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Prostate Cancer Foundation announces new urine test for prostate cancer available
Date:9/26/2013

SANTA MONICA, CA -- A new urine test for prostate cancer that measures minute fragments of RNA is now commercially available to men nationwide through the University of Michigan MLabs. The new testMi-Prostate Score (MiPS)improves the utility of the PSA blood test, increases physicians' ability to pick out high-risk prostate tumors from low-risk tumors in patients, and may help tens of thousands of men avoid unnecessary biopsies.

The MiPS test incorporates blood PSA levels and two molecular RNA markers specific for prostate cancer in one final score that provides men and their doctors with a personalized prostate-cancer risk assessment.

Drawbacks of stand-alone PSA testing for prostate cancer

  • The prostate specific antigen (PSA) is a protein made by the prostate. For decades the PSA test has been used as a marker for the presence of prostate cancer in menhigh or rising levels of PSA in blood may indicate the presence of a prostate tumor. However, the PSA test is a non-specific test for prostate cancer. That is, non-cancerous conditions such as an enlarged or inflamed prostate can cause elevations in PSA levels. And even when PSA levels rise above what has routinely been considered a trigger level (4.1 ng/ml in the blood) indicating the need for a needle biopsy to check prostate tissue for signs of cancer, less than half of those biopsies find cancerous cells. In addition, up to 44 percent of PSA-triggered biopsies find cancer cells that are non-lethal, indolent prostate cancer cells. Indolent prostate cancer is highly unlikely to shorten the lifespan of a man. However, treatment with surgery or radiation can carry significant risk of side effects such as incontinence or sexual dysfunction.

Improving upon the PSA test

  • The limited reliability of the PSA test, and its lack of specificity for prostate cancer, has led to sharp disagreement over the use of the PSA test as a rout
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Contact: Rebecca Levine
rlevine@pcf.org
310-570-4727
Prostate Cancer Foundation
Source:Eurekalert

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