Navigation Links
Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
Date:10/13/2010

PITTSBURGH, Oct. 13 A team led by a scientist at the University of Pittsburgh School of Medicine has discovered a regulatory protein that influences where genetic material gets swapped between maternal and paternal chromosomes during the process of creating eggs and sperm. The findings, which shed light on the roots of chromosomal errors and gene diversity, appear in tomorrow's issue of Nature.

Most cells contain 46 chromosomes, half coming from each parent. But eggs and sperm, known as germ cells, have half as many so that when they combine to form an embryo, the correct chromosome number is maintained, explained senior author Judith Yanowitz, Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences, Pitt School of Medicine, a member of the Magee-Womens Research Institute, and former staff associate at the Carnegie Institution of Washington, Baltimore.

"When germ cells form, segments of DNA are exchanged, or recombined, between maternal and paternal chromosomes, leading to greater diversity in the daughter cells," she said. "Our research reveals a protein that plays a key role in choosing where those crossovers occur."

Crossing over is essential for the correct movement, or segregation, of chromosomes into the germ cells. Failure to exchange DNA properly can lead to offspring with the wrong number of chromosomes and, in humans, defects in this process are a leading cause of infertility, Dr. Yanowitz noted.

Despite the importance of this process for development, little is known about the factors that influence where crossovers occur and how they are regulated. In the genome of the tiny round worm C. elegans that the researchers studied, gene recombination typically occurs toward the ends of the chromosomes, which contains fewer genes.

But the "crossover landscape," as Dr. Yanowitz calls it, changed in two ways in worms that had a mutation in a protein called X non-disjunction factor (x
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study finds monarch butterflies use medicinal plants to treat offspring for disease
2. UCLA-led research team finds that bacteria can stand up and walk
3. Long-extinct passenger pigeon finds a place in the family tree
4. Montana State team finds rare oasis of life on floor of Yellowstone Lake
5. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
6. National study finds strong link between diabetes and air pollution
7. Study finds language barriers may play role in health care disparities
8. First study of its kind finds children with food allergies are often victims of bullying
9. UM School of Medicine Center for Celiac Research finds rate of celiac disease is growing
10. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
11. Study finds possible persistence switch for tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... , Oct. 20, 2014  Leading identity analyst ... time half of the world,s population will have a ... Europe . Asia ... the market accounting for more than 60% of all ... Acuity,s report  -- "The Global National eID ...
(Date:10/19/2014)... access in India over the last 30 years ... emissions growth during that time, according to a ... Climate Change ., "Energy access is fundamental to ... life, including education, communication, and health," says IIASA ... While increased energy access is widely agreed to ...
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Improved electricity access has little impact on climate change 2Whole-exome sequencing shows potential as diagnostic tool 2
... new study of the wandering albatross one of the largest ... are breeding earlier in the season compared with 30 years ago. ... Oikos , a British team of scientists describe how they studied ... of South Georgia. They have discovered that because some birds are ...
... BOSTON -- One of the biggest health problems facing children ... causing obesity and how the U.S. can tackle this problem ... Academic Societies (PAS) annual meeting in Boston. The symposium, ... and How Do We Get Out?" will take place on Monday, ...
... traditional rectangular patchwork of fields in this time series animation ... panhandle near the town of Dalhart, this transformation is due ... to fields. It was invented by farmer Frank Zybach in ... center of the field through a long pipe that rotates ...
Cached Biology News:Antarctic albatross displays shift in breeding habits 2What is really causing the child obesity epidemic? 2NASA's Landsat satellites see Texas crop circles 2
(Date:10/20/2014)... Convey Computer , the leader in ... State University won first place in the 2014 ... the team’s solution achieved the highest overall performance in ... place finisher. , Experts from all segments of the ... challenge, using a variety of design tools, hardware and ...
(Date:10/20/2014)... -- PureTech , a science and technology ... announced today the closing of a $55 million ... Perpetual, a $120 Billion group of funds. The ... pipeline forward and to advance new healthcare related ... to really go for the big ideas that ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, ... Geography Trend and Forecast (2011 - 2016)," analyzes ... and studies the major market drivers, restraints, and opportunities ... Asia. , The global chocolate market is expected to ... 2016 at an estimated CAGR of 2.7% from 2011 ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... How fast an intense laser pulse can change the ... Kiel University in the current edition of Nature ... Bauer, Dr. Kai Ronagel and Professor Lutz Kipp from ... colleagues from the University of Kaiserslautern and the University ...
... CHAMPAIGN, Ill. Technophiles who have been dreaming of ... may soon find their wish has been granted. ... ultra-low-power digital memory that is faster and uses 100 ... could give future portable devices much longer battery life ...
... 10, 2011 Dyadic International, Inc. (OTC Pink: DYAI), ... the year ended December 31, 2010. The financial information ... conjunction with the financial statements, footnotes and independent auditors, ... website at www.otcmarkets.com and on Dyadic,s website ...
Cached Biology Technology:New technology would dramatically extend battery life for mobile devices 2New technology would dramatically extend battery life for mobile devices 3Dyadic International Reports 2010 Fiscal Year Financial Results 2Dyadic International Reports 2010 Fiscal Year Financial Results 3Dyadic International Reports 2010 Fiscal Year Financial Results 4Dyadic International Reports 2010 Fiscal Year Financial Results 5Dyadic International Reports 2010 Fiscal Year Financial Results 6
... JNK (c-Jun NH2-terminal kinase) signal transduction ... MAP kinase pathways in mammals. JNK ... environmental stress, is associated with the ... is implicated in the immune response, ...
... knockdown of all human, mouse, and ... Genomewide, predesigned siRNAs for a ... , Ready-to-use, convenient matching solutions for ... Cost-effective RNAi and downstream analysis ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... Genetic Analysis System, which processes two 96-well plates ... adds a higher level of throughput to the ... of Beckman Coulters new GenomeLab family of products*, ... Biomek series liquid handers, for increased automation. ...
Biology Products: