Navigation Links
Previously unknown mechanism identified in oncogene-induced senescence
Date:12/11/2012

Philadelphia, PA, December 12, 2012 Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology.

In many types of normal cells, OIS depends on induction of DNA damage response. Oxidative stress and hyper-replication of genomic DNA have already been proposed as major causes of DNA damage in OIS cells. A group of investigators from New York, Oregon, and Michigan reports that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage. In normal human cells, "OIS represents an important fail-safe mechanism that suppresses proliferation of pre-malignant cells," explains lead investigator Dr Mikhail Nikiforov, PhD, Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York. "Compelling evidence suggests that one of the intrinsic processes required for the induction of OIS is the cellular response to DNA damage."

The group investigated endogenous processes that caused DNA damage in human fibroblasts undergoing OIS and demonstrated that DNA damage, at least partially, originates from under-expression of key enzymes involved in deoxyribonucleoside biosynthesis and subsequent depletion of endogenous deoxyribonucleoside triphosphate (dNTP) pools. They found that even partial restoration of depleted intracellular dNTP pools is sufficient for substantial suppression of DNA damage and senescence.

"We believe our data identify a previously unknown role of deoxyribonucleotides in regulation of oncogene-induced senescence. Our results suggest that both nucleotide depletion and a
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green plants reduce city street pollution up to 8 times more than previously believed
2. Coppers previously unknown exit strategy
3. In protein folding, internal friction may play a more significant role than previously thought
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Fruit fly studies guide investigators to misregulated mechanism in human cancers
6. Missing link discovered in the defence mechanism of the tuberculosis pathogen
7. Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
8. Scientists uncover mechanism by which plants inherit epigenetic modifications
9. RUB researchers clarify catalysis mechanism of cell growth protein Ras
10. X-rays reveal the self-defence mechanisms of bacteria
11. A mechanism providing clues for research into pancreatic diabetes is described
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... University of Texas Medical Branch at Galveston has gone on ... completely protect monkeys against a lethal dose of Ebola virus ... the disease is severe. , Thomas Geisbert, professor of microbiology ... discussing advances in Ebola treatment research. The filoviruses known as ... of pathogens, with fatality rates of up to 90 percent. ...
(Date:8/29/2014)... connections in transcription factor networks (TFNs) to evaluate the ... in PLOS Computational Biology in August. ... a network,s resilience against mutations. , "In simulations, ... models has a greater effect on robustness than varying ... Dov A. Pechenick, PhD, lead author and former researcher ...
(Date:8/29/2014)... This news release is available in German . ... of chemical signals between organisms is considered the oldest ... social interactions between conspecifics, for example, the sexual attraction ... trigger social responses and to coordinate reproductive behavior in ... at the University of the Algarve in Faro, Portugal, ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Assortativity signatures of transcription factor networks contribute to robustness 2Ready for mating at the right time 2Ready for mating at the right time 3
... The most common cause of a mare,s reduced fertility is ... caused by the bacteria , Streptococcus equi subspecies ... negative for streptococci have a dormant infection without showing clinical ... to reduce the fertility of the mares," says Professor Anders ...
... Researchers at the Johns Hopkins University in Baltimore, Md., ... have found that nonself-donated cells (allografts) better survive implantation ... grafts are injected into the striatum (STR) of the ... region. In their study, all FM grafts were ...
... being passive wallflowers, are "secret gardeners" that actively engineer their ... team of scientists from Duke University and the University of ... that the distribution of plants within a marsh is a ... that,s where conditions like soil aeration and salinity best meet ...
Cached Biology News:Researchers make racehorses fertile 2Impact of stem cell transplantation location in brain a crucial factor for cell survival 2Marsh plants actively engineer their landscape 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... are important devices in spintronics, an electronic which ... electrons but also on their spin and the ... electric into magnetic signals and vice versa. Recently, ... the Institute of Physics at Johannes Gutenberg University ... Prague, and Japan, has for the first time ...
(Date:8/28/2014)... 2014 Sterlitech is proud to announce ... its stable of products . These additional ... and include membrane filters with surface charges. ... demand for our membrane process testing equipment, and correspondingly, ... sheet membranes,” explains Sterlitech President Mark Spatz. “The ...
(Date:8/28/2014)... this month, a report was created by Colorado ... Force on the performance of vehicles using an eco-friendly, ... fuel made from mustard seeds, offered great potential as ... friendly future. In fact, every branch of the U.S. ... foreign oil over the next few years. They will ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... U.S. Asthma Control, RESEARCH TRIANGLE PARK, N.C. and ... with asthma and more than a quarter of,children with ... have their disease well controlled, according to the Asthma ... of the American,Thoracic Society meeting in Toronto., The ...
... May 20 PreViser Corporation,( http://www.previser.com ), a ... assessment technology to the dental profession,announced today the ... (OHI) Ltd ( http://www.previser.co.uk ) of Birmingham, England ... Kingdom and the,Republic of Ireland., OHI Ltd ...
... living computers by genetically altering bacteria. The findings of ... of Biological Engineering, demonstrate that computing in living cells ... applications including data storage and as a tool for ... from the biology and the mathematics departments of Davidson ...
Cached Biology Technology:Asthma Uncontrolled in More Than 40 Percent of Adults With the Disease, New Landmark Survey Shows 2Asthma Uncontrolled in More Than 40 Percent of Adults With the Disease, New Landmark Survey Shows 3PreViser and Oral Health Innovations Ltd Form UK Partnership to Provide Oral Health Scoring and Risk Analysis 2Researchers bring new meaning to the term 'computer bug' 2
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Polyclonal Antibody to SHPRH...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biotin anti-mouse Ly-49C/F/I/H...
Biology Products: