Navigation Links
Probing matters of the heart
Date:9/14/2012

CAMBRIDGE, Mass. The fate of an embryonic stem cell, which has the potential to become any type of body cell, is determined by a complex interaction of genes, proteins that bind DNA, and molecules that modify those genes and proteins.

In a new paper, biologists from MIT and the University of California at San Francisco have outlined how those interactions direct the development of stem cells into mature heart cells. The study, the first to follow heart-cell differentiation over time in such detail, could help scientists better understand how particular mutations can lead to congenital heart defects. It could also assist efforts to engineer artificial heart tissue.

"We're hoping that some of the information we've been able to glean from our study will help us to approach a new understanding of heart development, and also lead to the possibility of using cells that are generated in a dish to replace heart cells that are lost as a consequence of aging and disease," says Laurie Boyer, an associate professor of biology at MIT and a senior author of the paper, which appears in the Sept. 13 online edition of Cell.

Research in Boyer's lab focuses on how DNA is organized and controlled in different cell types to create the wide variety of cells that make up the human body.

Inside a cell, DNA is wrapped around proteins called histones, which help control which genes are accessible at any given time. Histones may be tagged with different chemical modifications, which influence whether a particular stretch of DNA is exposed or hidden.

"These modifications cause structural changes that can act as docking sites for other factors to bind," says Joe Wamstad, a postdoc in Boyer's lab and one of the lead authors of the Cell paper. "It may make the DNA more or less accessible to manipulation by other factors, helping to ensure that you don't express a gene at the wrong time."

In this paper, the researchers found that h
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Probing the roots of depression by tracking serotonin regulation at a new level
2. Size matters: Large Marine Protected Areas work for dolphins
3. For the rooster, size matters
4. Heart-powered pacemaker could one day eliminate battery-replacement surgery
5. Geological Society of America Cordilleran section meets in the heart of Mexico
6. Cell therapy using patients own bone marrow may present option for heart disease
7. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
8. Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
9. Second-generation drug used for hypertension aids heart function independent of blood pressure
10. Scientists develop new technique that could improve heart attack prediction
11. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Americans across racial and ethnic groups describe losing ... their day-to-day life, more so than other conditions ... (57% of African-Americans, 49% of non-Hispanic whites, 43% ... which disease or ailment is the worst that ... African-Americans followed by AIDS/HIV. Hispanics and Asians ...
(Date:9/18/2014)... algal forests in the eastern Mediterranean Sea pose a ... distribution continues to expand as the climate warms, a ... of researchers led by Dr Adriana Vergs of UNSW ... for Advanced Studies in Spain, is published in the ... surveyed more than 1000 kilometres of coastline in Turkey ...
(Date:9/18/2014)... too stressed they are often grouchy, grumpy, nasty, distracted ... at EPFL have just highlighted a fundamental synaptic mechanism ... loss of social skills and cognitive impairment. When triggered ... in the brain. This was revealed by a work ... Sandi,s team went to look for answers in a ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3Tropical fish a threat to Mediterranean Sea ecosystems 2How stress tears us apart 2
... last couple decades have seen a virtual renaissance of ... functional magnetic resonance imaging (fMRI). Thanks to a ... scholars at Rutgers University will have the latest fMRI ... NSF has awarded Rutgers University in Newark a $1,820,000 ...
... natural organic pesticide for hundreds of years, is getting new ... pesticides. That,s the topic of a report in ACS, bi-weekly ... Cedric Briens and colleagues note that concerns about the health ... in some parts of the world. Scientists are looking for ...
... geoscientist Dr Veerle Huvenne of the United Kingdom,s National Oceanography ... 1.4 million Euros over five years to map complex habitats ... The European Research Council (ERC) ,Starting Grant, scheme aims ... their own research groups. The grants are highly competitive, and ...
Cached Biology News:$1,820,000 from NSF awarded to Rutgers-Newark to acquire fMRI dedicated to research 2
(Date:9/19/2014)... LONDON , September 19, 2014 ... Spain , available today on PharmaBoardroom.com ... of the Eurozone crisis that rocked the Spanish economy in ... the Spanish pharma community has remained pragmatic in times of ... is still the fifth biggest European market, and the ...
(Date:9/18/2014)... Mass. (PRWEB) September 18, 2014 A ... of an MRI scanner is currently being tested as ... and Women's Hospital in Boston with the aim of ... images, can make prostate cancer biopsies faster, more accurate, ... novel system also has the potential to deliver prostate ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... are undifferentiated biological cells that can differentiate into specialized ... stem cells. Stem cell therapy can be applied to ... system disease), nervous system diseases, damage or lesion of ...
(Date:9/18/2014)... 18, 2014  U.S. biotech company Kultevat ... license for technology developed by the Donald Danforth ... plants, including for applications in production of natural rubber ... technology was developed under the direction of Roger ... former president of the Danforth Plant Science Center, and ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Kultevat obtains license of gene switch technology 2
... CRANBURY, N.J., Sept. 12 Amicus Therapeutics,(Nasdaq: FOLD ... Officer, will present a corporate update at the Merrill ... United,Kingdom on Tuesday, September 18th at 4:00 pm BDT ... A live audio web cast of the presentation will ...
... MORRISVILLE, N.C., Sept. 12 AVOS Life Sciences,announced ... Vice President. His,primary responsibility will be providing advisory ... areas as well as selected investment,assignments in capital ... he will also have responsibility for AVOS, emerging ...
... Robotic-Assisted Coronary ... Artery Bypass Surgery, REDWOOD CITY, Calif., ... it has received European CE Mark,(Conformite Europeenne) approval for the C-Port(R) ... of Cardica,s C-Port(R) xA,Distal Anastomosis System product line and further facilitates ...
Cached Biology Technology:Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007 Conference 2Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007 Conference 3Senior Research Analyst Richard Evans Joins AVOS Life Sciences 2Cardica Receives European CE Mark for C-Port Flex A System for Use in Coronary Artery Bypass Surgery 2Cardica Receives European CE Mark for C-Port Flex A System for Use in Coronary Artery Bypass Surgery 3
... micro 1 is a dramatic breakthrough in accurate, ... with 10nL resolution, the micro 1 has unique ... And, the micro 1 never needs re-calibration as ... Screen programming on an LCD Display , Graphical ...
... B3 series of microscopes offer all of ... for laboratory work. Equipped with Koehler illumination, ... (ASC) objectives. The B3 is the workhorse ... binocular tube eliminates the need for re-focusing ...
... Dye Primer Manual Cycle Sequencing Kit is ... primers and high-resolution fluorescence scanners. Sequencing reactions ... slab gel electrophoresis and scanning of the ... The kit components have been optimized ...
Rabbit polyclonal to Esa1 ( Abpromise for all tested applications)....
Biology Products: