Navigation Links
Project aims to fuse top-down, bottom-up approaches in systems biology
Date:5/4/2011

The National Institutes of Health has awarded Virginia Tech researchers a $2.13 million grant to develop new systems biology approaches to study cells, one of the most basic units of life. Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

T.M. Murali, associate professor of computer science at Virginia Tech https://bioinformatics.cs.vt.edu/~murali/; John Tyson, university distinguished professor of biology, http://www.biol.vt.edu/faculty/tyson/; and Jean Peccoud of the Virginia Bioinformatics Institute http://www.vbi.vt.edu/faculty/personal/Jean_Peccoud, proposed to the National Institutes of Health a novel approach to link the two dominant paradigms in systems biology.

NIH is awarding the interdisciplinary team for their proposal titled "Integrating Top-Down and Bottom-Up Models in Systems Biology with Application to Cell Cycle Control in Budding Yeast."

Murali, principal investigator, described the project: "Two distinct approaches are being used to study complex cellular systems. The first, top-down approach automatically analyzes large-scale datasets for correlations between genes and proteins. However, it is often difficult to design experiments from these results.

"The second, bottom-up approach painstakingly crafts detailed models that can be simulated computationally. Although such simulations can suggest wet lab experiments, developing the models is a manual process that can take many years. These approaches have largely been developed separately until now. Our project will meld the strengths of these two approaches into a single framework
'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Page: 1 2

Related biology news :

1. €12 million ($16.9 million) project to develop new tools for malaria control
2. Uncertain future for Joshua trees projected with climate change
3. BGI to Play Pivotal Sampling, Next-Generation Sequencing and Bioinformatics Role in Earth Microbiome Project
4. Drier conditions projected to accelerate dust storms in the southwest
5. Climate projections show human health impacts possible within 30 years
6. Former ASPB president leading sustainable bioenergy education project
7. $4 million project to protect Irish and Scottish waterways
8. LCD projector used to control brain and muscles of tiny organisms such as worms
9. Water, water everywhere focus of new sustainability project
10. Grants fund projects that will tackle Grand Challenges
11. Patriot Data Solutions Group Selected to Assist Louisiana District Attorney Association with Pilot Project
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Project aims to fuse top-down, bottom-up approaches in systems biology 
(Date:8/18/2015)... Aug. 18, 2015  Navitas today announced ... to the Submission Content Management webinar scheduled ... non-profit forum. Dedicated to the Implementation of Regulatory ... platform for industry, vendors, health authorities, consultants ... work towards a standard method of implementing ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/6/2015)... REDWOOD CITY, Calif. , Aug. 6, 2015 ... (D-Silicon Valley) will visit Crossmatch ™ to ... secure networks and protect data. Crossmatch is a ... solutions whose technologies and expertise are helping federal ... operational efficiency and security.   "The ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Rep. Honda to Visit Crossmatch in Redwood City 2
... Malaspina expedition 2010 will set sail from the city ... National Research Council (CSIC) aims to evaluate how global ... their biodiversity. The expedition has the backing of the ... its name from mariner Alessandro Malaspina, the leader of ...
... , The terrestrial biosphere regulates atmospheric composition, and hence ... "carbon-climate feedbacks", which means that more CO 2 ... is taken up by plants due to photosynthesis. Climate ... of CO 2 and methane from wetlands, nitrous ...
... research team led by scientists at the Virginia Bioinformatics Institute ... that allows dangerous fungal microbes to infect plants and cause ... new intervention strategies to protect plant, and even some animal ... the July 23 edition of the journal Cell . ...
Cached Biology News:Malaspina expedition 2010 2Unaccounted feedbacks from climate-induced ecosystem changes may increase future climate warming 2Scientists discover how deadly fungal microbes enter host cells 2
(Date:9/1/2015)... ... September 01, 2015 , ... Knowledgent , the data and analytics ... advanced analytics utilizing data lakes in the healthcare industry. , As the Internet of ... of data over the last few years as more entities become technology enabled through ...
(Date:9/1/2015)... ... 2015 , ... Industry leader iLab Solutions recently announced Gerard ... position, Gibbs will lead iLab’s business operations in the region, with an emphasis ... not only introducing iLab to potential partners but support and management of accounts ...
(Date:9/1/2015)... CA (PRWEB) , ... September 01, 2015 , ... ... and colleagues from University of California Los Angeles, Boston University School of Medicine, ... Prevention appears in PLOS One, the world’s first multidisciplinary Open Access journal. ...
(Date:9/1/2015)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... of Directors as a Non-Executive Director. Sara will also be ... the Shire Board. Both appointments will be effective as of ... President and Chief Executive Officer of Dun & Bradstreet, Inc. ... D&B, she helped drive the transformation of the company from ...
Breaking Biology Technology:New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Shire Appoints Sara Mathew to Board of Directors 2
... SAN MATEO, Calif., Dec. 26 NeurogesX, Inc.,(Nasdaq: ... developing novel,pain management therapies, today announced that on ... agreement in connection with a private,placement to a ... closing conditions, will receive approximately $25 million in,gross ...
... Genta,Incorporated (Nasdaq: GNTA ) announced today that the ... The NASDAQ Stock Market,that it no longer complies with ... price of $1.00 per share. In accordance with,Marketplace Rule ... regain,compliance, which requires a closing bid price of the ...
... Sinovac Biotech Ltd. (Amex:,SVA), a leading provider of ... completed Phase II clinical trial of its pandemic,influenza ... trial of the vaccine was designed to assess ... received approval from the China State Food and ...
Cached Biology Technology:NeurogesX, Inc. Announces $25 Million Private Placement 2NeurogesX, Inc. Announces $25 Million Private Placement 3Genta Receives NASDAQ Non-Compliance Notice 2Genta Receives NASDAQ Non-Compliance Notice 3Sinovac Reports Top-Line Preliminary Phase II Results of Pandemic Influenza (H5N1) Whole Viron Vaccine 2Sinovac Reports Top-Line Preliminary Phase II Results of Pandemic Influenza (H5N1) Whole Viron Vaccine 3
Request Info...
... Calmodulin Sepharose 4B, ... single-step purification of ... proteins.Purification of calmodulin-regulated ... eukaryotic cells. Category: ...
...
AdestaTM Tissue/Cell Preservation Medium Sterile / Non-sterile: Sterility Tested Endotoxin: ...
Biology Products: