Navigation Links
Preclinical work shows how one gene causes severe mental retardation
Date:5/10/2009

Durham, N.C., and Chapel Hill, N.C. -- Researchers at Duke University Medical Center and the University of North Carolina have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome.

In a study published in the journal Nature Neuroscience, they found that the gene, UBE3A, is needed so that neurons in the brain can form and adjust their connections to other neurons for storing sensory information. They also made a promising discovery: When the mice were deprived of sensory stimulation, the brain connections could be recovered, a finding that indicated a pharmaceutical or behavioral treatment might be possible in the future.

The scientists undertook this project because of the developmental-onset period seen in Angelman syndrome, typically when children are between one and two years old. It is during this time in humans that the cortex, the sheet of convoluted folds at the surface of the brain, undergoes profound rearrangements driven by sensory experiences the experience of seeing reorganizes the visual cortex, for example, during the same time period when the deficits are becoming obvious in Angelman syndrome, part of the autism spectrum of disorders.

"We wanted to look at an animal model to learn if this experience-dependent reorganization of the cortex was abnormal in animals that were missing the gene," said Michael Ehlers, M.D., Ph.D., a Duke professor of neurobiology and co-senior author of the study. "We looked at the visual cortex, because in this well-studied model, we could precisely control the sensory stimulus and study the mice in the light or the dark. We speculated that similar deficits may be happening in areas of the cortex that are important for language, cognition and emotion, all of which are quite abnormal in Angelman syndrome patients."

The authors found that brains cells in Angelman syndrome mice lacked the ability to appropr
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Clones on task serve greater good, evolutionary study shows
3. Study shows link between alcohol consumption and hiv disease progression
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. New study shows greenback cutthroat trout involved in recovery effort misidentified
6. DNA analysis shows true dispersal of protozoa
7. New genetic research into nicotine addiction shows promise for personalized treatment
8. International team shows mercury concentrations in fish respond quickly to increased deposition
9. New study shows fish respond quickly to changes in mercury deposition
10. Amazon forest shows unexpected resiliency during drought
11. New study shows fish respond quickly to changes in mercury deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... population-based screening outcomes of approximately 3 million infants, a ... at the University of Massachusetts Medical School, have shown ... be successfully implemented across public health newborn screening programs. ... Aug. 20 issue of the Journal of the ... rate of SCID in newborns is higher than previously ...
(Date:8/20/2014)... scientists have discovered that acral melanomas the rare type ... are genetically distinct from other more common types of ... in the journal Pigment Cell & Melanoma Research . ... hands, soles of the feet, nail-beds and other hairless parts ... it,s not caused by UV damage from the sun. , ...
(Date:8/20/2014)... causes a burning spiciness that is irresistible to some, ... effect are using their findings to develop a new ... be caused by inflammation or other problems. They reported ... in clinical trials, in ACS, Journal of Medicinal ... decades ago, scientists had pegged a compound called capsaicin ...
Breaking Biology News(10 mins):Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3Scientists learn more about rare skin cancer that killed Bob Marley 2
... ,   SPO (SPOM.OB), a leading ... that it has entered into an Investment Agreement,with Dutchess Opportunity ... Under the terms of the signed agreement, for a ... and Dutchess the,obligation to purchase common stock at a 6% ...
... experts from the outside to develop a new energy source ... acknowledge the need to innovate collaboratively if they are to ... NineSigma, the leading provider of Open Innovation and ... organizations is greater than ever, and can make a difference ...
... Lithuania, July 28, 2011 Neurotechnology , ... announced that MegaMatcher and VeriFinger SDK fingerprint compression ... means that the FBI has certified that these ... Scalar Quantization (WSQ) Gray-Scale Fingerprint Image Compression Specification, ...
Cached Biology News:SPO Secures Equity Line Facility of US$5 Million 2SPO Secures Equity Line Facility of US$5 Million 3SPO Secures Equity Line Facility of US$5 Million 4NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 2NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 3NineSigma Declares "Innovate or Die" Is the Mantra for Business Success 4MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence 2MegaMatcher and VeriFinger SDK Fingerprint Compression Algorithms Receive WSQ Certification from FBI Biometric Center of Excellence 3
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... Brazil and ... The uptake of several newly approved agents, the ... this indication and the launch of emerging biologics ... markets. In particular, the emerging IL-5 inhibitors will ...
(Date:8/21/2014)... , Aug. 21, 2014  Four-dimensional (4-D) ... behaviors based on external stimuli such as changes ... have a disruptive effect in multiple industries.  In ... business landscape by printing objects ranging from human ... automotive sectors. Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... SoundConnect , a unified ... one of the nation’s Fastest Growing Private Companies ... 2nd consecutive year. Inc. magazine today ranked SoundConnect ... an exclusive ranking of the nation's fastest-growing private ... at the most important segment of the economy—America’s ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
Breaking Biology Technology:Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3
... Calif., Nov. 16, 2010 AVANIR Pharmaceuticals, ... it intends to offer and sell shares of its common ... is acting as sole book-running manager in the offering and ... Partners, and Merriman Capital are acting as co-managers for the ...
... ... ... var shortURL ... we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
... TRIANGLE PARK, N.C., Nov. 16, 2010 Scientists ... data demonstrating that the company,s lipid-conjugated drugs, ... human Organic Anion Transporters (hOATs) and thus have ... mechanism.  These data, presented at the International Pharmaceutical ...
Cached Biology Technology:AVANIR Pharmaceuticals Announces Proposed Public Offering of Common Stock 2Intel Corporation acquires Toronto start-up CognoVision 2Intel Corporation acquires Toronto start-up CognoVision 3Intel Corporation acquires Toronto start-up CognoVision 4Intel Corporation acquires Toronto start-up CognoVision 5Intel Corporation acquires Toronto start-up CognoVision 6Intel Corporation acquires Toronto start-up CognoVision 7Chimerix's PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157 2Chimerix's PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157 3Chimerix's PIM Conjugate Technology Reduces Risk of Nephrotoxicity for CMX001 and CMX157 4
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
CD45/CD34 combination 50 tests...
WASF2 Immunogen: WASF2 (NP_008921, 73 a.a. ~ 173 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Biology Products: