Navigation Links
Powerful drug's surprising, simple method could lead to better treatments
Date:1/16/2012

is fascinating. So my group asked, could we make it a better drug by making a derivative that's less toxic but still powerful? And what could it teach us about avoiding resistance in clinical medicine and possibly even replacing missing ion channels with small molecules? All of this depends upon understanding how it works, but up until now, it's been very enigmatic."

While amphotericin's efficacy is clear, the reasons for its remarkable infection-fighting ability remained uncertain. Doctors and researchers do know that amphotericin creates ion channels that permeate the cell membrane. Physicians have long assumed that this was the mechanism that killed the infection, and possibly the patient's cells as well. This widely accepted dogma appears in many scientific publications and textbooks.

However, several studies have shown that channel formation alone may not be the killing stroke. In fact, as Burke's group discovered, the mechanism is much simpler.

Amphotericin binds to a lipid molecule called ergosterol, prevalent in fungus and yeast cells, as the first step in forming the complexes that make ion channels. But Burke's group found that, to kill a cell, the drug doesn't need to create ion channels at all it simply needs to bind up the cell's ergosterol.

Burke's group produced a derivative of amphotericin using a molecule synthesis method Burke pioneered called iterative cross-coupling (ICC), a way of building designer molecules using simple chemical "building blocks" called MIDA boronates joined together by one simple reaction. They created a derivative that could bind ergosterol but could not form ion channels, and tested it against the original amphotericin.

If the widely accepted model was true, and ion channel formation was the drug's primary antifungal action, then the derivative would not be able to wipe out a yeast colony. But the ergosterol-binding, non-channel-forming derivative was almost equally potent to nat
'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Powerful mathematical model greatly improves predictions for species facing climate change
2. 2 top biological imaging centers offer powerful free online tool to researchers and public
3. Zeroing in on more powerful enzymes for degrading persistent pollutants
4. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
5. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
6. New fossils demonstrate that powerful eyes evolved in a twinkling
7. Finding is a feather in the cap for researchers studying birds big, powerful eyes
8. Giant fire-bellied toads brain brims with powerful germ-fighters
9. New device promises safer way to deliver powerful drugs
10. Structure of DNA repair complex reveals workings of powerful cell motor
11. K-State research channels powerful Kansas wind to keep electricity running
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Powerful drug's surprising, simple method could lead to better treatments
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
(Date:4/20/2015)... April 20, 2015 The announcement ... Glenbeigh Records Management (GRM), Ireland,s ... Islamic Bank. Having built up an impressive track record of ... leading player within the records management sector in ... double is GCC staffbase and employ a further eight staff ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... say "shade grown, please" when you order your morning ... under a canopy of multiple tree species, not only ... also maintain genetic diversity of native tree species and ... The finding comes from a study published by ...
... bone marrow that can continuously make red and white ... Michigan lab. This development could lead to ... defects and a continuous supply of blood for transfusions. ... mimics the tissues supporting bone marrow in the body, ...
... Dec. 22, 2008 NYU Langone Medical Center scientists and ... Calif., have discovered an unexpected cause for the fatal seizures ... central nervous system, according to a study published in the ... of thinking about how the human immune system responds to ...
Cached Biology News:Shade coffee benefits more than birds 2Shade coffee benefits more than birds 3Biomedical researchers create artificial human bone marrow in a test tube 2Peering inside the skull of a mouse to solve meningitis mystery 2Peering inside the skull of a mouse to solve meningitis mystery 3
(Date:5/28/2015)... Research and Markets( http://www.researchandmarkets.com/research/3nl6s2/neuroprotection ) has ... "Neuroprotection - Drugs, Markets and Companies" ... the role of neuroprotection in acute disorders such ... as well as in chronic diseases such as ... of damage to neural tissues are similar in ...
(Date:5/28/2015)... N.J. , May 28, 2015 Celsion ... that it has received commitments from two institutional healthcare ... of the Company,s common stock in an at-the-market registered ... to purchase common stock. The Company entered ... to which the Company agreed to sell an aggregate ...
(Date:5/28/2015)... 2015 DryLet, LLC a biotechnology ... such as animal waste reduction, bioremediation, wastewater treatment, ... wastewater treatment plants and restaurant kitchen settings, announced ... Expo, June 3-5 in Des Moines, Iowa. , ... Wall Street Journal article because of its industry-leading ...
(Date:5/28/2015)... May 28, 2015  PDS Biotechnology Corp. announces ... treatment targeting HPV-16, has generated strong T-cell responses ... pre-cervical cancer is treated by surgical removal of ... effective non-surgical alternative. Results show that it primes ... recognize, target, and kill precancerous and cancerous cells ...
Breaking Biology Technology:Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 3Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 3DryLet to Showcase Patented ManureMagicâ„¢ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2
... , ... Web Service Available Immediately to Researchers Worldwide,Free/Full NGS-based Runs Available to First Registrants ... Westborough, MA (PRWEB) ... and easy-to-use ChIP-Seq workflow solution available immediately as a web cloud service ...
... Corporation, a spinal and orthopaedic implant and instrument company ... the launch of four new product offerings. The ... Valeo(®) C VBR, Valeo(®) Concise Cervical Plating System and ... American Spine Society (NASS) prepares to meet in San ...
... Nov. 10 Genoptix, Inc. (Nasdaq: GXDX ), a ... the Lazard Capital Management 6th Annual Healthcare Conference at The ... 2009. , Genoptix,s EVP and CFO, Doug Schuling, ... beginning at approximately 11:25 a.m. EST. He will provide ...
Cached Biology Technology:GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 2GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 3GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 4Amedica Announces New Product Offering 2Genoptix Announces Participation at Lazard Capital Management 6th Annual Healthcare Conference 2
...
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
...
... Shakers combine high durability and capacity ... of use. The patented triple-counterbalanced heavy-duty ... to run at high speed with ... temperature range is delivered with tight ...
Biology Products: