Navigation Links
Protein involved in nerve-cell migration implicated in spread of brain cancer
Date:8/7/2013

The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published August 7 in the online journal PLOS ONE.

The researchers investigated similarities between the transition of neural stem cells into neurons and the process whereby cancer cells invade surrounding tissues.

"Both processes involve the mobilization of cells," says Anjen Chenn, director of clinical pathology and molecular diagnostics at UIC. "During embryonic development, stem cells that go on to become neurons must migrate long distances to other parts of the brain before they mature into adult neurons. We thought that this type of cell migration might have similarities with cancer cells that spread from tumors."

Chenn and colleagues analyzed the proteins expressed by embryonic mouse neural stem cells as they began their migration.

They found that one protein, cadherin11, was found in especially high concentrations in these transitioning cells.

Chenn said the protein "regulates how the cells stick to each other and is also important in helping cells pull themselves along certain pathways as they travel to their final destinations."

When the researchers caused the protein to be overexpressed in embryonic mice, the neural stem cells began their migration prematurely.

"This confirmed that cadherin11 was involved in the initiation of migration," said Chen.

To determine whether the protein was involved in the invasion of cancer cells into healthy tissues, the researchers looked at its function in glioblastoma, the most common and aggressive type of adult brain cancer. They examined survival data from patients with glioblastoma and noticed that patients whose tumors expressed elevated levels of the cadherin11 gene had the worst survival rates.

"We also saw that in our tissue samples, the tumor cells with high expression of cadherin11 tended to be located near blood vessels, suggesting that the protein could be involved in encouraging blood vessels to enervate tumors," Chenn said.

When Chenn and his colleagues mixed cells from blood vessel walls with human glioblastoma cells, the glioblastoma cells increased their expression of cadherin11.

"We have long known that tumors recruit their own blood supply, but this finding was particularly interesting because it suggests that blood vessels might actually be stimulating tumor cells to come to them," Chenn said. "Our results together indicate that cadherin11 is critical in inducing cell migration in cancer, and could be an important therapeutic target for preventing its spread."


'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
2. Small protein plays big role in asthma severity
3. Protein surfaces defects act as drug targets
4. Natural pest control protein effective against hookworm: A billion could benefit
5. New approach to protecting prion protein from altering shape
6. Protein targeted for cancer drug development is essential for normal heart function
7. Scientists decipher cellular roadmap of disease-related proteins
8. Toronto team IDs proteins key in stem cell production
9. Toronto team ID proteins key in stem cell production
10. Low levels of toxic proteins linked to brain diseases, study suggests
11. Liver protein crucial for pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... Whitehouse ... testing capabilities to encompass the full series of ISO 80369 standard test procedures. ... for medical device and drug delivery systems. With this recent expansion, Whitehouse Labs ...
(Date:7/17/2017)... ... July 17, 2017 , ... Neurodevelopmental disorders ... range of overlapping clinical features. The advancement of targeted next-generation sequencing (NGS) has ... research and testing. , However, designing a custom panel for disease research ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Rocking and Waving ... and waving shaker models (both analog and digital) for laboratory applications in a ...
(Date:7/14/2017)... ... ... Dr. Joshua Mondlick has introduced the LANAP® protocol to treat gum disease ... the Phoenix area. Dr. Mondlick is at the forefront of the future of ... re-grow bone and with significantly less pain than traditional surgery options. , “With traditional ...
Breaking Biology Technology: