Navigation Links
Protein involved in nerve-cell migration implicated in spread of brain cancer
Date:8/7/2013

The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published August 7 in the online journal PLOS ONE.

The researchers investigated similarities between the transition of neural stem cells into neurons and the process whereby cancer cells invade surrounding tissues.

"Both processes involve the mobilization of cells," says Anjen Chenn, director of clinical pathology and molecular diagnostics at UIC. "During embryonic development, stem cells that go on to become neurons must migrate long distances to other parts of the brain before they mature into adult neurons. We thought that this type of cell migration might have similarities with cancer cells that spread from tumors."

Chenn and colleagues analyzed the proteins expressed by embryonic mouse neural stem cells as they began their migration.

They found that one protein, cadherin11, was found in especially high concentrations in these transitioning cells.

Chenn said the protein "regulates how the cells stick to each other and is also important in helping cells pull themselves along certain pathways as they travel to their final destinations."

When the researchers caused the protein to be overexpressed in embryonic mice, the neural stem cells began their migration prematurely.

"This confirmed that cadherin11 was involved in the initiation of migration," said Chen.

To determine whether the protein was involved in the invasion of cancer cells into healthy tissues, the researchers looked at its function in glioblastoma, the most common and aggressive type of adult brain cancer. They examined survival data from patients with glioblastoma and noticed that patients whose tumors expressed elevated levels of the cadherin11 gene had the worst surv
'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
2. Small protein plays big role in asthma severity
3. Protein surfaces defects act as drug targets
4. Natural pest control protein effective against hookworm: A billion could benefit
5. New approach to protecting prion protein from altering shape
6. Protein targeted for cancer drug development is essential for normal heart function
7. Scientists decipher cellular roadmap of disease-related proteins
8. Toronto team IDs proteins key in stem cell production
9. Toronto team ID proteins key in stem cell production
10. Low levels of toxic proteins linked to brain diseases, study suggests
11. Liver protein crucial for pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... river turtle in North America, weighing in at up ... researchers from Florida and the University of Vermont have ... three. , Examining museum specimens and wild turtles, the ... , Once heavily hunted for turtle meat alligator ... in the 1960s the riverine populations have been ...
(Date:4/23/2014)... shows Africa,s Congo rainforest, the second-largest tropical rainforest in ... over the past decade. , The study, led by ... New York, shows between 2000 and 2012 the decline ... The research, published Wednesday in Nature , is ... the effects of long-term drought on the Congo rainforest ...
(Date:4/23/2014)... domestic heating may contribute to early fetal death according ... Research Institute of Children,s Hospital Los Angeles and Ulaanbaatar, ... , In a paper published today in the journal ... strong statistical correlations" between seasonal ambient air pollutants and ... has one of the highest levels of air pollution ...
Breaking Biology News(10 mins):Two new US turtle species described 2Two new US turtle species described 3NASA satellites show drought may take toll on Congo rainforest 2NASA satellites show drought may take toll on Congo rainforest 3Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2
... scientific results from an ambitious voyage led by a group ... San Diego offer a stark view of human pollution and ... been labeled as the "Great Pacific Garbage Patch." Two ... or SEAPLEX, found evidence of plastic waste in more than ...
... continuing partnership with Smithsonian Institution Scholarly Press, has converted ... to digital formats for use on Kindles, Nooks and ... unprecedented access to a vast research collection. These scholarly ... take up valuable physical space or face the threat ...
... Conservation Biology Institute and George Mason University broke ... that embodies the concept of the living classroom. ... Program has trained future conservationists with an interdisciplinary ... National Zoological Park,s 3,200-acre facility in Front Royal, ...
Cached Biology News:Scripps study finds plastic in 9 percent of 'garbage patch' fishes 2Scripps study finds plastic in 9 percent of 'garbage patch' fishes 3Smithsonian Conservation Biology Institute and George Mason University expand partnership 2
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... DIEGO and PHILADELPHIA, March 19, 2012 Toby Odenheim, director ... contract research organization (CRO), is slated to present on ... at the Outsourcing in Clinical Trials, East Coast ... Odenheim will speak at 11 a.m. EDT, Wed., March 28, ...
... the ,Scotch tape technique," researchers first extracted graphene with a ... of carbon atoms arranged in a honeycomb, hexagonal pattern. It ... material. It is one-hundred-times better at conducting electricity than silicon. ... thick, it is so thin as to be essentially a ...
...  Foundation for Health Improvement and Technology (FHIT), ... nonprofit, with the mission to rid the world ... educational programs promoting early detection and aggressive medical ... have made it entirely possible to detect many ...
Cached Biology Technology:Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 2Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 3Straintronics: Engineers create piezoelectric graphene 2Straintronics: Engineers create piezoelectric graphene 3Straintronics: Engineers create piezoelectric graphene 4Foundation for Health Improvement and Technology (FHIT) Launched to Beat Cardiovascular Disease 2
Request Info...
... blotted protein on PVDF membrane or with ... N-terminal sequence of proteins (5-20 residues) can ... HPLC or mono-and bidimensional SDS-PAGE, followed by ... the well known EDMAN degradation method. Pre-treatment ...
Mycoplasma Removal Agent (MRA) has been developed for cell culture, to combat the widespread problems caused by contamination of cell cultures with mycoplasma....
... 5 ml Dynabeads® (4.5 ... BerEP4 against the human epithelial ... molecule). Also available in ... 10e7 MNC in 1 ml ...
Biology Products: