Navigation Links
Pitt treats gum disease by bringing needed immune cells to inflamed tissue
Date:11/1/2013

PITTSBURGH, Nov. 1, 2013 The red, swollen and painful gums and bone destruction of periodontal disease could be effectively treated by beckoning the right kind of immune system cells to the inflamed tissues, according to a new animal study conducted by researchers at the University of Pittsburgh. Their findings, published this week in the early online version of the Proceedings of the National Academy of Sciences, offer a new therapeutic paradigm for a condition that afflicts 78 million people in the U.S. alone.

Periodontal disease currently is treated by keeping oral bacteria in check with daily brushing and flossing as well as regular professional deep cleaning with scaling and root planing, which remove tartar above and below the gum line. In some hard-to-treat cases, antibiotics are given. These strategies of mechanical tartar removal and antimicrobial delivery aim to reduce the amount of oral bacteria on the tooth surface, explained co-author and co-investigator Charles Sfeir, D.D.S., Ph.D., director, Center for Craniofacial Regeneration and associate professor, Departments of Periodontics and Oral Biology, Pitt's School of Dental Medicine.

"Currently, we try to control the build-up of bacteria so it doesn't trigger severe inflammation, which could eventually damage the bone and tissue that hold the teeth in place," Dr. Sfeir said. "But that strategy doesn't address the real cause of the problem, which is an overreaction of the immune system that causes a needlessly aggressive response to the presence of oral bacteria. There is a real need to design new approaches to treat periodontal disease."

In the healthy mouth, a balance exists between bacteria and the immune system response to forestall infection without generating inflammation, said senior author Steven Little, Ph.D., associate professor and chair of the Department of Chemical and Petroleum Engineering, Pitt's Swanson School of Engineering. But in many people, a chronic overloa
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-720-2058
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Icy therapy spot treats cancer in the lung
2. Pressure cooker on steroids treats human waste
3. Largest therapy trial worldwide: Psychotherapy treats anorexia effectively
4. Moderate exercise not only treats, but prevents depression
5. Parkinsons disease stopped in animal model
6. Disease-carrying colonizers on the move: Predicting the spread of ticks across Canada
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Common North American frog identified as carrier of deadly amphibian disease
9. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
10. Genetic research develops tools for studying diseases, improving regenerative treatment
11. Researchers discover novel therapy for Crohns disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... MILFORD, Mass. , Sept. 30, 2014 ... process control solutions for the biotech and ... of its new RECONN Bioprocess Manager, an ... reporting solution geared towards bioprocess development laboratories. ... facilities have disparate bioreactor and analyzer systems. ...
(Date:9/29/2014)... A new study confirms that the exposure to tar ... than of regular cigarettes. Similarly, exposure to nicotine ... increasingly popular type of cigarette in several countries around ... of certain toxic chemicals in the smoke of these ... because lower levels of chemicals in the smoke are ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2
... Hall of Fame quarterback Dan Marino and VitaCore Health ... specific nutritional supplements based on authentic sciences. Marino joined ... develop health products that will strongly impact how consumers ... specifically in terms of their joints, heart, wellbeing, endurance, ...
... The stories they could tell, these fishes that once swam ... In the 1960s and ,70s, Richard Rosenblatt, a marine ... on field expeditions to remote places to study the fishes ... waters, Rosenblatt and other scientists retrieved hundreds of specimens of ...
... (BRONX, NY) Scientists at Albert Einstein ... a desktop genome analyzer and browser that allows biologists ... data. The open-source software, called GenPlay, is described in ... genomic data is analyzed mainly by information specialists rather ...
Cached Biology News:Dan Marino Teams up with VitaCore Health Products 2Dan Marino Teams up with VitaCore Health Products 3'Library of Fishes' to feature thousands of specimens from remote locations 2'Library of Fishes' to feature thousands of specimens from remote locations 3Einstein offers easy-to-use genome analyzer to scientific community 2
(Date:10/1/2014)... Oct. 1, 2014  Discovery Laboratories, Inc. (Nasdaq: ... awarded a Phase II Small Business Innovation Research ... from the National Institute of Allergy and Infectious ... (NIH) to support the development of the Company,s ... countermeasure to mitigate acute and chronic/late-phase radiation-induced lung ...
(Date:10/1/2014)... , Oct. 1, 2014  Spherix Incorporated (Nasdaq: ... fostering and monetization of intellectual property, announced today ... VTech and Uniden in the U.S. District Court ... has been rescheduled for November 10, ... 2, 2014.  The Court Order setting the Markman ...
(Date:10/1/2014)... (PRWEB) September 30, 2014 The participants ... designs, but to spending their own time adjusting, tweaking ... their complex designs were ready for judging. , “I ... design firm thought leader. “The entries showed a ... the physical characteristics of the print medium and the ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
Breaking Biology Technology:Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Array Architects Challenges Staff to Create with 3D Printer 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3
... , , WASHINGTON , Jan. 27 ... which are increasingly used for research and therapeutic interventions, but extracting ... have found evidence that fat tissue, known as adipose tissue, may ... called hematopoietic stem and progenitor cells (HSPCs), according to a ...
... , , , , , , ... Biologic,Products, Inc. (Nasdaq: CBPO ) ("China Biologic," or the "Company"), ... responded to,allegations regarding the Company, certain members of its Board of ... online,financial websites. , The article, which was ...
... Obtain Stem Cells From Embryos , WHITE PLAINS, N.Y. ... reprogrammed adult cells into embryonic-like stem cells has been chosen to receive ... Shinya Yamanaka , MD, PhD, of the Gladstone Institute of Cardiovascular Disease, ... will be honored with the 2010 March of Dimes Prize for his ...
Cached Biology Technology:Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 2Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 3Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 4China Biologic Products Responds to Allegations on Financial Websites 2China Biologic Products Responds to Allegations on Financial Websites 3China Biologic Products Responds to Allegations on Financial Websites 4China Biologic Products Responds to Allegations on Financial Websites 5March of Dimes Awards $250,000 Prize to Scientist Who Discovered How to Reprogram Human Cells 2
For microscopy...
... that enables fully automated hybridization of microarrays ... has been designed to offer researchers improved ... to perform a wide range of applications. ... range 485C; denaturations of up to 99C. ...
... microarray slide processing offering reproducibility, reliability ... to miniaturization, automation and massive parallel ... tool with many applications in both ... range from gene expression profiling, gene ...
... The user-friendly Eppendorf Thermomixer R offers ... that require shaking, heating, and cooling. ... expanded its application and temperature control ... each accommodate 24 micro test tubes, ...
Biology Products: