Navigation Links
Predicting the next eye pathogen; analysis of a novel adenovirus
Date:4/10/2013

BOSTON (April 10, 2013) The ongoing dance between a virus and its host distinctly shapes how the virus evolves. While human adenoviruses typically cause mild infections, recent reports have described newly characterized adenoviruses that can cause severe, sometime fatal, human infections.

Researchers from the Massachusetts Eye and Ear and Harvard Medical School, Provincial Laboratory for Public Health, School of Systems Biology, George Mason University, and the Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center report a systems biology approach to show how evolution has affected the disease potential of a recently identified novel human adenovirus. Their approach is based on the belief that understanding viral evolution and pathogenicity is essential to our capacity to foretell the potential impact on human disease for new and emerging viruses. Their study is now published in mBio.

Since the first adenovirus was characterized in 1953, 69 human adenoviruses (HAdVs) have been recognized as unique types. Analysis of whole-genome sequence data for existing and new HAdVs confirmed a critical role for homologous recombination in adenovirus evolution, leading to new and sometime serious human infections. The emergence of new HAdV types, with several associated with severe eye infection, promoted the investigators to apply a systems biology approach to try to predict the ocular tropism of a previously uncharacterized and highly novel HAdV, isolated by nasopharyngeal swab from a 4-month-old boy with several bronchiolitis.

A combined genomic, bioinformatics and biological analysis identified a unique deletion in a key protein of the viral capsid and further suggested the potential of the virus to cause severe ocular infection. The results point toward a possible approach for predicting pathogenicity for newly identified and recently emergent human pathogens.


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Page: 1

Related biology news :

1. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
2. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
3. Discovery of mechanisms predicting response to new treatments in colon cancer
4. Predicting how patients respond to therapy
5. New model could help fill data gap in predicting historical air pollution exposure
6. Cellular landscaping: Predicting how, and how fast, cells will change
7. Predicting the age at menopause of women having suffered from childhood cancers
8. Predicting a low carbon future for Toronto
9. Beyond the microscope: Identifying specific cancers using molecular analysis
10. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
11. A new application allows online statistical analysis of gene-expression data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 21, 2014 Diabetes affects nearly 10 percent ... of diabetics: constant finger pricking to test blood ... Biology reports the development of a protein that ... results for diabetes patients. In the American Chemical ... Ph.D., shows off her "designer protein" that could ...
(Date:8/22/2014)... release is available in German . ... substances, in PCFs proteins are fixated in a way ... crystals. Next, the HZB and Fudan University researchers are ... as functional materials. Their findings are being published today ... 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone knows that ...
(Date:8/22/2014)... In 2015, American consumers will finally be able to ... Although touted as zero-emissions vehicles, most of the cars ... fossil fuel that contributes to global warming. , Now ... device that uses an ordinary AAA battery to produce ... electric current through two electrodes that split liquid water ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... have created an application that enables cell phones and ... English speakers and could be used for people who ... type in the menu listing and the application translates ... "Mimi" Boutin, an associate professor in Purdue University,s School ...
... Belmont, MAA new study from McLean Hospital/Harvard Medical ... genetic research drawing correlations between specific genes, environmental ... the development of some psychiatric illnesses needs additional ... , McLean Hospital investigator Laramie Duncan, PhD, ...
... faster than ever and not only when it ... bodies are reaching puberty at an increasingly earlier age, ... adult lives. That,s bad news, according to Tel Aviv ... Hyperostosis Frontalis Interna (HFI), a hormonal condition once typically ...
Cached Biology News:New translator app makes sense of foreign-language food menus 2New translator app makes sense of foreign-language food menus 3McLean: Improvements are needed for accuracy in gene-by-environment interaction studies 2McLean: Improvements are needed for accuracy in gene-by-environment interaction studies 3Is estrogen going to your head? 2Is estrogen going to your head? 3
(Date:8/21/2014)... Aug. 21, 2014 OTC Markets ... Inc., a biotechnology company, on its approval to ... traded on OTCQX®, the best marketplace for established ... Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... successful execution of its growth strategy and achievement ...
(Date:8/21/2014)... 21, 2014 Pursuit Solutions ( ... technology and services for Life Sciences sales and ... Use of New Commercial Sales Models” by Peter ... , The article examines some innovative models used ... being tested in the pharmaceutical market. Robinson grades ...
(Date:8/21/2014)... 21, 2014 SoundConnect , ... recognized as one of the nation’s Fastest Growing ... for the 2nd consecutive year. Inc. magazine today ... Inc. 500|5000, an exclusive ranking of the nation's ... comprehensive look at the most important segment of ...
(Date:8/20/2014)... to biotechnology firms has revealed early bottlenecks on ... the researchers suggest that better communication of basic ... to faster commercialization down the road. , Biopharmaceutical ... university laboratories and licensed to biotechnology firms. Bottlenecks ... a high failure rate. But a new study ...
Breaking Biology Technology:OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3
... SAN DIEGO, Feb. 27 Anadys Pharmaceuticals,Inc. (Nasdaq: ... the Susquehanna,Second Annual SIGnificant Options in Healthcare Conference on ... PST). The conference is being,held at the W Hotel ... Chief Executive Officer of Anadys,Pharmaceuticals, Inc., will present an ...
... researchers at North Carolina State University have demonstrated ... or chemically different so-called Janus particles ... electrical field is applied to liquid surrounding the ... in the Feb. 8, 2008, edition of Physical ...
... of Stock Repurchase Program -, LIONVILLE, Pa., Feb. 27 ... that its Board of Directors,approved a second quarter 2008 cash ... May 7, 2008 to shareholders of record on April 23,2008., ... shares of,its common stock at an average price of $40.23 ...
Cached Biology Technology:Anadys Pharmaceuticals to Present at the Susquehanna SIGnificant Options in Healthcare Conference 2'2-faced' particles act like tiny submarines 2
... HT is designed for extended ... HT is ideal for applications ... primer extension assays. iEMS Incubator/Shaker ... one-cabinet model, allowing the capacity ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
... Anti-Reverse Cap Analog (ARCA) is a modified ... group (closer to m7G) is replaced with ... polymerase can only initiate transcription with the ... in the forward orientation. As a result, ...
Biology Products: