Navigation Links
Potential new flu drugs target immune response, not virus
Date:7/21/2014

The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity, says Juliet Morrison of the University of Washington, Seattle. She and her collaborators have now taken the first step in doing just that for the H7N9 influenza, and their work has already led to identification of six potential therapeutics for this highly virulent strain. The research is published ahead of print in the Journal of Virology.

"We set out to characterize the response to the severe disease-causing H7N9 virus and compare it to responses elicited by other serious flu viruses in a mouse model of infection," says Morrison. That work involved determining which genes are turned on by this infection.

"We have found that viruses that cause severe illness, like H7N9 and the infamous 1918 virus, trigger gene expression signatures that are different from the signatures seen in milder infections," says coauthor and University of Washington colleague Michael Katze, in whose laboratory the work was performed. "Importantly, we can exploit these signatures for antiviral drug discovery," he adds.

The investigators then used a computational approach to identify potentially therapeutic drugs. They searched databases containing gene expression profiles of cultured human cells that had been treated with different drugs, in order to find those that were the reverse of expression profiles induced by the H7N9 flu virus, and noting the drugs that accomplished this, says Morrison. These drugs could potentially dampen the harmful host response, she says.

"Six of these drugs are FDA approved and could potentially be repurposed as H7N9 influenza therapeutics," says Morrison. "I believe that computational biology represents an exciting new way to study viruses and to discover drugs to fight them," says Morrison. A
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Epigenetic signatures direct the repair potential of reprogrammed cells
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Interventional radiology: Potential breakthrough to treat mens enlarged prostate
4. Researchers report potential for a moderate New England red tide in 2012
5. Gallbladder shown as potential stem cell source for regenerative liver and metabolic disease
6. Researchers find potential dark side to diets high in beta-carotene
7. Beehive extract shows potential as prostate cancer treatment
8. Gene therapy for hearing loss: Potential and limitations
9. Folic acid food enrichment potentially protective against childhood cancers
10. Nuisance seaweed found to produce compounds with biomedical potential
11. Potential new approach to regenerating skeletal muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/29/2014)... A new study on a large cohort of kidney ... architecture of the disease -- and reveals an apparent ... kidney cancer, particularly in Romania. , The research, by ... University and Genome Quebec Innovation Centre in Montreal, underscores ... aristolochic acid. The compound, found in plants of the ...
(Date:10/28/2014)... North America, Europe and China have published a paper ... Sciences that reveals important details about key transitions ... From strange and exotic algae, mosses, ferns, trees and ... and vegetables we eat and the ornamental plants adorning ... a billion years of history., "Our study generated DNA ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3
... Two nurses have won recognition as emerging leaders in ... for Nursing Informatics (ANI) to participate in a jointly ... based on a number of criteria, including a mid-level ... current license to practice as a registered nurse, and ...
... An orchid researcher based on the island of Reunion in ... Botanic Gardens, Kew (RBG Kew) has used motion sensitive night ... functioning as a pollinator of flowering plants. Not only is ... a member of the Orthoptera order of insects who ...
... STATION - Mango. If you know little about this fruit, ... colon and breast cancer cells in the lab. ... food scientists, who examined the five varieties most common in ... Though the mango is an ancient fruit heavily consumed in ...
Cached Biology News:2 nurses emerge as leaders in informatics 2First known instance of a cricket as an orchid pollinator captured on film by Kew scientist 2Mango effective in preventing, stopping certain colon, breast cancer cells 2
(Date:10/31/2014)... Jeffrey T. Manuel, assistant professor in Southern Illinois ... of Arts and Sciences, is teaming up with the ... fuels in Illinois. , “Farmers, researchers, business ... build Illinois’ biofuels industry for decades,” Manuel said. “This ... agricultural and business history. , “Fuel alcohol has ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market ... Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, Convenience ... to 2018," defines and segments the dairy alternative ... revenue and volume for plant-based dairy alternative beverages. ... $14 Billion by 2018 with the Asia-Pacific region ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... 30, 2014 The report “Fragrance Ingredients ... Application (Cosmetics & Toiletries, and Soaps & Detergents) & ... has defined and segmented the Fragrance Ingredients Market with ... terms of value. The market has been segmented on ... Europe, Asia-Pacific, Latin America, and Rest of the World ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5
... 1, 2012   Reportlinker.com announces that a ... its catalogue: Cell ... http://www.reportlinker.com/p0203537/Cell-Therapy---Technologies-Markets-and-Companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy This ... and methods, which have already started to ...
... Force Research Laboratory in Dayton, Ohio, has experimentally confirmed ... foretold a pair of interesting properties about nanotube growth: ... of its growth, and that armchair nanotubes should grow ... toward defining all the mysteries inherent in what Yakobson ...
... , Graphene leaves a rather modest impression at a ... ordered in a mono-layered "carpet". Yet, what makes graphene ... This property is particularly useful in the development of ... and transform it into electrical signals. Graphene,s ...
Cached Biology Technology:Cell Therapy - Technologies, Markets and Companies 2Cell Therapy - Technologies, Markets and Companies 3Cell Therapy - Technologies, Markets and Companies 4Cell Therapy - Technologies, Markets and Companies 5Cell Therapy - Technologies, Markets and Companies 6Cell Therapy - Technologies, Markets and Companies 7Cell Therapy - Technologies, Markets and Companies 8Cell Therapy - Technologies, Markets and Companies 9Cell Therapy - Technologies, Markets and Companies 10Cell Therapy - Technologies, Markets and Companies 11Cell Therapy - Technologies, Markets and Companies 12Cell Therapy - Technologies, Markets and Companies 13Cell Therapy - Technologies, Markets and Companies 14Cell Therapy - Technologies, Markets and Companies 15Cell Therapy - Technologies, Markets and Companies 16Rice professor's nanotube theory confirmed 2Rice professor's nanotube theory confirmed 3Ultra-fast photodetector and terahertz generator 2
...
Fetal Calf Serum Replacement (Bistec) serum...
NEWBORN CALF SERUM AND PLASMA...
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Biology Products: