Navigation Links
Protecting cells
Date:8/24/2011

Scientists at Northwestern University report a surprising discovery that offers a possible new route for the treatment of neurodegenerative diseases. In a study of the transparent roundworm C. elegans, they found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins.

Neurodegenerative diseases, ranging from Huntington's and Parkinson's to amyotrophic lateral sclerosis and Alzheimer's, are believed to stem from early events that lead to an accumulation of damaged proteins in cells. Yet all animals, including humans, have an ancient and very powerful mechanism for detecting and responding to such damage, known as the heat shock response.

"Why are these diseases so widespread if our cells have ways to detect and prevent damaged proteins from accumulating?" said Richard I. Morimoto, who led the research together with postdoctoral colleague Veena Prahlad. "Can our body fix the problem? That is the conundrum."

"In our study, much to our surprise, we discovered that the nervous system sends negative signals to other tissues in the animal that inhibit the ability of cells to activate a protective heat shock response," Morimoto said. "The machinery to repair the damaged proteins is intact, but the nervous system is sending a signal that prevents it from doing its job."

When the signal from the nervous system was reduced, the cells' heat shock response returned, leading to elevated levels of special protective proteins, called molecular chaperones, that kept the damaged proteins in check.

Morimoto is the Bill and Gayle Cook Professor of Biology in the department of molecular biosciences and the Rice Institute for Biomedical Research in Northwestern's Weinberg College of Arts and Sciences.

The findings are published by the Proceedings of the National Academy of Sciences (PNAS).


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research identifies type of vaccine that holds promise in protecting against TB
2. Protecting neurons could halt Alzheimers, Parkinsons diseases
3. NC State takes research lead in protecting Puerto Ricos unique freshwater fisheries
4. Protecting fresh-cut produce
5. Protecting the food crops of the future
6. Protecting cells from their neighbors
7. Strategy outlined for growing bioenergy while protecting wildlife
8. Protecting humans and animals from diseases in wildlife
9. Vidient SmartCatch Protecting Exit Lanes at Major UK Airport
10. Protecting the future: How plant stem cells guard against genetic damage
11. Researchers: EPA should recognize environmental impact of protecting foreign oil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 10, 2014  That blood pressure plays a role in ... – the medical term for high blood pressure – was ... the inflatable cuff that,s used in measuring blood pressure was ... nothing new about hypertension, its triggers and its effects. In ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into your ... the answer to your secret question. What,s your dog,s birthday? Who ... Labs , a digital infrastructure security company, launches the ... comes with usernames, passwords and PINs – 1U TM ...
(Date:12/10/2014)...  Wake Forest Baptist Medical Center today announced plans for a ... for this $50 million capital project is part of a ... The medical education building will be located ... adjacent to 525@vine in Wake Forest Innovation Quarter. Construction will ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... human mouth teems with millions of enamel-eroding, gum-inflaming microbes. ... homesteader that stakes a claim deep within the spaces ... of tooth loss ?secreting proteins that destroy the soft ... disease. , Now scientists have identified the thousands of ...
... of the world's most bio-diverse ecosystems, is at ... urban development ?problems expected to be compounded by ... Covering more than 165,000 square kilometers ?an area ... South America, the Pantanal is the world's largest ...
... a strategy involving a genetically modified baculovirus and caterpillar ... to speed up a key step in the development ... findings today at the 2005 American Society for Microbiology ... the next flu pandemic strain. It could happen at ...
Cached Biology News:UF Researchers Map Bacterial Proteins That Cause Tooth Loss 2UF Researchers Map Bacterial Proteins That Cause Tooth Loss 3South America's vast pantanal wetland may become next everglades, UNU experts warn 2South America's vast pantanal wetland may become next everglades, UNU experts warn 3South America's vast pantanal wetland may become next everglades, UNU experts warn 4South America's vast pantanal wetland may become next everglades, UNU experts warn 5South America's vast pantanal wetland may become next everglades, UNU experts warn 6Influenza vaccine uses insect cells to speed development 2
(Date:12/24/2014)...   BioLife Solutions , Inc. (NASDAQ: BLFS ), ... hypothermic storage and cryopreservation freeze media ... tissues  ("BioLife" or the "Company"), today announced that it will ... 2015 (the "Annual Meeting"). Because the expected date ...
(Date:12/24/2014)... Earlier this year in a June 24 international ... Stem Cell Technology Center, LLC ( ASCTC ) focused attention ... adult tissue stem cells. His title “Asymmetric Self-Renewal by ... Future,” embodied the essence of his message to congress participants. ...
(Date:12/24/2014)... 23, 2014 According to Ross Selinger, President ... of ITRA Global, the national office market continues to be ... This is evidenced by the third quarter’s surprising 3.9% GDP, ... Low energy costs have held inflation down and the Fed ...
(Date:12/24/2014)... expects global cell isolation and expansion market to grow at ... about the vital drivers, restraints, trends, opportunities, strategies and challenges ... http://bit.ly/1yUxy0T , According to the report, the global market ... CAGR during near future. It expects this growth to be ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... May 13 Celsis International Ltd. announced today that Celsis In ... Sekisui Chemical Co. Ltd., and Sekisui Medical Co. Ltd. in a patent ... , , , ... patent owned by Celsis IVT relating to processes for producing its LiverPool™ ...
... Pa. , May 13 A guide to BRCA1 ... Inc. This comprehensive resource is designed to equip physicians and other healthcare ... help them understand the complexities of BRCA1/2 gene ... According to the ...
... , May 13 U.S. Renal Care, Inc. ("USRC"), ... it is extending its previously announced cash tender offer, through its ... of common stock of Dialysis Corporation of America (Nasdaq: DCAI ... time, on June 1, 2010 , unless further extended. ...
Cached Biology Technology:Celsis IVT Settles LiverPool Patent Infringement Suit With XenoTech, LLC 2Hayes, Inc. Releases Guide to BRCA1 and BRCA2 Genetic Testing 2U.S. Renal Care, Inc. Announces Extension of Tender Offer for Dialysis Corporation of America 2U.S. Renal Care, Inc. Announces Extension of Tender Offer for Dialysis Corporation of America 3
... Species Tissue Array (MSTA) slides were designed to ... tissues from multiple species. Tissue slices from ... slide which can then be treated as a ... in situ hybridization. This format ...
... Gene Pulser Xcell eukaryotic system, ... Hz, is used for electroporation ... includes the main unit, CE ... range) or square-wave pulses, ShockPod ...
Request Info...
... The Sub-Cell Model 96 and PowerPac basic power ... of nucleic acids in agarose gels. This Model ... x 10 cm UV-transparent gel tray with fluorescent ... power supply, 100-120 and 220-240 V, provides output ...
Biology Products: