Navigation Links
Preclinical work shows how one gene causes severe mental retardation
Date:5/10/2009

Durham, N.C., and Chapel Hill, N.C. -- Researchers at Duke University Medical Center and the University of North Carolina have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome.

In a study published in the journal Nature Neuroscience, they found that the gene, UBE3A, is needed so that neurons in the brain can form and adjust their connections to other neurons for storing sensory information. They also made a promising discovery: When the mice were deprived of sensory stimulation, the brain connections could be recovered, a finding that indicated a pharmaceutical or behavioral treatment might be possible in the future.

The scientists undertook this project because of the developmental-onset period seen in Angelman syndrome, typically when children are between one and two years old. It is during this time in humans that the cortex, the sheet of convoluted folds at the surface of the brain, undergoes profound rearrangements driven by sensory experiences the experience of seeing reorganizes the visual cortex, for example, during the same time period when the deficits are becoming obvious in Angelman syndrome, part of the autism spectrum of disorders.

"We wanted to look at an animal model to learn if this experience-dependent reorganization of the cortex was abnormal in animals that were missing the gene," said Michael Ehlers, M.D., Ph.D., a Duke professor of neurobiology and co-senior author of the study. "We looked at the visual cortex, because in this well-studied model, we could precisely control the sensory stimulus and study the mice in the light or the dark. We speculated that similar deficits may be happening in areas of the cortex that are important for language, cognition and emotion, all of which are quite abnormal in Angelman syndrome patients."

The authors found that brains cells in Angelman syndrome mice lacked the ability to appropr
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Clones on task serve greater good, evolutionary study shows
3. Study shows link between alcohol consumption and hiv disease progression
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. New study shows greenback cutthroat trout involved in recovery effort misidentified
6. DNA analysis shows true dispersal of protozoa
7. New genetic research into nicotine addiction shows promise for personalized treatment
8. International team shows mercury concentrations in fish respond quickly to increased deposition
9. New study shows fish respond quickly to changes in mercury deposition
10. Amazon forest shows unexpected resiliency during drought
11. New study shows fish respond quickly to changes in mercury deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... of metastasis, yet progress in preventing and treating ... been particularly challenging to design drugs that work ... systems biology at Harvard Medical School. , ... already metastasized." , Gujral and colleagues have now ... better understand how metastasis begins. Their findings may ...
(Date:11/5/2014)... dedicated his career to understanding the Earth,s climate ... , As deputy director and regional climatologist for ... Research Institute, Redmond has more than three decades ... of climate data to the general public. , ... Francisco on December 15-19, 2014 the American Geophysical ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
... The next time you,re outdoors, see if you can spot the ... an easy task trees there are few and far between, ... In the temperate Northeast, dense forests make the exercise a bit ... sequoias often reach higher than the eye can estimate. Knowing ...
... The United States joined more than 50 countries Thursday ... to better track vessels engaged in illegal, unreported and ... highly migratory species. Annual global economic losses due to ... $23 billion. This action is a first step ...
... This release is available in French . ... Neanderthals and is found exclusively in people outside Africa, according ... of the Department of Pediatrics at the University of Montreal ... in the July issue of Molecular Biology and Evolution. ...
Cached Biology News:MIT: The tallest tree in the land 2MIT: The tallest tree in the land 3US joins over 50 nations in adopting recommendation to list vessels engaged in illegal fishing 2US joins over 50 nations in adopting recommendation to list vessels engaged in illegal fishing 3Genetic research confirms that non-Africans are part Neanderthal 2
(Date:11/26/2014)... SoundConnect , an award winning unified ... that Darren Suders has joined the team as Director ... the partner program through innovative offerings, consistent ... Darren brings more than 10-years of channel telecommunication experience ... operations, from policy development, to partner education and to ...
(Date:11/26/2014)... 25, 2014 Bio-Techne Corporation (NASDAQ: ... Robert Gavin to serve in a newly created ... Division.  Mr. Gavin will be responsible for managing the ... the ProteinSimple business acquired in July 2014 and the ... Jose, California -based ProteinSimple develops and commercializes proprietary ...
(Date:11/24/2014)... UAE, November 24, 2014 Five ... Bin Rashid Al Maktoum Awards for Medical Sciences", in ... Dubai, United Arab Emirates , on 15 December ... , The Carter Center which won the ... actively involved in numerous programs that aim to improve ...
(Date:11/24/2014)... SOUTH SAN FRANCISCO, Calif. , Nov. 24, 2014 /PRNewswire/ ... announced that Bonnie H. Anderson , president and chief ... the Piper Jaffray 26 th Annual Healthcare Conference on ... New York . The live audio ... website at http://investor.veracyte.com . Please connect to the website ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Five US Winners Among Recipients of Hamdan Medical Awards 2Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2
... age rests on our ability to control how electric ... circuitry. Doing so requires particular precision, for applications ranging ... task falls to semiconductors. Now, a research team ... Applied Science and Arts and Sciences has shown how ...
... (Nasdaq: SGMO ) today announced the pricing of ... common stock at a price to the public of $7.70 ... or around Wednesday, April 13, 2011, subject to customary closing ... this offering and Sangamo has granted the underwriter a thirty ...
... Inc. (Nasdaq: SGMO ) announced today that it ... pursuant to an effective shelf registration statement in an underwritten ... in this offering and Sangamo will grant the underwriter a ... shares. The securities described above are being ...
Cached Biology Technology:Penn research advances understanding of lead selenide nanowires 2Penn research advances understanding of lead selenide nanowires 3Sangamo Announces Pricing of Public Offering of Common Stock 2Sangamo Announces Pricing of Public Offering of Common Stock 3Sangamo Announces Public Offering of Common Stock 2Sangamo Announces Public Offering of Common Stock 3
... Jouan RCT series of refrigerated cold traps ... trapping of low volatility/aqueous solvents or high ... and other vacuum concentrators/centrifugal evaporators. Also used ... systems such as used in electron microscopes. ...
... The RVT405DDA Refrigerated Vapor Trap ... of high boiling solvents such as ... DDA™ systems. Its constant temperature refrigeration ... creates optimum cryopumping conditions for DMSO, ...
96 Well Plate Sterile, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
Biology Products: