Navigation Links
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier

The research was published early in the January issue of the journal Technology in Cancer Research and Treatment. The article describes experiments using ultrasonic molecular imaging (USMI) and Dynamic Contrast Enhanced-Perfusion Imaging (DCE-PI) to measure response to therapy for pancreatic cancer.

Paul Dayton, PhD, senior author says, "What we found is that using two non-invasive technologies, we can detect response to therapy earlier than by relying on tumor volume changes. Having new non-invasive, inexpensive technologies available to measure response to therapy earlier during the course of treatment would be a significant advance in the ability to tailor a person's treatment to improve outcomes."

Dr. Dayton, an Associate Professor of Biomedical Engineering, worked with Jen Jen Yeh, MD, Associate Professor of Surgery and Pharmacology, to evaluate the imaging technologies on human pancreatic cancer in a pre-clinical model. Both faculty are members of the Lineberger Comprehensive Cancer Center.

USMI has the ability to characterize non-invasively the biologic processes at the cellular and molecular levels. It does this through the use of targeted contrast agents, which are markers that bind to specific proteins expressed on cancer cells within the body. These contrast agents enable a standard ultrasound system to detect signals from cancer cells that would otherwise be undetectable.

Ultrasound DCE-PI is a method used to non-invasively monitor the blood flow in the microcirculation. Since growing tumors require abnormally increased blood flow, changes in blood vessel structure or density can provide information regarding tumor malignancy.

The team used a drug that inhibits a protein specific to tumors. They then used the imaging tools to measure the response of two different tumors, one known to respond to the drug therapy, and a second known not to respond. The results indicated that USMI was able to detect molecular signs of tumor response to therapy after only 2 days. A change in blood flow in the tumor was observed to detect response after day 14 using DCE-PI. Over the same period, standard volume measurements were not able to detect therapeutic response, and prior studies suggested that volume measurements do not become indicative of response until approximately 28 days. Thus, these methods showed a notable improvement in the early identification of tumor response to therapy, using contrast enhanced ultrasound imaging.

Although the contrast agents for USMI are not yet available in the United States, they are currently in clinical trials in Europe for cancer imaging.


Contact: Dianne Shaw
University of North Carolina Health Care

Related biology news :

1. Preclinical studies use specialized ultrasound to detect presence of cancer
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Virology researcher awarded nearly $2 million to study chronic hepatitis E
4. New study shows how seals sleep with only half their brain at a time
5. Study shows that diet of resistant starch helps the body resist colorectal cancer
6. Breakthrough study opens door to broader biomedical applications for Raman spectroscopy
7. Phosphorus starvation linked to symptoms of citrus disease Huanglongbing in new study
8. Yale Study links common chemicals to osteoarthritis
9. CU-Boulder amphibian study shows how biodiversity can protect against disease
10. Busy beavers give Canada geese a lift, study shows
11. Video study shows which fish clean up coral reefs, showing importance of biodiversity
Post Your Comments:
Related Image:
Preclinical study shows potential of new technologies to detect response to cancer therapy earlier
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/9/2016)... control systems is proud to announce the introduction of fingerprint attendance control software, allowing ... are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Alex,s Lemonade Stand Foundation (ALSF), a leading national childhood ... state-of-the-art bioinformatics lab, using ,big data, to advance the ... Liz Scott , co-executive director of ALSF and ... Washington, D.C. , hosted by Vice ... of pediatric cancer research and awareness. ...
(Date:6/27/2016)... 2016  Global demand for enzymes is forecast ... to $7.2 billion.  This market includes enzymes used ... biofuel production, animal feed, and other markets) and ... Food and beverages will remain the largest market ... of products containing enzymes in developing regions.  These ...
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
Breaking Biology Technology: