WEST LAFAYETTE, Ind. - Researchers at Purdue University are working with the U.S. Army and neurosurgeons at the Walter Reed National Military Medical Center to create a new type of "bioactive" coating for stents used to treat brain aneurisms including those caused by head trauma from bomb blasts.
"Stents coated with a bioactive coating might be inserted at the site of an aneurism to help heal the inside lining of the blood vessel," said Jean Paul Allain, an associate professor of nuclear engineering. "Aneurisms are saclike bulges in blood vessels caused by weakening of artery walls. We're talking about using a regenerative approach, attracting cells to reconstruct the arterial wall."
He will speak before Congress on Thursday (May 24) during the first Brain Mapping Day to discuss the promise of nanotechnology in treating brain injury and disease.
Purdue researchers are working with Col. Rocco Armonda, Dr. Teodoro Tigno and other neurosurgeons at Walter Reed National Military Medical Center in Bethesda, Md. Collaborations also are planned with research scientists from the University of Queensland in Australia, Universidad de Antioqua and Universidad de Los Andes, both in Colombia.
Portions of the stents - tubular structures made of a metallic mesh - will be designed using bioactive coatings to attract magnetized cells to repair blood vessels damaged in trauma.
The stent coatings are modified in a Purdue facility that uses beams of charged particles called ions to modify the stent coatings with a magnetic material. The ion beams also are used to create lifelike or "biomimetic" surface textures designed to promote cellular proliferation and repair damaged vessels, Allain said.
Findings will be detailed in an invited talk to be delivered by Allain during the Ninth Annual World Congress of SBMT on Brain, Spinal Cord Mapping and Image Guide Therapy on June 2-4 in Toronto.
Currently, aneurisms are t
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