Navigation Links
Preventing ear infections in the future: Delivering vaccine through the skin
Date:5/21/2009

An experimental vaccine applied the surface of the skin appears to protect against certain types of ear infections. Scientists from the Research Institute at Nationwide Children's Hospital in Columbus, Ohio, report their findings today at the 109th General Meeting of the American Society for Microbiology in Philadelphia.

"Our data are the first to show that transcutaneous immunization is an effective way to prevent experimental ear infections and lays the foundation for an effective, yet simple, inexpensive and potentially transformative way to deliver vaccines," says Laura Novotny, one of the study researchers.

Nontypeable Haemophilus influenzae (NTHi) is one of the three main bacterial causes of otitis media (OM), an infection or inflammation of the middle ear. OM is one of the most significant health problems for children in the United States, costing approximately $5 billion annually. It is estimated that 83% of all children will experience at least one ear infection prior to 3 years of age.

Currently infections are managed with antibiotics; however, the emergence of antibiotic-resistant microorganisms is of concern. Surgery to insert tubes through the tympanic membrane relieves painful symptoms, but the procedure is invasive and requires the child to be under general anesthesia. Thus, it is necessary to develop different ways to treat or preferably prevent this disease.

"We have designed several vaccine candidates which target proteins on the outer surface of this bacterium. Previous work in our lab showed that after immunization by injection, each of the three vaccine candidates prevented experimental ear infections caused by NTHi. In this study, we now wanted to test an alternative but potentially equally effective method to deliver a vaccine," says Novotny.

The method, known as transcutaneous immunization, involved placing a droplet of each vaccine onto the ear and rubbing it into the skin.


'/>"/>
Contact: Jim Sliwa
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preventing tuberculosis reactivation
2. Environmental epigenetics has potential for preventing and treating disease
3. Streams remove significant amounts of nitrogen, preventing downstream dead zones
4. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
5. MIT: Preventing forest fires with tree power
6. Kazak apple research key to preventing blue mold
7. Preventing a broken heart: Research aims to reduce scarring from heart attacks
8. Preventing soil erosion in continuous corn
9. Fast-food diet cancels out benefits of breastfeeding in preventing asthma
10. New vaccine developed for preventing uncommon cold virus
11. Preventing rangeland erosion: Developing better management practices in Iran
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 , Europe,s ... The European Patent Office to present a video retrospective of ... to be featured: Christofer Toumazou and Sophie Wilson ... and winners of the Award   Starting on 22 ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal genetics ... fine-scale differences in genetic ancestry of individuals from across ... first arrived more than four hundred years ago, ... place for peoples from different continents. This study illuminates how ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Department of Energy,s Oak Ridge National Laboratory and St. ... nerve cells may hold a key to predicting and ... St. Jude scientists have linked movement and changes ... retinas of young mice to certain diseases. Now, for ...
... have 43 percent increased odds of having moderate ... birth compared to mothers of single-born children, according ... of Public Health. Researchers examined the relationship between ... that multiple births increased the odds of maternal ...
... animals of omega 3 fatty acids in fish oils have ... improving meat quality and reducing methane emissions. These last ... is important for the environment, as methane given off by ... Today (Monday 30 March) researchers from University College Dublin reported ...
Cached Biology News:ORNL, St. Jude track neurons to predict and prevent disease 2Mothers of multiple births at increased odds of postpartum depression 2
(Date:1/22/2015)... The laboratory information management systems market ... number of technological advancements due to factors such as ... to integrate healthcare systems, and increasing government support for ... integration. Key players in the market focus on technological ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... CHARLOTTESVILLE, Va., Dec. 21 Diffusion Pharmaceuticals,LLC, ... utilizing a novel mechanism of action that ... its key advisors, Mr. Thomas,Byrne, was recently ... of Amgen,s blockbuster drug Aranesp(R) (darbepoietin alpha), ...
... to serve Pacific Northwest, SEATTLE, Dec. 21 ... the western Washington state congressional delegation has,resulted in ... development,of a state-of-the-art proton-beam therapy center by the ... in the 2008 Omnibus Appropriations,bill signed by President ...
... 21 Abbott (NYSE: ABT ),will present at ... 7, 2008. Thomas C. Freyman, executive vice president, finance ... the company at,11:00 a.m. Central time., A live ... Investor Relations Web site at http://www.abbottinvestor.com . An,archived ...
Cached Biology Technology:Co-Inventor of Amgen's Aranesp(R) Technology Directs Worldwide Patent Strategy for Diffusion Pharmaceuticals' First-in-Class Oxygen Enhancing Therapeutics 2Murray Leads Delegation in Securing $2.1 Million for Proton Therapy Center 2Murray Leads Delegation in Securing $2.1 Million for Proton Therapy Center 3
Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides Assay: ~ 95 % Suitab tst: differential staining of nucleic acids and prote...
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
... patented MasterAmp™ 10X PCR Enhancer (with ... allows improved sensitivity and specificity for ... MasterAmp™ PCR Enhancer in PCR eliminates ... melting, increases enzyme?s thermal stability, suppresses ...
... The simple three step procedure (PCR, Exonuclease ... completed in one day. The typical cloning ... 80%. , Features and Benefits: , , ... into any expression vector , High Cloning ...
Biology Products: