Navigation Links
Predicting the next eye pathogen; analysis of a novel adenovirus
Date:4/10/2013

BOSTON (April 10, 2013) The ongoing dance between a virus and its host distinctly shapes how the virus evolves. While human adenoviruses typically cause mild infections, recent reports have described newly characterized adenoviruses that can cause severe, sometime fatal, human infections.

Researchers from the Massachusetts Eye and Ear and Harvard Medical School, Provincial Laboratory for Public Health, School of Systems Biology, George Mason University, and the Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center report a systems biology approach to show how evolution has affected the disease potential of a recently identified novel human adenovirus. Their approach is based on the belief that understanding viral evolution and pathogenicity is essential to our capacity to foretell the potential impact on human disease for new and emerging viruses. Their study is now published in mBio.

Since the first adenovirus was characterized in 1953, 69 human adenoviruses (HAdVs) have been recognized as unique types. Analysis of whole-genome sequence data for existing and new HAdVs confirmed a critical role for homologous recombination in adenovirus evolution, leading to new and sometime serious human infections. The emergence of new HAdV types, with several associated with severe eye infection, promoted the investigators to apply a systems biology approach to try to predict the ocular tropism of a previously uncharacterized and highly novel HAdV, isolated by nasopharyngeal swab from a 4-month-old boy with several bronchiolitis.

A combined genomic, bioinformatics and biological analysis identified a unique deletion in a key protein of the viral capsid and further suggested the potential of the virus to cause severe ocular infection. The results point toward a possible approach for predicting pathogenicity for newly identified and recently emergent human pathogens.


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Page: 1

Related biology news :

1. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
2. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
3. Discovery of mechanisms predicting response to new treatments in colon cancer
4. Predicting how patients respond to therapy
5. New model could help fill data gap in predicting historical air pollution exposure
6. Cellular landscaping: Predicting how, and how fast, cells will change
7. Predicting the age at menopause of women having suffered from childhood cancers
8. Predicting a low carbon future for Toronto
9. Beyond the microscope: Identifying specific cancers using molecular analysis
10. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
11. A new application allows online statistical analysis of gene-expression data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
(Date:4/27/2015)... 2015 Profile Solutions, Inc. (OTC: PSIQ), a ... is pleased to announce that Dr Gerry Bedore ... member of its scientific advisory board. ... thought leader in technology-enhanced learning models. He was a ... published studies and books focused on online student success ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... of the Canadian Journal of Forest Research presents ... one of the first landscape-scale experiments on how ... The Blacks Mountain Interdisciplinary Research team includes U.S. ... U.C. Riverside, University of Georgia and Wildlife Conservation ...
... ago, bird beaks are exquisitely adapted to the birds, feeding ... explained exactly how some shorebirds use their long, thin beaks ... The phalarope, commonly found in western North America, takes advantage ... propel bits of food from the tip of its long ...
... Mass.--Having found that whether bacteria stick to surfaces depends ... have created ultrathin films made of polymers that could ... control microbe accumulation. The inexpensive, easy-to-produce films could ... care industry by helping to reduce the spread of ...
Cached Biology News:Pioneering landscape-scale research releases first findings 2MIT solves gravity-defying bird beak mystery 2MIT solves gravity-defying bird beak mystery 3MIT crafts bacteria-resistant films 2MIT crafts bacteria-resistant films 3
(Date:5/28/2015)... 28, 2015 The Fertility Centers of ... Dr. Danielle Vitiello has taken on a new and ... Vitiello will provide guidance, leadership, oversight and quality assurance ... Dr. Vitiello among our team of experienced reproductive endocrinologists,” ... Joseph A. Hill, M.D. “Her expertise and compassionate, individualized ...
(Date:5/28/2015)... 28, 2015 Global futurist and ... to ask his audiences if they are ready ... robotics, solar cells, fuel cells, rapid health care ... battery storage technology, driverless cars, artificial intelligence masquerading ... inexpensive online education. , While the majority ...
(Date:5/28/2015)... 28, 2015 In two different ... Sherley, M.D., Ph.D., will present the company’s unique approach ... a conference talk, he will describe Asymmetrex ’s ... with computer simulation to produce the first-ever technology for ... quality over time in culture. When leading an ...
(Date:5/27/2015)... , May 27, 2015 RXi ... company focused on discovering and developing innovative therapies ... today announced that it has commenced a public offering ... purchase shares of its common stock and overallotment ... stock. The shares of common stock, warrants and ...
Breaking Biology Technology:Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Futurist Jack Uldrich to Deliver 4 Keynote Addresses in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3
... China, April 8 Sinobiopharma Pharmaceutical Group (OTC ... appointment of Ms. Yan Tan as Director of ... Ltd., Netherlands. She served as a China-based Unit ... to Schering-Plough. Prior to Organon, Ms. Tan held ...
... the simplicity of protein precipitation with the ... of phospholipids and proteins from biological samples ... Supelco, a division of Sigma-Aldrich (Nasdaq: ... supplier of chromatography products for analysis and ...
... April 8 ImQuest Life Sciences presented their ... their novel small molecule piperazine compound for the ... Therapeutics meeting held in Whistler, British Columbia. The ... lead microtubule inhibitor, IQP-0304. The piperazines demonstrate potent ...
Cached Biology Technology:Sinobiopharma, Inc. Appoints New Director of Marketing 2HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008 2HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008 3ImQuest Presentation at Keystone Symposium Focuses on Advancements in Their Cancer Research and Development Program 2