Navigation Links
Previously unknown mechanism identified in oncogene-induced senescence
Date:12/11/2012

Philadelphia, PA, December 12, 2012 Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology.

In many types of normal cells, OIS depends on induction of DNA damage response. Oxidative stress and hyper-replication of genomic DNA have already been proposed as major causes of DNA damage in OIS cells. A group of investigators from New York, Oregon, and Michigan reports that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage. In normal human cells, "OIS represents an important fail-safe mechanism that suppresses proliferation of pre-malignant cells," explains lead investigator Dr Mikhail Nikiforov, PhD, Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York. "Compelling evidence suggests that one of the intrinsic processes required for the induction of OIS is the cellular response to DNA damage."

The group investigated endogenous processes that caused DNA damage in human fibroblasts undergoing OIS and demonstrated that DNA damage, at least partially, originates from under-expression of key enzymes involved in deoxyribonucleoside biosynthesis and subsequent depletion of endogenous deoxyribonucleoside triphosphate (dNTP) pools. They found that even partial restoration of depleted intracellular dNTP pools is sufficient for substantial suppression of DNA damage and senescence.

"We believe our data identify a previously unknown role of deoxyribonucleotides in regulation of oncogene-induced senescence. Our results suggest that both nucleotide depletion and a
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green plants reduce city street pollution up to 8 times more than previously believed
2. Coppers previously unknown exit strategy
3. In protein folding, internal friction may play a more significant role than previously thought
4. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
5. Fruit fly studies guide investigators to misregulated mechanism in human cancers
6. Missing link discovered in the defence mechanism of the tuberculosis pathogen
7. Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
8. Scientists uncover mechanism by which plants inherit epigenetic modifications
9. RUB researchers clarify catalysis mechanism of cell growth protein Ras
10. X-rays reveal the self-defence mechanisms of bacteria
11. A mechanism providing clues for research into pancreatic diabetes is described
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2015)... HAUPPAUGE, N.Y. , Aug. 19, 2015 /PRNewswire/ ... announced that it has entered into a Definitive ... intellectual property, of iris authentication market leader EyeLock ... transaction, VOXX will have a controlling interest in ... is subject to completion of due diligence.  Expanding ...
(Date:8/12/2015)... 12, 2015 As the digital ... innovation and advanced biometrics technology is accelerating beyond expectations.  ... rely on using their credit cards, the digital currency, ... for payment services led by companies in the space ... Google, Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
(Date:8/10/2015)... , August 10, 2015 The latest ... offers comprehensive analysis of the global border security market ... revenues of $16.4bn in 2015. Now: Border security ... an example of the business critical issue you need to ... visiongain ,s objective analysis of how this will impact ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9
... identified the role of transforming growth hormone factor-Beta (TGF-Beta) ... lung, has been selected to receive the inaugural AACR ... spent more than two decades defining how TGF-Beta affects ... of TGF-Beta receptors led to the spread of cancer ...
... a Brown University scientist, and graduate student Adrian Nestor ... dozens of faces. They determined that men tend to ... common for women. The finding has important implications ... face perception. But the information also has a ...
... ARBOR, Mich.---Scientists have identified 12 new genes that are ... levels, others link melatonin and sleep patterns to small ... risk of diabetes. While these associations are ... and some of them could help explain conditions that ...
Cached Biology News:Men are red, women are green, Brown researcher finds 2Men are red, women are green, Brown researcher finds 3New genes present drug targets for managing cholesterol and glucose levels 2New genes present drug targets for managing cholesterol and glucose levels 3
(Date:9/2/2015)... , September 2, 2015 ... Gewinner des Wettbewerbs BeHEARD von 2015 bekanntgeben zu ... vom Rare Genomics Institute. Biovista unterstützt ... Medikamenten für die Behandlung anderer Krankheiten als denen, ... Steven Laffoon und sein Team bei der ...
(Date:9/2/2015)... ... September 02, 2015 , ... Temarry Recycling's new $100,000 waste ... energy process and continue to contribute to the sustainability of our natural resources. ... Energy process has been operating at their Mexico facility, Recicladora Temarry, for the ...
(Date:9/1/2015)... 2, 2015 Swecure, ... Forschung und Entwicklung neuartiger Therapien für Störungen ... und Reizdarm konzentriert, erhält vom US Patent ... neues Medikament patentiert wird. Das Medikament basiert ... Kindern verhindert und Entzündungen vorbeugt.   ...
(Date:9/1/2015)... EDISON, N.J. , Sept. 1, 2015  ContraVir ... focused on the development and commercialization of targeted antiviral ... Rodman & Renshaw 17 th Annual Global Investment ... taking place September 8-10, 2015 at The St. Regis ... James Sapirstein , Chief Executive ...
Breaking Biology Technology:Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2Temarry Recycling’s New $100,000 Waste to Energy Renovation 2Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2ContraVir to Present at Rodman & Renshaw 17th Annual Global Investment Conference 2
... CHAPEL HILL, N.C., March 21, 2011 Although top ... critical in the successful launch of a new product, ... levels of KOL engagement. Consequently, the role of Medical ... leaders has grown dramatically in recent years. ...
... 21, 2011 ICAP Ocean Tomo will ... nebulizer on March 31st at the ICAP Ocean Tomo ... technology of this patent portfolio provides improvements to existing ... Recent technological advancements have triggered the use of ...
... 21, 2011 Peter M. DeComo, Chairman of the ... (PLSG), the organization providing capital investments and customized company ... sciences enterprises, today congratulated John W. Manzetti and the ... 2011 Outstanding Leadership in Technology category winner at ...
Cached Biology Technology:Newly Updated for 2011: Medical Science Liaison Study Shows Growth in KOL Outreach, Impact 2ICAP Ocean Tomo Announces the Auction of an Improved Compact, Portable Nebulizer Developed and Patented by Tidal Air 2ICAP Ocean Tomo Announces the Auction of an Improved Compact, Portable Nebulizer Developed and Patented by Tidal Air 3ICAP Ocean Tomo Announces the Auction of an Improved Compact, Portable Nebulizer Developed and Patented by Tidal Air 4John W. Manzetti and the Pittsburgh Life Sciences Greenhouse Recognized as 2011 Outstanding Leader in Technology 2
... The PROTEAN II xi multi-cell is for ... with efficient cooling capabilities. The PROTEAN II xi ... length, comb, type of glass plates, and cooling ... be converted to the PROTEAN II XL multi-cell ...
F40 piston seals are supplied as 2 seals with a seal tool to service one F40 pump of a BioLogic DuoFlow workstation....
... Cell permeable fluorescent minor groove-binding probe for ... double-stranded DNA (preferentially to AT rich DNA), ... 20 times greater than DAPI alone. DAPI ... bromide for staining DNA in agarose gels. ...
Mol wt: monoisotopic mol wt1,045.5423 Da by calculation...
Biology Products: