Navigation Links
Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
Date:10/13/2010

PITTSBURGH, Oct. 13 A team led by a scientist at the University of Pittsburgh School of Medicine has discovered a regulatory protein that influences where genetic material gets swapped between maternal and paternal chromosomes during the process of creating eggs and sperm. The findings, which shed light on the roots of chromosomal errors and gene diversity, appear in tomorrow's issue of Nature.

Most cells contain 46 chromosomes, half coming from each parent. But eggs and sperm, known as germ cells, have half as many so that when they combine to form an embryo, the correct chromosome number is maintained, explained senior author Judith Yanowitz, Ph.D., assistant professor of obstetrics, gynecology and reproductive sciences, Pitt School of Medicine, a member of the Magee-Womens Research Institute, and former staff associate at the Carnegie Institution of Washington, Baltimore.

"When germ cells form, segments of DNA are exchanged, or recombined, between maternal and paternal chromosomes, leading to greater diversity in the daughter cells," she said. "Our research reveals a protein that plays a key role in choosing where those crossovers occur."

Crossing over is essential for the correct movement, or segregation, of chromosomes into the germ cells. Failure to exchange DNA properly can lead to offspring with the wrong number of chromosomes and, in humans, defects in this process are a leading cause of infertility, Dr. Yanowitz noted.

Despite the importance of this process for development, little is known about the factors that influence where crossovers occur and how they are regulated. In the genome of the tiny round worm C. elegans that the researchers studied, gene recombination typically occurs toward the ends of the chromosomes, which contains fewer genes.

But the "crossover landscape," as Dr. Yanowitz calls it, changed in two ways in worms that had a mutation in a protein called X non-disjunction factor (x
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study finds monarch butterflies use medicinal plants to treat offspring for disease
2. UCLA-led research team finds that bacteria can stand up and walk
3. Long-extinct passenger pigeon finds a place in the family tree
4. Montana State team finds rare oasis of life on floor of Yellowstone Lake
5. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
6. National study finds strong link between diabetes and air pollution
7. Study finds language barriers may play role in health care disparities
8. First study of its kind finds children with food allergies are often victims of bullying
9. UM School of Medicine Center for Celiac Research finds rate of celiac disease is growing
10. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
11. Study finds possible persistence switch for tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015 Research and Markets ( ... "Global Biometrics Market (2014-2020): Market Forecast By ... report to their offering. , ... is anticipated to overtake North ... government spending towards IT security, government biometric based ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
(Date:1/22/2015)... 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), the ... campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz will ... capacity to meet customer demand. Logo ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by Dr. ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2
... PASADENA, Calif.The frontal lobes are the largest part of ... that expanded most during human evolution. Damage to the ... eyescan result in profound impairments in higher-level reasoning and ... parts of the frontal lobes do, neuroscientists at the ...
... London and the University of Exeter Medical School has identified ... responsible for controlling eye muscles, resulting in movement disorders such ... could provide the key to reversing the condition and unlocking ... body. The research is published in Proceedings of ...
... Life in the world,s oceans faces far greater change and ... human history, a team of the world,s leading marine scientists ... Germany, Panama, Norway and the UK have compared events which ... what is observed to be taking place in the seas ...
Cached Biology News:Thinking and choosing in the brain 2Thinking and choosing in the brain 3Research identifies mechanism responsible for eye movement disorder 2Research identifies mechanism responsible for eye movement disorder 3Sea life 'facing major shock' 2Sea life 'facing major shock' 3
(Date:3/3/2015)... 3, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... are for odour control projects in North America ... Asia . "Bidding activity in 2015 continues to ... "After a high volume year for bidding in 2014, we are ... The recent orders reflect the organization,s renewed focus on select market ...
(Date:3/3/2015)... , March 3, 2015 Adaptive Biotechnologies ... CFO, is joining its Board of Director as Chair ... officer at Zillow Group, Chad oversees all finance, treasury ... built the company,s core finance, treasury and accounting functions, ... and nine acquisitions. In 2013, he was named Puget ...
(Date:3/3/2015)... March 3, 2015 Fried, Frank, Harris, Shriver ... Lewis has joined the Firm as a partner ... New York office. Mr. Lewis ... as well as other intellectual property and general litigation. ... Lewis represents both plaintiffs and defendants in a range ...
(Date:3/3/2015)... N.J. , March 3, 2015  Thingee Corporation, ... will be delivering a presentation entitled, "Technology Adoption: Making ... Thriving through Innovations and Technology ,  in ... March 11 to 13, 2015. Audiences looking to learn ... effectively will want to be in the audience for ...
Breaking Biology Technology:Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3Thingee to present at 11th Annual Synergistix Users Conference 2
... BOSTON, Jan. 10, 2011 Entrega, Inc., a ... announced its formation by Enlight Biosciences, a Boston-based ... leading global pharmaceutical companies. As part of its ... spatially-directed proprietary drug delivery platform to create orally ...
... win. The professor of biotechnology at Delft University of ... in Rice University,s Matteo Pasquali. Together with ... (CNRS), the University of Bordeaux, France, and Vrije University, ... a long-standing controversy in the field of polymer dynamics: ...
... The Pittsburgh Life Sciences Greenhouse (PLSG), the organization ... growth programs to the region,s life sciences enterprises, issued ... John W. Manzetti announcing the first close of the ... Fund) at $5 million. The Accelerator Fund ...
Cached Biology Technology:New Oral Biologics Delivery Company, Entrega, Announces Strategic Partnership with Pharma 2New Oral Biologics Delivery Company, Entrega, Announces Strategic Partnership with Pharma 3Bendy tubes get around 2Bendy tubes get around 3Pittsburgh Life Sciences Greenhouse Announces the First Close of the PLSG Accelerator Fund LLC at $5 Million 2
PGC-1 (H-300)...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Anti-human CD48/BLAST-1, clone MEM102, Monoclonal Antibody...
Affinity Purified Anti-Human NP-1...
Biology Products: