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Prenatal exposure to certain pesticides may negatively impact cognitive development in children
Date:4/20/2011

metabolizes organophosphates, paraoxonase 1 (PON1). They found that the negative effects of organophosphates were limited to children of mothers who carried a genotype associated with a less efficient version of this enzyme.

"Nearly a third of the mothers in this study carried the PON1 genotype that would put their children at highest risk of negative effects from organophosphate pesticide exposure," said Dr. Engel, who is currently Associate Professor of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. "These highly susceptible individuals may account for the majority of exposure-related cognitive impairment. However, it's not clear how the changing nature of general population exposure following the ban on residential use will impact our understanding of these effects. Exposure source may play an important role, and exposure through diet may now be the predominant source of exposure for the general population rather than indoor pest control."

Dr. Engel added, "Our study will be published along with two independent studies that examined prenatal organophosphate pesticide exposure in relation to childhood IQ using similar research methods. There are definite similarities in our findings that, taken as a whole, warrant careful consideration."


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Contact: Christie Corbett
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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