Navigation Links
Powerful drug's surprising, simple method could lead to better treatments
Date:1/16/2012

is fascinating. So my group asked, could we make it a better drug by making a derivative that's less toxic but still powerful? And what could it teach us about avoiding resistance in clinical medicine and possibly even replacing missing ion channels with small molecules? All of this depends upon understanding how it works, but up until now, it's been very enigmatic."

While amphotericin's efficacy is clear, the reasons for its remarkable infection-fighting ability remained uncertain. Doctors and researchers do know that amphotericin creates ion channels that permeate the cell membrane. Physicians have long assumed that this was the mechanism that killed the infection, and possibly the patient's cells as well. This widely accepted dogma appears in many scientific publications and textbooks.

However, several studies have shown that channel formation alone may not be the killing stroke. In fact, as Burke's group discovered, the mechanism is much simpler.

Amphotericin binds to a lipid molecule called ergosterol, prevalent in fungus and yeast cells, as the first step in forming the complexes that make ion channels. But Burke's group found that, to kill a cell, the drug doesn't need to create ion channels at all it simply needs to bind up the cell's ergosterol.

Burke's group produced a derivative of amphotericin using a molecule synthesis method Burke pioneered called iterative cross-coupling (ICC), a way of building designer molecules using simple chemical "building blocks" called MIDA boronates joined together by one simple reaction. They created a derivative that could bind ergosterol but could not form ion channels, and tested it against the original amphotericin.

If the widely accepted model was true, and ion channel formation was the drug's primary antifungal action, then the derivative would not be able to wipe out a yeast colony. But the ergosterol-binding, non-channel-forming derivative was almost equally potent to nat
'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Powerful mathematical model greatly improves predictions for species facing climate change
2. 2 top biological imaging centers offer powerful free online tool to researchers and public
3. Zeroing in on more powerful enzymes for degrading persistent pollutants
4. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
5. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
6. New fossils demonstrate that powerful eyes evolved in a twinkling
7. Finding is a feather in the cap for researchers studying birds big, powerful eyes
8. Giant fire-bellied toads brain brims with powerful germ-fighters
9. New device promises safer way to deliver powerful drugs
10. Structure of DNA repair complex reveals workings of powerful cell motor
11. K-State research channels powerful Kansas wind to keep electricity running
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Powerful drug's surprising, simple method could lead to better treatments
(Date:6/24/2015)... The biologics safety testing market is growing ... market include growth of the pharmaceutical and biological industries ... the years, the number of drug approvals in North ... FDA approved 225 drug applications and Health Canada approved ... accounted for 3,822 of the pharmaceutical and ...
(Date:6/24/2015)... 24, 2015 Biometry authentication provider KeyLemon ... password solution one face in. ... one face in, entering the expanding biometric authentication ... multifactor-authentication biometric answer to the password problem. With ... partnership with KeyLemon, one face in allows users ...
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... Medical Center and colleagues at four other medical centers ... genes that may contribute to early atherosclerosis. , ... early adult life who have a genetic predisposition to ... heart disease and stroke sooner and more aggressively," said ...
... may one day help physicians detect cancerous tumors during ... to group together inside cancerous tumors, creating masses with ... a magnetic resonance imaging (MRI) machine. , The work ... of Angewandte Chemie International Edition, one of the world's ...
... increased plant respiration in response to higher global temperatures ... into account plants' ability to adjust to changing conditions, ... In a Perspectives paper published April 28 by Science, ... suggesting that about 9 percent more carbon will be ...
Cached Biology News:Scientists work to identify genes that contribute to early heart attack risk 2MIT nanoparticles may help detect, treat tumors 2Plants' role in global warming re-examined 2
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome ... new insights on mechanics of fecal microbiota transplantation in C. difficile patients. , ... microbiome of patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium ...
(Date:6/30/2015)... ... ... The maximum number of shares proposed to be purchased in the tender offer ... stock). On June 29, 2015, the last trading day prior to the commencement of ... was $2.29 per share. , The tender offer will expire on July 28, 2015 ...
(Date:6/30/2015)... , June 30, 2015  Custom Computer Specialists, ... today that they are silver sponsors of the Primary ... PCDC sponsor, Custom is lending their support of PCDC,s ... communities. Since its founding in 1993, PCDC ... primary care area.  PCDC has financed over 100 completed ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... She has accepted the position of vice president of instruction at Chippewa Valley ... , “I greatly appreciated the opportunity to lead SIUE during the past three ...
Breaking Biology Technology:uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3
... - To develop a more robust information technology ... according to keynoters at this week's E-Business Best Practices ... technology executives, most notably RedPrairie's John Jazwiec, ... make. But leaders attending the annual E-Business conference did ...
... Healthcare Technology , a Milwaukee-based medical informatics company, ... Cancer Center in Sacramento to install its ... adds UC-Davis experts to TeraMedica's oncology advisory board ... , ,The Evercore technology comes with oncology-specific electronic ...
... Madison Chapter of the Telecommunications Professionals of Wisconsin ... , a networking and business support organization focused ... the partnership "reflects the increasingly blurred line between ... across operations in companies of all sizes and ...
Cached Biology Technology:To drive IT, Wisconsin may need entrepreneurial makeover 2To drive IT, Wisconsin may need entrepreneurial makeover 3Accelerate Madison to merge with Telecommunications Professionals 2
...
Collected from sexually mature mice....
Sterile concentration of Dithiothreitol (DTT) solution in phosphate buffer (pH 7.0). Dilute contents in one vial (10- fold) to 100 ml. For use in liquefying sputum samples....
5 minutes from gel band to purified DNA...
Biology Products: