Navigation Links
Previously unknown mechanism identified in oncogene-induced senescence
Date:12/11/2012

Philadelphia, PA, December 12, 2012 Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology.

In many types of normal cells, OIS depends on induction of DNA damage response. Oxidative stress and hyper-replication of genomic DNA have already been proposed as major causes of DNA damage in OIS cells. A group of investigators from New York, Oregon, and Michigan reports that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage. In normal human cells, "OIS represents an important fail-safe mechanism that suppresses proliferation of pre-malignant cells," explains lead investigator Dr Mikhail Nikiforov, PhD, Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York. "Compelling evidence suggests that one of the intrinsic processes required for the induction of OIS is the cellular response to DNA damage."

The group investigated endogenous processes that caused DNA damage in human fibroblasts undergoing OIS and demonstrated that DNA damage, at least partially, originates from under-expression of key enzymes involved in deoxyribonucleoside biosynthesis and subsequent depletion of endogenous deoxyribonucleoside triphosphate (dNTP) pools. They found that even partial restoration of depleted intracellular dNTP pools is sufficient for substantial suppression of DNA damage and senescence.

"We believe our data identify a previously unknown role of deoxyribonucleotides in regulation of oncogene-induced senescence. Our results suggest that both nucleotide depletion and a
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green plants reduce city street pollution up to 8 times more than previously believed
2. Coppers previously unknown exit strategy
3. In protein folding, internal friction may play a more significant role than previously thought
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Fruit fly studies guide investigators to misregulated mechanism in human cancers
6. Missing link discovered in the defence mechanism of the tuberculosis pathogen
7. Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
8. Scientists uncover mechanism by which plants inherit epigenetic modifications
9. RUB researchers clarify catalysis mechanism of cell growth protein Ras
10. X-rays reveal the self-defence mechanisms of bacteria
11. A mechanism providing clues for research into pancreatic diabetes is described
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... has received from the National Institutes of Health ... project to support the further development of 23andMe,s ... , Specifically, the grant supports four areas ... to improve the company,s ability to identify novel ... to support the collection of a broader set ...
(Date:7/29/2014)... 1 in 100,000 people characterized by a loss of ... unknown, a new study by a team of researchers at ... and other European institutions confirms for the first time that ... July in Nature Genetics , is an important step ... sphincter in the lower esophagus opens, allowing food to enter ...
(Date:7/28/2014)... of two additional coral communities showing signs of damage from ... the 2010 spill in the Gulf of Mexico. The discovery ... of biology at Penn State University. A paper describing this ... the Gulf of Mexico will be published during the last ... the journal Proceedings of the National Academy of Sciences ...
Breaking Biology News(10 mins):23andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 3Mysterious esophagus disease is autoimmune after all 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2
... of the potential health effects associated with accidental exposure ... , The study, "An Analysis of Uranium Dispersal and ... by Sandia scientist Al Marshall, employs analytical capabilities used ... risks associated with uranium handling. , U.S. and British ...
... Cornell University researchers have revealed a process that has ... derived from vitamin A enters a cell's nucleus, where ... basic transport mechanism opens a new door for future ... for the fight against cancer and other diseases. , ...
... HIV is so difficult to contain and treat is its ... to that evolution is vital. , Host cells produce two ... ability to replicate. But HIV produces a protein, called Vif, ... full of variation, both in sequence and in function, according ...
Cached Biology News:Sandia completes depleted uranium study 2Study shows how retinoic acid enters a cell's nucleus 2Study shows how retinoic acid enters a cell's nucleus 3
(Date:7/29/2014)... Second generation biofuels are a viable solution to ... as natural gas is very cheap, this is affecting the ... valuable as they could be in comparison to natural gas. ... made it difficult for renewable energy developers to get the ... For these reasons, certain companies have shifted their focused within ...
(Date:7/29/2014)... , July 29, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, applauds the ... taking a strong position in opposition to current ... 27, 2014 publication.  The New York Times also ... this week exploring the issue called "High Time:  ...
(Date:7/29/2014)... Tenn. (PRWEB) July 29, 2014 ... in biomass feedstock supply innovation and supply chain ... proprietary feedstock management systems, Energy Grangeā„¢ and Supply ... of R&D and in-the-field testing aimed at consolidating ... offering benefits to landowners, farmers and feedstock end ...
(Date:7/29/2014)... 29, 2014 G-CON Manufacturing Inc., the ... today announced a new leadership appointment designed to drive ... and abroad. , Maik Jornitz, Chief Operating Officer ... President charged with leading the pioneering company through its ... this stage of development and look forward to providing ...
Breaking Biology Technology:Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2
... Consortium With Broad ... Portfolio of IV Products, ... BAX ) announced today that Novation, the University HealthSystem,Consortium,s (UHC) ... behalf of UHC valued at over $200 million over the,contract ...
... (Pink Sheets: BIEL), announced today that the ... sale by its,distributor, Endotherapeutics Party Limited. ... professionals of,Endotherapeutics will successfully launch ActiPatch in ... of experience in the,medical devices market and ...
... to Identify Pathways and ... to Metabolomic Data, REDWOOD CITY, Calif., Oct. ... solutions to help life science researchers,generate insights from ... solution within Ingenuity,Pathways Analysis to help researchers understand ...
Cached Biology Technology:Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 2Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 3Australian Therapeutics Goods Administration Approval for ActiPatch Achieved 2Ingenuity Systems Launches New Metabolomics Solution Within IPA 2
Request Info...
Prepared in distilled water....
... white. The extinction coefficient , E(1%) at ... phosphate-buffered saline, pH 7.4, containing ... 50% glycerol. Avidin (from egg white) is conjugated ... molecular sieving and is completely ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Biology Products: