Navigation Links
Predicting the next eye pathogen; analysis of a novel adenovirus
Date:4/10/2013

BOSTON (April 10, 2013) The ongoing dance between a virus and its host distinctly shapes how the virus evolves. While human adenoviruses typically cause mild infections, recent reports have described newly characterized adenoviruses that can cause severe, sometime fatal, human infections.

Researchers from the Massachusetts Eye and Ear and Harvard Medical School, Provincial Laboratory for Public Health, School of Systems Biology, George Mason University, and the Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center report a systems biology approach to show how evolution has affected the disease potential of a recently identified novel human adenovirus. Their approach is based on the belief that understanding viral evolution and pathogenicity is essential to our capacity to foretell the potential impact on human disease for new and emerging viruses. Their study is now published in mBio.

Since the first adenovirus was characterized in 1953, 69 human adenoviruses (HAdVs) have been recognized as unique types. Analysis of whole-genome sequence data for existing and new HAdVs confirmed a critical role for homologous recombination in adenovirus evolution, leading to new and sometime serious human infections. The emergence of new HAdV types, with several associated with severe eye infection, promoted the investigators to apply a systems biology approach to try to predict the ocular tropism of a previously uncharacterized and highly novel HAdV, isolated by nasopharyngeal swab from a 4-month-old boy with several bronchiolitis.

A combined genomic, bioinformatics and biological analysis identified a unique deletion in a key protein of the viral capsid and further suggested the potential of the virus to cause severe ocular infection. The results point toward a possible approach for predicting pathogenicity for newly identified and recently emergent human pathogens.


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Page: 1

Related biology news :

1. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
2. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
3. Discovery of mechanisms predicting response to new treatments in colon cancer
4. Predicting how patients respond to therapy
5. New model could help fill data gap in predicting historical air pollution exposure
6. Cellular landscaping: Predicting how, and how fast, cells will change
7. Predicting the age at menopause of women having suffered from childhood cancers
8. Predicting a low carbon future for Toronto
9. Beyond the microscope: Identifying specific cancers using molecular analysis
10. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
11. A new application allows online statistical analysis of gene-expression data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2016)... New York , January 13, 2016 ... Market Research has published a new market report titled ... Growth, Trends, and Forecast, 2015 - 2023. According to the ... in 2014 and is anticipated to reach US$1,625.8 mn ... 2015 to 2023. In terms of volume, the biometric ...
(Date:1/8/2016)... and MANCHESTER, United Kingdom , Jan. ... developer of innovative sensor-based diagnostic products, today announced the closing ... new and existing investors.  Proceeds from the financing will be ... , a hand-held device for detecting early-stage pressure ulcers. ... Ireland after receiving CE Mark approval. The device,s ...
(Date:1/7/2016)... -- A United States District Court in Illinois ... to interpret a biometric privacy statute in a decision ... photo website Shutterfly brought by the law firm Carey Rodriguez ... SHUTTERFLY, INC.; and THISLIFE, INC ( N.D. Ill ., ... Illinois Biometric Privacy Act by collecting and scanning face ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... program for the development of future natural products for crop ... and development center in Israel and ... Stockton has a variety of products adapted to ... in more than 35 counties worldwide. ... product Timorex Gold ® is used to control a ...
(Date:2/5/2016)... ATCC, the premier global biological materials resource ... and life science researchers that are working to address ... CDC website . --> CDC ... a single-stranded RNA virus of the Flaviviridae family, genus ... Chikungunya Viruses. Zika virus is transmitted to humans primarily ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf Media ... announced an interactive FDA compliance training course, Writing Effective SOPs ... Society) accredited interactive course on Morf Playbook—now conveniently available on smartphones and PCs--provides ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, ... various medical institutions attended a ceremony in late 2015 ... personalized cell therapy in 2016. --> ... Clinical Translation Platform for Personalized Cell Therapy" was hosted ... Cell Production Center, both subsidiaries of Beike Biotechnology Co., ...
Breaking Biology Technology: