Navigation Links
Potential new flu drugs target immune response, not virus
Date:7/21/2014

The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity, says Juliet Morrison of the University of Washington, Seattle. She and her collaborators have now taken the first step in doing just that for the H7N9 influenza, and their work has already led to identification of six potential therapeutics for this highly virulent strain. The research is published ahead of print in the Journal of Virology.

"We set out to characterize the response to the severe disease-causing H7N9 virus and compare it to responses elicited by other serious flu viruses in a mouse model of infection," says Morrison. That work involved determining which genes are turned on by this infection.

"We have found that viruses that cause severe illness, like H7N9 and the infamous 1918 virus, trigger gene expression signatures that are different from the signatures seen in milder infections," says coauthor and University of Washington colleague Michael Katze, in whose laboratory the work was performed. "Importantly, we can exploit these signatures for antiviral drug discovery," he adds.

The investigators then used a computational approach to identify potentially therapeutic drugs. They searched databases containing gene expression profiles of cultured human cells that had been treated with different drugs, in order to find those that were the reverse of expression profiles induced by the H7N9 flu virus, and noting the drugs that accomplished this, says Morrison. These drugs could potentially dampen the harmful host response, she says.

"Six of these drugs are FDA approved and could potentially be repurposed as H7N9 influenza therapeutics," says Morrison. "I believe that computational biology represents an exciting new way to study viruses and to discover drugs to fight them," says Morrison. And that, she says, is what drew her to join Katze's laboratory.

The H7N9 avian influenza, which emerged in February, 2013, has caused those infected to become extremely ill, reminiscent of the 1918 influenza pandemic, the deadliest on record. The data suggests that such severe influenzas are associated with increased transcription of inflammatory cytokine genes, and reduced transcription of lipid metabolism and coagulation genes, according to the paper. Further study of these phenomena will lead to a better understanding of severe influenza, and could help investigators to identify potential therapeutics aimed at turning down the response.

Investigators from the Centers for Disease Control and Prevention, and the United States Department of Agriculture, took part in this research.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
4. Researchers report potential for a moderate New England red tide in 2012
5. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
6. Researchers find potential dark side to diets high in beta-carotene
7. Beehive extract shows potential as prostate cancer treatment
8. Gene therapy for hearing loss: Potential and limitations
9. Folic acid food enrichment potentially protective against childhood cancers
10. Nuisance seaweed found to produce compounds with biomedical potential
11. Potential new approach to regenerating skeletal muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:6/2/2016)... The Weather Company , an IBM Business (NYSE: IBM ... which consumers will be able to interact with IBM Watson ... or text and receive relevant information about the product or ... long sought an advertising solution that can create a one-to-one ... valuable; and can scale across millions of interactions and touchpoints. ...
(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: