Navigation Links
Protecting cells
Date:8/24/2011

"Currently, we have no solution for these devastating diseases," Morimoto said. "This master neuronal switch could offer a new target for therapy. If we can restore the natural ability of cells to prevent protein damage, our cells should be healthier longer and the quality of life will be better."

The findings are also applicable to other diseases that involve protein misfolding, such as cancer and metabolic diseases, Morimoto said.

Morimoto and Prahlad studied C. elegans, specifically models with different forms of protein misfolding diseases. The transparent roundworm is a valued research tool as its biochemical environment is similar to that of human beings and its genome, or complete genetic sequence, is known.

They interfered with the nervous system signal, the "master switch," to see what would happen to the animals. When the signal was working, the animals accumulated damaged proteins in their cells that interfered with cellular function. But when the researchers reduced the neuronal signal a little bit, the normal cellular response to protein damage returned and the animals were healthy.

While the downregulation of the neuronal signal in the study was done genetically, in humans the idea would be to alter the signal chemically, Morimoto said.

"This work gives us an appreciation that animals are not just a bundle of cells, each on its own to sense and respond to damage," he said. "The cells are organized into tissues, tied into a network that is organized by the brain. The brain can tell the cells to turn on a stress response or not. The nervous system is talking to all the parts to orchestrate an organismal response to stress. That's what's so fascinating."


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research identifies type of vaccine that holds promise in protecting against TB
2. Protecting neurons could halt Alzheimers, Parkinsons diseases
3. NC State takes research lead in protecting Puerto Ricos unique freshwater fisheries
4. Protecting fresh-cut produce
5. Protecting the food crops of the future
6. Protecting cells from their neighbors
7. Strategy outlined for growing bioenergy while protecting wildlife
8. Protecting humans and animals from diseases in wildlife
9. Vidient SmartCatch Protecting Exit Lanes at Major UK Airport
10. Protecting the future: How plant stem cells guard against genetic damage
11. Researchers: EPA should recognize environmental impact of protecting foreign oil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Geologists are letting the air out of a nagging mystery ... have long speculated as to why animal species didn,t flourish ... to prosper at the end of the Proterozoic period, about ... stretch before that, when most researchers think there also was ... so great then, after all. , In a study published ...
(Date:10/31/2014)... University of Adelaide-led project has developed a new test ... against the H5N1 strain of avian influenza virus or ... , This is a significant step in the fight ... is widespread in the poultry populations of South East ... concern because of its possible transmission to humans and ...
(Date:10/30/2014)... Mich. – When most animals begin life, cells immediately ... a vital organ. However, mammals, including humans, are special. ... different first choice – to become the protective placenta ... during this critical first step that research from Michigan ... in the current issue of PLOS Genetics ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2New step towards eradication of H5N1 bird flu 2Identifying the source of stem cells 2
... Biobanks are repositories for tissue samples, usually in ... from surgical procedures. These samples are collected and used ... linked to personal health information regarding the sample donor. ... researchers who want to use them face important questions ...
... The Life Sciences Discovery Fund (LSDF) today announced awards ... therapies and key resources for medical researchers and health-care ... the three programs. The programs will be led ... across the state. Dr. David Flum will work with ...
... MADISON, WI, JUNE 28, 2011 -- The ... provides information needed to sustainably manage agroforestry systems. ... increase yields and also reduce financial and environmental ... that allows for site-specific evaluation of nutrient-production imbalances ...
Cached Biology News:Public prefers limited informed consent process for biobanks 2Public prefers limited informed consent process for biobanks 3Life Sciences Discovery Fund helps launch 3 programs to advance health research and development 2Analyzing agroforestry management 2
(Date:10/30/2014)... James Sherley says he has been working ... cell technology since his days as a principal investigator at ... late 1990’s. Sherley founded the ASCTC as a new ... the intellectual property developed in Sherley’s research over the years ... of Technology (MIT), and more recently as a senior scientist ...
(Date:10/30/2014)... UAE (PRWEB) October 30, 2014 Grace Century ... Dr. James A. Manganello, Chairman of the Board, to the ... Bahamas. The appointment was made by the Ministry of ... September 24th, 2014. , More than a year ... Research Bill , Prime Minister Perry Christie said the government ...
(Date:10/30/2014)... one of the key challenges in the development of ... physicists. , In a paper published today (28 October) ... colleagues show how to make a new type of ... devices, such as high-precision sensors and specialised superfast computers, ... But the methods for trapping these tiny particles are ...
(Date:10/27/2014)... 2014 The Italian company ... and sell its artificial "lower limb", after the ...      (Photo: http://photos.prnewswire.com/prnh/20141027/713097 ) ... the definitive judgement has arrived: Roadrunnerfoot, the small ... accessible hi-tech prostheses with composite materials, has won ...
Breaking Biology Technology:Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2
... ... space, ... the newest member of its surface disinfection line,CaviWipes in a flat ... slim, flexible packaging and,adhesive-backed strips. Each flat pack contains convenient, durable,nonwoven, ...
... Pharmaceuticals,a division of Wyeth (NYSE: WYE ), ... (FDA) has approved PRISTIQ(TM) (desvenlafaxine), a,structurally novel, once-daily ... major depressive disorder (MDD). Wyeth,expects to begin shipping ... 2008., "We are pleased to be able ...
... Asbestos-Cancer Group: CNN Expose Highlights Urgent Need for ... ... CNN,s recent expose on,asbestos in children,s toys demonstrates the shocking reality ... decades, asbestos was used heavily in Navy ships and shipyards; in,workplaces; ...
Cached Biology Technology:CaviWipes(R): Taking Surface Disinfection to a New Level 2FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 2FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 3FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 4FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 5FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 6FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 7FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 8FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder 9Calling for a Cure 2
... assays utilize the membrane-permeant ester forms ... charged fluorescent beta-lactamase substrates, CCF2 and ... the cell, where cleavage by endogeneous ... their negatively charged forms, thereby trapping ...
... utilize the membrane-permeant ester forms (CCF2-AM ... fluorescent beta-lactamase substrates, CCF2 and CCF4. ... cell, where cleavage by endogeneous cytoplasmic ... negatively charged forms, thereby trapping them ...
1M stock solution (238mg/ml)...
Request Info...
Biology Products: