Navigation Links
Progress in tissue engineering to repair joint damage in osteoarthritis

Medical scientists now have "clear" evidence that the damaged cartilage tissue in osteoarthritis and other painful joint disorders can be encouraged to regrow and regenerate, and are developing tissue engineering technology that could help millions of patients with those disorders. That's the conclusion of a new analysis of almost 100 scientific studies on the topic, published in ACS's journal Molecular Pharmaceutics.

Tong Cao, Wei Seong Toh and colleagues point out that damage to so-called articular cartilage the smooth, white, rubbery tissue that covers and cushions the ends of bones in joints is one of the most challenging problems in medicine. That's because the tissue lacks blood vessels and has little ability to repair itself and regrow. Wear-and-tear damage thus builds up over the years, resulting in conditions like osteoarthritis, which affects 27 million people in the United States alone. Osteoarthritis is a fast-growing public health problem because of the world's aging population and because of a sharp increase in obesity, which increases wear on joint cartilage. To assess progress toward medical use of tissue engineering to treat joint damage, the researchers scanned global research on the topic.

They found that scientists have developed many new tissue engineering methods, including implantation of so-called "scaffolds" made of biomaterials that mimic cartilage matrix in the body. The scaffolds could guide the transplanted cells, orchestrate the host cell response, provide structures and microenvironment substances to help rebuild cartilage at the injury site. "In summary, there is promise in future research involving the development of multi-functional biomaterial delivery systems that affect cartilage tissue regeneration on multiple levels," the article states.


Contact: Michael Bernstein
American Chemical Society

Page: 1

Related biology news :

1. Chesapeake Bay programs 2-year milestones improve upon past strategies, but accounting of progress remains a challenge
2. GOLFIG increased progression-free survival in colorectal cancer patients
3. Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
4. Older and stronger: Progressive resistance training can build muscle, increase strength as we age
5. Researchers find drug that stops progression of Parkinsons disease in mice
6. Neiker-Tecnalia makes progress in detection and prevention of infection by visna maedi virus
7. Researchers learn why PSA levels reflect prostate cancer progression
8. Progress toward treating infections by silencing microbes smart phones
9. Progress toward first commercial repellent for East Coasts stinker
10. Erlotinib improves progression-free survival as first-line therapy in advanced lung cancer
11. Gene-environmental interactions and MS progression is focus of new study
Post Your Comments:
(Date:9/30/2015)... -- With nearly 300,000 Americans living with spinal cord injuries ... reach 12,500 annually, the role of Independent Living Centers ... Living (SCRS-IL) is increasingly important. SCRS-IL is one ... opening doors to independence for individuals with SCIs by ... technology services and education. "In serving people ...
(Date:9/29/2015)... Sept. 29, 2015 News facts: ... while also saving energy , Minimized design shrinks ... Power Active Mode and embedded Fujitsu PalmSecure authentication enable ... Fujitsu today shows that good things come in ... models to its enterprise desktop and mobile portfolio. Featuring ...
(Date:9/28/2015)... , Sept. 28, 2015  The monitoring of ... and body temperature, is an essential component of ... indicators of deterioration in a patient,s condition. However, ... signs are typically taken during routine observation rounds ... a patient deteriorates between these observation rounds, the ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... ROSEVILLE, Minn. , Oct. 12, 2015 /PRNewswire/ ... Drug Administration (FDA) has designated its lead Microbiota ... for the treatment of recurrent Clostridium difficile ... gastrointestinal (GI) infection that causes 29,000 deaths in ... clinical stage biotechnology company that was founded to ...
(Date:10/12/2015)... , 12 de octubre de 2015 El ... llegó a un récord en el congreso con su ... de la International Plasma Awareness Week (IPAW), que se ... está patrocinada por la Plasma Protein Therapeutics Association ... , Aumentar la concienciación mundial acerca ...
(Date:10/12/2015)... 2015  Patara Pharma, a clinical-stage biotechnology company ... and conditions, today announced the closing of a ... with the close of its sale of preferred ... Security Agreement with Silicon Valley Bank whereby the ... will use the funds from the financing to ...
(Date:10/12/2015)... 2015 offers ... enriched online experience --> ... version for enriched online experience --> ... alternative to print version for enriched online experience ... technical and medical information products and services, announced today ...
Breaking Biology Technology: