Navigation Links
Plasticity of hormonal response permits rapid gene expression reprogramming
Date:5/15/2011

Gene expression is the process of converting the genetic information encoded in DNA into a final gene product such as a protein or any of several types of RNA. Scientists have long thought that the gene programs regulated by different physiological processes throughout the body are robustly pre-determined and relatively fixed for every specialized cell. But a new study by researchers from the University of California, San Diego School of Medicine reveals the unsuspected plasticity of some of these gene expression programs.

Their findings, to be published in the May 15 advanced on-line edition of journal Nature, show the existence of distinct regulated gene programs that can be alternatively induced, depending on the intracellular conditions. The study helps explain why, for example, the same signaling event such as cellular response to circulating hormones in the human body can be beneficial for normal development, but also becomes cancerous when combined with other genetic lesions.

The UCSD scientists found that the response to the hormone androgen in prostatic epithelial cells can be subject to dramatic reprogramming events that lead to alternative gene programs and profiles. They suggest that this plasticity could be the basis for development and progression of at least some forms of cancer, as well as for cell differentiation during development.

From a patient perspective, the results of this study may explain how hormonal therapy, applied to prostate cancer patients to block the pre-established, hormone-regulated tumor growth, escapes this treatment in a more malignant way.

"Aggressive cell types, such as those found in prostate cancer, basically learn to ignore the hormone therapy," said co-principal investigator Xiang-Dong Fu, PhD, professor in the UCSD Department of Cellular and Molecular Medicine, who collaborated with co-principal investigator Michael G. Rosenfeld, MD, professor in the UCSD Department of
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Astrocytes and synaptic plasticity
2. Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
3. Ritalin boosts learning by increasing brain plasticity
4. New period of brain plasticity created with transplanted embryonic cells
5. Plasticity of plants helps them adapt to climate change
6. Breast cancer cells recycle to escape death by hormonal therapy
7. Major NSF grant boosts UNH research on hormonal genomics
8. The pill for him: Scientists find a hormonal on-and-off switch for male fertility
9. Soy germ-based supplement SE5-OH containing natural S-Equol examined for safety, hormonal influence
10. Hormonal contraceptives associated with higher risk of female sexual dysfunction
11. U of A researcher questions whether genius might be a result of hormonal influences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
(Date:11/12/2014)... PALM BEACH GARDENS, Fla. , Nov. 12, 2014 ... management solutions, announced today that its U.are.U ® ... upscale retail bakery chain in Central Mexico ... solution in June 2014 to eliminate payroll issues caused ... Prior to installing the U.are.U fingerprint readers, Montparnasse ...
(Date:11/7/2014)... BURBANK, Calif. , Nov. 7, 2014  In conjunction ... Burbank Police Departments, The Community Foundation of the ... BURBANK DNA JUSTICE PROJECT," a $250,000 initiative to ... successful initial phase. In its first six months of existence, ... desperately needed evidence support for local law enforcement. ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... highly toxic fumigant pesticide which is injected into soil to ... a post-harvest decontaminant of products and storage areas. Although ... weeds, insects and rodents, it depletes the ozone layer and ... forms part of the 20th anniversary of the Montreal Protocol ...
... New Brunswick, NJ The National Science Foundation has ... million to support outreach beyond the borders of the ... by the new NSF funding build upon the Waksman ... than 1,500 high school students and 72 teachers from ...
... often critical to how successful treatment can be. Therefore, ... research field, where every small step is of great importance. ... & Cellular Proteomics, Uppsala University researchers describe a technique that ... the bodys cells and tissues, and our knowledge of the ...
Cached Biology News:CABI helps phase out dangerous pesticide in EU 2Rutgers' high school outreach gets $3 million boost from NSF 2
(Date:11/24/2014)... November 24, 2014 Five American ... Rashid Al Maktoum Awards for Medical Sciences", in its ... United Arab Emirates , on 15 December 2014. ... The Carter Center which won the Hamdan ... involved in numerous programs that aim to improve health ...
(Date:11/24/2014)... , Nov. 24, 2014   Veracyte, Inc. (Nasdaq: ... Anderson , president and chief executive officer, will present in ... Annual Healthcare Conference on Tuesday, December 2, 2014 at ... The live audio webcast and subsequent replay may ... Please connect to the website at least 15 minutes prior ...
(Date:11/24/2014)... Massachusetts (PRWEB) November 24, 2014 ... Panels ” from METTLER TOLEDO demonstrates how to ... , Power analytics and sample panel design can ... cycle chemistry and protect against corrosion and deposition. ... up a significant amount of panel space. Additionally, ...
(Date:11/22/2014)... 2014 Two new educational webinars hosted by ... for ALS research and how the pharmaceutical industry can make ... Bucket Challenge: Where Does the ALS Money Go? , Featuring ... 2014, Time: 1:30pm ET, Register to attend , ... Merit Cudkowicz, Julianne Dorn Professor of Neurology at Massachusetts General ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2
... ... 5th Annual Conference set for October 11-13, 2010 in Denver, CO , ... Portland, Maine (PRWEB) June 3, ... market leading event where new technologies, trends, developments in applications, new guidelines and waste ...
... Continuing ... of Five Attendees Plan to Return for Next Edition of www.CardioCareLive.com December 7-8 ... Boston, MA (PRWEB) June ... University School of Medicine and produced by PlatformQ , today announced that its May ...
... Reportlinker.com announces that a new market research report is available in its catalogue: , ... Biomarkers - technologies, markets and companies , , ... , , ... This report follows the broad definition of a biomarker as a ...
Cached Biology Technology:'Biopolymers Symposium 2010' Agenda Announced 2CardioCareLive, the Largest Online Cardiology Conference, Attracts 2,300 Attendees and Enjoys 92% Recommendation Rate 2CardioCareLive, the Largest Online Cardiology Conference, Attracts 2,300 Attendees and Enjoys 92% Recommendation Rate 3CardioCareLive, the Largest Online Cardiology Conference, Attracts 2,300 Attendees and Enjoys 92% Recommendation Rate 4CardioCareLive, the Largest Online Cardiology Conference, Attracts 2,300 Attendees and Enjoys 92% Recommendation Rate 5Reportlinker Adds Biomarkers - Technologies, Markets and Companies 2Reportlinker Adds Biomarkers - Technologies, Markets and Companies 3Reportlinker Adds Biomarkers - Technologies, Markets and Companies 4Reportlinker Adds Biomarkers - Technologies, Markets and Companies 5Reportlinker Adds Biomarkers - Technologies, Markets and Companies 6Reportlinker Adds Biomarkers - Technologies, Markets and Companies 7Reportlinker Adds Biomarkers - Technologies, Markets and Companies 8Reportlinker Adds Biomarkers - Technologies, Markets and Companies 9Reportlinker Adds Biomarkers - Technologies, Markets and Companies 10Reportlinker Adds Biomarkers - Technologies, Markets and Companies 11Reportlinker Adds Biomarkers - Technologies, Markets and Companies 12Reportlinker Adds Biomarkers - Technologies, Markets and Companies 13Reportlinker Adds Biomarkers - Technologies, Markets and Companies 14Reportlinker Adds Biomarkers - Technologies, Markets and Companies 15Reportlinker Adds Biomarkers - Technologies, Markets and Companies 16Reportlinker Adds Biomarkers - Technologies, Markets and Companies 17Reportlinker Adds Biomarkers - Technologies, Markets and Companies 18Reportlinker Adds Biomarkers - Technologies, Markets and Companies 19Reportlinker Adds Biomarkers - Technologies, Markets and Companies 20Reportlinker Adds Biomarkers - Technologies, Markets and Companies 21Reportlinker Adds Biomarkers - Technologies, Markets and Companies 22Reportlinker Adds Biomarkers - Technologies, Markets and Companies 23Reportlinker Adds Biomarkers - Technologies, Markets and Companies 24Reportlinker Adds Biomarkers - Technologies, Markets and Companies 25
Preparation TW--Compatibility: no end cap seals -Hybridization Tube for Hybrigene -Comp Dim: 240 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-15...
... Biometra TProfessional Thermocycler combines top performance with ... achieves high speed and unparalleled temperature uniformity. ... providing programming in a spreadsheet or alternatively ... Smart Lid opens on the push of ...
...
... provide a rapid and simple method for recovering ... 10 kb) from stained agarose gels or EtBr ... an agarose gel and loaded into the spin ... are a series of membranes and filters that ...
Biology Products: