Navigation Links
Promising compound restores memory loss and reverses symptoms of Alzheimer's
Date:1/2/2013

A new ray of hope has broken through the clouded outcomes associated with Alzheimer's disease. A new research report published in January 2013 print issue of the FASEB Journal by scientists from the National Institutes of Health shows that when a molecule called TFP5 is injected into mice with disease that is the equivalent of human Alzheimer's, symptoms are reversed and memory is restoredwithout obvious toxic side effects.

"We hope that clinical trial studies in AD patients should yield an extended and a better quality of life as observed in mice upon TFP5 treatment," said Harish C. Pant, Ph.D., a senior researcher involved in the work from the Laboratory of Neurochemistry at the National Institute of Neurological Disorders at Stroke at the National Institutes of Health in Bethesda, MD. "Therefore, we suggest that TFP5 should be an effective therapeutic compound."

To make this discovery, Pant and colleagues used mice with a disease considered the equivalent of Alzheimer's. One set of these mice were injected with the small molecule TFP5, while the other was injected with saline as placebo. The mice, after a series of intraperitoneal injections of TFP5, displayed a substantial reduction in the various disease symptoms along with restoration of memory loss. In addition, the mice receiving TFP5 injections experienced no weight loss, neurological stress (anxiety) or signs of toxicity. The disease in the placebo mice, however, progressed normally as expected. TFP5 was derived from the regulator of a key brain enzyme, called Cdk5. The over activation of Cdk5 is implicated in the formation of plaques and tangles, the major hallmark of Alzheimer's disease.

"The next step is to find out if this molecule can have the same effects in people, and if not, to find out which molecule will," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Now that we know that w
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford geoscientist cites critical need for basic research to unleash promising energy sources
2. Alzheimers disease in mice alleviated promising therapeutic approach for humans
3. Stem cells + nanofibers = Promising nerve research
4. Berkeley Lab scientists help develop promising therapy for Huntingtons disease
5. Promising new drug target for inflammatory lung diseases
6. Space research institute awards funding to promising medical products
7. American Health Assistance Foundation announces grants to advance promising vision research
8. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
9. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
10. Ultrasensitive biosensor promising for medical diagnostics
11. Promising developments in early diagnosis and treatment of mesothelioma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/28/2014)... in German . ... acquire sufficient food when times are lean? By studying ... d,Ivoire researchers of the Max Planck Institute for Evolutionary ... how great apes can acquire extra energy needed to ... their sleeping nests more en route to breakfast sites ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3The early chimp gets the fig 2The early chimp gets the fig 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3
... the growing demand for organic food products has led to ... of Science, University of Copenhagen, a European research project will ... of a food product and deciding whether or not it ... as olive oil, coffee and wine are sold at a ...
... Among overweight and obese adults, a diet rich ... and other high-fiber foods, significantly reduces markers of inflammation ... by Fred Hutchinson Cancer Research Center. Such a "low-glycemic-load" ... also increases a hormone that helps regulate the metabolism ...
... Every year, a group of anti-whaling nonprofit organizations that ... spend, by conservative estimates, some $25 million on a ... And every year, commercial whaling not only continues, but ... number of whales harvested annually has doubled since the ...
Cached Biology News:Research prevents eco-fraud 2Research prevents eco-fraud 3A diet rich in slowly digested carbs reduces markers of inflammation in overweight and obese adults 2Can we save the whales by putting a price on them? 2Can we save the whales by putting a price on them? 3
(Date:10/25/2014)... Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) ... the development of oral drug delivery systems, announced today ... present at FireRock Capital,s Micro-Cap Conference. ... Tuesday, October 28, 2014 ,Time: 9:15am EST ,Location: The ... , About The FireRock Conference  ...
(Date:10/25/2014)... 2014  RegeneRx Biopharmaceuticals, Inc. (OTCBB: RGRX) ("the Company" ... Fourth International Symposium on Thymosins in Health and Disease ... "When thymosin beta 4 (TB4) linked with rhodamine ... cavity in a rodent model of stroke, it was ... parenchyma (the functional tissue of the brain).   The leakage ...
(Date:10/25/2014)... Research and Markets has announced the addition ... Area & by End User - Global Forecast to ... In this report, the global epigenetics market is segmented ... users. The product segments of the epigenetics market included ... and reagents. The subsegments of the enzymes product segment ...
(Date:10/22/2014)... , Oct. 22, 2014 New test ... the in vitro diagnostic (IVD) test industry, especially as ... healthcare market researcher listed more than 25 testing innovations ... be the future of IVD products. Kalorama details the new ... The Worldwide Market for In Vitro Diagnostic Tests ...
Breaking Biology Technology:Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3
... works how people can tune in to a single ... solved this week in the journal Nature by ... Psychologists have known for decades about the so-called "cocktail ... in which it was coined. It is the remarkable human ...
... are single-cell plants that comprise nature,s smallest and ... thrive is water, light, and air. When bred ... to wastewater treatment to biofuels. Current microalgae breeding ... allowed by the laws of nature. Scientists at ...
... , Expanded clinical study ...   TMC435 and BMS-986094 (formerly ... in clinical trial , ... on the development of high-value treatments for infectious diseases, ...
Cached Biology Technology:How selective hearing works in the brain 2How selective hearing works in the brain 3Medivir Announces TMC435 in an Expanded Clinical Collaboration 2Medivir Announces TMC435 in an Expanded Clinical Collaboration 3Medivir Announces TMC435 in an Expanded Clinical Collaboration 4
... Y2 Receptor antiserum This NPY Y2 ... level and is currently being characerized in brain. ... and mouse and appears to work better on ... rat. For full characterizarion in dorsal root ganglion ...
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
... Rabbit polyclonal to Peroxiredoxin 1 ... family, whose mammalian members have been ... differentiation, and apoptosis. Many isoforms (about ... the amino acid sequence homology, particularly ...
Spectrolyse (pL) PAI kit is a two-stage indirect enzymatic assay for the quantitative determination of Plasminogen Activator Inhibitor (PAI-1) activity in plasma. Sample Type: plasma...
Biology Products: