Navigation Links
Preclinical work shows how one gene causes severe mental retardation
Date:5/10/2009

iately strengthen or weaken in the cortex, an area of the brain important for cognitive abilities. Angelman syndrome is one among a small family of single gene, autism-related, neurodevelopmental disorders. Children with the condition appear to respond normally to stimuli during their first year, but around 12-18 months, they start missing milestones of cognitive development and language, typically learning only a 2-3 words over their lifetime.

"When we have experiences, connections between brain cells are modified so that we can learn," said Ben Philpot, Ph.D., a University of North Carolina professor in Cell and Molecular Physiology and co-senior author of the study. "By strengthening and weakening appropriate connections between brain cells, a process termed synaptic plasticity, we are able to constantly learn and adapt to an ever-changing environment."

"It is difficult to study how experiences lead to changes in the brain in models of mental retardation," said Koji Yashiro, Ph.D., a former University of North Carolina graduate student and lead author of the study. "Instead of studying a complex learning model, we studied how connections between brain cells change in visual areas of mice exposed to light or kept in darkness. This approach revealed that brain cells in normal mice can modify their connections in response to changes in visual experiences, while the brain cells in Angelman syndrome mice could not."

The inability of brain cells to encode information from experiences in the Angelman syndrome model suggested that this is the basis for the profound learning difficulties in these patients.

The scientists didn't expect to find that the plasticity of the cellular connections could be restored in visual areas of the brain after brief periods of visual deprivation.

"By showing that brain plasticity can be restored in Angelman syndrome model mice, our findings suggest that brain cells in Angelman syndrome pati
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Clones on task serve greater good, evolutionary study shows
3. Study shows link between alcohol consumption and hiv disease progression
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. New study shows greenback cutthroat trout involved in recovery effort misidentified
6. DNA analysis shows true dispersal of protozoa
7. New genetic research into nicotine addiction shows promise for personalized treatment
8. International team shows mercury concentrations in fish respond quickly to increased deposition
9. New study shows fish respond quickly to changes in mercury deposition
10. Amazon forest shows unexpected resiliency during drought
11. New study shows fish respond quickly to changes in mercury deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Australian National University (ANU), have developed a new ... variability over the past 5.3 million years., The ... surrounding ice ages over the past two million ... carbon dioxide levels, global temperatures and sea levels., ... (UoS) and the National Oceanography Centre (NOC) in ...
(Date:4/17/2014)... of our ideas about domestication derive from Charles ... by British animal-breeding practices during the 19th century, ... improvement. , It is from Darwin that ... of captive animals from wild species and total ... But animal management in this industrial setting has ...
(Date:4/16/2014)... in museum collections two new species of yellow-shouldered bats have been ... The Field Museum of Natural History and described in the open ... to the genus Sturnira are part of a recent ... the third one still waiting to be officially announced. , Up ...
Breaking Biology News(10 mins):Ancient sea-levels give new clues on ice ages 2The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4Two new species of yellow-shouldered bats endemic to the Neotropics 2
... Scientists and engineers from around the world will convene ... discuss recent advances in optics and photonics -- the ... -- affecting renewable energy and environmental research. Journalists ... Photonics Congress: Renewable Energy & the Environment, which will ...
... rats, European researchers have proved that eating strawberries reduces ... mucous membrane. Published in the open access journal Plos ... of stomach ulcers. A team of Italian, Serbian ... strawberries have in a mammal stomach that has been ...
... brain protein that regulates gene expression may play a role ... disabling psychiatric disease. As reported in the latest issue of ... for Bipolar Disorders, levels of SP4 (specificity protein 4) were ... samples from patients with bipolar disorder. The study suggests that ...
Cached Biology News:Space debris, more efficient LEDs, and thinner, cheaper solar cells 2Space debris, more efficient LEDs, and thinner, cheaper solar cells 3Space debris, more efficient LEDs, and thinner, cheaper solar cells 4Space debris, more efficient LEDs, and thinner, cheaper solar cells 5Strawberries protect the stomach from alcohol 2Gene regulatory protein is reduced in bipolar disorder 2Gene regulatory protein is reduced in bipolar disorder 3
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... 15, 2014 A study has been launched ... Formula 1 track could help to tackle the problem of ... Stowhealth (a GP surgery based in Stowmarket) and academics at ... Telemetry technology, which is inspired by equipment used ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... For a successful bioscience company there are many moving ... knowledgeable workforce to suppliers and market access, each of ... today,s modern scientific challenges. Yet, leveraging these solutions in ... R&D are high. Complexity in the supply chain can ...
... 2011 NeoStem, Inc. ("NeoStem" or the "Company") (NYSE ... with product and service revenues, global research and development ... U.S. adult stem cells, China adult stem cells, and ... today announced steps forward in their partnership designed to ...
... June 16, 2011 /PRNewswire-Asia/ -- WuXi AppTec announced today that ... Outsourcing Enterprises in China for 2011 by China,s Ministry of ... Service Outsourcing Cooperation Conference, held in Nanjing on June 10, ... WuXi AppTec, was named a Top Ten Contributor to China,s ...
Cached Biology Technology:Ohio's Bioscience Industry Thrives With World-Class Industry Collaboration 2Ohio's Bioscience Industry Thrives With World-Class Industry Collaboration 3Ohio's Bioscience Industry Thrives With World-Class Industry Collaboration 4The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 2The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 3The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 4The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 5The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 6The Pontifical Council for Culture and NeoStem Announce Steps Forward in their Partnership to Advance Adult Stem Cell Research 7
...
Quinolinate phosphoribosyltransferase...
This antibody is specific for human J-chain as defined by ELISA assay using purified human immunoglobulin fragments as solid phase target antigen....
Tissue-Stat ( Tissue Adherent for Mounting Formalin-Fixed and Frozen Tissue Sections.)...
Biology Products: