Navigation Links
Prenatal testosterone levels influence later response to reward
Date:11/5/2012

els are also heightened during critical periods of fetal brain development, but the impact of such prenatal surges in sex hormone levels on subsequent adult brain and behavioral development has received relatively little attention.

"This study is the first to directly examine whether testosterone in fetal development predicts tendencies later in life to engage in approach-related behavior (e.g., fun-seeking, impulsivity, reward responsivity) and also how it may influence later brain development that is relevant to such behaviors," said first author Lombardo.

In this study, they tested a unique cohort of boys, 8 years of age, whose fetal testosterone had been previously measured from amniotic fluid at 13 weeks gestation. The boys were scanned with functional magnetic resonance imaging technology to assess changes in brain activity while viewing pictures of negative (fear), positive (happy), neutral, or scrambled faces.

They found that increased fetal testosterone predicted more sensitivity in the brain's reward system to positively, compared to negatively, valenced facial cues. This means that reward-related brain regions of boys with higher fetal testosterone levels respond more to positive facial emotion compared to negative facial emotion than boys who with smaller levels of fetal testosterone.

In addition, increased fetal testosterone levels predicted increased behavioral approach tendencies later in life via its influence on the brain's reward system. Lombardo explained, "This work highlights how testosterone in fetal development acts as a programming mechanism for shaping sensitivity of the brain's reward system later in life and for predicting later tendency to engage in approach-related behaviors. These insights may be especially relevant to a number of neuropsychiatric conditions with skewed sex ratios and which affect approach-related behavior and the brain's reward system."

Dr. John Krystal, Editor of Biolog
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Tracking the effects of prenatal alcohol exposure through to 9 years of age
2. Prenatal whole genome sequencing: Just because we can, should we?
3. Prenatal micronutrient, food supplementation intervention in Bangladesh decreases child death rate
4. Prenatal exposure to air pollution linked to childhood obesity
5. Testosterone regulates solo song of tropical birds
6. Testosterone-fuelled infantile males might be a product of Moms behaviour
7. New genes discovered for adult BMI levels
8. Measuring mercury levels: Nano-velcro detects water-borne toxic metals
9. High levels of DDT in breast milk
10. Climate change could increase levels of avian influenza in wild birds
11. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market announces that its Wocket® smart wallet will be the ... scheduled to air on WABC Radio (am770) in ... The broadcast air- time for the extensive one ... Inc.,s CEO Gino Pereira will be discussing its ...
(Date:6/17/2015)... Germany , June 17, 2015 ... QIA) today launched new Investigator ® STR assay kits ... the United States . The new genetic fingerprint ... genomic markers (short tandem repeats or STRs) for DNA matching. ... the quality of DNA in each sample, a novel QIAGEN ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
... an important role in various addictions, such as alcoholism ... is due, in part, to genetic factors, reveals new ... is a neuropeptide that both activates the brain,s reward ... are hungry, levels of ghrelin increase, activating the brain,s ...
... Alberta-led research team has determined that the mountain pine beetle ... possibility for an infestation that could stretch across the Prairies ... of U of A tree biologists and geneticists discovered that, ... Columbia, it successfully jumped species from its main host, the ...
... in the United States in late 2004, many producers feared ... of the world. In response to this threat, researchers have ... fungus, and a recent report in Crop Science ... to determine which of the soybean germplasm accessions were resistant ...
Cached Biology News:Genetic changes behind sweet tooth 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 2Soybean germplasm evaluations give US a head start against soybean rust pathogen 3
(Date:6/30/2015)... Japan , July 1, 2015 R-Japan Co.,Ltd. ... on the Safety of Regenerative Medicine from the Ministry of ... on June 29, 2015. The fact that ... processing facility through the auditing from Pharmaceuticals and Medical Devices ... the application, allows it to provide stem cell manufacturing service ...
(Date:6/30/2015)... , June 30, 2015  NASA astronaut Kjell Lindgren ... month on his first mission to the International Space ... 8 to 9 a.m. EDT Tuesday, July 7. ... Star City, Russia . The interviews will ... Television highlighting his mission training. To schedule an ...
(Date:6/30/2015)... ... June 30, 2015 , ... With its ... sacrifice selectivity to achieve faster flow rates in comparison to nylon or polyethersulfone ... open space to allow easy liquid flow while trapping particulates as small as ...
(Date:6/30/2015)... June 30, 2015  The University of California, ... (CCE/Bio) and UC San Diego Extension announced their ... held Aug.  12 – 14, 2015, at UC ... workshop provides an intense exposure to best practices ... is well-suited to biologists, process engineers and business ...
Breaking Biology Technology:R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2New Nanofiber Membrane Provides Fast, Efficient Filtration 2UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2
... with Pfizer,s recently ... MALIBU, Calif., Nov. 15 Pathway Diagnostics announces,that the ... Patent,number 7,294,458 (the ,458 patent) entitled "Analysis of HIV-1 ... Diagnostics,has licensed the ,458 patent (with rights to sub-license) ...
... At a meeting of the,Board of ... ), held today, a dividend of ... outstanding shares of Preferred Stock was,declared ... stockholders of record at the close,of ...
... George Abercrombie, Pfizer R&D Head Martin,Mackay, HHS Deputy Secretary ... Headline Agenda at FDA/CMS Summit 2007, WASHINGTON, Nov. ... for drug approvals. Unfortunately for the biopharma sector and,investors, ... is on track,to grant marketing approval to 18 or ...
Cached Biology Technology:Pathway Diagnostics Announces Patent Issuance for the Diagnostic Measurement of HIV Tropism for the Initiation or Modification of HIV Therapy 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 3