct. 30, 2014 Isis Pharmaceuticals, ... therapeutics, today announced that management will present a company overview ... at 8:30 a.m. ET in Boston, MA. ... be available on the "Investors & Media" section of the ... on the Isis website within 48 hours and will be ...
(Date:10/30/2014)... (Oct. 29, 2014) – The severe flooding that devastated ... been less destructive if the bridges, roads and other ... new study from the University of Colorado Denver. , ... infrastructure," said Jimmy Kim, PhD, associate professor of structural ... Applied Science and lead author the study. "There is ...
(Date:10/27/2014)... and TORONTO , Oct. 27, ... ) (OTCQB: GNBT) today announced two presentations demonstrating ... by its novel proprietary cancer immunotherapeutic AE37 vaccine ... cancer patients. The AE37 cancer vaccine is being ... Inc. ( www.antigenexpress.com ). The presentations are being ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2CU Denver study says upgrading infrastructure could reduce flood damage 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4
... When Hurricane Dennis reached landfall in the Florida ... surprising a development. Weather Central Inc. , a ... almost the exact location two days earlier. , ,On ... a service used by more than 100 television stations ...
... unexpectedly, this sudden accident incubates a branding process, which can ... gives birth to an extreme name identity, whereupon a major ... not stirred -- and that's how we refer to today's ... the secrets of the various branding tricks and become aware ...
... by thousands of U.S. companies since the 1970s, it ... in more than 35 states have introduced legislation restricting ... effective cost-cutting tool has begun to soar. Early in ... outsourcing, it was often viewed as a way ...
Cached Biology Technology:Accidental naming 2Accidental naming 3Accidental naming 4Consider the legal issues before outsourcing offshore 2Consider the legal issues before outsourcing offshore 3Consider the legal issues before outsourcing offshore 4Consider the legal issues before outsourcing offshore 5
... Clarin represents the state-of-the-art in ... for the permanent preservation of immunohistochemical ... (DAB), Vega Red, New Fuchsin, and ... substrates on tissue sections. Clarin can ...
... Gene Inspector can perform many sophisticated DNA analysis ... much more than just another sequence analysis product. ... suite of analyses to be performed each time ... custom style sheets which specify exactly how your ...
... columns is a well-known separation technique in ... are in DNA/RNA extraction in microbiology, viral ... in chemical or analytical laboratories. ,This ... series instruments for smaller scales. The extraction ...
... is a revolutionary new application for ... a novel interface, Expression makes complex ... simple. Expression uses the very latest ... in the way sequences are analysed. ...
Biology Products: