Navigation Links
Purdue researcher invents molecule that stops SARS
Date:11/11/2008

WEST LAFAYETTE, Ind. - A Purdue University researcher has created a compound that prevents replication of the virus that causes SARS and could lead to a treatment for the disease.

"The outbreak of SARS in 2003 led to hundreds of deaths and thousands of illnesses, and there is currently no treatment," said Arun Ghosh, the Purdue professor that led the molecular design team. "Although it is not currently a threat, there is the concern that SARS could return or be used as a biological weapon. It is important to develop a treatment as a safeguard."

According to the Centers for Disease Control and Prevention, the virus can be transmitted through coughing or sneezing, and the infection can quickly spread from person to person. SARS, or Severe Acute Respiratory Syndrome, spread through two dozen countries over a period of a few months before it was contained. A total of 8,098 people worldwide became ill and 774 died.

In addition to its ability to block the SARS virus, the molecular compound that inhibits the virus provides new insights into a group of proteins found in a range of diseases including childhood croup, herpes and cancer, Ghosh said.

"The molecular inhibitor we developed is very potent against the SARS virus by binding to and blocking the use of a specific protein, called papain-like protease, or PLpro, involved in viral replication and evasion of the immune system," said Ghosh who has a joint appointment in chemistry and medicinal chemistry and molecular pharmacology. "This is the first design and discovery of an inhibitor for this class of proteins. We are hopeful that this will open the door to new treatments for other diseases as well."

Ghosh's group teamed with a research group led by Andrew Mesecar at the University of Illinois at Chicago. The National Institutes of Health infectious disease biodefense program selected the team and funded the research that has been published in the online version of the jo
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Purdue researchers obtain a snapshot clarifying how materials enter cells
3. Purdue research finds similarities in dog, human breast cancer pre-malignant lesions
4. Purdue researchers click nutrition with camera diet study
5. Clemson researchers advance nano-scale electromechanical sensors
6. MSU researcher studies ties between cholesterol drugs, muscle problems
7. Damage inflicted during cardiac attacks more widespread, MSU researchers find
8. Battling bacteria in the blood: Researchers tackle deadly infections
9. Researchers use chemical from medicinal plants to fight HIV
10. Yale researchers unravel mystery of brain aneurysms
11. Montana State University researchers find gene that regulates molds resistance to drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)...  For more than four decades, AUVSI,s Unmanned ... premier worldwide event for the unmanned land, sea, and ... for any local, national, or trade news organization interested ... and current applications of unmanned technologies. The conference will ... billion industry, and how it will soon impact the ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... retreat from equatorial seas and oceans as the Earth continues ... Working on clues in the fossil coral record from ... the last two ice ages about 125,000 years ago, the ... near the equator. "When the climate warmed rapidly during ...
... researchers have revealed the secrets of survival of an ... desert, and suggest that recent violence in Mali may ... study, to appear in January,s edition of Biological ... System (GPS) collars. Its findings advance conservation efforts for ...
... 12, 2012 Cell aging, or cellular senescence, has ... tumor development. Activated oncogenes are able to induce senescence, ... could play a key role in future cancer therapy. ... the regulation of OIS. This study is published online ...
Cached Biology News:Scary news for corals -- from the Ice Age 2Violence in Mali threatening survival of endangered elephants 2Previously unknown mechanism identified in oncogene-induced senescence 2
(Date:5/21/2015)... 21, 2015  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced positive updated results from ... for the treatment of unresectable glioblastoma multiforme (GBM), ... multisite trial is designed to investigate the preliminary ... tumors have progressed following prior treatment with surgery, ...
(Date:5/21/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: ... on the development of autologous cell therapies, announced ... Society for Cellular Therapy (ISCT) on RepliCel,s autologous ... a Phase 1/2 clinical trial.  The presentation, taking ... PM to 7:00 PM local time, will review ...
(Date:5/20/2015)... , May 20, 2015 ... presented preliminary data demonstrating the ability of the ... fibrosis (IPF) from other interstitial lung diseases (ILDs) ... the classifier,s potential to help thousands of patients ... ambiguity in IPF diagnosis – a frequent challenge ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... of the "Global Cell Therapy Market Outlook 2020 ... of cell therapy in tissue and regenerative medicine is ... no other options which could help in the growth ... this segment but they are unable to form new ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... Pioneering Field, BETHESDA, Md., Sept. 10 ... an ownership interest in,ClinResearch GmbH, a global leader ... clinical trials. Headquartered in Cologne, Germany,with more than ... programs over the past seven years. ClinResearch,s co-founder,Reinhard ...
... a broad array, of biometric enrollment ... Sept. 10 Aware, Inc. (Nasdaq:,AWRE), a global ... long history of success in providing high-quality,innovative software ... comprehensive suite of products in their booth (#501) ...
... September 13 to Discuss Phase 1 Trial and Other Major ... ... CA, Sept. 10 /PRNewswire-FirstCall/ - Nventa,Biopharmaceuticals Corporation (TSX:NVN) today announced the ... tolerability of new,HspE7 (HspE7 dosed with an adjuvant) in 24 patients ...
Cached Biology Technology:United BioSource Acquires Interest in Leading Adaptive Design Technology Service Provider 2Aware Celebrates Fifteen Years of Innovation and Leadership in the Biometrics Industry 2Aware Celebrates Fifteen Years of Innovation and Leadership in the Biometrics Industry 3Aware Celebrates Fifteen Years of Innovation and Leadership in the Biometrics Industry 4Aware Celebrates Fifteen Years of Innovation and Leadership in the Biometrics Industry 5Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial 2Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial 3Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial 4Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial 5Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial 6
MOUSE ANTI PORCINE SLA 1:FITC Immunogen: Porcine peripheral blood mononuclear cells....
An excellent carbonyl-reactive FRET quencher paired with Trp or Tyr. Minimum Purity: 95%. Abs(max): ~350 nm; Em(max): none. Solvent System:DMSO or DMF....
EDG-6 (1)...
Complexin-1/2 (FL-134)...
Biology Products: