Navigation Links
Protein explains increased asthma severity in children exposed to diesel exhaust from traffic
Date:9/23/2013

A new study shows that exposure to diesel exhaust particles from traffic pollution leads to increased asthma severity in children. Moreover, the study finds that this is due to increased blood levels of IL-17A, a protein associated with several chronic inflammatory diseases, in children with high diesel exposure.

The study by researchers at Cincinnati Children's Hospital Medical Center is published online in the Journal of Allergy and Clinical Immunology.

The research, conducted in mice and in humans, showed that neutralizing IL-17A prevented airway inflammation. Neutralization of IL-17A "may be a useful potential therapeutic strategy to counteract the asthma-promoting effects of traffic-related air pollution, especially in highly exposed, severe allergic asthmatics," says Gurjit Khurana Hershey, MD, PhD, director of asthma research at Cincinnati Children's and senior author of the study.

Dr. Hershey and her colleagues studied 235 children and teens with asthma. The researchers plotted each person's primary address and estimated their diesel exposure attributable to traffic based on where they lived. The researchers also studied mice exposed to diesel particles and dust mites, a common household allergen.

In children with asthma, diesel exposure was associated with more frequent asthma symptoms and increased IL-17A blood levels. Similarly, exposure to both diesel and dust mites resulted in more severe asthma in mice compared to dust mite exposure alone. When IL-17A was neutralized in mice, it alleviated airway inflammation induced by diesel exposure.

"Blocking IL-17A may be a useful strategy to counteract the effects of traffic-related air pollution, especially in highly exposed allergic asthmatic children," says Dr. Hershey.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. USC scientists ID protein that regulates cellular trafficking, potential for anti-cancer therapy
2. Lifestyle, age linked to diabetes-related protein
3. UCI researchers fabricate new camouflage coating from squid protein
4. Doubling the daily allowance of protein intake with diet and exercise protects muscle loss
5. Rice, MD Anderson researchers win NIH grant to study protein networks
6. Researchers discover protein that helps plants tolerate drought, flooding, other stresses
7. Multi-disciplinary Penn research identifies protein required for cell movement
8. Neuroscientists identify protein linked to Alzheimers-like afflictions
9. Protein involved in nerve-cell migration implicated in spread of brain cancer
10. Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins
11. Small protein plays big role in asthma severity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... VetStem Biopharma ’s CEO and founder, Dr. Bob Harman ... Riordan’s new book "Stem Cell Therapy: A Rising Tide". Dr. Harman and Dr. Riordan ... bonded over an interest in the potential of stem cell therapy and a fast friendship ...
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical Services, ... of its 2017 Science Student Award. The scholarship program is dedicated to helping ... service defray the costs of obtaining their science education. , Avomeen began the ...
(Date:9/18/2017)... ... September 18, 2017 , ... Transportable biomass conversion ... and torrefied wood is the topic of a September 27 webinar ... economic viability of transportable biomass conversion facilities for producing biochar, briquettes, and torrefied ...
(Date:9/17/2017)... ... September 17, 2017 , ... GeneOne Life Science, ... Food and Drug Safety (KMFDS) for an Investigational New Drug application for a ... Syndrome coronavirus (MERS-CoV). The study in Korea represents the second clinical trial for ...
Breaking Biology Technology: