Navigation Links
Purdue researcher invents molecule that stops SARS
Date:11/11/2008

WEST LAFAYETTE, Ind. - A Purdue University researcher has created a compound that prevents replication of the virus that causes SARS and could lead to a treatment for the disease.

"The outbreak of SARS in 2003 led to hundreds of deaths and thousands of illnesses, and there is currently no treatment," said Arun Ghosh, the Purdue professor that led the molecular design team. "Although it is not currently a threat, there is the concern that SARS could return or be used as a biological weapon. It is important to develop a treatment as a safeguard."

According to the Centers for Disease Control and Prevention, the virus can be transmitted through coughing or sneezing, and the infection can quickly spread from person to person. SARS, or Severe Acute Respiratory Syndrome, spread through two dozen countries over a period of a few months before it was contained. A total of 8,098 people worldwide became ill and 774 died.

In addition to its ability to block the SARS virus, the molecular compound that inhibits the virus provides new insights into a group of proteins found in a range of diseases including childhood croup, herpes and cancer, Ghosh said.

"The molecular inhibitor we developed is very potent against the SARS virus by binding to and blocking the use of a specific protein, called papain-like protease, or PLpro, involved in viral replication and evasion of the immune system," said Ghosh who has a joint appointment in chemistry and medicinal chemistry and molecular pharmacology. "This is the first design and discovery of an inhibitor for this class of proteins. We are hopeful that this will open the door to new treatments for other diseases as well."

Ghosh's group teamed with a research group led by Andrew Mesecar at the University of Illinois at Chicago. The National Institutes of Health infectious disease biodefense program selected the team and funded the research that has been published in the online version of the jo
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Purdue researchers obtain a snapshot clarifying how materials enter cells
3. Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
4. Purdue researchers click nutrition with camera diet study
5. Clemson researchers advance nano-scale electromechanical sensors
6. MSU researcher studies ties between cholesterol drugs, muscle problems
7. Damage inflicted during cardiac attacks more widespread, MSU researchers find
8. Battling bacteria in the blood: Researchers tackle deadly infections
9. Researchers use chemical from medicinal plants to fight HIV
10. Yale researchers unravel mystery of brain aneurysms
11. Montana State University researchers find gene that regulates molds resistance to drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... have survived the asteroid strike that wiped them out ... in history, scientists say. , A fresh study using ... palaeontologists to build a new narrative of the prehistoric ... found that in the few million years before a ... experiencing environmental upheaval. This included extensive volcanic activity, changing ...
(Date:7/27/2014)... potential for global climate change to cut food supplies. ... the interactions between increasing temperature and air pollution ... , A new study involving researchers at MIT shows ... policymakers need to take both warming and air pollution ... looked in detail at global production of four leading ...
(Date:7/25/2014)... SYRACUSE, N.Y., July 25, 2014 In the first broad-scale ... Forest Service scientists and collaborators calculated that trees are ... preventing 670,000 incidences of acute respiratory symptoms. , While ... improvement of less than 1 percent, the impacts of ... effects of the reduced air pollution at nearly $7 ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3First national study finds trees saving lives, reducing respiratory problems 2
... ORLEANSAlzheimer,s disease (AD) is a tragic disease that robs an individual ... the age of 65 now suffer from the disease and one ... to popular belief, Alzheimer,s does not only affect the elderly. Familial ... young as 30. The Study , Alzheimer,s ...
... for adults, teens, and youngsters. It is less clear ... growth during gestation. Now that scientists have determined that, ... a fetus, studies are underway to examine the mother/fetus/exercise/health ... Entitled The Effects of Maternal Exercise on Fetal Breathing ...
... of people around the world, causing numerous problems ranging ... issues. Initial drug use can be motivated by curiosity ... rats, it can also be the result of a ... new study examines the impact of social isolation on ...
Cached Biology News:Computational model examines the pathways of Alzheimer's that strikes at the young 2Effects of maternal exercise on fetal breathing movements 2Early isolation linked to enhanced response to cocaine 2
(Date:7/28/2014)... DC (PRWEB) July 28, 2014 It’s a ... GI Bill benefits to further their post-secondary education are failing ... a study released this year. And according to an analysis ... this shortfall is veteran students’ uninformed choice of college majors, ... The details of the study: Some 51.7 percent of post-9/11 ...
(Date:7/28/2014)... BRISBANE, Calif. , July 28, 2014  InterMune, ... it will release its second quarter 2014 financial results ... August 6, 2014. A live conference call and webcast will ... that same day. Interested investors and others ... (U.S.) or +1 212-231-2900 (international), conference ID#21728775. A replay of ...
(Date:7/28/2014)... DUBLIN , July 28, 2014 Research ... "Global Particle Size Analysis Market 2014-2018" report to their ... Particle size analysis is a technique used to determine ... powder or liquid. It is crucial to analyze the size ... material. Therefore, particle size analysis is performed to determine the ...
(Date:7/26/2014)... NY (PRWEB) July 26, 2014 ... provides key market data on the Canada Endoscopy ... millions of US dollars, volume (in units) and ... - High-End Endoscopy Visualization Systems, Mid-Range Endoscopy Visualization ... Full Report at http://www.marketresearchreports.biz/analysis/213254 . , The ...
Breaking Biology Technology:Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4InterMune to Release Second Quarter Financial Results on August 6 2Global Particle Size Analysis Market 2014-2018 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5
... College (CVTC) will receive a $500,000 grant from ... nanotechnology incubator on their Gateway Manufacturing Technology Center in ... systems at the scale of the atom. , ,"Through ... nanotechnology industry can grow, expand, and reach its full ...
... Wis. Small Tree Communications , a ... announced its 10Gb Ethernet solution for Apples Xserve G5. ... Mac OS X Server 10.4 Tiger, the company claims ... ,In addition to proprietary networking drivers, Small Trees solution ...
... Medical imaging software developer Cedara Software and ... for Kodak to offer Cedara B-CAD to its customers ... CARESTREAM Mammography Workstation. , ,Cedara B-CAD is a Computer ... of breast lesions using ultrasound images, providing tools for ...
Cached Biology Technology:
...
Anti-VDAC (Voltage-Dependent Anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
A powerful, easy-to-use solution, the SORVALL RC12BP Blood Processing System allows you to manufacture blood components quickly and cost-effectively while ensuring product quality, safety, and GMP co...
... Reverse Transcriptase is a recombinant Moloney ... MultiScribe Reverse Transcriptase is similar to ... its recommended usage. MuLV reverse transcriptase ... that uses single-stranded RNA as a ...
Biology Products: