Navigation Links
Pressurized virus blasts its infectious DNA into human cells
Date:7/24/2013

The virus that causes those painful lip blisters known as cold sores has an internal pressure eight times higher than a car tire, and uses it to literally blast its infectious DNA into human cells, scientists are reporting in a new study. Discovery of the pressure-driven infection mechanism the first in a human virus opens the door to new treatments for viral infections, they add in a study in the Journal of the American Chemical Society.

Alex Evilevitch and colleagues point out that the viruses responsible for influenza, AIDS and other infections that affect millions of people annually are quick to develop resistance to drugs that target viral proteins. Through genetic mutations, these proteins can quickly disguise themselves and evade anti-viral drugs. That has led to a search for vulnerabilities that don't involve viral proteins. Evilevitch's team looked at the pressure inside the herpes simplex virus 1 (HSV-1), the virus that causes cold sores.

They describe how HSV-1 enters cells, docks with portals on the nucleus and injects DNA with high pressure caused by tight packing of the capsid, the tough shell that houses the viral genome. Researchers already knew that several viruses that infect bacteria, called bacteriophages, use the same high-pressure mechanism to shoot their DNA into bacteria nuclei. Evilevitch and colleagues conclude that evolution has preserved this effective technique as a key step in viral infection making it a desirable target for future treatments to defeat HSV-1 and other viruses that work the same way. The same mechanism exists in eight related viruses, including those responsible for mononucleosis and chickenpox in children, and shingles in adults. Drugs that interfere with it thus could limit "the potential for development of drug resistance that can occur due to rapid adaptive mutations of viral genomes," the scientists state.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
3. To drive infections, a hijacking virus mimics a cells signaling system
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Researchers identify Achilles heel of dengue virus, target for future vaccines
7. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
8. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
9. Berkeley Lab scientists generate electricity from viruses
10. Virus barcodes offer rapid detection of mutated strains
11. Army study: DNA vaccine and duck eggs protect against hantavirus disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/19/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... group of leading UK scientists and social scientists led by the ... joined-up thinking on the emerging politics of plants. Green is ... of plants from food to fuel, industrial feedstocks to carbon ... cornerstone of the global economy. But such fame comes ...
... Feb. 24 BIO-key International, Inc. (OTC Bulletin Board: ... biometric identification solutions, today reported results for the fourth ... Company,s results reflected profitability for the fourth quarter and ... strong revenue growth for the quarter and the year. ...
... Damon Runyon Cancer Research Foundation named 13 new ... Award Committee review. The recipients of this ... basic and translational cancer research in the laboratories ... The Fellowship is specifically intended to encourage the ...
Cached Biology News:Plants are political hot potatoes 2BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 2BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 3BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 4BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 5BIO-key(R) Reports Profitability for Fourth Quarter and Full Year 2008 6Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 3Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators 4
(Date:5/22/2015)... , May 22, 2015 ... by Product (1D & 2D Gel Electrophoresis, Agarose & ... MEKC, Reagents, Informatics), by Application & by End User ... Electrophoresis Market is expected to reach around $1.98 Billion ... forecast period 2015 to 2020. Browse ...
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)...  Prima Biomed Ltd. (NASDAQ: PBMD ) a ... a leader in the development of immunotherapeutic products for ... CVac data from the Phase II CAN-003 ovarian cancer ... clinically meaningful improvement in Overall Survival ("OS") over standard ... In the group of second remission patients (n=20), the ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 W. ... its manufacturing facility in Worms, Germany has received ... independent subsidiary of the International Pharmaceutical Excipient Council ... facilities that produce its SYLOID® FP brand of ... GMP certification, following the Curtis Bay, Maryland (USA) ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Correction Continues after Big Move - BrokerBank Securities, Inc. 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... Fisher,Scientific Inc. (NYSE: TMO ) today ... a leading third-party logistics provider to the,pharmaceutical ... was previously majority-owned by Arsenal Capital,Partners. With ... Priority,Solutions offers a comprehensive range of services ...
... With a special eye for the,details hidden from casual ... G. Aspinall. Photographs of architectural details from beaches,to buildings ... fore. The,collection includes images from seven different countries., ... the,president of Genzyme Genetics, is also a talented artist ...
... - Biomira Inc. (Nasdaq: BIOM ),(TSX: BRA) ... Chief,Executive Officer, is scheduled to present at the ... EDT on Wednesday, October 10. The presentation ... be accessed at: http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=BIOM&item_id=1 ,657575 ...
Cached Biology Technology:Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4An Uncommon Eye: Photography Exhibit by Biotechnology Executive at BHCC Gallery 2