Navigation Links
Pressurized virus blasts its infectious DNA into human cells
Date:7/24/2013

The virus that causes those painful lip blisters known as cold sores has an internal pressure eight times higher than a car tire, and uses it to literally blast its infectious DNA into human cells, scientists are reporting in a new study. Discovery of the pressure-driven infection mechanism the first in a human virus opens the door to new treatments for viral infections, they add in a study in the Journal of the American Chemical Society.

Alex Evilevitch and colleagues point out that the viruses responsible for influenza, AIDS and other infections that affect millions of people annually are quick to develop resistance to drugs that target viral proteins. Through genetic mutations, these proteins can quickly disguise themselves and evade anti-viral drugs. That has led to a search for vulnerabilities that don't involve viral proteins. Evilevitch's team looked at the pressure inside the herpes simplex virus 1 (HSV-1), the virus that causes cold sores.

They describe how HSV-1 enters cells, docks with portals on the nucleus and injects DNA with high pressure caused by tight packing of the capsid, the tough shell that houses the viral genome. Researchers already knew that several viruses that infect bacteria, called bacteriophages, use the same high-pressure mechanism to shoot their DNA into bacteria nuclei. Evilevitch and colleagues conclude that evolution has preserved this effective technique as a key step in viral infection making it a desirable target for future treatments to defeat HSV-1 and other viruses that work the same way. The same mechanism exists in eight related viruses, including those responsible for mononucleosis and chickenpox in children, and shingles in adults. Drugs that interfere with it thus could limit "the potential for development of drug resistance that can occur due to rapid adaptive mutations of viral genomes," the scientists state.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
3. To drive infections, a hijacking virus mimics a cells signaling system
4. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
5. Harmless human virus may be able to boost the effects of chemotherapy
6. Researchers identify Achilles heel of dengue virus, target for future vaccines
7. Recapitulation of the entire hepatitis C virus life in engineered mouse cell lines
8. BGI, GMU, Mass. Eye and Ear and OUHSC announce agreement to sequence 100 human adenoviruses
9. Berkeley Lab scientists generate electricity from viruses
10. Virus barcodes offer rapid detection of mutated strains
11. Army study: DNA vaccine and duck eggs protect against hantavirus disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Migratory songbirds are disappearing, and though conservationists are examining ... habitat, acid rain and light pollution, a key piece ... birds go once they leave their breeding sites, and ... , To answer this question, a team of researchers ... migratory connectivity map produced for a songbird, using tracking ...
(Date:7/23/2014)... around the world have no access to clean drinking ... million people die from water-related diseases every year. ETH ... a contribution to solving this problem. Working with researchers ... the Functional Materials Laboratory, the 23-year-old spent a year ... "What makes our DrinkPure filter unique is that you ...
(Date:7/23/2014)... available in German . ... cells, drive metabolic processes and transmit signals. To perform ... Scientists at the Max Planck Institute for Developmental Biology ... constructed of similar amino acid chains even when their ... that exist today arose from common precursors. Presumably, in ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2ETH student develops filter for clean water around the world 2Protein evolution follows a modular principle 2
... small nucleus, is the term coined by early biologists ... saw under the microscope. In this structure within the ... ribosomes, the true protein factories of cells. ... diseases, most recently also in neurodegenerative disorders such as ...
... Feb. 1, 2011/PRNewswire-Asia-FirstCall/ -- Weikang Bio-Technology Group Co., ... ("Weikang" or the "Company"), a leading developer, manufacturer ... prescription and OTC pharmaceuticals and other health and ... today announced the completion of its private placement ...
... future diagnosis and treatment of lupus, an immune ... researchers at the Virginia-Maryland Regional College of Veterinary ... the breakdown in the body,s lymphocyte molecular regulatory ... and her colleagues in the veterinary college,s Department ...
Cached Biology News:A possible cause of Parkinson's disease discovered 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 3Research uncovers key to understanding cause of lupus 2
(Date:7/23/2014)... 2014  Sofinnova Ventures, a Menlo Park ... of Sofinnova Venture Partners IX, L.P. at the hard ... initial fund target of $425 million. Sofinnova ... Consistent with recent funds, SVP IX will provide capital ... along with select investments in earlier stage opportunities. Investments ...
(Date:7/23/2014)... 2014 With the ability to record continuously ... more than 15 minutes, Fastec Imaging has brought the same ... speed imaging. “Finally, a high speed camera that can be ... our everyday lives.” proclaims Matt Kearney, VP of Sales for ... to demystify and simplify the traditionally complicated workflow of a ...
(Date:7/23/2014)... Columbia, MD (PRWEB) July 23, 2014 ... Booth and ChirpE Mobile App, AACC Pathfinder, in its ... event offerings. AACC’s annual meeting is planned for July ... is the place to be to connect with global ... medicine, lab management, and other areas of breaking science ...
(Date:7/23/2014)... Cambridge, MA (PRWEB) July 23, 2014 ... provider of innovative and comprehensive consultancy and pharma ... Research Excellence and Safety (ACRES) , a non-profit ... worldwide to build and maintain a global system ... strategic alliance collaboration to improve the expertise of ...
Breaking Biology Technology:Sofinnova Raises $500 Million Biotech Venture Fund 2Fastec Imaging Introduces the First High Speed Camcorder 2Fastec Imaging Introduces the First High Speed Camcorder 3AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 2Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 3
... chemists at Lehigh University have experimentally verified the "rainbow" ... light waves over a broad range of wavelengths. ... be slowed down or stopped using plasmonic structures has ... The Lehigh experiment employed focused ion beams to mill ...
... Taiho Pharmaceutical Co., Ltd., and its parent company, Otsuka ... (EC) has granted marketing authorization for Teysuno™ (S-1), a ... adults with advanced gastric cancer when given in combination ... Member States and the three European Economic Area (EEA) ...
... Co., Inc. (NYSE Amex: TPI ), a ... traditional Chinese medicine, branded generics and other pharmaceuticals is ... Growth Stock Conference from March 13 - 16, 2011 ... Dr. James Jiayuan Tong, Chief Financial Officer, Chief ...
Cached Biology Technology:Trapping a rainbow: Lehigh researchers slow broadband light waves with nanoplasmonic structures 2Teysuno™ (S-1) Receives European Marketing Authorization as First-Line Therapy for Advanced Gastric Cancer 2Teysuno™ (S-1) Receives European Marketing Authorization as First-Line Therapy for Advanced Gastric Cancer 3TPI Attends 23rd ROTH Annual OC Growth Stock Conference from March 13-16, 2011 2
Mouse polyclonal antibody raised against a partial recombinant CSRP3. NCBI Entrez Gene ID = 8048...
...
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
Rabbit polyclonal to MCP2 ( Abpromise for all tested applications). entrezGeneID: 6355 SwissProtID: P49873...
Biology Products: