Navigation Links
Protein called YAP gives blood vessels strength, shape
Date:3/24/2014

AUGUSTA, Ga. - A protein known to promote cancer appears to give the blood vessels strength and shape, researchers report. When yes-associated protein, or YAP, is deleted from vascular smooth muscle cells during development, the protein makes thin-walled blood vessels that over-dilate in response to the usual pressure of blood flow, said Dr. Jiliang Zhou, vascular biologist at the Medical College of Georgia at Georgia Regents University.

"The thickness of the arterial wall decreases from three or four layers of smooth muscle cells to one or two layers," said Zhou, corresponding author of the study featured on the cover of the American Heart Association journal, Circulation Research.

The researchers also found that YAP appears to manage vascular smooth muscle cells by controlling expression of the cell cycle arrest gene, Gpr132. During growth, YAP suppresses this suppressor then, when blood vessels walls are the right size, YAP expression decreases and Gpr132 expression increases.

"The balance shifts," Zhou said. When the scientists deleted YAP in mice, Gpr132 expression increased and cell proliferation decreased. Conversely, knocking down Gpr132 expression increases vascular smooth muscle cell proliferation.

The study required deleting YAP from both vascular smooth muscle cells and heart cells technology does not enable more selective removal so the mice also were born with significant heart defects, confirming the protein's key role in heart formation. YAP's absence has been shown to cause, for example, ventricular septal defects, a common congenital heart defect in which a persistent hole between the right and left ventricle can lead to heart failure.

The mice in this study died shortly after birth from significant heart and vascular defects. Zhou suspects that less severe alterations in YAP may also produce aneurysms, weak points in the vascular system that often go undetected before rupturing
'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Unfolded proteins collapse when exposed to heat and crowded environments
2. Proteins that control energy use necessary to form stem cells
3. Protein rescues stuck cellular factories
4. Protein key to cell motility has implications for stopping cancer metastasis
5. Fruit flies help uncover tumor-preventing protein complex
6. Diets high in animal protein may help prevent functional decline in elderly individuals
7. Phosphorylation of tau protein in rats subjected to cerebral ischemia-reperfusion injury
8. New probes from Scripps research quantify folded and misfolded protein levels in cells
9. Characterization of stink bug saliva proteins opens door to controlling pests
10. A key protein is discovered as essential for malaria parasite transmission to mosquitos
11. A*STAR scientists discover proteins role in human memory and learning functions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein called YAP gives blood vessels strength, shape
(Date:10/31/2014)... 31, 2014 – Dr. John Schoggins , Assistant ... received a prestigious New Innovator Award from the National ... understand why bats can harbor numerous viruses without becoming ... over five years is one of 85 awards given ... NIH Common Fund. The New Innovator Awards were created ...
(Date:10/31/2014)... have been studying the behavior of approximately 300 ... years. They observed that ravens slowly build alliances ... However, they also observed that these affiliative interactions ... in about 50 % of the cases these ... affiliating ravens, intervening can be potentially risky when ...
(Date:10/30/2014)... is available in German . ... prompt our fellow humans to behave socially? This is ... in game theory. Previous studies assumed that it is ... scientists from the Max Planck Institute for Evolutionary Biology ... an influence on the cooperative behaviour of others. However, ...
Breaking Biology News(10 mins):UT Southwestern Microbiologist awarded prestigious NIH research grant 2Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4
... researchers at the University of Rochester Medical Center have discovered ... to harm the function of T-cells, which regulate the body's ... discovery adds insight to the latest trend in lead research, ... threat to understanding the long-term burden on the body, said ...
... successfully converted human embryonic stem cells into cartilage cells, ... grown for transplantation. , Cartilage is the dense connective ... movement of joints. , Research to be published ... embryonic stem cells to become cartilage cells. This could ...
... amateur fossil finder Van Turner discovered a small vertebra at ... the creature was unlike anything in the fossil record. Scientists ... of an extinct line of lizards with an evolutionary twist: ... the remains to paleontologists at the Dallas Museum of Natural ...
Cached Biology News:The dangerous legacy of lead 2Scientists use stem cells to grow cartilage 2Missing fossil link 'Dallasaurus' found 2Missing fossil link 'Dallasaurus' found 3Missing fossil link 'Dallasaurus' found 4
(Date:10/31/2014)... 2014 Jeffrey T. Manuel, assistant professor ... within the College of Arts and Sciences, is teaming ... history of alcohol-based fuels in Illinois. , ... been working to build Illinois’ biofuels industry for decades,” ... of the state's agricultural and business history. , ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) ... Flavored, Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, ... Forecast to 2018," defines and segments the dairy ... of revenue and volume for plant-based dairy alternative ... reach $14 Billion by 2018 with the Asia-Pacific ...
(Date:10/31/2014)... NY (PRWEB) October 31, 2014 ... as healthcare, construction, finance and consumer electronics will ... this reason, industry research firm IBISWorld has added ... to its growing industry report collection. , The ... software for biometric technologies such as fingerprint, iris, ...
(Date:10/30/2014)... The report “Fragrance Ingredients Market by Type (Essential Oils ... Soaps & Detergents) & by Geography - Global Trends ... Fragrance Ingredients Market with analyses and projection of the ... has been segmented on the basis of major regions ... Rest of the World (ROW); and their value has ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5
... Oct. 7 Castle Access, Inc. announces the ... appointment aligns the Castle Access organization with that ... IT services provider, and gives clients in Southwestern ... of enterprise data center and mission-critical managed services. ...
... is developing and commercializing breakthrough single-molecule genomic analysis ... Officer, Han Cao, Ph.D., was awarded the Chinese ... Economic and Technical Cooperation Forum in Beijing, China ... recognition of Dr. Cao,s entrepreneurial spirit and success ...
... 7 GeneGo, Inc., a leading provider of databases, ... today that they have integrated GenomeQuest,s Sequence Data Management ... Using GenomeQuest,s interactive analysis, scientists who have drilled down ... of millions of reads, to thousands of expressed genes, ...
Cached Biology Technology:Castle Access Names New Managing Director 2Castle Access Names New Managing Director 3BioNanomatrix Founder and CSO Dr. Han Cao Awarded Chinese Rising Star Entrepreneur Award 2GeneGo Announces Integration With GenomeQuest for Pathway Analysis of Next Generation Sequencing Data 2
... C-terminal reactive. Cross-reacts fully with GLP-1(1-36) ... with the unamidated forms GLP-1(7-37) and ... as hGLP-2, glucagon, hGIP and VIP.,SPECIES ... identical in all mammalian species studied ...
Anti Human JAM-1, Monoclonal Antibody, Clone M.Ab.F11...
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Immunogen: Tissue / cell preparation. (Murine EHS laminin preparation) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: