Navigation Links
Protein involved in nerve-cell migration implicated in spread of brain cancer
Date:8/7/2013

The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published August 7 in the online journal PLOS ONE.

The researchers investigated similarities between the transition of neural stem cells into neurons and the process whereby cancer cells invade surrounding tissues.

"Both processes involve the mobilization of cells," says Anjen Chenn, director of clinical pathology and molecular diagnostics at UIC. "During embryonic development, stem cells that go on to become neurons must migrate long distances to other parts of the brain before they mature into adult neurons. We thought that this type of cell migration might have similarities with cancer cells that spread from tumors."

Chenn and colleagues analyzed the proteins expressed by embryonic mouse neural stem cells as they began their migration.

They found that one protein, cadherin11, was found in especially high concentrations in these transitioning cells.

Chenn said the protein "regulates how the cells stick to each other and is also important in helping cells pull themselves along certain pathways as they travel to their final destinations."

When the researchers caused the protein to be overexpressed in embryonic mice, the neural stem cells began their migration prematurely.

"This confirmed that cadherin11 was involved in the initiation of migration," said Chen.

To determine whether the protein was involved in the invasion of cancer cells into healthy tissues, the researchers looked at its function in glioblastoma, the most common and aggressive type of adult brain cancer. They examined survival data from patients with glioblastoma and noticed that patients whose tumors expressed elevated levels of the cadherin11 gene had the worst surv
'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
2. Small protein plays big role in asthma severity
3. Protein surfaces defects act as drug targets
4. Natural pest control protein effective against hookworm: A billion could benefit
5. New approach to protecting prion protein from altering shape
6. Protein targeted for cancer drug development is essential for normal heart function
7. Scientists decipher cellular roadmap of disease-related proteins
8. Toronto team IDs proteins key in stem cell production
9. Toronto team ID proteins key in stem cell production
10. Low levels of toxic proteins linked to brain diseases, study suggests
11. Liver protein crucial for pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... --  News Highlights: , ... Partners Data Lake, an agile data and analytics ... allow researcher and clinicians to explore and develop ... of patients , The Partners Data Lake ... Partners system, breaking down physical barriers for collaboration ...
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... as career killers, Achilles tendon injuries are among the most ... in post WWII tests, scientists have learned why: Like our ... is a tissue that does not repair itself. This discovery ... . "Tendon injury is a very common disease, which ...
... academic journal publisher, founded on the principles of affordability, innovation, ... launched by Jason Hoyt (formerly at Mendeley and Stanford University) ... been shaped from the premise that ,if society can set ... then why shouldn,t academics be given the opportunity to openly ...
... University researchers "cured" a strain of bacteria of its ... has implications for a long-standing public health crisis. ... managed to remove the ability of the Pseudomonas aeruginosa ... its access to food and oxygen. Over ...
Cached Biology News:Fallout from nuclear testing shows that the Achilles tendon can't heal itself 2PeerJ publishes its first articles 2Lack of energy an enemy to antibiotic-resistant microbes 2Lack of energy an enemy to antibiotic-resistant microbes 3
(Date:12/17/2014)... 16, 2014 “Never say, ‘I ... Universität Marburg’s Department of Physics, advises young women ... newly released SPIE Women in Optics 18-month ... shy to ask questions.” , In the annual ... mathematics) occupations ranging from university professor and laboratory ...
(Date:12/17/2014)... December 17, 2014 Once more, EMAAR ... a larger packaged waste water treatment plant to phase ... Economic City (KAEC). Two years ago Bioshaft successfully supplied ... Development, serving two residential towers with an occupancy of ... a quarter million gallons per day and was signed ...
(Date:12/17/2014)... Park, CA (PRWEB) December 17, 2014 ... announces today that it has entered into a ... Midland Company (ADM) to apply DNA2.0’s proprietary protein ... enzyme engineering process. , “We are extremely excited ... ProteinGPS engineering platform. This proprietary bioengineering technology ...
(Date:12/17/2014)... SPRING, Md. , Dec. 17, 2014  United ... two senior executive promotions as well as changes to ... Senior Executive Promotions United Therapeutics ... to President and Co-Chief Executive Officer and David ... Operating Officer.  In connection with these promotions, Dr. Rothblatt,s ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... MISSISSAUGA, ON, Jan. 6 /PRNewswire-FirstCall/ - Vasogen Inc. ... update on corporate activities. Pursuant to a previously ... alternatives for the purpose of enhancing shareholder value. ... potential opportunities including the sale of the Company, ...
... 6 Accumetrics, Inc. has appointed Andrew Chisholm to ... brings the right mix of energy and expertise to ... next level in terms of our market penetration," says ... knowledge of the medical diagnostics industry and his relationships ...
... Corp. (OTC Bulletin Board: BSTC), a biopharmaceutical company developing ... it has received notification from The NASDAQ Stock Market ... listing on the NASDAQ Global Market. The Company,s common ... at market open under the symbol "BSTC" and will ...
Cached Biology Technology:Vasogen Provides Corporate Update 2Vasogen Provides Corporate Update 3Andrew Chisholm Appointed Vice President, Sales and Corporate Accounts at Accumetrics 2BioSpecifics Technologies Corp. Announces Listing on NASDAQ Global Market 2
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... Reverse Transcriptase (AMV RT) catalyzes the polymerization ... RNA:DNA hybrids (1). It requires a primer ... primers) as well as Mg2+ or Mn2+. ... activity. Both nonionic detergents and sulfhydryl compounds ...
... - Neurosphere is a system designed for ... neurospheres in a serum free environment. The kit ... which has been optimized for neural stem cell ... Genes & Development 10 :3129). Two growth ...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
Biology Products: