Navigation Links
Preclinical studies use specialized ultrasound to detect presence of cancer
Date:7/10/2012

From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel "bendiness" can indicate the presence and progression of cancer.

This principle led UNC scientists to a new method of using a high-resolution ultrasound to identify early tumors in preclinical studies. The method, based on vessel bendiness or "tortuosity," potentially offers an inexpensive, non-invasive and fast method to detect cancer that could someday help doctors identify cancers when tumors are less than a centimeter in size.

Their findings were published in the July 6, 2012 online issue of the journal Radiology.

Paul Dayton, PhD, associate professor of biomedical engineering explains, "The correlation between vessel tortuosity and cancer is well-established. What's new about our finding is that we can visualize these vessels in minutes with a very quick scan, using very inexpensive imaging methods." Dr. Dayton is a member of UNC Lineberger Comprehensive Cancer Center.

The UNC team used a new high-resolution ultrasound method, called "acoustic angiography," with an intravascular contrast agent that allowed them to acquire images of only the blood vessels. "Unlike current clinical 'grayscale' ultrasound, this method filters out all tissue signals, so we can see small blood vessels clearly." says Dayton.

"Our results showed a definitive difference between vessels within and surrounding tumors versus those associated with normal healthy vasculature. The limitation that we must now address is that our method works only for tumors at a shallow depth into tissue, such as melanomas or thyroid cancer. Our next studies will focus on this imaging-depth issue as well as evaluating the ability of this technology to determine a tumor's response to therapy.

"We know from several clinical and preclinical MRI studies at UNC by Elizabeth Bullitt, MD, and others, and at other institutions that vessels can unbend, or "normalize," in response to effective therapy. We need to see if our inexpensive ultrasound-based method of blood vessel visualization and tortuosity analysis can detect this normalization prior to conventional assessments of tumor response to therapy, such as measurements of tumor size.


'/>"/>
Contact: Dianne G. Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care
Source:Eurekalert  

Related biology news :

1. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
2. Studies reveal structure of EV71, a virus causing childhood illnesses
3. Autism Speaks awards $1.1 million to fund high priority studies
4. Improving equine health: Research studies vaccinations to protect newborn foals
5. Miniature Sandia sensors may advance climate studies
6. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
7. GSA Bulletin presents studies in Antarctica, Italy, Mexico, Algeria, Mongolia, and more
8. Dinosaur fossil: Even specialized predators didnt turn down free meals
9. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
10. Acoustic tweezers capture tiny creatures with ultrasound
11. Gold nanoantennas detect proteins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Preclinical studies use specialized ultrasound to detect presence of cancer
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... The Academy of Model Aeronautics ... and 29, 2017, to promote AMA’s programs, member services, and the model aviation ... including but not limited to model aviation and other RC activities. , Thousands ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... includes executive, engineering and manufacturing functions to The LaunchPort™ Accelerator at the City ... a full range of manufacturing and business services to its Residents. , ...
(Date:9/21/2017)... ... September 21, 2017 , ... The 3rd World Congress on ... latest knowledge on these products, which are increasingly used in crop production around ... Biostimulants on Plant Nutrition, Abiotic Stresses, Plant Growth and Development, as well as ...
(Date:9/21/2017)... ... September 21, 2017 , ... Executives and ... world’s most progressive pharma and biotech organizations to do more clinical trials will ... biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s first ...
Breaking Biology Technology: