Navigation Links
Preventing ear infections in the future: Delivering vaccine through the skin
Date:5/21/2009

An experimental vaccine applied the surface of the skin appears to protect against certain types of ear infections. Scientists from the Research Institute at Nationwide Children's Hospital in Columbus, Ohio, report their findings today at the 109th General Meeting of the American Society for Microbiology in Philadelphia.

"Our data are the first to show that transcutaneous immunization is an effective way to prevent experimental ear infections and lays the foundation for an effective, yet simple, inexpensive and potentially transformative way to deliver vaccines," says Laura Novotny, one of the study researchers.

Nontypeable Haemophilus influenzae (NTHi) is one of the three main bacterial causes of otitis media (OM), an infection or inflammation of the middle ear. OM is one of the most significant health problems for children in the United States, costing approximately $5 billion annually. It is estimated that 83% of all children will experience at least one ear infection prior to 3 years of age.

Currently infections are managed with antibiotics; however, the emergence of antibiotic-resistant microorganisms is of concern. Surgery to insert tubes through the tympanic membrane relieves painful symptoms, but the procedure is invasive and requires the child to be under general anesthesia. Thus, it is necessary to develop different ways to treat or preferably prevent this disease.

"We have designed several vaccine candidates which target proteins on the outer surface of this bacterium. Previous work in our lab showed that after immunization by injection, each of the three vaccine candidates prevented experimental ear infections caused by NTHi. In this study, we now wanted to test an alternative but potentially equally effective method to deliver a vaccine," says Novotny.

The method, known as transcutaneous immunization, involved placing a droplet of each vaccine onto the ear and rubbing it into the skin.


'/>"/>
Contact: Jim Sliwa
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preventing tuberculosis reactivation
2. Environmental epigenetics has potential for preventing and treating disease
3. Streams remove significant amounts of nitrogen, preventing downstream dead zones
4. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
5. MIT: Preventing forest fires with tree power
6. Kazak apple research key to preventing blue mold
7. Preventing a broken heart: Research aims to reduce scarring from heart attacks
8. Preventing soil erosion in continuous corn
9. Fast-food diet cancels out benefits of breastfeeding in preventing asthma
10. New vaccine developed for preventing uncommon cold virus
11. Preventing rangeland erosion: Developing better management practices in Iran
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... essential fatty acids and energy to infants and ... concern that soybean-based emulsions could compromise immune functions ... Combination lipid emulsions based on triglyceride oil, fish ... address this concern. , However, researchers at Rutgers ... unwarranted, according to a review published today in ...
(Date:7/22/2014)... The exhibit consists of both still images and ... of scientific research. Forty-four still images were chosen ... students, postdocs, staff, and alumni representing more than ... from more than 50 submissions. , Zach Donnell, ... of the 2014 organizers, noted that the exhibit ...
(Date:7/22/2014)... Aware, Inc. (NASDAQ: AWRE ), a ... results for its second quarter ended June 30, 2014. ... million, an increase of 53% compared to $4.4 million in ... income in the second quarter of 2014 was $1.4 million ... The increase in revenue and operating income was driven by ...
Breaking Biology News(10 mins):Art of Science 2014 2Aware, Inc. Reports Second Quarter 2014 Financial Results 2Aware, Inc. Reports Second Quarter 2014 Financial Results 3Aware, Inc. Reports Second Quarter 2014 Financial Results 4Aware, Inc. Reports Second Quarter 2014 Financial Results 5Aware, Inc. Reports Second Quarter 2014 Financial Results 6Aware, Inc. Reports Second Quarter 2014 Financial Results 7
... (NASDAQ: ABPI) announces evidence that most, if not all ... fungal-induced inflammation as originally proposed by investigators at the ... of the Companys ongoing pivotal Phase 3 clinical trial ... of the antifungal amphotericin B 0.01% suspension. In ...
... most renowned physicists and engineers, OSA,s Frontiers in Optics meeting ... developments in the science of light. What: Frontiers ... 16-20, 2007 Where: Fairmont Hotel, San Jose, Calif. ... A new device that may help give sight to the ...
... great flood of Noahs generation really occur thousands of years ... ancient tsunami" Will pollution levels in our deep seas remain ... of the questions that are being addressed by a new ... non-profit research and education organization, EcoOcean. The team, ...
Cached Biology News:SinuNase Phase 3 show almost 100 percent of chronic sinusitis cases are from fungal-induced inflamma 2Frontiers in Optics presents scientific advancements 2TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 2TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 3
(Date:7/22/2014)... phylum so full of mean little creatures, the yellow-colored Ormia ... -- at least to crickets. Native to the southeastern U.S. ... sort of parasite. It swoops onto the back of a ... its wicked brood to invade, kill and consume the cricket ... possible without the fly,s ability to find a cricket -- ...
(Date:7/22/2014)... engineering at the University of Texas at Dallas, has ... Texas section of the American Society of Mechanical Engineers ... 158 countries who develop engineering standards and training. They ... the world. , ASME recognized Baughn earlier this year ... Baughn retired as an engineering fellow in 2012 after ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer and ... and other markets, announced today that it has closed ... private investors led by Novit L.P., an investment arm ... involved the signing of a Securities Purchase Agreement under ... at a price per share of $1.00, resulting in ...
(Date:7/22/2014)... 22, 2014 The DNA Spectrum ... concise visual representation of history, migration, and culture. ... regaled by family history stories stemming from Europe. His ... "old country." Pictures and 8mm home movies painted an ... the family, and Steve ordered a test from DNA ...
Breaking Biology Technology:Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4UT Dallas professor receives Engineer of the Year award 2CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 2DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 3DNA Test from DNA Spectrum Shows Heritage Like a Map of the Past 4
... Calif., May 28 CV Therapeutics,Inc. (Nasdaq: ... Nasdaq,marketplace rule 4350, the Company issued new inducement ... hiring, primarily in connection,with its commercialization efforts in ... cover an aggregate 151,800 shares of,common stock and ...
... with research institute to aid in successful mid-career changes, ... Center,( http://www.biocareercenter.com ) an online job board and careers ... Research,Institute who has developed Career Navigator -- a new ... within their fields with success --,to launch this new ...
... SoluLinK, Inc., a leader in,next-generation conjugation products ... of a new product, NanoLink(TM) Streptavidin Magnetic,Microspheres. ... of any commercially available polymer-encapsulated streptavidin,magnetic microsphere. ... throughput robotic applications where high biotin loads,must ...
Cached Biology Technology:CV Therapeutics Reports Option Grants Under Nasdaq Marketplace Rule 4350 2Online Career Service Turns Focus to 'Switching Gears' 2SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres 2
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: filling ...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... A simultaneous dual parameter assay ... poly caspase activity. Active caspases are ... peptide inhibitors, which are cell-permeable, non-cytotoxic ... caspases within the cells. At the ...
... in DMEM and harvested at the log phase ... antigens in their native forms, cells were fixed ... a 12-well (5 mm) adhesive coated slide, with ... attachment and to minimize background staining. Each ...
Biology Products: