Navigation Links
Purdue-designed tool helps guide brain cancer surgery
Date:7/3/2014

bolite biomarker that provides information about tumor classification, genotype and the prognosis for the patient," said Cooks, the Henry Bohn Hass Distinguished Professor of Chemistry. "Through mass spectrometry all of this information can be obtained from a biopsy in a matter of minutes and without significantly interrupting the surgical procedure."

For this study, which included validation on samples and use during two patients' surgical procedures, the tool was tuned to identify the lipid metabolite 2-hydroxyglutarate or 2-HG. This biomarker is associated with more than 70 percent of gliomas and can be used to classify the tumors, he said.

A paper detailing the results of the National Institutes of Health-funded study will be published in an upcoming issue of the Proceedings of the National Academy of Sciences and is published online.

In mass spectrometry molecules are electrically charged and turned into ions so that they can be identified by their mass. The new tool relies an ambient mass spectrometry analysis technique developed by Cooks and his colleagues called desorption electrospray ionization, or DESI, which eliminated the need for chemical manipulations of samples and containment in a vacuum chamber for ionization. DESI allows ionization to occur directly on surfaces outside of the mass spectrometers, making the process much simpler, faster and more applicable to surgical settings.

The tool couples a DESI mass spectrometer with a software program designed by the research team that uses the results to characterize the brain tumors and detect boundaries between healthy and cancerous tissue. The program is based on earlier studies of lipid patterns that correspond to different types and grades of cancer and currently covers the two most common types of brain tumors, gliomas and meningiomas. These two types of tumors combined account for about 65 percent of all brain tumors and 80 percent of all malignant brai
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. White bread helps boost some of the guts good microbes
2. CU researchers explain mechanism that helps viruses spread
3. Tree hugging helps koalas keep their cool
4. Listening helps scientists track bats without exposing the animals to disease
5. Relaxation helps pack DNA into a virus
6. Boosting Immune process with IFN-γ helps clear lethal bacteria in cystic fibrosis
7. The color of blood: Pigment helps stage symbiosis in squid
8. Enzyme helps stem cells improve recovery from limb injuries
9. Extinct relative helps to reclassify the worlds remaining 2 species of monk seal
10. Molecular tumor board helps in advanced cancer cases
11. A transcription factor called SLUG helps determines type of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market announces that its Wocket® smart wallet will be the ... scheduled to air on WABC Radio (am770) in ... The broadcast air- time for the extensive one ... Inc.,s CEO Gino Pereira will be discussing its ...
(Date:6/17/2015)... Germany , June 17, 2015 ... QIA) today launched new Investigator ® STR assay kits ... the United States . The new genetic fingerprint ... genomic markers (short tandem repeats or STRs) for DNA matching. ... the quality of DNA in each sample, a novel QIAGEN ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... an important role in various addictions, such as alcoholism ... is due, in part, to genetic factors, reveals new ... is a neuropeptide that both activates the brain,s reward ... are hungry, levels of ghrelin increase, activating the brain,s ...
... Alberta-led research team has determined that the mountain pine beetle ... possibility for an infestation that could stretch across the Prairies ... of U of A tree biologists and geneticists discovered that, ... Columbia, it successfully jumped species from its main host, the ...
... in the United States in late 2004, many producers feared ... of the world. In response to this threat, researchers have ... fungus, and a recent report in Crop Science ... to determine which of the soybean germplasm accessions were resistant ...
Cached Biology News:Genetic changes behind sweet tooth 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 3
(Date:6/30/2015)... YORK , June 30, 2015  The Dr. Samadi ... is now offering a full suite of new genetic ... had a biopsy, for diagnosing prostate cancer. ... range of genetic tests for assessing the risk and optimizing ... "We,re very excited to now offer these revolutionary ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making is a ... 12 distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter that lets ... the NIR range. Previous spectrophotometer calibration standards, such as those made from didymium glass ...
(Date:6/29/2015)... Lexington, KY and Manhattan, KS (PRWEB) , ... ... ... it has acquired US PATENT 7736892 B2. Under the terms of the agreement, ... using Umbilical Cord Matrix Stem Cells (UCMSCs). MB-007 is currently in pre-clinical development ...
Breaking Biology Technology:New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3
... with Pfizer,s recently ... MALIBU, Calif., Nov. 15 Pathway Diagnostics announces,that the ... Patent,number 7,294,458 (the ,458 patent) entitled "Analysis of HIV-1 ... Diagnostics,has licensed the ,458 patent (with rights to sub-license) ...
... At a meeting of the,Board of ... ), held today, a dividend of ... outstanding shares of Preferred Stock was,declared ... stockholders of record at the close,of ...
... George Abercrombie, Pfizer R&D Head Martin,Mackay, HHS Deputy Secretary ... Headline Agenda at FDA/CMS Summit 2007, WASHINGTON, Nov. ... for drug approvals. Unfortunately for the biopharma sector and,investors, ... is on track,to grant marketing approval to 18 or ...
Cached Biology Technology:Pathway Diagnostics Announces Patent Issuance for the Diagnostic Measurement of HIV Tropism for the Initiation or Modification of HIV Therapy 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 3