Navigation Links
Potential new flu drugs target immune response, not virus
Date:7/21/2014

The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity, says Juliet Morrison of the University of Washington, Seattle. She and her collaborators have now taken the first step in doing just that for the H7N9 influenza, and their work has already led to identification of six potential therapeutics for this highly virulent strain. The research is published ahead of print in the Journal of Virology.

"We set out to characterize the response to the severe disease-causing H7N9 virus and compare it to responses elicited by other serious flu viruses in a mouse model of infection," says Morrison. That work involved determining which genes are turned on by this infection.

"We have found that viruses that cause severe illness, like H7N9 and the infamous 1918 virus, trigger gene expression signatures that are different from the signatures seen in milder infections," says coauthor and University of Washington colleague Michael Katze, in whose laboratory the work was performed. "Importantly, we can exploit these signatures for antiviral drug discovery," he adds.

The investigators then used a computational approach to identify potentially therapeutic drugs. They searched databases containing gene expression profiles of cultured human cells that had been treated with different drugs, in order to find those that were the reverse of expression profiles induced by the H7N9 flu virus, and noting the drugs that accomplished this, says Morrison. These drugs could potentially dampen the harmful host response, she says.

"Six of these drugs are FDA approved and could potentially be repurposed as H7N9 influenza therapeutics," says Morrison. "I believe that computational biology represents an exciting new way to study viruses and to discover drugs to fight them," says Morrison. A
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
4. Researchers report potential for a moderate New England red tide in 2012
5. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
6. Researchers find potential dark side to diets high in beta-carotene
7. Beehive extract shows potential as prostate cancer treatment
8. Gene therapy for hearing loss: Potential and limitations
9. Folic acid food enrichment potentially protective against childhood cancers
10. Nuisance seaweed found to produce compounds with biomedical potential
11. Potential new approach to regenerating skeletal muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)...     Jifflenow ...   Jifflenow, a leading provider ... business-to-business (B2B) events, today announced a partnership with ... communication (NFC), Bluetooth low energy (BLE), and cloud-based ... Jifflenow will integrate its meeting scheduling ...
(Date:12/3/2014)... 2014 As part of our commitment to ... pleased to announce the release of a new reader ... the workforce data that they need. The ... by existing readers. Many such devices have serious shortcomings ... technology. Older models force users to navigate numerous complicated ...
(Date:11/21/2014)... SAN JOSE, Calif. , Nov. 20, 2014 /PRNewswire/ ... a global leader in microcontroller (MCU) and touch technology ... digital temperature sensors with the widest V ... family delivers higher temperature accuracy and faster I 2 ... nonvolatile registers and serial EEPROM memory making them ideal ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... scientists have shown that chromosomal abnormalities are present in ... by young, fertile couples. Ms Evelyne Vanneste, a PhD ... University Fertility Center, Leuven University, Belgium, told the 25th ... and Embryology today (Wednesday July 1), that the surprising ...
... function declines as we get older. Moreover, recent studies have ... in during the course of our lives appears to influence ... Technische Universitt Berlin are studying how division of labour among ... they have found that, by switching their social role, aging ...
... batty over a new discovery which could lead to ... longer lifespans. The discovery, featured on the cover of ... Journal ( http://www.fasebj.org ), shows that proper protein ... live significantly longer than other mammals of comparable size, ...
Cached Biology News:Chromosomal problems affect nearly all human embryos 2Chromosomal problems affect nearly all human embryos 3A young brain for an old bee 2
(Date:12/17/2014)... SILVER SPRING, Md. , Dec. 17, 2014 /PRNewswire/ ... today two senior executive promotions as well as changes ... Senior Executive Promotions United ... Ph.D. to President and Co-Chief Executive Officer and ... Chief Operating Officer.  In connection with these promotions, Dr. ...
(Date:12/15/2014)... December 15, 2014 METTLER TOLEDO ... PVM tool, ParticleView V19 with PVM technology ... probe-based particle vision and measurement tool continuously captures ... conditions. ParticleView V19 then automatically prepares a report ... particle size and concentration changes. This compelling blend ...
(Date:12/15/2014)... Agritech Limited (NASDAQ GS: SEED) (" Origin ", or the ... China , today announced that the Company ... 30, 2014, before the market opens on Thursday, January 8, ... January 8, 2015, at 8:00 a.m. ET / 9:00 p.m. ... To participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Calif., Aug. 30, 2011 ProteinSimple today introduced a revolutionary ...  The Simple Western is a complete reinvention of the Western ...  For the first time in 30 years, researchers have access ... The Western Blot was invented in 1979 and ...
... is crucial to preventing countless human diseases. In a ... discovered a new approach for studying molecules within their ... of how bacteria infect people. The research, led ... published in the Proceedings of the National Academy ...
... (ACerS) today announced the names of the organization,s two ... Koichi Niihari are the 2011 recipients of the Distinguished ... ACerS. The award is given in recognition of an ... "The Society,s Distinguished Life Member is presented annually ...
Cached Biology Technology:ProteinSimple Reinvents the Western Blot 2Scientists develop new technologies for understanding bacterial infections 2Scientists develop new technologies for understanding bacterial infections 3The American Ceramic Society selects Marshall, Niihara as 2011 Distinguish Life Members 2