Navigation Links
Pitt treats gum disease by bringing needed immune cells to inflamed tissue
Date:11/1/2013

d of bacteria sets up the immune system to stay on red alert, causing harm to the oral tissues while it attempts to eradicate germs.

"There is a lot of evidence now that shows these diseased tissues are deficient in a subset of immune cells called regulatory T-cells, which tells attacking immune cells to stand down, stopping the inflammatory response," Dr. Little said. "We wanted to see what would happen if we brought these regulatory T-cells back to the gums."

To do so, the researchers developed a system of polymer microspheres to slowly release a chemokine, or signaling protein, called CCL22 that attracts regulatory T-cells, and placed tiny amounts of the paste-like agent between the gums and teeth of animals with periodontal disease. The team found that even though the amount of bacteria was unchanged, the treatment led to improvements of standard measures of periodontal disease, including decreased pocket depth and gum bleeding, reflecting a reduction in inflammation as a result of increased numbers of regulatory T-cells. MicroCT-scanning showed lower rates of bone loss.

"Mummified remains from ancient Egypt show evidence of teeth scraping to remove plaque," Dr. Little noted. "The tools are better and people are better trained now, but we've been doing much the same thing for hundreds of years. Now, this homing beacon for Treg cells, combined with professional cleaning, could give us a new way of preventing the serious consequences of periodontal disease by correcting the immune imbalance that underlies the condition."

Next steps include developing the immune modulation strategy for human trials. In addition to Drs. Sfeir and Little, the research team included Ph.D. candidate Andrew J. Glowacki,, Sayuri Yoshizawa, D.D.S., Ph.D., Siddharth Jhunjhunwala, Ph.D., all of the University of Pittsburgh; and Andreia E Vieira, Ph.D., and Gustavo P. Garlet, D.D.S., Ph.D., of Sao Paulo University, Brazil.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-720-2058
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Icy therapy spot treats cancer in the lung
2. Pressure cooker on steroids treats human waste
3. Largest therapy trial worldwide: Psychotherapy treats anorexia effectively
4. Moderate exercise not only treats, but prevents depression
5. Parkinsons disease stopped in animal model
6. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Common North American frog identified as carrier of deadly amphibian disease
9. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
10. Genetic research develops tools for studying diseases, improving regenerative treatment
11. Researchers discover novel therapy for Crohns disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Showcase, Hall E -   EyeLock Inc. , a market ... showcase its EyeLock ID technology integrated in a 3D printed ... Oak Ridge National Laboratory (ORNL) at the 2015 ... technology is being used to validate the driver and authorize ...
(Date:1/22/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a ... the recent success of the Wocket™ smart wallet at CES 2015 in ... was named as one of the "11 Hot Products at CES" in ... At CES So Far" by Newseveryday.com and "The top 10 gadgets from ...
(Date:1/22/2015)... , Europe,s most prestigious ... Office to present a video retrospective of the most exciting and ... Christofer Toumazou and Sophie Wilson   A ... Award   Starting on 22 January 2015 on   http://www.epo.org/european-inventor ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... PARIS, Oct. 7 Cellectis (Alternext: ALCLS), the French ... head of the Meganuclease Recombination System group at Cellectis ... th Annual Congress of the European Society of ... Milano, Italy, on October 22-25, 2010. Targeted ...
... a hormone acting like molecular glue could hold a key ... with environmental stress. The study, which is featured in ... the plant hormone jasmonate binds two proteins together an ... study also identifies the receptor,s crystal structure to provide the ...
... Rochelle, NY, October 6, 2010The introduction of a new, ... to help standardize gene therapy protocols in research applications ... in Human Gene Therapy , a peer-reviewed journal ... The article, which is published online ahead of print, ...
Cached Biology News:Cellectis to Present at the Annual Congress of the European Society of Gene & Cell Therapy 2Hormone acting as 'molecular glue' could boost plant immune systems 2Novel reference material to standardize gene therapy applications 2
(Date:1/22/2015)... , Nueva Jersey , 22 de enero ... for Biomedical Research abre hoy su llamada a nominaciones ... cuya investigación científica ha hecho, o tiene el potencial ... salud humana. Las nominaciones se aceptarán hasta el 15 ...
(Date:1/22/2015)... Mass. , Jan. 22, 2015   GenoSpace , a ... of tools to enable the broad use of genomic, imaging ... announced the appointment of Michelle Munson , CEO of ... director. Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/24/2014)... 24, 2014  United Therapeutics Corporation (NASDAQ: UTHR ... MDT ) has submitted a pre-market approval application to ... use of Medtronic,s SynchroMed ® II implantable drug ... with United Therapeutics, Remodulin ® (treprostinil) Injection delivered ...
(Date:12/24/2014)... BioLife Solutions , Inc. (NASDAQ: BLFS ), a ... hypothermic storage and cryopreservation freeze media and ... ("BioLife" or the "Company"), today announced that it will hold ... (the "Annual Meeting"). Because the expected date for ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... In connection with its proposed acquisition of London based, ... 5 2009, Inverness Medical Innovations, Inc. (NYSE: IMA ... remind Inverness shareholders through this announcement of their dealing disclosure ... , Dealing disclosure requirements of the UK Takeover ...
... Call Tuesday, August 4, 2009, 5:00 p.m. U.S. EDT ... ) has scheduled its regular quarterly earnings conference call covering second quarter 2009 results ... August 4, 2009 Schedule , , 4:10 p.m. ... 4:50 p.m. EDT To participate in the conference call, dial 913-312-0379, ...
... , LAKE FOREST, Ill., June 30 Hospira, Inc. ... and medication delivery company, today announced agreements with MedAssets ... a renewal of its agreement for infusion devices. The ... 2009, for I.V. solutions and equipment, and July 1, ...
Cached Biology Technology:Inverness Medical Innovations - Concateno plc, Further Announcement Regarding UK Takeover Code Share Dealing Disclosure Requirements. 2Hospira Announces New Contract With MedAssets for Intravenous Solutions, Renewal of Infusion Devices Agreement 2
...
Mouse Iduronate 2-Sulfatase Affinity Purified Polyclonal Ab Keywords: Sulfatases, Iduronate 2-Sulfatase, Mucopolysaccharidosis, Hunter Syndrome, Glycobiology Protein Family: Proteoglycan Regu...
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Complete kit for all types of yeast two-hybrid ... Choice of two bait ... baits , Triple ... Complete set of ...
Biology Products: