Navigation Links
Probing matters of the heart
Date:9/14/2012

istone-modification patterns shift rapidly as a stem cell differentiates. Furthermore, the patterns reveal genes that are active at different stages, as well as regulatory elements that control those genes.

Tracking development

To discover those patterns, the researchers grew mouse embryonic stem cells in a lab dish and treated them with proteins and growth factors that drive heart cell development. The cells could be followed through four distinct stages, from embryonic stem cells to fully differentiated cardiomyocytes (the cells that compose heart muscle). At each stage, the researchers used high-throughput sequencing technology to analyze histone modifications and determine which genes were being expressed.

"It's basically watching differentiation over time in a dish, and being able to take snapshots of that and put it all together to try to understand how the complex process of cardiac commitment is regulated," Boyer says.

The researchers found that they could identify groups of genes with related functions by comparing their modification patterns and whether they were being transcribed at a particular time. They also identified regulatory regions located far away from the genes they regulate. Many of these regions were located in sections of DNA previously thought to be "junk." Recent studies have revealed that much of this DNA actually plays important roles in regulating gene expression.

"We're starting to link genes with the regulatory elements that may be activating them, and beginning to draw a picture of the molecular circuitry that is controlling and driving these cardiac-specific programs the DNA elements that are important for turning on all the genes that you need to make a heart cell," Wamstad says.

The team also identified transcription factors proteins that initiate the expression of genes that appear to work collaboratively at regulatory regions to drive transcription of genes importan
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Probing the roots of depression by tracking serotonin regulation at a new level
2. Size matters: Large Marine Protected Areas work for dolphins
3. For the rooster, size matters
4. Heart-powered pacemaker could one day eliminate battery-replacement surgery
5. Geological Society of America Cordilleran section meets in the heart of Mexico
6. Cell therapy using patients own bone marrow may present option for heart disease
7. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
8. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
9. Second-generation drug used for hypertension aids heart function independent of blood pressure
10. Scientists develop new technique that could improve heart attack prediction
11. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... 20, 2015   Sensory, Inc ., a ... user experience and security of consumer electronics through ... that its TrulySecure™ is the first ... be FIDO Certified™. The FIDO (Fast ... the FIDO UAF (Universal Authentication Framework) 1.0 specifications, ...
(Date:8/19/2015)... 2015  VOXX International Corporation (Nasdaq: VOXX ... a Definitive Agreement to purchase the assets, inclusive ... leader EyeLock through an acquiring entity.  Upon consummation ... interest in the acquiring entity. The closing of ... diligence.  Expanding on its existing supply chain and ...
(Date:8/18/2015)... Aug. 17, 2015 Research and Markets ... the "Global Biometric Authentication & Identification Market: ... & Forecast, 2015-2020" report to their offering. ... identification systems market is expected to grow at ... 2020 and generate over $25 billion (approximately) by ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... in Earth and Space Sciences More than 2,200 ... and space sciences in Foz do Iguau at the 2010 ... place from 8 to 12 August, are planning 377 scientific ... earthquakes, extreme weather events in the Americas, climate impacts of ...
... a set of ultra-strength cleaners that could be used ... formulas are tough enough to get rid of nerve ... are also non-toxic, based on ingredients found in foods, ... the cleansers appears in ACS, Industrial Engineering and ...
... DNA methylation - an event that affects cell function by ... time by stem cell researchers at UCLA, a finding that ... in human stem cell lines. The team of scientists ... nucleosomes, which compact and regulate access to DNA in the ...
Cached Biology News:2010 Meeting of the Americas, Brazil: News media registration open 22010 Meeting of the Americas, Brazil: News media registration open 32010 Meeting of the Americas, Brazil: News media registration open 4Military develops multi-purpose 'green' decontaminants for terrorist attack sites 2UCLA stem cell researchers uncover previously unknown patterns in DNA methylation 2
(Date:9/2/2015)... Wellinton, Florida (PRWEB) , ... September 02, 2015 ... ... has been treated and managed with the use of special anti-vascular endothelial growth ... occurs in many more patients, currently does not have a scientific protocol for ...
(Date:9/2/2015)... ... September 02, 2015 , ... Drug companies ... compounds. BCC Research reveals in its new report that the U.S. will ... the category and generates the most market demand. , BCC Research examines ...
(Date:9/2/2015)... September 2, 2015 BioLight ... or the "Company"), a firm that invests in, ... cancer diagnostics, announced today that presentations highlighting its ... be delivered at the Ophthalmology Futures European Forum ... of Cataract & Refractive Surgeons ("ESCRS"), both taking ...
(Date:9/2/2015)... ... September 02, 2015 , ... Temarry Recycling's ... entire waste to energy process and continue to contribute to the sustainability of ... Temarry’s Waste to Energy process has been operating at their Mexico facility, Recicladora ...
Breaking Biology Technology:StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2
... Mich., Sept. 27 Neogen Corporation,(Nasdaq: NEOG ) ... quarter of,FY 2008, which ended Aug. 31, increased 25% ... a 3-for-2 stock split, net income per,share was $0.21 ... for the,same period in the prior year. First ...
... provides additional treatment option for asthma patients not fully ... ... NAPA, Calif., Sept. 27 Dey, L.P., an,affiliate of Merck ... (zileuton) extended-release tablets with its,marketing partner, Critical Therapeutics, Inc. (Nasdaq: ...
... Systems (NYSE: VAR ) and one of ... IGRT (image guided radiotherapy),training school, enabling hospitals across ... most precise radiotherapy technologies available to radiation,oncologists. ... the venue for,the first event of its kind, ...
Cached Biology Technology:Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 2Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 3Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 4Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 5Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 2Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 3First European IGRT School Takes Place for Radiotherapy Practitioners in UK 2First European IGRT School Takes Place for Radiotherapy Practitioners in UK 3
QCPN...
... Axima range, the AXIMA-CFR provides a ... sensitivity and mass range, and offers ... reflectron time-of-flight analysis. The unique patented ... of seamless PSD, providing efficient and ...
... creates a new category for MALDI. It ... has been licensed to the PerkinElmerSCIEX joint ... As the first single MALDI-TOF mass spectrometer ... the prOTOF 2000 represents a substantial leap ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
Biology Products: