Navigation Links
Preventing ear infections in the future: Delivering vaccine through the skin
Date:5/21/2009

An experimental vaccine applied the surface of the skin appears to protect against certain types of ear infections. Scientists from the Research Institute at Nationwide Children's Hospital in Columbus, Ohio, report their findings today at the 109th General Meeting of the American Society for Microbiology in Philadelphia.

"Our data are the first to show that transcutaneous immunization is an effective way to prevent experimental ear infections and lays the foundation for an effective, yet simple, inexpensive and potentially transformative way to deliver vaccines," says Laura Novotny, one of the study researchers.

Nontypeable Haemophilus influenzae (NTHi) is one of the three main bacterial causes of otitis media (OM), an infection or inflammation of the middle ear. OM is one of the most significant health problems for children in the United States, costing approximately $5 billion annually. It is estimated that 83% of all children will experience at least one ear infection prior to 3 years of age.

Currently infections are managed with antibiotics; however, the emergence of antibiotic-resistant microorganisms is of concern. Surgery to insert tubes through the tympanic membrane relieves painful symptoms, but the procedure is invasive and requires the child to be under general anesthesia. Thus, it is necessary to develop different ways to treat or preferably prevent this disease.

"We have designed several vaccine candidates which target proteins on the outer surface of this bacterium. Previous work in our lab showed that after immunization by injection, each of the three vaccine candidates prevented experimental ear infections caused by NTHi. In this study, we now wanted to test an alternative but potentially equally effective method to deliver a vaccine," says Novotny.

The method, known as transcutaneous immunization, involved placing a droplet of each vaccine onto the ear and rubbing it into the skin.


'/>"/>
Contact: Jim Sliwa
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preventing tuberculosis reactivation
2. Environmental epigenetics has potential for preventing and treating disease
3. Streams remove significant amounts of nitrogen, preventing downstream dead zones
4. Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
5. MIT: Preventing forest fires with tree power
6. Kazak apple research key to preventing blue mold
7. Preventing a broken heart: Research aims to reduce scarring from heart attacks
8. Preventing soil erosion in continuous corn
9. Fast-food diet cancels out benefits of breastfeeding in preventing asthma
10. New vaccine developed for preventing uncommon cold virus
11. Preventing rangeland erosion: Developing better management practices in Iran
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... , Oct. 15, 2014 Sandata ... for home and community-based care, today announced it ... implementing Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™) ... is a home health company founded in 1996 ... . The study details ...
(Date:10/15/2014)... linked increased resistance to bacterial pneumonia in female mice ... estrogen. , Females are naturally more resistant to respiratory ... has shown that increased resistance to bacterial pneumonia in ... synthase 3 (NOS3). They also show that this enzyme ... sex hormone estrogen. , The team, lead by Professor ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to inhibit ... development of skin cancers by turning on an enzyme ... cells. , Previously considered protective, SIRT6 is part of ... regulate genomic stability and prevent some of the genetic ... which can lead to cancer. This study, in the ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... of light for more than a billion people in developing ... overlooked in greenhouse gas estimates, according to a new study ... the University of Illinois. Results from field and ... kerosene in wick lamps used for light in 250-300 ...
... varieties with higher yields and enhanced nutritional content, researchers ... with scientists at nine other institutions in an attempt ... endeavor, led by researchers at the U.K.-based Biotechnology and ... in the journal Nature . "This work ...
... white blood cells has a surprising second role in protecting ... researchers report. The molecule, microRNA-223, affects how cells respond to ... and thus the cells, likelihood of suffering permanent damage. ... very specific effects in the brain, one that could be ...
Cached Biology News:Study IDs kerosene lamps as big source of black carbon 2UC Davis researchers aid effort to sequence the complex wheat genome 2Double duty: Immune system regulator found to protect brain from effects of stroke 2
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... October 20, 2014 Earle ... LLC, announced today that Ellen Teplitzky, an experienced ... for the pharmaceutical industry, has joined the firm ... its legal services practice. NDA Partners provides ... witness and testimony, to top law firms and ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Joshua Hare to Chair the Board LA JOLLA, Calif., ... CDXP) announced today the formation of a Medical Advisory ... program of CDP-1050 for the treatment of heart failure.The ... in the design and oversight of the planned CDP-1050 ...
... /PRNewswire-Asia-FirstCall/ -- China Biologic,Products, Inc. (OTC ... the,Company,), one of the leading plasma-based ... China (,PRC,), today announced that the ... Products Co.,Ltd. (,Shandong Taibang,) has been ...
... Pain IndicationsLA JOLLA, Calif., Feb. 11 TorreyPines ... announced that oral administration of NGX426, an AMPA/kainate-type ... healthy male and female subjects when dosed once ... this Phase I trial demonstrating the safety and ...
Cached Biology Technology:Cordex Pharma Forms Heart Failure Medical Advisory Board 2Cordex Pharma Forms Heart Failure Medical Advisory Board 3Cordex Pharma Forms Heart Failure Medical Advisory Board 4Cordex Pharma Forms Heart Failure Medical Advisory Board 5China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 2China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 3First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 2First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 3First Multiple Dose Clinical Trial of TorreyPines Therapeutics' Oral Compound NGX426 Demonstrates Compound Is Safe and Well-Tolerated 4